BEGIN:VCALENDAR METHOD:PUBLISH PRODID:-//Apple Inc.//iCal 3.0//EN CALSCALE:GREGORIAN X-WR-CALNAME:CHEMISTRY X-WR-RELCALID:128F0571-7B4A-461C-8104-FD3EFDB45271 VERSION:2.0 X-WR-TIMEZONE:US/Eastern BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:20070311T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU TZNAME:EDT END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:20071104T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU TZNAME:EST END:STANDARD END:VTIMEZONE BEGIN:VTIMEZONE TZID:US/Eastern BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:19551030T020000 RRULE:FREQ=YEARLY;UNTIL=20061029T060000Z;BYMONTH=10;BYDAY=-1SU TZNAME:EST END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:19870405T020000 RRULE:FREQ=YEARLY;UNTIL=20060402T070000Z;BYMONTH=4;BYDAY=1SU TZNAME:EDT END:DAYLIGHT BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 DTSTART:20070311T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU TZNAME:EDT END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 DTSTART:20071104T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU TZNAME:EST END:STANDARD END:VTIMEZONE BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:ABSTRACT: The primary treatment for chronic pain remains the opioid analgesic morphine. Morphine effectively treats pain\, but has l imitations due to undesired effects. The aim of the current research is the development of analogs of morphine to which tolerance does not devel op\, thereby eliminating the need for dose escalation. Synthetic studies towards such compounds will be presented. UID:E02681B0-DA89-452B-B29B-F62BA08B7663-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071127T110000 DTSTAMP:20071119T185204Z SUMMARY:Organic Seminar: Andrew Coop\, University of Maryland\, School o f Pharmacy. 11:00 - 12:30\, GC 351. \"Synthetic Studies Towards Opioid A nalgesics Lacking Tolerance.\" Host: Jason Sello. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071127T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:8FDD8672-716E-11D9-8919-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050317T150000 DTSTAMP:20050309T162201Z SUMMARY:Physical Tea Session: Veronica Vaida\, University of Colorado. 3:00 - 4:15\, GC 351. \"Photochemistry by Visible Solar Radiation.\" Hos t: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050317T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:D33AA018-CF88-431C-A0AD-8F25B0C63E3C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071018T150000 DTSTAMP:20071012T184520Z SUMMARY:Physical Tea Session: Steven L. Bernasek\, Princeton University. 3:00 - 4:15\, GC 351. \"Self-Assembly of Organic Monolayers on Graphite : Chiral Structures\, Nanopatterning & Energetics.\" Host: Jimmie Doll. (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071018T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Predictive first principles simulations play an in creasingly important role in the design and development of novel materia ls for a wide variety of applications. I will describe our effort to dev elop and utilize first principles methods for materials design and techn ology development for hydrogen storage and semiconductor devices. \n\nTh e search for materials capable of storing hydrogen with large gravimetri c and volumetric densities at ambient conditions represents one of the g rand challenges in contemporary materials science. We have discovered a class of polyaromatic compounds\, some of which can be liquefied\, as hy drogen carriers. Hydrogen storage and release can be realized via cataly tic hydrogenation and dehydrogenation. A novel concept on onboard hydrog en storage was proposed. The technology based on an organic liquid hydro gen carrier would require little infrastructural change and radically re duce hydrogen delivery cost for the incipient hydrogen economy. The pred icted chemical and physical properties were validated by a series of exp eriments and the storage technology is currently on its way to commercia lization. \n\nAs the feature size of semiconductor devices continues to shrink\, there has been an increasing demand for new precursors to deliv er extremely thin\, highly conformal copper films via atomic layer depos ition or chemical vapor deposition techniques. Using ab initio molecular dynamics simulations\, we demonstrated that direct deposition of copper films on surfaces of diffusion barrier materials\, such as Ta and W\, u sing organometallic copper precursors would result in severe surface con tamination\, leading to device degradation. A surface passivation techno logy was then developed. A series of “computational experiments” were pe rformed to guide our lab experimental efforts to stabilize the copper fi lms using the “glue layer” technology developed based on the simulation results. Fundamental conditions on adhesion enhancement of metallic thin films were proposed.\n UID:BEF42172-C818-470E-B44E-269430E150A0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100319T160000 DTSTAMP:20100310T195017Z SUMMARY:Friday Chemistry Colloquium: Hansong Cheng\, Air Products & Chem icals\, Inc. \"The Design & Development of Novel Materials for Hydrogen Storage & Semiconductor Applications.\" Host: Lai-Sheng Wang. MM 115\, 4 :00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100319T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: T cells contribute to a variety of immune patholog ies in autoimmune diseases. In response to antigen-induced T cell activa tion\, phosphorylation is a key mechanism by which T-cells regulate prot ein function. Many proteins within the T-cell pathway have been identifi ed. In particular\, SLP-76\, an adaptor protein\, has been shown to be r equired for T-cell development and activation. Furthermore\, it has been reported that SLP-76 contains three domains\, the N-terminal tyrosine p hosphorylation sites\, the Gads-binding site and P-I region\, that are e ssential for its function. Previous attempts to characterize these domai ns have provided some insight on their specific functionality\, but a lo t is still unknown. I propose to perform a phosphoproteomic analysis to study how these domains within SLP-76 influence the temporal dynamics in global phosphorylation in response to T cell activation. With this use of SLP-76 domain deletion mutants\, we hope to gain a greater understand ing of the function of these domains in T cell signaling. UID:B50112C2-7ABC-4390-9C5E-14FAF16E8DB3-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080513T110000 DTSTAMP:20080511T184435Z SUMMARY:1st Year Student Organic Seminars: Yiyuan Ding\, Brown Universit y. \"Quantitative Phosphoproteomic Study of SLP-76 in T Cell Signaling.\ " Host: Jason Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080513T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:D916326E-0D8D-11DA-A757-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051202T160000 DTSTAMP:20051117T142457Z SUMMARY:Friday Chemistry Colloquium: Shana O. Kelley\, Boston College. 4 :00 -5:30\, MM115. \"DNA-Modified Nanostructures for Ultrasensitive Bios ensing.\" Host: Brian Moulton. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051202T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:FD988297-288E-45E7-8E5C-381CC2663709-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101118T150000 DTSTAMP:20100622T131229Z SUMMARY:Physical Chemistry Tea Session: Cheuk-Yiu Ng\, University of Cal ifornia. Title & abstract to come. Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101118T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The sigma-1 receptor (Sig-1R) has been implicated in processes associated with cancer\, neuronal degeneration and drug add iction and is an important potential target for therapeutic intervention . A systematic study of its amino acid sequence was conducted in order t o understand its structure\, which may shed light on its ability to part icipate in numerous biological processes. We prepared an affinity resin by coupling reduced-haloperidol (RHAL)\, a high-affinity S1R ligand\, to epoxide-activated silica beads. Using our RHAL-resin\, S1R was quantita tively recovered from membrane extracts derived from breast cancer cells . Sequence coverage of >90% of the receptor was achieved after in-gel p roteolysis using multiple enzymes and LC-MS/MS. Our results reveal novel post-translational modifications and amino acid substitutions of Sig-1R that could potentially explain Sig-1R ability to translocate from the E R to the plasma membrane\, remodel lipid rafts and act as a molecular ch aperone. UID:2AFB801D-18F7-401A-80C2-36EE9FE9F4BA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100511T110000 DTSTAMP:20100510T203852Z SUMMARY:Organic Chemistry Seminar: Hongbo Gu\, Brown University. \"Ident ification of Post-Translational Modifications & Amino Acid Substitutions in the Human Sigma-1 Receptor using Ligand-Affinity Purification & Mass Spectrometry.\" Host: Jason Sello. GC 351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100511T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Dynamics problems can be complicated even in a sim ple liquid system. To understand such many-body dynamics\, one needs the information about the potential energy landscape of the system. However \, the potential energy landscape is rugged with many barriers and saddl e points\, making it difficult to predict the long-time motion. Instead of thinking about these local features of the landscape\, we have adopte d a new way to gain dynamical information by calculating the shortest pa ths\, known as the geodesic paths. We propose that for slow dynamics pro blems the geodesic paths map out the most accessible pathways through th e landscape. I will discuss an application of this idea: the diffusive b ehavior in an environment of randomly distributed scatterers\, known as the Lorentz model. The Lorentz model has the property of shutting off di ffusion as the density of the scatterers increases\, a phenomenon known as percolation. Our theory will attempt to predict the percolation trans ition. Although the Lorentz system is the minimal model for the transpor t of particles through a disordered media\, it can help to better unders tand the relation between diffusion and the path lengths. UID:790CA765-770C-463E-9516-46C2814D8A55-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080424T150000 DTSTAMP:20080422T130119Z SUMMARY:Physical Tea Session: Crystal Nguyen\, Brown University. 3:00\, GC 351. \"Using Geodesic Theory to Study Slow Diffusion in Disordered Sy stems.\" Host: Jimmie Doll CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080424T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:B66A63A4-151B-4B39-938F-0CE056A36A84-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T111500 DTSTAMP:20080813T124052Z SUMMARY:Denise M. Barnes\, PhD\, '81. National Science Foundation. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T114500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:4E9ED8AB-94B5-467C-B9C5-2FFF549DBD96-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20091111T093000 DTSTAMP:20091020T212339Z SUMMARY:Back Up Care Informational Session. Come by for a \"drop in\" se ssion on Back Up Care Benefit for child/elder care. Learn how this benef it can help you when your regular care arrangments for a loved one fall through. 9:30 - 11:00\, GC 246. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091111T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Nanoscale carbon materials including fullerenes\, carbon nanotubes and “nanosheets” and small carbon nanoparticles have in teresting and\, in many cases\, unique properties. We have been studying these amazing carbon nanomaterials\, from fullerene conjugates with ant icancer drugs and bulk-separated metallic/semiconducting single-walled c arbon nanotubes for electrical/electronic materials and applications to more recently carbon nanosheets for thermal and mechanical nanocomposite s and carbon-based photoluminescent nanoparticles (“carbon dots”) as eff ective imaging agents. Some interesting and representative recent result s from our research will be highlighted. UID:611D93D1-24CB-43EB-99C0-558B5FB97131-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090226T120000 DTSTAMP:20090213T202225Z SUMMARY:Inorganic Chemistry/Materials Seminar: Ya-Ping Sun\, Clemson Uni versity. \"Carbon Nanomaterials: From Nanotubes to Carbon Dots & from Ex ploration to Applications.\" Host: Shouheng Sun. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090226T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:554D5750-60F5-11D9-8110-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050304T160000 DTSTAMP:20050223T212658Z SUMMARY:Friday Colloquium: Gary Weisman\, UNH. 4:00 - 5:30\, MM 115. \"C ross-Bridged Tetraamines: Synthesis\, Coordination Chemistry\, Biomedica l Utility & Conformational Contortions.\" Host: Paul Williard. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050304T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:65D25EDE-E221-4788-B5F5-684C343FAEE9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090501T160000 DTSTAMP:20090423T173928Z SUMMARY:Friday Chemistry Colloquium: Dwight A. Sweigart\, Brown Universi ty. \"Organometallic Complexes in Supramolecular Self-Assembly & Multifu nctional Catalyis.\" Host: Eunsuk Kim. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090501T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: DNA sequencing is usually implemented by the Sange r method\, a process by which nucleotides are read one at a time. In the interests of time and cost\, one would rather have a method to read sev eral bases simultaneously. This is the fundamental goal of my research – to rapidly sequence nucleobases by a process called sequencing by hybri dization (SBH). I will discuss synthetic progress towards incorporating ferrocene as a base-pair step analog in a peptide nucleic acid probe for SBH. This project lent itself to several side-projects. Atypical reacti vity patterns in simple ferrocenes have been exploited to re-explore the properties of ferrocene acetonitrile and ferrocenyl sulfonic acid. Curr ent work focuses on using ferrocenes with radical degradation pathways t o potentially cleave DNA. UID:3A009AA9-8FA0-44B0-809F-A5D85013730E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100316T110000 DTSTAMP:20100311T185126Z SUMMARY:Organic Chemistry Seminar: Daniel Cooper\, Brown University. \"F errocenes: Oligonucleotides & Reversible Autooxidation.\" Host: Jason Se llo. GC 351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100316T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Streptomyces are Gram-positive\, filamentous\, soi l-dwelling saprophytic bacteria that are the source of a vast array of b ioactive secondary metabolites. The albaflavenone biosynthesis gene clus ter in S. coelicolor A3(2) contains two ORFs\, sco5222 and sco5223. The 1086-bp sco5222 gene encodes a protein of 361 amino acids (aa)\, which h as been expressed in E. coli and characterized to catalyze the cyclizati on of farnesyl diphosphate (FPP) to epi-isozizaene. The sco5223 gene sha res a four-nucleotide ATGA transcriptional overlap with sco5222 at its 5 ’-end\, and was demonstrated to catalyze the two-step allylic oxidation of epi-isozizaene to albaflavenone through the intermediacy of a an eipm eric mixture of albaflavenols. The incubation experiments of labeled FPP and NPP with SCO5222 protein not only confirmed the intermediacy of (3R )-NPP in the cyclization mechanism\, but also shed valuable new light on the stereochemistry of other reaction intermediates. In addition\, the site-directed mutagenesis gave rise to the affected distribution of aber rant products\, providing strong support for the presence of proposed in termediates. Recombinant SAV3032 in S. avermitilis has been expressed in E. coli and refolded from inclusion bodies\, and the purified protein w as characterized to catalyze the cyclization of FPP to epi-isozizaene. T his result therefore implied the presence of albaflavenone biosynthesis pathway in S. avermitilis. UID:E7595471-F441-4A0A-8B95-F247F65C1151-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081203T120000 DTSTAMP:20081124T160053Z SUMMARY:Thesis Defense: Xin Lin\, Brown University. \"Biosynthesis of th e Sesquiterpene Antibiotic Albaflavenone.\" Presiding Officer: David Can e. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081203T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:2DA307CC-8154-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060504T170000 DTSTAMP:20060426T185500Z SUMMARY:Physical Chemistry Tea Session : Clifford Frez\, Brown Universit y. 3:00 -4:15\, GC 351. \"Laser Induced Gratings of Particle Suspensions : The Thermal Nonlinearity of Water.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060504T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:0DFED2B4-E1D3-4E2C-92DA-EEE392AC26FC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090430T150000 DTSTAMP:20090209T184027Z SUMMARY:Physical Chemistry Tea Session: Brett Lucht\, URI. Title and abs tract to come. Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090430T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:38422196-7BD6-11DA-84F7-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060117T110000 DTSTAMP:20060110T140933Z SUMMARY:Organic Seminar: Sirong Gao\, Brown University. 11:00 - 12:30\, GC 351. Title to come. Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060117T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: Electron capture dissociation (ECD) studies of pro teins have shown non-ergodic fragmentation patterns. This break from typ ical fragmentation pathways has led to two proposed mechanisms for ECD\, one involving ultra-fast hydrogen hopping and the other with the initia l population of Rydberg states\, which then cross over to dissociative c hannels leading to the observed products. The design of a MS/PES system that is currently under construction to probe this question and others r elated to it will be discussed. Preliminary experiments on dimethylforma mide and dimethylacetamide will be shown and discussed. UID:8F11C8B1-9C05-4BDF-A0FF-25177FED76BA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070913T150000 DTSTAMP:20071119T203242Z SUMMARY:Physical Tea Session: Joseph Bush\, Brown University. 3:00 - 4:1 5\, GC 351. \"Moving towards Rydberg States of Proteins.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070913T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:1C69596F-8C64-4507-91DB-EE5D9EDD4371 DTSTART;TZID=US/Eastern:20100525T103000 DTSTAMP:20100519T172340Z SUMMARY:norma robles CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100525T113000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:C4B7F28C-BAB1-11DA-88FC-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060330T170000 DTSTAMP:20060323T211517Z SUMMARY:Physical Chemistry Tea Session: Anastasios Maurudis\, University of Connecticut. 3:00 - 4:15\, GC351. \"Implementation of a Photo-acoust ic Imaging System.\" Host: Gerald Diebold. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060330T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: Interactions between aromatic rings via *-stacking are at the origin of many phenomena of organic material science and bio logical chemistry including the electron transport in DNA through stacke d *-bases. Unfortunately\, owing to the synthetic difficulties\, the exa mples of such *-stacked molecules with multiple layers are scarce. We ha ve recently discovered/synthesized multi-layered stacked polyfluorenes i n which the van der Waals contacts between the cofacially-oriented fluor ene moieties allow effective electronic coupling amongst them. These sta cked * -systems are now being utilized for the systematic investigation of electron and energy transport phenomenon through stacked polyaromatic moieties as spacers for the development of (next-generation) conducting wire-like materials. These cofacially-arrayed polybenzenoid structures hold potential for applications in the areas ranging from molecular elec tronics and nanotechnology to solar energy storage. UID:BD5EEF4E-91DD-46F9-9802-4A8CD258E9AA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081003T160000 DTSTAMP:20080918T171135Z SUMMARY:Friday Chemistry Colloquium: Rajendra (Raj) Rathore\, Marquette University. \"Electronic Communication through Cofacially-Arrayed Polybe nzenoid Nano Structures.\" Host: Matthew Zimmt. 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081003T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: A variety of metal oxides have been used in automo bile catalysts due to their unique functions. For example\, CeO2 is used for keeping oxygen concentration in the exhaust gas\, based on its oxyg en storage capacity. TiO2\, which is one of the acidic metal oxides\, in hibits the catalyst deactivation caused by sulfur oxide. Recently\, thes e techniques require precisely controlled structure on a nanoscale for e xcellent catalytic performance. I will discuss the synthesis of nanoscal e metal oxides and introduce their applications to automobile catalysts through the examples of CeO2 and TiO2. UID:283891CF-04D5-4B57-AD3B-F684A89208A7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081120T120000 DTSTAMP:20081114T155240Z SUMMARY:Inorganic Chemistry Seminar: Haruo Imagawa\, Brown University. \ "Controlled Synthesis of Nanoscale Metal Oxides: Application of CeO2 & T iO2 to Automobile Catalysts.\" Host: Shouheng Sun. 12:00 - 1:15\, GC 351 . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081120T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:7A0012A5-2D30-11DB-A99C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060905T110000 DTSTAMP:20060822T162316Z SUMMARY:Organic Seminar: Michael D. Burkart\, University of California. 11:00 - 12:30\, GC 351. \"Coenzyme A & Carrier Protein Mediated Biosynth esis.\" Host: Jason K. Sello. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060905T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:CE023567-130D-11DA-B858-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050908T150000 DTSTAMP:20050822T131232Z SUMMARY:Physical Chemistry Tea Session: Clyde Briant\, Dean of Engineeri ng\, Brown University. 3:00 - 4:15\, GC 351. \"Hydrogen Embrittlement of Ti-Based Materials.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050908T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:B6E640A6-79E9-4FF7-B0F6-A4A4C687AA22-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070301T150000 DTSTAMP:20070205T201607Z SUMMARY:Physical Chemistry Tea Session: Bradley Marston\, Brown Universi ty. 3:00 - 4:15\, GC 351. \"Actinides in Solution: Nuclear Waste\, Stron g Correlations & Emergence.\" Host: Jimmy Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070301T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:1D321304-09AD-11DA-B7FF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060217T160000 DTSTAMP:20060130T204550Z SUMMARY:Friday Chemistry Colloquium: Jeffrey Johnson\, University of Nor th Carolina. 4:00 - 5:30\, MM115. \"Polarity Reversal Catalysis: New Str ategies & Applications.\" Host: William Trenkle. The Inn at Brown. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060217T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:12C4A704-159D-11DA-869D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060310T160000 DTSTAMP:20060224T225441Z SUMMARY:Friday Chemistry Colloquium: Christine D. Keating\, Pennsylvani a State University. 4:00 -5:15\, MM115. Metal \"Particle–Biomolecule Con jugates for Biosensing & Self-Assembly.\" Host: Shouheng Sun. Inn at Bro wn 3/9-11 CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060310T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: Polymers have been traditionally used as electrica lly insulating materials: after all\, metal wires are coated in plastics to insulate them. Various conjugated macromolecules with alternating si ngle and double bonds can now be synthesized with unusual electrical and optical properties through the π-electron delocalization. Due to the mo lecular rigidity intrinsically associated with the delocalized conjugate d structure\, however\, most unfunctionalized conjugated macromolecules are intractable (i.e. insoluble and/or infusible). A number of synthetic techniques have been devised to produce conjugated macromolecules with the processing advantages of plastics and the optoelectronic properties of inorganic semiconductors for various flexible device applications\, i ncluding organic light-emitting diodes and photovoltaic cells. Having co njugated all-carbon structures\, carbon nanotubes also possess certain s imilar optoelectronic characteristics as conjugated macromolecules\, apa rt from their superior thermal and mechanical properties. While there is currently a large effort worldwide in developing nanocomposites from no naligned carbon nanotubes and polymers\, the combination of the unique p hysicochemical properties of aligned carbon nanotubes with comparable op toelectronic properties of appropriate conjugated macromolecules or cert ain other materials (e.g.\, DNA chains\, metal nanoparticles) has yielde d some interesting synergetic effects. In this talk\, I will present som e of our work in these exciting areas\, along with various rational conc epts for the design and development of multifunctional materials based o n conjugated macromolecules and vertically-aligned carbon nanotubes for device applications. UID:C23F0530-D92D-4F2C-AE27-A491C6EFC6C0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080129T160000 DTSTAMP:20080125T171732Z SUMMARY:Nano Faculty Candidate: Liming Dai. 4:00 - 5:30\, MM 115. \"Opto electronic Conjugated Macromolecules & Aligned Carbon Nanotubes: From Ma terials Syntheses to Device Applications.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080129T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:57050D84-B5FE-11DA-87EC-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060404T110000 DTSTAMP:20060317T215328Z SUMMARY:Organic Chemistry Literature Seminars: Naomi Kim & Adam Pangilin an\, Brown University. 11:00 -12:30\, GC 351. Titles to come. Host: Will iam C. Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060404T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:E3BE89E9-E09B-46F3-B6D9-F25E9AE67420-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090929T110000 DTSTAMP:20090908T144508Z SUMMARY:Organic Chemistry Seminar: Takeo Kawabata\, Kyoto University. \" Short-Lived Axially Chiral Enolates for Reliable Asymmetric Synthesis.\" Host: Paul G. Williard. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090929T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Gold and silver nanorods and\, in the case of silv er\, nanowires\, have been prepared in our laboratory in a seed-mediated growth procedure that can be done in water at room temperature. Shape control is provided by a cationic surfactant in solution. High-resoluti on transmission electron microscopy\, selected area electron diffraction \, and screening of reaction conditions have all led to a proposed react ion mechanism whereby the counterion to the cationic surfactant adsorbs preferentially to certain crystal faces of the growing nanomaterial to c ontrol its overall shape. Experiments in which the nanorods self-assemb le\, or are rationally connected via chemical linkers\, will be presente d. The surface chemistry of the nanorods can be tuned for to change the overall charge or hydrophobicity of the nanoparticles. The optical pro perties of the nanomaterials depend on aspect ratio\, and the longitudin al plasmon bands can be tuned from the visible into the near-infrared. The metal nanorods also Rayleigh-scatter light well\, and in addition ar e good substrates for surface-enhanced Raman scattering. Nanorod-based sensing and imaging applications will be discussed. UID:21DCBFCB-DB70-4404-9D28-E1FE5B998B1F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080125T160000 DTSTAMP:20080118T142928Z SUMMARY:Chemistry Colloquium: Catherine Murphy\, University of South Ca rolina. 4:00 - 5:30\, MM115. \"Synthesis\, Assembly\, Sensing & Imaging with Metallic Nanorods.\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080125T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:AA65125E-419A-11DA-9BED-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051027T150000 DTSTAMP:20051027T144020Z SUMMARY:Physical Chemistry Tea Session: Michael Minitti\, Brown Univers ity. 3:00 -4:15\, GC 351. \"Linewidth Narrowing as a Probe of Structural Change: An Application of Rydberg Fingerprint Spectroscopy.\" Host: Jim mie Doll CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051027T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:86473F6A-1D79-11DB-A99C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070206T110000 DTSTAMP:20070130T164645Z SUMMARY:Organic Seminar: John J. Lavigne\, University of South Carolina. 11:00 - 12:30\, GC 351. \"Dynamic Polymer Assemblies: From Self-Repairi ng Materials to Food Quality Sensors.\" Host: Amit Basu. (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070206T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:9F4E0F24-1301-11D9-88BD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20040910T130000 DTSTAMP:20040930T165630Z SUMMARY:S. Thayumanavan (UMASS Amherst): colloquium CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20040910T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Bidentate phosphines with metallocene backbones ar e very commonly used ligands particularly in catalytic applications. In addition to the steric and electronic properties of these ligands\, the presence of a redox active metal in the backbone can influence the prope rties of compounds containing these ligands. We have examined the electr ochemistry of a variety of these ligands\, both free and coordinated to another transition metal. In addition\, we have synthesized and characte rized the phosphinechalcogenides\, in particular sulfide and selenide\, of these compounds. The electrochemistry of the selenides is quite diffe rent from that of the sulfides. UID:C12DFE8B-C72B-49AB-A848-DA0ED38005AA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090123T160000 DTSTAMP:20090121T153536Z SUMMARY:Friday Chemistry Colloquium: Chip Nataro\, Lafayette College. \" Synthesis & Electrochemistry of Bidentate Phosphinechalcogenides with Me tallocene Backbones.\" Host: Sarah Delaney. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090123T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:14 TRANSP:OPAQUE UID:D087D18E-F2A7-4DFA-9E25-D6A4E9B4E73E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T090000 DTSTAMP:20080829T160025Z SUMMARY:William M. Risen Jr. Symposium: Welcome Remarks - Peter W. Weber \, Chair\, Dept. of Chemistry\, Brown University. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T091500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:8BA435F9-31C9-11DA-88B5-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051003T150000 DTSTAMP:20050930T154855Z SUMMARY:Defense Thesis: Paul Santacroce. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051003T163000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: The research effort that is aimed to provide atomi c scale understanding of chemical processes and materials that are capab le to address research and technological needs for clean and efficient e nergy production\, storage and conversion will be presented. Fundamental knowledge related to the electrified solid-liquid interfaces is conside red to be the key in further advancement of nanoscale materials that cou ld be implemented in valuable electrochemical applications such as elect rolyzers\, batteries and fuel cells. \nIt has been demonstrated that fi ne tuning of the surface properties on extended well-defined systems can lead towards unprecedented improvements in functional nanomaterials tha t are relevant for energy conversion and storage [1]. This approach invo lves the following: studies of well-defined solid materials obtained by varying their surface structure\, composition profile and electronic pr operties\; atomic/molecular level characterization of electrified solid- liquid interfaces by state-of-the-art ex-situ and in-situ surface techni ques\; theoretical modeling aimed to reveal relationships between the su rface properties and electrochemical performance [2]\; identification of the real active sites as well as the most vulnerable surface sites for degradation processes during relevant reaction conditions\; insight into chemical nature between the surface\, reactants and molecular species i n the electrolyte that govern efficient bond making and bond breaking pr ocesses at the electrochemical interfaces\; modification of the surface and subsurface composition by other elements in order to improve efficie ncy and stability\; design and synthesis of advanced nanoscale materials with desired size\, shape and concentration profile [3]\; and ex-situ a nd in-situ characterizations of tailored nanoscale systems.\nThis synerg istic approach that encompasses highly diverse experimental and theoreti cal methods has been proven to provide solid foundation in the developme nt of advanced nanomaterials for energy applications. \n\n[1] Stamenko vic et al. Science 315 (2007) 493.\n[2] Stamenkovic et al. Angewandte C hemie International Edition 45 (2006) 2897.\n[3] Stamenkovic et al. Nat ure Materials 6 (2007) 241.\n UID:AFF4F6CE-5D52-4A74-8377-28F3BC57CABF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091214T160000 DTSTAMP:20091211T141004Z SUMMARY:Nanoscience Faculty Search Candidate: Vojislav Stamenkovic\, Arg onne National Laboratory. \"Nanoscale Materials for Energy Applications. \" Host: Shouheng Sun. 4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091214T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:1399DD7C-5FB2-421B-BFDB-F1136708DE2A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T151500 DTSTAMP:20080813T125046Z SUMMARY:Costas Tzinis\, PhD\, '81. Consultant. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T154500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:D4FB23F0-F694-4E09-B156-50168867A559-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101022T160000 DTSTAMP:20100713T190442Z SUMMARY:Friday Chemistry Colloquium: Jo Handelsman\, Yale University. Ti tle and abstract to come. Host: Jason Sello. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101022T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: The interaction of molecules with metal surfaces i s important in a variety of experimental systems. For instance\, adsorpt ion of gas phase reactants onto a metal catalyst is the first step in ma ny heterogeneous catalysis reactions. However\, the theoretical treatmen t of these processes is challenging due to the presence of a continuum o f electronic states that can interact with the approaching molecule. The se continuum states provide an efficient pathway for the transfer of ene rgy from the gas molecule to the metal electrons. Metal-adsorbate system s therefore pose an interesting problem both in terms of simulation comp lexity and underlying physics. I present several novel approaches that I am developing to simulate adsorbate dynamics and show how these methods contribute to our understanding of the physical processes that occur du ring adsorption\, scattering and chemical reaction. UID:7542F428-46EB-4153-B2FC-2BF8B4B19752-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080207T160000 DTSTAMP:20080129T195953Z SUMMARY:Nano Faculty Candidate: Neil Shenvi\, Yale University. 4:00 - 5: 30\, B&H 153. \"Chemical Dynamics at Metal Surfaces: Coupled Nuclear-Ele ctronic Motion.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080207T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:B26DF06F-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041026T130000 DTSTAMP:20040930T164940Z SUMMARY:Weiguo He: organic seminar CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041026T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:20409533-A82F-4E5D-98AC-A7A524C35D91-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T104500 DTSTAMP:20080813T123841Z SUMMARY:Robert W. Stearns\, ScB\, '71. Sternhill Partners. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T111500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: There are several applications that take advantage of the light-emitting properties of nanoscale systems\, with diodes and lasers\, single-photon sources and bio-labels being notable examples. A growing and important area of application for these same materials is i n the field of renewable energy and the harvesting of solar photons. The foundation for such applications is the study of photophysics on the na noscale. Inspired by the pioneers of molecular spectroscopy\, this prese ntation will explore the spectroscopy\, relaxation dynamics and light-in itiated reactivity of semiconductor nanocrystals. The rich potential of the field will be introduced. It will be shown how some properties paral lel those of molecules\, while other phenomena are unique to nanoscale e xcitons. Starting from a deep understanding of the optical properties of nanoparticles it will be shown how and why light-initiated processes ar e controlled using suitably designed multi-component nanocrystal heteros tructures. UID:3E69F551-9412-4381-8171-9AC4B04D00A1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080924T160000 DTSTAMP:20080924T173307Z SUMMARY:Special Colloquium: Greg Scholes\, University of Toronto. \"Ligh t-Initiated Processes in Nanoscale Systems.\" Host: Richard M. Stratt. 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080924T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Femtosecond time-resolved resonant two-photon ioni zation coupled with photoelectron and mass spectroscopy is applied to st ilbene\, a popular model for dynamics studies. In order to explore the u nknown electronic surfaces\, highly excited states of stilbene are probe d and different dynamical motions are revealed. The results also suggest that stilbene’s structural dynamics are strongly electronic surface dep endant. UID:7B4766B0-970C-48F9-BAD4-68D47602EDE5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091022T150000 DTSTAMP:20091014T191348Z SUMMARY:Physical Chemistry Tea Session: Jie Bao\, Brown University. \"Ul trafast Structural Dynamics of Highly Excited Stilbene.\" Host: Gerald D iebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091022T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:C80B6588-76B7-11D9-AD63-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050428T150000 DTSTAMP:20100625T144141Z SUMMARY: CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050428T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:DEECCB6E-A80E-41E2-8869-357BBAE0D246-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070503T150000 DTSTAMP:20070503T130654Z SUMMARY:Physical Chemistry Tea Session: Clifford Frez\, Brown University . 3:00 - 4:15\, GC 351.\" The Photoacoustic Effect from Bubbles.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070503T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Focused solely on intellectual property law\, Wolf Greenfield attracts\, trains and invests long-term in technical and leg al specialists at the forefront of their fields: MDs and PhDs in biotech nology and chemistry with pharmaceutical expertise\, electrical and mech anical engineers with industry experience developing valuable innovation s\, litigators who have won landmark IP cases and negotiated market-movi ng settlements. UID:EBBD38FD-3817-47C2-A163-19C3931D85A6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091109T160000 DTSTAMP:20091105T220640Z SUMMARY:Careers in Chemistry Seminar: Representative from Wolf Greenfiel d. Host: Sarah Delaney. 4:00\, MM 317. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091109T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The ability of certain transition-metal centers (M L\,) to activate normally unreactive pi-hydrocarbons (R) toward nucleoph ilic attack has been known for several decades. By activating aromatic h ydrocarbon with manganese tricarbonyl moiety\, a wide range of novel rou tes has been developed to organic molecules often inaccessible by conven tional strategies. The presentation will mostly focus on the electrochem ical response of the monoarene manganese tricarbonyl (both homogeneously and heterogeneously)\; also the possible electropolymerization based up on the following mechanism. Future work will be optimizing the heteroge neous electrochemistry of our manganese compound and designing tunable b uilding block for growing organometallic polymer. UID:2F94A696-0E70-4A10-868C-063D537F29BB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100325T120000 DTSTAMP:20100325T141034Z SUMMARY:Inorganic Chemistry Seminar: Wei Dai\, Brown University. \"Monoa rene Manganese Tricarbonyl.\" Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100325T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:11BC7E50-3061-4AD5-8F68-5B9909B38276-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20081204T150000 DTSTAMP:20081202T211148Z SUMMARY:Physical Chemistry Tea Session: Brian Ahr\, Brown University. Ti tle and abstract not supplied. Host: Christoph Rose-Petruck. 3:00\, GC 3 51. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081204T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Major histocompatibility complex (MHC) proteins bi nd peptides with a cell and present them at the cell surface for inspect ion by antigen receptors on T cell\, as part of the mechanism by which t he immune system senses and responds to foreign material in the body. Re cent structural and biochemical studies of the human class II MHC protei n HLA-DR1 have extended our understanding of peptide selection by MHC pr oteins\, such that it is possible to identify antigenic peptides even fr om very complex pathogens\, for use in tracking immune responses ev vivo . Examples from influenza\, vaccinia and herpes viruses will be presente d. In a cell\, antigen loading onto class II MHC proteins is promoted by the peptide exchange factor HLA-DM\, which appears to function catalyti cally by effecting a conformational change in the MHC-peptide complex. R ecent modeling and mutagenesis results will be described that suggest a model for the MHC conformational change effected by HLA-DM. Finally\, a peptide carrying an environmentally-sensitive fluorogenic amino acid sid e chain has been developed for use in tracking peptide loading on MHC pr otein in vivo. UID:C7E53354-4729-4A4E-8904-DDD00C1CB3D6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090410T160000 DTSTAMP:20090406T160055Z SUMMARY:Friday Chemistry Colloquium: Lawrence Stern\, University of Mass achusetts Medical School\, Dept. of Pharmacology. \"Class II MHC Protein s: Selection & Presentation of Peptides for Generation of Immune Respons es.\" Host: Carthene Bazemore-Walker. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090410T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:2A094FED-CD2F-4E5D-BBBD-3E96A5D62D80-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071018T120000 DTSTAMP:20071012T184508Z SUMMARY:Inorganic Seminar: Kaylie Young\, Brown University. 12:00 - 1:15 \, GC 351. \"Organic to Aqueous & Vice Versa: Taking Advantage of the Ve rsatility of Nanomaterials for Biomedical Applications\". Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071018T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:5968DCFB-2D44-11DB-A99C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061102T120000 DTSTAMP:20061025T194425Z SUMMARY:Inorganic/Materials Seminar: Hongyou Fan\,\nSandia National Labo ratories. 12:00 - 1:15\, GC 351. \"Nanoparticle-Micelles: Ordered 2\, 3- D Nanoparticle Arrays Made Easy.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061102T133000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:82E6D438-419E-11DA-9BED-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051101T170000 DTSTAMP:20051020T192013Z SUMMARY:Clapp Lecture: Harry Kroto\, Vega Science Trust/Florida State Un iversity. 6:30 - 7:45\, MM 117. \"Architecture in NanoSpace.\" Host: Bri an Moulton. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051101T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:166310C3-4B44-4C5B-A61F-FC4F2E7F9F3B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100422T150000 DTSTAMP:20100416T190035Z SUMMARY:Physical Chemistry Tea Session: Xiang Sun\, Brown University. Ti tle and abstract to come. Host: Gerald Diebold. GC 351\, 3:00. (Refreshm ents Binbin Wu) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100422T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:564EAF1B-19AB-4CCB-9646-F297E33A0286-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070312T100000 DTSTAMP:20070307T140053Z SUMMARY:Organic Seminar: Ying-jin Yuan\, Tianjin University\, Tianjin\, PR China. 3:30 - 4:30\, MM 317. \"Potential Applications of Shotgun Prot eomic Strategies in Solving Bioengineering Problems.\" Host: Jason Sell o CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070312T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: The nervous system\, a three-dimensional network o f interconnected neurons and glia\, both maintains physiological homeost asis and enables communication with the external world by responding to stimuli\, processing information and mediating proper reactions. One of the most influential hypotheses in modern neuroscience states that the f unctions of these neuronal networks arise from the formation and modulat ion of the synaptic connections among the network’s constituent neurons. To map a network’s spatiotemporal connectivity and correlating it to th at network’s function\, we need tools that can perturb and record neuron al activity in a cell-specific fashion. Toward this end\, we have genera ted vertically-grown silicon nanowire arrays to introduce biologically i mportant molecules into cells with minimized cytotoxicity and high deliv ery efficiency and\, using patterned arrays\, showed site-specific contr ol of cellular functions\, such as apoptosis and neural precursor differ entiation. In conjunction\, we have been developing planar patch-clamp a rrays to monitor individual cellular activity in a mid-size neuronal net work (up to several hundred neurons). Thus far\, our prototypical device s have successfully made whole-cell patch clamp recordings from rat hipp ocampal neurons\, suggesting the viability of our design for network-sca le measurements. In the near future\, we envision that the combination o f both tools will serve as a spatially resolvable means of controlling a nd probing complicated neurobiological phenomena and\, thus\, of getting closer to cracking the neuronal code. UID:37E4F69A-CDA1-4A8D-B420-C4ADDF776561-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090120T160000 DTSTAMP:20090107T215230Z SUMMARY:Nano Chemistry Search Candidate: Myung-Han Yoon\, Harvard Univer sity. \"Neuronal Interfacing: Controlling Cellular Function & Monitoring Activity.\" Host: Shouheng Sun. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090120T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:863732CD-7D58-4559-B520-C1DEBAD07014-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070302T160000 DTSTAMP:20070207T151720Z SUMMARY:Friday Chemistry Colloquium: Martin Brechbiel\, National Cancer Institute\, 4:00 - 5:30\, MM 115. \"Better Imaging & Therapeutics throug h Chelation Chemistry.\" Host: Shouheng Sun. (Fletcher House) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070302T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:ABFF3328-C64D-11DA-B1E5-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060511T120000 DTSTAMP:20060504T204806Z SUMMARY:Inorganic Seminar: Sang Bok Kim\, Brown University. 12noon - 1:1 5pm\, GC 351. \"IR Analysis of a Long Alkyl Chain Derivatized Hydroquino ne Manganese Tricarbonyl Complex & its Applications.\" Host: Shouheng Su n. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060511T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: This presentation is about our theoretical and exp erimental efforts directed towards the design of artificial enzymes. Nat ural enzymes are extraordinarily efficient catalysts\, possessing high a ctivity and specificity under mild conditions. It is\, therefore\, invit ing to mimic strategies that Nature employs\, especially\, in the design of catalysts for reactions that Nature seems to have overlooked. Howeve r\, the challenge in trying to approach the performance of biological ca talysts is great. An efficient “inside-out” enzyme design protocol that we developed will be described. Using the Kemp elimination of 5-nitroben zisoxazole as an example\, we will demonstrate how enzymes are being des igned\, tested in silico and in vitro\, and optimized to perform catalys is. Numerous active artificial enzymes have been designed\, and they yie lded a maximal experimental kcat/kuncat of 1.2 x 106. The “inside-out” a pproach is general and can now be applied to the design of many other ar tificial enzymes. UID:B60BA852-9233-480D-8AD2-83179BC8786F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081202T160000 DTSTAMP:20081126T202009Z SUMMARY:Biophysical Faculty Candidate Seminar: Anastassia Alexandrova\, Yale University. “Theo-Zymes: Catalysis Ahead of Nature.” Host: Christop h Rose-Petruck. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081202T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:042FFBF2-7914-11D9-8D71-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050421T150000 DTSTAMP:20050415T142230Z SUMMARY:Physical Tea Session: Theron Hamilton\, Brown University. GC 351 \, 3:00 - 4:15. \"Detection of Spectral Overtones in Molecular Hydrogen with Photothermal Methods.\" Host: Christoph Rose-Petruck. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050421T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Tetrahydroisoquinolines (THIQs) are an important s tructural motif in many alkaloids\, and they display significant biologi cal and pharmacological properties. A majority of these compounds posses s a chiral center at the C-1 position\, while stereoisomers at this posi tion exhibit very different activities. Thus\, the enantioselective synt hesis of 1-substituted-THIQs is of great interest to both organic and me dicinal chemists.\n In this thesis\, we first report the enantioselectiv e addition of vinylzinc reagents to 3\,4-dihydroisoquinoline N-oxide. Wi th an N-acylethylenediamine ligand as the catalyst\, we obtained a group of chiral N-hydroxyl-1-vinyl-THIQs in 62-85% yield and 90-95% ee. A var iety of aliphatic\, cyclic and aromatic vinylzinc reagents was employed in the reaction. This method was used to synthesize a single enantiomer of the unnatural amino acid N-Cbz-D-1\,2\,3\,4-tetrahydroisoquinoline-1- carboxylic acid. \n Next\, we describe a novel\, expedient synthesis o f chiral 1-aryl-THIQs\, in which the key step is the asymmetric addition of arylzinc reagents to 3\,4-dihydroisoquinoline N-oxide catalyzed by t he diamine ligand. With aryl pinacolyl boronic esters as arylzinc precur sors\, we achieved good yields (35-99%) and excellent enantioselectiviti es (97-99% ee) in the reaction. This methodology was demonstrated throug h the enantioselective synthesis of the GlaxoSmithKline drug – Solifenac in. \n Finally\, we investigated the mechanism of the enantioselective addition of arylzinc reagents to 3\,4-dihydroisoquinoline N-oxide. We ad opted a systematic strategy to study this complex system by using a wide range of NMR techniques. This includes 1D and 2D NMR\, diffusion-order NMR spectroscopy\, job plot\, NMR titration and in-situ NMR kinetic meas urement. Through these studies\, we obtained information about bonding\, structure and molecular interactions of reactive intermediates along th e reaction pathway. We also found that the reaction occurs via a binucle ar-zinc intermediate in which one zinc atom serves as a Lewis acid while the other zinc atom carries the aryl nucleophile. Comparison of reactio n rates showed that the catalyzed arylation reaction proceeds faster tha n the non-catalyzed process. Altogether\, we propose a catalytic cycle f or the asymmetric arylation reaction. The preference for formation of th e (S)-product was rationalized by examining the conformations of differe nt transition states.\n UID:8C841781-07EC-40E8-8D96-17A50D7BD929-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090930T130000 DTSTAMP:20090924T130011Z SUMMARY:PhD Thesis Defense: Synthesis\, Application & Mechanistic Studie s of Asymmetric Addition of Organozinc Reagents to 3\,4-Dihydroisoquinol ine N-Oxide\, Sa Wang\, Brown University. Presiding Officer: Christopher T. Seto. GC 351\, 1:00.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090930T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Dehaloperoxidase (DHP) from the terebellid polycha ete Amphitrite ornata is a bifunctional enzyme that possesses both hemog lobin and peroxidase activities. Of the two DHP isoenzymes identified to date\, much of the recent focus has been on DHP A\, whereas very little is known pertaining to the activity\, substrate specificity\, mechanism of function or spectroscopic properties of DHP B. To address this\, the recombinant expression and purification of DHP B will be presented\, as well as the details of our investigations into its catalytic cycle usin g biochemical assays\, stopped-flow UV-visible\, resonance Raman and rap id-freeze-quench electron paramagnetic resonance spectroscopies\, and sp ectroelectrochemistry. The experimental design reveals mechanistic insig hts and kinetic descriptions of the dehaloperoxidase mechanism which hav e not been previously reported for isoenzyme A. Namely\, a novel reactio n pathway is demonstrated in which the products of the oxidative dehalog enation of trihalophenols (dihaloquinones) are themselves capable of ind ucing formation of oxyferrous DHP B\, and an updated catalytic cycle for DHP will be presented. We further demonstrate that unlike the tradition al monofunctional peroxidases\, the oxyferrous state in DHP is a peroxid ase competent starting species\, which suggests that the ferric oxidatio n state may not be an obligatory starting point for the enzyme. Taken to gether\, these studies on DHP provide the link between the peroxidase an d oxygen transport activities which furthers our understanding of how th is bifunctional enzyme is able to unite its two inherent activities that are seemingly incongruent in one system. UID:888D8934-55F1-4E07-B763-86ED409AC3EF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100430T160000 DTSTAMP:20100423T194300Z SUMMARY:Friday Chemistry Colloquium: Reza Ghiladi\, North Carolina State University. \"Structural\, Spectroscopic & Mechanistic Investigations o f Dehaloperoxidase B from Amphitrite Ornata.\" Host: Eunsuk Kim. MM 115\ , 4:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100430T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: This dissertation is centered on two areas: (i) ra tional design and synthesis of robust porous metal-organic frameworks us ing well-defined building blocks and (ii) synthesis of crystalline and a morphous coordination polymers based upon traditional organic chemistry. For the rational design and synthesis\, we demonstrated how to achieve maximum interpenetration by fine-tuning the size of the organic spacer u sing the Secondary Building Units (SBUs) approach\, and how to avoid int erpenetration using almost the same size of organic spacer via a pillare d-layer strategy. For synthesis based on organic chemistry\, we have dev eloped a complementary and alternative covalent-based synthetic strategy for the synthesis of new coordination compounds in an effort to incorpo rate a wider range of compounds in the family of coordination materials. \n\nWe synthesized a 4-fold mixed parallel/diagonal interpenetrating cu bic metal-organic framework using octahedral zinc carboxylate Zn4O(OOC-) 6 SBUs as nodes and a long and narrow organic ligand\, 1\,4-(4-carboxyli c-phenyl) butydiyne\, as linkers. Despite the maximum 4-fold interpenetr ation\, it contains large void space and high specific surface area. We synthesized two pillared-layer metal-organic frameworks using infinite 2 D tetragonal grid lattices and kagomé lattices as Supramolecular Buildin g Blocks (SBBs)\, respectively. The interpenetration was forbidden in th ese two frameworks by judicious choice of impenetrable 2D SBBs. Both pil lared-layered frameworks possess unprecedented levels of porosity. The p illared-layer architecture paradigm we demonstrated in this dissertation points to a design strategy for the synthesis of large microporous\, ev en mesoporous metal organic frameworks (MOFs).\n\nWe modified discrete S BUs\, synthesized coordination polymer gels and crystalline coordination polymers by using common organic coupling reactions including Huisgen 1 \, 3-dipolar cycloaddition and homo-alkyne coupling reactions. We modifi ed coordination nanospheres with long hydrocarbon chains by esterificati on reactions. The new covalent-based synthetic method can provide a wide r range of coordination materials.\n UID:B7B37F6E-8456-46AC-9F63-03D1759054E7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080828T090000 DTSTAMP:20080822T182948Z SUMMARY:PhD Thesis Defense: Shuangbing Han\, Brown University. 9:00\, GC 351. \"Design & Synthesis of Crystalline & Amorphous Coordination Mater ials.\" Presiding Officer: Brian D. Moulton. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080828T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:51500A03-82B4-4347-A51D-7A483473A961-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070511T160000 DTSTAMP:20070316T193116Z SUMMARY:Kerry LaPlante\, URI. 4:00 - 5:30\, MM115. Title to come. Host: Jason K. Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070511T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:8D9E8BCF-814F-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060413T150000 DTSTAMP:20060407T155038Z SUMMARY:Physical Chemistry Tea Session: Hersch Rabitz\, Princeton Univer sity. 3:00 - 4:15\, GC351. \"Controlling Quantum Dynamics Phenomena with Shaped Laser \nPulses acting as Photonic Reagents.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060413T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Tetrahydroisoquinolines (THIQs) are an important s tructural motif in many alkaloids\, and they display significant biologi cal and pharmacological properties. A majority of these compounds posses s a chiral center at the C-1 position\, while stereoisomers at this posi tion exhibit very different activities. Thus\, the enantioselective synt hesis of 1-substituted-THIQs is of great interest to both organic and me dicinal chemists.\n In this thesis\, we first report the enantioselectiv e addition of vinylzinc reagents to 3\,4-dihydroisoquinoline N-oxide. Wi th an N-acylethylenediamine ligand as the catalyst\, we obtained a group of chiral N-hydroxyl-1-vinyl-THIQs in 62-85% yield and 90-95% ee. A var iety of aliphatic\, cyclic and aromatic vinylzinc reagents was employed in the reaction. This method was used to synthesize a single enantiomer of the unnatural amino acid N-Cbz-D-1\,2\,3\,4-tetrahydroisoquinoline-1- carboxylic acid. \n Next\, we describe a novel\, expedient synthesis o f chiral 1-aryl-THIQs\, in which the key step is the asymmetric addition of arylzinc reagents to 3\,4-dihydroisoquinoline N-oxide catalyzed by t he diamine ligand. With aryl pinacolyl boronic esters as arylzinc precur sors\, we achieved good yields (35-99%) and excellent enantioselectiviti es (97-99% ee) in the reaction. This methodology was demonstrated throug h the enantioselective synthesis of the GlaxoSmithKline drug – Solifenac in. \n Finally\, we investigated the mechanism of the enantioselective addition of arylzinc reagents to 3\,4-dihydroisoquinoline N-oxide. We ad opted a systematic strategy to study this complex system by using a wide range of NMR techniques. This includes 1D and 2D NMR\, diffusion-order NMR spectroscopy\, job plot\, NMR titration and in-situ NMR kinetic meas urement. Through these studies\, we obtained information about bonding\, structure and molecular interactions of reactive intermediates along th e reaction pathway. We also found that the reaction occurs via a binucle ar-zinc intermediate in which one zinc atom serves as a Lewis acid while the other zinc atom carries the aryl nucleophile. Comparison of reactio n rates showed that the catalyzed arylation reaction proceeds faster tha n the non-catalyzed process. Altogether\, we propose a catalytic cycle f or the asymmetric arylation reaction. The preference for formation of th e (S)-product was rationalized by examining the conformations of differe nt transition states.\n UID:05FBA3E5-8EF0-4A20-8174-72D9D377EDE7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090930T130000 DTSTAMP:20090924T130011Z SUMMARY:PhD Thesis Defense: Synthesis\, Application & Mechanistic Studie s of Asymmetric Addition of Organozinc Reagents to 3\,4-Dihydroisoquinol ine N-Oxide\, Sa Wang\, Brown University. Presiding Officer: Christopher T. Seto. GC 351\, 1:00.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090930T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: During the onset and progression of cancer\, cells undergo dramatic changes in carbohydrate expression. As a result\, ther e has been significant interest in understanding the biological effects of these changes as well as exploiting these differences for the develop ment of diagnostics and vaccines. A key element for both basic and appli ed research involves detecting and analyzing carbohydrate-protein intera ctions. Carbohydrate arrays are a powerful technology for the rapid and high-throughput evaluation of carbohydrate-macromolecule interactions. W e have developed a carbohydrate microarray containing more than 110 diff erent neoglycoconjugates and glycoproteins spotted on a glass slide. We are currently using the array to: 1) evaluate the specificities of antib odies and lectins used routinely to monitor expression of carbohydrate t umor antigens\, 2) profile the repertoire of anti-carbohydrate antibodie s in human serum to discover new cancer biomarkers and 3) evaluate antib ody responses generated with carbohydrate-based cancer vaccines. UID:7DB86361-AB34-4E9E-8E08-503F64C7A8E5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080429T110000 DTSTAMP:20080422T193935Z SUMMARY:Organic Seminar: Jeff Gildersleeve\, Center for Cancer Research\ , Natinal Cancer Institute. 11:00\, GC 351. \"Application of Carbohydrat e Microarray Technology to Cancer Research.\" Host: Amit Basu CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080429T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:BC177670-0CF8-402E-B632-7096DDD0C551 DTSTART;TZID=US/Eastern:20100917T150000 DTSTAMP:20100713T185950Z SUMMARY:Friday Chemistry Colloquium: Dr. Charlene Mello. Title and abst ract to come. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100917T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The photo-induced electron transfer (PET) in donor -acceptor (D-A) structure has received considerable attention due to its potential application for optoelectronics\, photonics\, sensors and oth er functional nanoscale molecular devices. In recent years\, self-assemb led monolayers (SAMs) and multilayer thin films of C60-containing system s have been demonstrated as the most prominent devices for artificial ph otosynthetic cells.\n\nOur new artificial photosynthetic dyad and triad systems and their application to photovoltaic cells will be discussed. T he two artificial light harvesting antenna and reaction center arrays\, [60]fullerene metal cluster-zinc porphyrin dyad (2) and [60]fullerene me tal cluster-zinc porphyrin-boron dipyrrin triad (3)\, have been prepared and characterized by various spectroscopic (1H NMR\, MS\, IR\, UV-Vis\, PL\, transient absorption spectroscopy) methods. Electrochemical proper ties of 2 and 3 have been studied by the cyclic voltammetry in chloroben zene solution. Detailed kinetics of energy and electron transfers in 2 a nd 3 have been investigated by fluorescence lifetime measurements and tr ansient absorption spectroscopy. The photovoltaic cell application based on SAMs of 2 and 3 will be discussed. Our results provide valuable info rmation on the new strategy for the construction of artificial photosynt hetic systems using C60-metal cluster complexes.\n UID:B6FE5522-2720-48A3-8BA6-F201B0181DBB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080117T120000 DTSTAMP:20080103T204351Z SUMMARY:Inorganic Seminar: Joon T. Park\, KAIST. 12:00 - 1:15\, GC 351. \"Solar Cell Application Of [60]Fullerene-Triosmium Metal Cluster Comple xes.\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080117T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:F5331DB5-4585-49DD-88F7-0B75C66A71DB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071109T160000 DTSTAMP:20071113T160844Z SUMMARY:Friday Colloquium: Barney Grubbs\, Dartmouth College. 4:00 - 5:3 0\, MM 115. Controlled Radical Polymerization as a Tool for the Preparat ion of Nanomaterials. Host: Amit Basu CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071109T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Musty-odor methylisoborneol (MIB)\, produced by a wide variety of soil actinomycetes bacteria (especially Streptomyces) an d cyanobacteria (blue-green algae)\, is one of the most widespread terpe noid volatiles. The human nose is extremely sensitive to MIB and is able to detect it at an unusually low concentration. MIB\, together with geo smin\, contaminates water supplies and various foodstuffs\, e.g.\, fish\ , wine and beer\, and is difficult to remove by conventional water treat ments. However\, despite considerable interest in detection and remediat ion of MIB\, the biosynthesis of this methylated monoterpene has been ob scure. A two-gene operon (sco7700 and sco7701) in Streptomyces coelicolo r is shown to be responsible for MIB biosynthesis. A series of incubatio n and structural characterization have established that the cyclization of geranyl diphosphate (GPP) to MIB by SCO7700 and SCO7701 proteins invo lves S-adenosylmethionine (SAM) as the methyl group donor and the interm ediacy of 2-methylgeranyl diphosphate\, a previously unknown compound. S teady-state kinetics for both biochemical reactions have also been deter mined.\n\nThe fungus Botrytis cinerea is a necrotrophic plant pathogen t hat causes the economically important gray mold disease that affects mor e than 200 crop hosts worldwide. In contrast\, B. cinerea is also known as “noble rot”: the infection of wine grapes with B. cinerea plays a vit al role in the production of the Sauternes dessert wines. The gray mold fugus secretes nonspecific phytotoxins\, including the sesquiterpene bot rydial and the polyketide botcinic acid\, that kill cells from a large s pectrum of plants. Recently\, the botrydial biosynthetic gene cluster ha s been identified and the CND15/BcBOT2 gene\, encoding the key sesquiter pene cyclase\, has been shown to be responsible for the committed step o f botrydial biosynthesis. Recombinant CND15 protein has been shown to co nvert farnesyl diphosphate (FPP) to the parent sesquiterpene alcohol of the botrydial biosynthetic pathway\, presilphiperfolan-8β-ol\, as predic ted. The mechanism and stereochemistry of the cyclization of FPP by CND1 5p have been further investigated.\n UID:EA592BF5-7799-4EF4-AC6B-382DC896F9F4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081028T110000 DTSTAMP:20081024T143853Z SUMMARY:Organic Seminar: Chieh-Mei Wang\, Brown University. \"Biosynthes is of Methylisoborneol (in S. coelicolor) & Botrydial (in B. cinerea).\" 11:00 - 12:15\, GC 351. Host: Jason Sello. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081028T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: The Center for High-Rate Nanomanufacture (CHN) at the University of New Hampshire is developing a set of new templates (na notemplates) that enable the guided self-assembly and transfer of nanosc ale objects at high rates and over large areas. One focus in the Chemist ry Department is the generation of\ntwo-dimensional patterns on suitable substrates via the bottom-up self-assembly of small molecules.\n\nIn co llaboration with the Miller group\, we are developing modeling tools to predict the potential for spontaneous two-dimensional pattern formation of functionalized fullerenes on a Au(111) surface. In particular\, we ar e looking at the effect of intermolecular hydrogen bonding as the drivin g force for self-assembly.\n\nI will describe the development and calibr ation of intermolecular potential energy functions to describe the syste m. I will present the results of some of our Monte Carlo explorations of the potential energy landscapes we generate. Finally\, I will present o ur preliminary findings on what molecular features may control pattern f ormation for functionalized fullerenes on gold.\n UID:B80A8B61-A1EB-480D-9F61-4932D2A1CCD8-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080124T150000 DTSTAMP:20080131T152749Z SUMMARY:Physical Tea Session: Howard R. Mayne\, UNH. 3:00 - 4:15\, GC 35 1. \"Molecular Modeling Approaches to the Self-Assembly of Functionalize d Fullerenes on Au (111).\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080124T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:24902B28-0A21-4EA6-85C6-559663A4E1FB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070209T160000 DTSTAMP:20070112T225738Z SUMMARY:Friday Chemistry Colloquim: David M. Bartels\, Notre Dame Radiat ion Lab. 4:00 - 5:30\, MM 115. \"Cracking Supercritical Water with Ioniz ing Radiation: Properties & Reactions of H Atoms\, OH Radicals & Hydrate d Electrons in Hot\, Pressurized Water.\" Host: Gerald Diebold. (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070209T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:BD86FFE6-424B-11D9-BE93-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041209T170000 DTSTAMP:20041129T211515Z SUMMARY:Milan Kalal: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041209T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:D735654F-69B4-48A3-B9D2-0E277AB648BE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100504T130000 DTSTAMP:20100416T200912Z SUMMARY:Senior Talks in Chemistry/Chemical Physics. GC 351\, 1:00 - 6:00 . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100504T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Marine cyanobacteria are extraordinarily rich in t heir production of biologically active and structurally unique natural p roducts. I will present a comparative biosynthetic case study of Curacin A and Jamaicamide A/B\, bioactive natural products isolated from the ma rine cyanobacterium\, Lyngbya majuscula using genetic\, biochemical and enzymatic approaches. Our investigation is focused on analyzing how the pathway enzymes generate the unique structural components in Curacin A a nd Jamaicamide\, such as cyclopropane\, vinyl chloride\, thiazoline ring s\, cis- and terminal double bonds. Currently\, by employing gene over-e xpression\, enzyme purification\, systematic biochemical assays and stru ctural biology\, we have characterized sets of novel enzymes catalyzing unique biosynthetic reactions that significantly diversify the PKS/NRPS models\, thus demonstrating the great potential of marine cyanobacteria to generate novel and structurally diverse secondary metabolites. UID:E24B09FA-8D12-4B70-809A-DB592E6A8BEA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090327T110000 DTSTAMP:20090316T191400Z SUMMARY:Friday Chemistry Colloquium: David H. Sherman\, University of M ichigan. \"Understanding the Biosynthetic Capability of Marine Cyanobact eria: Enzymatic Analysis of the Curacin A & Jamaicamide Natural Product Pathways.\" Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090327T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:C4E87E62-46F6-4361-8676-BEAA589650D0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110311T160000 DTSTAMP:20100625T121540Z SUMMARY:Friday Chemistry Colloquium: Sheila David\, University of Califo rnia. Title & abstract to come. Host: Sarah Delaney. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110311T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: This seminar will be an overview of the accomplish ments and future plans of the Sello research group. We are focused on th e development of new antibiotics\, understanding mechanisms of antibioti c resistance\, engineering and manipulating microorganisms for the over- production of antibiotics\, and the exploitation of microorganisms for t he conversion of biomass into biofuels. The research seminar will addres s each of these topics. UID:B5B26AF2-1DF7-4A73-8440-136F272E66B7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080905T160000 DTSTAMP:20080916T173707Z SUMMARY:Friday Chemistry Colloquium: Jason Sello\, Brown University. \" From Antibiotics to Biofuels\, the Peculiar Chemistry of Streptomyces Ba cteria.\" Host: Amit Basu. 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080905T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: The multifunctional heterodimer nanoparticles such as dumbbell-like Au-Fe3O4 nanoparticles (Au-IONP) have recently shown g reat promise as targeted delivery vehicles with enhanced imaging sensiti vity and therapeutic efficacy in the nanomedical research. The Au-IONPs can be made biocompatible and suitable for coupling different biological targeting agents and drug molecules on each component separately. An an tibody of MUC-1 (a type I transmembrane glycoprotein of the mucin family ) can be conjugated with Au-IONPs to show high specificity for human bre ast cancer cells (MCF-7). Moreover\, the Au surfaces of Au-IONPs are ava ilable for attachment of a chemotherapeutic agent\, doxorubicin (DOX)\, with a pH-sensitive linker for intracellular delivery. In MCF-7 cells\, DOX loaded Au-IONPs showed efficient internalization that was comparable to that observed in MUC-1 knocked-down cells. Consistent with the in vi tro cytotoxicity and confocal image results\, DOX loaded Au-IONPs exhibi ted controlled or sustained release behavior. More interestingly\, the n anoparticles are magnetically and optically active and are therefore use ful for simultaneous magnetic and optical detections. UID:C4171A35-77FE-49C5-8544-C4634B7E61C2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100218T120000 DTSTAMP:20100216T140235Z SUMMARY:Inorganic Chemistry Seminar: Kai Cheng\, Brown University. \"Tar geting Delivery & pH-Controlled Release of Doxorubicin for Breast Cancer Therapy.\" Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100218T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:8C3631A7-B2AD-4404-880F-27D56A54BEB9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070426T150000 DTSTAMP:20070420T160522Z SUMMARY:Physical Chemistry Tea Session/Thesis Defense: Job Cardoza\, Bro wn University. 3:00 - 4:15\, GC 351. Rydberg States as Sensitive Probes of Molecular Structure & Dynamics. Host: Peter Weber. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070426T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: The investigation of reactive processes is of para mount importance in chemistry and biology. Chemical reactions can often be described with surprisingly few variables\, such as the highest energ y barrier that is crossed. However\, if the aim is to describe the chore ography of chemical reactions and not just their rates\, then a more com plete description is needed that includes details such as whether the lo w-energy path widens or narrows as the reaction proceeds. The vast area between the stable points on this energy landscape dictates how a reacti on takes place but is usually the most challenging piece to survey. New experimental techniques (femtosecond time resolved X-ray\, femtosecond t ransient impulsive Raman spectroscopy) have opened up ways to study atom istic details of chemical reactions. In parallel\, computational methods also made considerable progress to reach the accuracy required for mean ingful comparison and interpretation of reactions in the condensed phase .\n\nI will discuss computational strategies to quantitatively investiga te reaction dynamics in complex systems by using atomistic simulations a nd compare them with experimental results. Systems of particular interes t range from proton transfer dynamics to ligand rebinding in proteins.\n UID:6099D4A5-689A-4CAB-A915-9810EE6818DB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081209T160000 DTSTAMP:20081202T211203Z SUMMARY:Biophysical Faculty Candidate Seminar: Marcus Mewly\, University of Basel. \"Investigating Reactions 'Without QM'.\" Host: Peter Weber. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081209T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Electrokinetic effects in fluidic channels reflect the coupled mechanical motion of the liquid with the electrical motion of dissolved ions. The microscopic picture behind this is that the charg ed inner surface of a fluidic channel attracts a neutralizing layer of m obile counterions\, called the double layer\, whose motion is coupled to that of the fluid by viscosity. The electrokinetic phenomena known as s treaming currents and streaming potentials arise when a pressure-driven fluid flow transports ions in the double layer by advection. It has long been recognized that these effects can be used to drive an external loa d\, and therefore represent a mechanism for converting mechanical work i nto electrical power. However\, this is usually a very inefficient propo sition because the counterion density is concentrated at the channel wal ls\, where the no-slip boundary condition tells us that the fluid is sta tionary.\n\nRecent experimental and numerical studies (including importa nt contributions from the Breuer group here at Brown) have demonstrated the breakdown of the fluidic no-slip boundary conditions at nanometer sc ales\, and the strong dependence of the slip length on the properties of the solid-liquid interface. Furthermore\, work in our group suggests th at the presence of slip should significantly enhance electrokinetic phen omena\, such as streaming currents. The implications of these results wi ll be explored in an IMNI seed project that is underway between the Stei n and Breuer groups. I will describe how our fundamental studies of slip 's influence on electrokinetic transport in nanochannels may pave the wa y to an efficient harvester of mechanical energy.\n UID:71FE7763-4EBD-4A9E-BA6C-340E5E78ED43-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090212T150000 DTSTAMP:20090202T204918Z SUMMARY:Physical Chemistry Tea Session: Derek Stein\, Brown University. \"Energy Harvesting in Nanofluidic Structures Using Electrokinetics & Hy drodynamic Slip.\" Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090212T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: We observe the sonoluminescence of collapsing gas bubbles generated by laser irradiation of aqueous suspensions of carbon particles over pressures ranging from one to six atmospheres. The mechan ism for generation of a gas bubble is chemical in origin: the heating of the carbon particles in the suspension by absorption of laser radiation generates a highly compressed bubble of H2 and CO through the carbon st eam reaction. The subsequent expansion of the bubble past its equilibriu m diameter results in oscillation of the bubble diameter. Tens of μs aft er the initial formation of the bubble\, sonoluminescence is found to ta ke place on collapse of the bubble. Experiments show that the sonolumine scent intensity is increased by a factor of more than ten as the externa l pressure is increased from one to six atmospheres. The time of appeara nce of optical radiation following the initial firing of the laser is fo und to decrease with increasing external pressure as well. The laser irr adiation of hydrogen peroxide solution with carbon particles generates t he sonoluminescence twice brighter than aqueous suspensions due to the m ore exothermic reactivity. UID:F879C944-5588-4274-9292-3E5C1B1222BC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091029T150000 DTSTAMP:20091019T141938Z SUMMARY:Physical Chemistry Tea Session: Han Jung Park. \"Sonoluminescenc e Initiated by Laser Irradiation of Carbon Suspensions: The Effects of E xternal Pressure & Exothermic Reaction on Sonoluminescent Intensity.\" H ost: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091029T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Pathogenic bacteria are developing and acquiring r esistance to clinically used antimicrobial drugs faster than new ones ar e being developed. Highly transmissible infections caused by drug-resist ant pathogens are an impending public health crisis that could dramatica lly increase mortality rates. We are working to provide solutions to thi s problem by studying potential antibacterial drugs and by searching for ways to deactivate drug resistance mechanisms in bacteria. In the forme r approach\, we are studying indolmycin and chuangxinmycin\, two natural ly occurring antibiotics that competitively inhibit bacterial tryptophan yl-tRNA synthetase. In the latter\, we are studying compounds that deact ivate bacterial resistance to chloramphenicol\, a clinically used antimi crobial agent. UID:A713D247-56A6-4B49-A887-24FDEDCBC963-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091006T110000 DTSTAMP:20090930T145038Z SUMMARY:Fourth Year Organic Student Seminar. James Vecchione\, Brown Uni versity. \"Using Chemical\, Genetic & Biochemical Approaches to Understa nd & Circumvent Antimicrobial Resistance.\" Host: Jason Sello. 11:00\, G C 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091006T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:0 DESCRIPTION:test UID:6813E4ED-4701-454C-B99F-6B3A1ABD0461-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE STATUS:CONFIRMED DTSTART;TZID=America/New_York:20091201T145500 DTSTAMP:20091216T195543Z SUMMARY:Test CREATED:20100714T131812Z DTEND;TZID=America/New_York:20091201T155500 LOCATION:Watson Institute\, Room 114 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:8549CA6B-6E5E-11DA-8D2F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060512T160000 DTSTAMP:20060421T202540Z SUMMARY:Friday Chemistry Colloquium: Nicola Pohl\, University of Iowa. 4 :00 - 5:30\, MM115. \"Synthetic Strategies to Decipher the Glycocode.\" Host: Amit Basu. (TOO) The Inn at Brown CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060512T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: We build up a 1-D partial differential wave equati on for an artificial crystal with the periodic structure modulated by th e factor \, in order for the research in the photoacoustic effect in th e phononic crystals\, a novel material in acoustics. Here “γ” is the mod ulation factor and “α” is the periodic length of the phononic crystal. W e derive a series of methods to obtain the theoretical results. In the f requency domain\, we not only use green functions to solve the inhomogen eous problems\, but also derive a new complete set of Mathieu Functions which are all orthogonal to get the acoustic solutions based on differen t sources. In the time domain\, we use a finite difference method to sol ve the PDE numerically and get the wave movement picture in the phononic crystal under the infinite length model. UID:96F5F41B-8854-45F8-912E-97C244991CC5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100304T150000 DTSTAMP:20100226T163343Z SUMMARY:Physical Chemistry Tea Session: Binbin Wu\, Brown University. \" Photoacoustic Effect in Phononic Crystals.\" Host: Gerald Diebold. GC 35 1\, 3:00. (Refreshments by Han Jung Park) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100304T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:86F65C4F-6DB0-451D-BA8F-17D6D556B4E1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090924T150000 DTSTAMP:20090918T173943Z SUMMARY:Physical Chemistry Tea Session: Xinsheng \"Sean\" Ling\, Brown U niversity. \"Nanopore DNA Sequencing: The Progress & the Prospect.\" Ho st: Gerald Diebold. GC 351\, 3:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090924T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:DA124BFB-54FE-40B3-9818-2F885CA2F904-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061102T150000 DTSTAMP:20061020T154053Z SUMMARY:Physical Chemistry Tea Session: Chengju Wang\, Brown University. 3:00 - 4:30\, GC 351. \"The Geodesic Path Picture for the Dynamics in t he Condensed Matter System.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061102T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:82B664A2-2468-11DA-A844-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050930T160000 DTSTAMP:20050916T171728Z SUMMARY:First Superfund Basic\nResearch Seminar/Friday Chemistry Colloqu ium: John Warner\, University of Massachusetts\, Lowell. 4:00 - 5:30\, M M 115. \"Green Chemistry: Necessary Steps to a Sustainable Future.\" Hos t: Shouheng Sun. No schedule. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050930T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Carbohydrate-carbohydrate interactions (CCIs) make up a separate genre of interactions that have been implicated in interc ellular adhesion and signaling. As with most carbohydrate-binding intera ction\, CCIs in nature are multimerized to enhance inherently weak bindi ng affinities. The molecular details underlying the formation of multime ric or multivalent CCIs are poorly understood\, especially in the contex t of how they mediate recognition at the cellular interface. Consequentl y\, multivalent carbohydrate mimics have been synthesized and evaluated in assays intended to simulate the multivalent binding mode of CCIs. Thi s thesis discusses the use of Langmuir monolayer assays to simulate the CCIs that mediate the adhesion of mouse B16 melanoma cells to the endoth elium. A series of PAMAM-glycodendrimers were prepared and evaluated as mimics of endothelial lactosylceramide (LacCer) clusters\, by exposing t hem to monolayers containing monosialosyllactosylceramide (GM3)\, a high ly expressed ganglioside on the surface of B16 melanoma cells. The relat ive activities of these glycodendrimers were ranked according to the ext ent of their interaction with the monolayer\, which was quantified by ch anges in surface pressure (Δπ).\n\nOur study indicates that excessive ca rbohydrate valency on the glycodendrimer inhibits interactions with the GC3/DPPC monolayer. Also\, the interactions between GC3/DPPC monolayers and glycodendrimers are driven by specific CCIs\, whereby lactose-GM3 in teractions are favoured over cellobiose-GM3 or maltose-GM3 interactions. The specificity of this interaction is contingent on the presence of ca lcium ions.\n UID:E9EE1EB0-B47D-4412-8031-4EA0BA760893-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090429T130000 DTSTAMP:20090417T160216Z SUMMARY:PhD Thesis Defense: Nicole Seah\, Brown University. \"Carbohydra te-Carbohydrate Interactions.\" Presiding Officer: Amit Basu. 1:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090429T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Membrane proteins are involved in critical cellula r processes such as intracellular signal transduction and molecule trans port. However\, their structural analysis is notoriously difficult due t o their hydrophobicity and association with lipid membranes. In this pre sentation\, I will discuss two projects that highlight our efforts to an alyze this class of proteins using mass spectrometry. The first half of the presentation will focus on the comprehensive characterization of an integral membrane protein\, the human sigma-1 receptor (S1R). S1R mediat es a pro-survival signaling pathway and has been implicated in processes associated with cancer\, cardiovascular disease and neurological disord ers. My laboratory has developed an affinity purification technique that not only allows for the characterization of native S1R\, but also facil itates identification of its binding partners. Detailed information on S 1R including novel post-translational modifications and amino acid subst itutions will be discussed. \n\nDuring the second half of the presentati on\, I will discuss our efforts to characterize the outer membrane (OM) subproteome of Caulobacter crescentus. C. crescentus is a gram-negative bacterium that permanently attaches itself to marine substrata (includin g hulls of ships) using an adhesive organelle known as the holdfast. The holdfast is the strongest naturally occurring glue and is localized to the bacterium's outer membrane. However\, attempts to directly character ize the holdfast have been unsuccessful. I will describe our optimized m ass spectrometry-based approach to (1) characterize the OM proteins of C . crescentus and (2) identify holdfast proteins through comparative pro teomic analysis.\n UID:7974AEC7-26C1-4DA3-AA86-4ACB4C3FA3DB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090911T160000 DTSTAMP:20090908T144634Z SUMMARY:Friday Chemistry Colloquium: Carthene Bazemore-Walker\, Brown U niversity. \"Proteomic Analysis of Membrane Proteins.\" Host: Eunsuk Kim . 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090911T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Species of the bacterial genus Streptomyces are a predominant component of the microbial population of soil throughout the world\, where they are thought to contribute to the degradation of comp lex organic materials and facilitate nutrient recycling. Streptomyces sp ecies produce a wide array of medically and commercially important secon dary metabolites\, such as streptomycin and chlortetracycline\, and memb ers of this genus were of particular interest during the pharmaceutical industry's \"golden age\" of antibiotics. The systematics of the genus Streptomyces\, which has the greatest number of validly described specie s of any bacterial genus\, has long been a challenge. The classification of Streptomyces species was originally based almost exclusively on morp hological characteristics\, a factor that contributed to the large numbe r of valid and invalid species described in the literature and patents. Over the years\, researchers have applied different methods\, such as nu merical taxonomic analysis of phenotypic traits or various molecular bio logy techniques\, to clarify the species concept in Streptomyces and sim plify the identification of newly isolated strains. The 16S rRNA gene se quences for virtually all validly described species within the family St reptomycetaceae\, which contains the genus Streptomyces and others\, ar e now available from the public sequence databanks and it is possible to calculate phylogenetic relationships among the species. However\, becau se of the relatively high similarity in 16S rRNA gene sequence among alm ost all species\, it may not be feasible to propose phylogenetic relatio nships between individual species or species groups based on this gene a lone\, although nearly identical similarity of this sequence is a strong indication of identity. The study of sequences of multiple housekeeping protein-coding genes may provide some insight into the phylogenetic rel ationships among species. It is possible\, however\, to examine the dist ribution of phenotypic characteristics such as morphology or secondary m etabolites as related to the overall phylogeny of the species within the Streptomycetaceae. UID:A29E660B-4261-4057-A0C9-5C8AD8D39E3D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081021T110000 DTSTAMP:20081015T183412Z SUMMARY:Organic Seminar: David Labeda\, USDA. \"Systematics of the Genus Streptomyces: Will a Phylogeny Based on 16S Ribosomal RNA Genes Yield T axonomic Resolution or Confusion?\" Host: Jason Sello. 11:00 - 12:15\, G C 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081021T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:D42F020C-73A9-11D9-85F4-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051104T160000 DTSTAMP:20051102T215702Z SUMMARY:Friday Chemistry Colloquium: Laura L. Kiessling\, University of Wisconsin-Madison. 3:00 - 4:00\, MM115. \"A Chemical Approach to Studyin g Human Embryonic Stem Cells.\" Host: ChemDUG. (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051104T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:0044435B-2D75-44C4-A4E4-EE1ADC5E3100-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100419T134500 DTSTAMP:20100416T194209Z SUMMARY:Sc.B Biochemistry Thesis Talks\, GC 246\, 1:40. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100419T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The results of investigations of single metal nick el\, cadmium\, and lead\, and copper/nickel mixtures in the particulate spouted bed of conductive particles from acidic aqueous solution are pre sented. It was determined that\, in general\, the rates of single metal nickel\, cadmium\, lead electrowinning increase with increasing pH and i ncreasing temperature in acidic solutions over the experimental range in vestigated. Nitrogen sparging of the electrolyte solution in the holdin g tank was effective in reducing the dissolved oxygen concentration\, su ppressing metal corrosion rates\, and\, thereby\, improving the net meta ls recovery rate. A numerical model based on the Tafel equations\, incor porating a constant corrosion rate as an approximation was used to simul ate the electrochemical removal behavior of single metal nickel. The mod el captured the behavior reasonably well.\n\nThe quantitative and qualit ative behavior of co-deposition of copper and nickel from mixtures was s ignificantly different from that of the single metal solutions. This was attributed to the differences in reduction potential of the two metals\ , as well as the metal displacement reaction between Ni(0) and Cu(II)\, which effectively eliminated the copper corrosion reaction and augmented that for nickel. It also amplified the separation of the deposition reg imes in time for both metals\, suggesting that the recovery of each as a relatively pure metal deposit was possible under certain conditions.\n\ nData from the spouted particulate electrode system was incorporated int o the design and operation of the cyclic electrowinning/precipitation (C EP) system for the removal of complex heavy metal mixtures from contamin ated wastewaters at low concentrations. The removal of the heavy metals copper\, nickel and cadmium from aqueous solutions at low concentrations was investigated in the CEP system. It was found that the optimal remov al times for single metal removal increased in the order copper > nickel > cadmium\, while the maximum net CEP removal rates decreased in the sa me order. These orderings correlated with decreasing reduction potential s for these metals\, both in terms of the metal displacement reaction ra tes\, as well as the propensity of corrosion of the deposited metals. Th e CEP system shows significant promise for the effective removal of a nu mber of heavy metal mixtures from contaminated water.\n UID:012EE8B3-3755-4A3C-9B99-DDF4C762EC5D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091009T110000 DTSTAMP:20091006T134607Z SUMMARY:PhD Thesis Defense: Pengpeng Yao\, Brown University. \"The Remo val of Heavy Metal Pollutants With Electrowinning Techniques.\" Presidin g Officer: Joseph Calo. 11:00\, GC 246. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091009T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:4E54F95A-7706-4D58-AAAC-F5647F3B4B49-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070410T110000 DTSTAMP:20070328T134516Z SUMMARY:Organic Seminar: Michael G. Thomas\, University of Wisconsin. 11 :00 - 12:30\, GC 351. \"Discovering\, Deciphering & Harnessing Bacterial Secondary Metabolism.\" Host: Jason Sello. (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070410T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: I will first give a brief overview of our research on photovoltaic\, thermoelectric and spintronics applications of chalco genide and silicide nanomaterials and bioinspired assembly of nanomateri als. Then I will focus on a “new” nanowire formation mechanism that is d ifferent from the well-known metal catalyzed vapor-liquid-solid mechanis m. Axial screw dislocations provide the self-perpetuating steps to enabl e 1-dimensional crystal growth\, unlike previously understood mechanisms that require metal catalysts. This mechanism was first found in hierarc hical nanostructures of lead sulfide (PbS) nanowires resembling “Christm as trees” that were synthesized via chemical vapor deposition. Structura l characterization reveals a screw-like dislocation in the nanowire trun ks with helically rotating epitaxial branches. The rotating trunks and b ranches are the consequence of the Eshelby twist of screw dislocations. We have further used dislocation mechanism and elasticity theory to expl ain the spontaneous formations of other intriguing nanostructures. Dislo cation-driven growth is underappreciated in modern literature on one-dim ensional nanomaterials and should be general to many materials. Our stud y will enable more complex nanostructures to be rationally synthesized f or diverse applications. UID:95B4FA27-B03B-4FD9-BAA2-32137D878939-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090312T120000 DTSTAMP:20090211T213452Z SUMMARY:Inorganic Chemistry/Materials Seminar: Song Jin\, University of Wisconsin\, Madison. \"How to Make Nanowire Christmas Trees: Screw Dislo cation Driven Nanowire Growth.\" Host: Shouheng Sun. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090312T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Au in bulk is generally known to be inert\, but sh ows catalytic activity when it comes to nano scale. Regarding this\, Au nanoparticles (NPs) with high monodispersity and tunable sizes were synt hesized by a burst of nucleation with the injection of a reducing agent to Au salt in organic solution phase. The resulting Au NPs are polycryst alline with an icosahedral shape consisting of multiply-twinned structur e which may have more catalytically active sites for reactions that cann ot be catalyzed by bulk Au. The Au NPs showed high catalytic activity to wards oxygen reduction in alkaline media.\n\nMoreover\, the Au NPs were used as seeds for synthesizing Au-Fe3O4 composite NPs which showed highe r catalytic activity and stability towards H2O2 reduction compared to th eir individual components\, Au or Fe3O4. We demonstrate that Au and Fe3O 4 in close contact in the Au-Fe3O4 structure give a synergetic effect at the Au-Fe3O4 interface resulting in enhanced catalysis.\n UID:F0CE1B7E-F565-4520-9892-BC11930D9915-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100225T120000 DTSTAMP:20100218T163814Z SUMMARY:Inorganic Chemistry Seminar: Youngmin Lee\, Brown University. \" Synthesis of Au\, Au-Fe3O4 Composite Nanoparticles & their Catalytic App lications.\" Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100225T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Electrons in Rydberg orbits are sensitive spies of molecular structure. Typically\, the motions of flexible hydrocarbon ch ains are famously difficult to observe. Large amplitude vibrations born from high internal temperatures where the molecules vibrate in soft pote ntials blur the conformeric snapshot. We explore the equilibrium composi tion and dynamics between conformeric structures of N\,N-dimethyl-2-buta namine (DM2BA) and N\,N-dimethyl-3-hexanamine (DM3HA) using the Rydberg Fingerprint method. Initial excitation prepares the molecule in the 3p s tate and subsequent relaxation to 3s deposits 1.8 eV of vibrational ener gy\, elevating the internal temperature to some 900 K. The time-dependen t Rydberg spectrum reveals the conformational dynamics of the hot hydroc arbon chains\, enabling us to measure time constants for both the forwar d and backward reactions.\n\nIn addition\, investigations on the tertiar y diamine\, N\,N\,N’\,N’-tetramethyl-1\,2-ethanediamine\, revealed that the line width of the 3s Rydberg state dramatically narrows on a time sc ale of tens of picoseconds. We interpret this observation as a sign that the electrostatic interaction between the positive ion core and the neg ative part of the second amine group causes a stiffening of the intramol ecular bonds on a pico-second time scale. A discussion of the significan ce in observing structural dispersion in non-trivial molecular samples w ill be presented in the context of our most recent remto-second resolved experimental results. \n UID:88C88C9D-429E-4BCF-BBF5-AB844DD504B9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080410T150000 DTSTAMP:20080411T141412Z SUMMARY:Physical Tea Session: Michael Minitti\, Brown University. 3:00\, GC 351. \"Rydberg States: Stealthy Spies of Molecular Structure.\" Host : Jimmie Doll\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080410T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 DESCRIPTION:meet at the faculty club UID:F69468BF-520B-4971-9FD2-7ABC3377750F TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100428T000000 DTSTAMP:20100330T180845Z SUMMARY:sorensons - faculty club CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100428T010000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: Streptomyces are gram-positive\, filamentous soil bacteria that are renowned for their complex morphology and for their ab ility to produce a wide array of medically- and pharmaceutically-importa nt secondary metabolites\, including antibiotics\, antitumor and immunos uppressive compounds. A less well-known characteristic of these microorg anisms is the ability of some species to function as pathogens of econom ically important root and tuber crops such as potatoes. The most importa nt disease\, potato scab\, is found world-wide and is characterized by t he formation of raised\, corky or pitted lesions on the surface of the p otato tuber. All species that cause this disease produce a secondary met abolite\, thaxtomin A\, which is the primary virulence determinant in sc ab disease development. Biosynthesis of this novel phytotoxin involves t wo non-ribosomal peptide synthetases\, a nitric oxide synthase and addit ional modifying enzymes. Recent advances have revealed a unique mechanis m of thaxtomin biosynthesis involving an unusual cytochrome P450 and a n ovel biosynthetic intermediate\, 4-nitrotryptophan. In addition\, the re cently available genome sequence of Streptomyces scabies 87-22 has revea led the presence of additional secondary metabolite gene clusters in thi s pathogen\, including a mixed type I/type II polyketide synthase pathwa y predicted to synthesize a novel coronafacic acid (CFA)-like compound. CFA is a component of coronatine\, a toxin produced by plant pathogenic strains of Pseudomonas syringae. This is the first instance of a CFA-lik e biosynthetic cluster identified in a gram-positive bacterium\, and ana lysis of this cluster in S. scabies 87-22 indicates that it may be impor tant for plant-microbe interactions. UID:844E5BBF-7C9A-4CDE-94FD-3968992695EB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081121T160000 DTSTAMP:20081114T155223Z SUMMARY:Friday Chemistry Colloquium: Dawn Bignell\, Cornell University. \"Secondary Metabolism & Plant Pathogenesis in Streptomyces.\" Host: Jas on K. Sello. 4:00 - 5:30\, MM115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081121T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Mixed liquids commonly exhibit different propertie s than pure liquids such as an unusual long relaxation after an electron ic excitation of a solute. The extremely slow dynamics is a consequence of ‘preferential solvation\,’ a preference that a solute has for one kin d of solvent over another. Probing its mechanism by MD simulation\, we f ound an electrostriction-like response of the solvent followed by a much slower solvent redistribution. However\, the molecular details of these events are unclear. Previously\, we showed that for glass-forming liqui ds\, the shortest path gives the dominant accessible path in the potenti al energy landscape\; all that one needs to calculate diffusion constant s. Now\, we demonstrate that one can investigate the molecular events in preferential solvation via the geodesic path. Our goal is to use the ge odesic (shortest) pathways through the landscape to unravel the unknown mechanism of preferential solvation. UID:76023FD4-0A19-4877-96DF-912C7AE38BC6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090910T150000 DTSTAMP:20090908T144758Z SUMMARY:Physical Chemistry Tea Session: Crystal Nguyen\, Brown Universit y. \"Study of Preferential Solvation Dynamics using Geodesic Theory.\" H ost: Gerald Diebold. 3:00\, GC 351 CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090910T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:413C20AB-5130-11DA-A682-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060303T160000 DTSTAMP:20060224T225455Z SUMMARY:Friday Chemistry Colloquium: Veronica Vaida\, University of Colo rado. 4:00 - 5:30\, MM115. \"Sun-Light Initiated Processes in Atmospheri c Chemistry & Climate.\" Host: Jimmie Doll/Shouheng Sun. (TOO) Fletcher House 3/2-4 CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060303T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:3BE8F05D-85B0-11D9-B613-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050322T110000 DTSTAMP:20050223T153343Z SUMMARY:Organic First Year Seminar: Xiang Liu & Mary Paquette\, Brown Un iversity. GC 351\, 11:00 - 12:00. Host: William Trenkle. Title to come. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050322T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:No abstract. UID:B464AEF8-27E1-4A65-8843-4D6FAA1C4216-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080208T160000 DTSTAMP:20080130T212710Z SUMMARY:Inorganic Faculty Candidate: John Gordon\, Los Alamos National L aboratory. 4:00 - 5:30\, MM115. \"Some f-Element & Main Group Chemistry From Alamos.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080208T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:DE0E31AA-2D57-11DB-8778-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060914T120000 DTSTAMP:20060822T154212Z SUMMARY:Inorganic Seminar: Brian Luisi\, Brown University. 12:00 - 1:15 \, GC351. Title to come. Host: Shuangbing Han CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060914T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: The supply of clean and sustainable energy is one of the most important scientific challenges in the 21st century. Most cl ean and sustainable options such as solar energy\, produce electricity\, which requires electrical storage in order to link energy supply with e nergy demand. Our research concerns the science and engineering of mater ials for electrochemical energy conversion and storage. Fundamental rese arch on the materials and catalysts that convert and store energy is nee ded to increase the performance and cost characteristics of electrochemi cal devices. We tackle these challenges from a fundamental perspective t hrough the following framework: understanding the bulk and surface atomi c and electronic structures of materials\, uncovering reaction mechanism s\, and application of mechanistic understanding to design new materials . We will discuss how surface atomic structures and near-surface chemica l compositions of nanoparticles affect the catalytic activity for oxygen reduction and methanol oxidation in fuel cells\, and how the surface ch emistry of nanostructured materials can promote the energy and power for lithium storage. UID:C8DA2185-A3A3-42E7-AD95-4A518A13FD78-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100205T160000 DTSTAMP:20100201T202019Z SUMMARY:Friday Chemistry Colloquium: Yang Shao-Horn\, MIT. \"Understandi ng Nanomaterial Surfaces for Electrochemical Energy Conversion & Storage .\" Host: Shouheng Sun. MM 115\, 4:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100205T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:7303532F-2596-49F7-A20E-C4250906EE9B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100312T140000 DTSTAMP:20100121T184444Z SUMMARY:Prospective Graduate Student Visitation CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100312T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Aminoacyl-tRNA synthetases (aaRSs ) catalyze the a ttachment of amino acids to their cognate transfer RNAs in an ATP-depend ent reaction (aminoacylation) during the initiation of protein synthesis . There are two classes of enzymes that perform this reaction\; our lab focuses on the class II enzymes. As part of our efforts to understand th ese enzymes\, we use classic enzymology and biochemistry\, structural bi ology and molecular biophysics approaches. I will review our work over t he last decade and a half\, focusing on how we have deduced details of t heir mechanism\, identified related proteins with diverse functions and studied the action of an interesting class of novel inhibitors. While th e basic function of these enzymes has been known for more than four deca des\, new surprises in the form of interesting chemistry and biology eme rge regularly. For the aaRSs\, protein synthesis is only the beginning. UID:D8EC1BC1-4D08-49E5-B0BE-87644A1F9A7E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081024T160000 DTSTAMP:20080905T193836Z SUMMARY:Friday Chemistry Colloquium: Christopher Francklyn\, University of Vermont. \"Substrate Facilitated Catalysis by Aminoacyl-tRNA Synthet asess: Creating the Precursors for Protein Synthesis.\" Host: Jason Sell o. 4:00 - 5:30\, MM115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081024T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:47EAEFDC-6C7A-44B9-8363-48CD1AA5762C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T094500 DTSTAMP:20080813T122525Z SUMMARY:Joseph A. Abys\, PhD\, '81. Enthone Division\, Cookson Electroni cs. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T101500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:D67E4260-17F2-4BFC-9AE0-E7F8EBB5FBD2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100211T120000 DTSTAMP:20100202T203410Z SUMMARY:Inorganic Chemistry Seminar: Don Ho\, Brown University. Title an d abstract to come. Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100211T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:B90B6375-EE04-491A-940E-85704D5F3BBB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110408T160000 DTSTAMP:20100630T210150Z SUMMARY:Friday Chemistry Colloquium: Dong-Sheng Yang\, UKY. Title & abst ract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110408T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:C8096F47-A86D-43A4-B676-053F29B27584-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061010T090000 DTSTAMP:20061002T153624Z SUMMARY:Organic Seminar: Xiaoliang Wei\, Brown University. 11:00 - 12:30 \, GC 351. Title to come. Host: Jason K. Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061010T100000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:F8230F92-4688-4AE5-B656-5EE8E98F6F3E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101210T160000 DTSTAMP:20100625T191511Z SUMMARY:RESERVED: Faculty Search CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101210T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:FDDCADFA-C8A5-11DA-A161-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060425T150000 DTSTAMP:20060410T152427Z SUMMARY:Thesis Defense: Chunhua Yao\, Brown University. Time. location\, title to come. Presiding Officer: William Risen. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060425T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Pt and Pd monometallic and Pt-Pd bimetallic (alloy ) nanoparticles containing up to an average of 180 atoms were prepared w ithin 6th-generation\, hydroxyl-terminated\, poly(amidoamine) dendrimers . Transmission electron microscopy\, energy dispersive X-ray spectroscop y\, UV-vis spectroscopy and EXAFS measurements confirmed that the size a nd composition of these materials could be precisely controlled. Cyclic voltammetry and rotating disk voltammetry were used to measure the elect rocatalytic properties of these materials for the oxygen reduction react ion. Particular compositions of the bimetallic nanoparticles exhibited a n enhancement of up to a factor of 2.5 compared to monometallic Pt. Howe ver\, the most important result of this project is the demonstration tha t electrocatalysts containing just 180 atoms and having uniform composit ions can be synthesized and characterized ex situ and then subsequently be immobilized on an electrode surface. This provides a means to correla te the structure of the nanoparticles to their electrocatalytic function . In contrast\, previous studies have relied on electrocatalysts being p repared in situ\, which makes it difficult to control and analyze their properties. UID:E02B7B22-3EBE-4E5F-960E-205BBB2FFC6D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080425T160000 DTSTAMP:20080415T131959Z SUMMARY:Friday Colloquium: Richard Crooks\, University of Texas. 4:00\, MM 115. \"Synthesis\, Characterization & Electrocatalytic Applications o f Dendrimer-Encapsulated Nanoparticles.\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080425T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:857A5CD4-93C5-42E0-8B01-7F0A4847A1DF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071011T120000 DTSTAMP:20071010T162726Z SUMMARY:Inorganic Seminar: Brian Moulton\, Brown University. 12:00 - 1:1 5\, GC 351. \"Amorphous Coordination Polymers.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071011T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: The determination of molecular structure in the ga s phase is important\, as the molecules are free from intermolecular for ces that can affect solid-state structures. Such experimentally determin ed gas-phase structures are used by chemists to gain further insight int o chemical and physical properties of molecules and into chemical reacti ons\, the thermodynamics and mechanisms of processes. Structural data fo r model systems are also vital for theoreticians\, who can use the infor mation to gauge the accuracy of new computational methods.\n\nUtilising a combination of gas electron diffraction (GED) and computational method s\, gas-phase structures for ever-larger systems can be determined. Usin g computational methods for isolated and periodic systems also allows th e distinctions between gaseous and solid-state structures to be rational ised in terms of energy differences and the influence of intermolecular interactions.\n\nThis presentation will illustrate several systems where very different molecular structures are obtained upon vaporisation incl uding tetra(disyl)diphosphine\,* N-methyldichloroacetamide and hexa-tert -butyldisilane. The differences can be dramatic and are often unexpected . The reasons for these differences will also be discussed.\n\n*disyl = bis(trimethylsilyl)methyl\n UID:80900C2D-FF87-4A47-88B0-ED7E1E41997C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080229T160000 DTSTAMP:20080307T214618Z SUMMARY:Friday Colloqium: Sarah L. Masters\, University of Edinburgh. 4: 00\, MM 115. \"Molecular Structures in Different Phases: Are They the Sa me?\" Host: Peter Weber. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080229T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: BioTrove\, Inc. advances life science and drug dis covery research through two revolutionary micro- and nano-scale technolo gies\, including ultra high-throughput mass spectrometry. A privately he ld company\, BioTrove is backed by leading venture capitalist firms Cata lyst Health and Technology Partners\, CB Health Ventures\, Vox Equity Pa rtners I & II\, Echelon Ventures and Fletcher Spaght\, Inc. UID:B93803DB-EEB2-4D06-B559-1DEC87E10860-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091002T160000 DTSTAMP:20090924T151758Z SUMMARY:Careers in Chemistry Seminar: Lauren Frick & Peter Rye\, Biotrov e. Host: Sarah Delaney.4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091002T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:5AFC173C-41A3-11DA-9BED-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051213T110000 DTSTAMP:20051207T180917Z SUMMARY:Organic Seminar: Xin Lin\, Brown University. 11:00 - 12:30\, GC 351. \"Expression & Characterization of a Novel Sesquiterpene Synthase f rom Streptomyces Coelicolor.\" Host: William Trenkle CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051213T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:12 DESCRIPTION:Abstract: The field of chemical neurobiology is rapidly evol ving and providing insights into the molecules and interactions involved in brain development\, neuronal communication and synaptic plasticity. We will describe the synergistic application of organic chemistry and ne urobiology to explore the structure and function of carbohydrates in the nervous system and their impact on neuronal communication\, growth and spinal cord regeneration. UID:26C3E721-0674-4472-BD6F-A44605C25CA2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081209T110000 DTSTAMP:20081126T202017Z SUMMARY:Organic Seminar: Linda Hsieh-Wilson\, CalTech. “Chemical Approac hes to Neurobiology.” Host: Amit Basu. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081209T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 TRANSP:OPAQUE UID:BA591EC1-2C5A-4ED0-8512-FFF68E9C278B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071102T160000 DTSTAMP:20071031T201518Z SUMMARY:Friday Colloquium: Steven Bruner\, Boston College. 4:00 - 5:30\, MM 115. \"The Structure & Chemistry of Nonribosomal Peptide Natural Pro duct Biosynthesis.\" Host: Jason Sello. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071102T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: X-rays from synchrotron radiation sources are an i mportant tool in the study of ultrafast processes in chemistry and conde nsed matter. Hard x-rays at wavelengths of the order of 0.1 nm can be di ffracted for structural studies and can be used for element-specific spe ctroscopy of electronic and structural processes. X-rays from a synchrot ron radiation source are intense and highly collimated. They have a natu ral time structure with pulses typically < 100 ps long. In most cases\, a pulsed laser is timed to the synchrotron to trigger a process\, such a s a chemical reaction\, which is then studied with the x-rays (laser pum p\, x-ray probe experiment). To reach time resolutions better than the c a. 100 ps pulse length\, x-ray streak cameras are employed. I will give an overview of time-resolved x-ray science at the advanced photon source \, which is one of three high-energy synchrotron radiation sources world wide. Present and future efforts to reach a time resolution of ca. 1 ps will be presented and future\, 4-th-generation x-ray sources will be dis cussed\, such as the LCLS free-electron laser project. UID:5A0B5F23-73AF-468E-B16B-B1EBBAB10CB1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081023T150000 DTSTAMP:20081020T192733Z SUMMARY:Physical Chemistry Tea Session: Bernhard Adams\, Argonne Nationa l Laboratory. \"Time-Resolved X-Ray Science at the Advanced Photon Sourc e.\" Host: Christoph Rose-Petruck. 3:00 - 4:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081023T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 TRANSP:OPAQUE UID:0CE034FD-F0A7-499A-AA8F-AB3E4106F809-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071016T110000 DTSTAMP:20071012T184422Z SUMMARY:Student Organic Seminar: Kebing Yu\, Brown University. 11:00 - 1 2:30\, GC 351. \"A Proteomic Study of Insulin-Stimulated Signal Transduc tion in Hepatocellular Carcinoma\". Host: Jason Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071016T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:62EE021D-79EF-4B79-B2BD-C59627FF11E1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061109T120000 DTSTAMP:20061107T173147Z SUMMARY:Inorganic Seminar: Yanglong Hou\, Brown University. 12:00 -1:15\ , GC 351. \"Chemical Synthesis & Characterization of SmCo5 & Fe/Co-Doped SmCo5 Hard Magnetic Materials.\" Host: Shuangbing Han CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061109T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Water at biological interfaces has structural and dynamical properties that are substantially different from the bulk\, an d these differences have a profound influence in determining the structu re\, dynamics and function of proteins and DNA. Molecular dynamics simul ations are used to connect directly to recent time-dependent fluorescenc e experiments of the Hoechst 33258 (H33258) and Coumarin 102 (C102) prob e molecules both free in aqueous solution and bound to DNA. These two pr obes interrogate different sub-ensembles of water molecules at the DNA i nterface\, because H33258 binds within the DNA minor-groove\, whereas C1 02 is a base pair analogue. The goal of the simulations is to gain molec ular-level insight into how the specific structural properties\, interac tions\, and motions of water molecules affect processes at biological in terfaces. The calculations provide a more comprehensive interpretation o f time-dependent Stokes shift experiments by partitioning the measured s olvation response into components from water\, counterions and DNA. UID:2BC3A682-39BF-4A7F-BF2B-2D9CE53C6A29-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091112T150000 DTSTAMP:20091104T142345Z SUMMARY:Physical Chemistry Tea Session: Steven Corcelli\, Notre Dame Un iversity. \"Computational Studies of DNA Hydration Dynamics.\" Host: Ger ald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091112T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Thermal diffusion effect is the phenomenon in whic h a temperature gradient in a mixture induces a concentration gradient. In the linear temperature gradient field\, we predict the shock wave for mation in the nonlinear binary mixture system in the process of the ther mal diffusion. Here\, we investigate its theoretical prediction and comp are the experimental results to it.\n\nAt the end of the presentation\, we will briefly present and discuss some preliminary results of the expe riment of the investigating ultrasonic atomization as a potential new me thod of distillation.\n\n[J Chem Phys. 2001\; 114: 2382-2386]\n UID:208B9D16-21C4-45F1-81DB-098C3C47F880-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081009T150000 DTSTAMP:20081009T141513Z SUMMARY:Physical Chemistry Tea Session: Hye Yun Jung\, Brown University. \"Thermal Diffusion Shock Waves & Ultrasonic Atomization.\" Host: Chris toph Rose-Petruck. 3:00 - 4:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081009T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: The surfactants-mediated method is adapted in the chemical synthesis of FePt nanoparticles. The size and structure of FePt nanoparticles can be simply tuned by controlling the surfactants/solven t ratio and reaction temperature. These simply-tuned FePt nanostructures show spherical\, nanocubes and nanowires/nanorods. As-synthesized near equiatomic FePt nanoparticles show chemically disordered face-centered ( fcc) structures\, which are superparamagnetic. Through high temperature heat treatment\, the fcc-structured FePt nanoparticles can be changed in to a chemically ordered face-centered tetragonal (fct) structure\, which is ferromagnetic. This fct-structured FePt nanoparticle shows high magn etocrystalline anisotropy constant K\, reaching up to 107J/m3 along easy axis [001] direction\, that is one of the largest among the known hard magnetic materials. To block sintering problems during the annealing pro cess\, MgO is coated on fcc-FePt nanoparticles\, which is high temperatu re endurable robust material and easily removable by dilute acid after t hermal treatment. Phase-changed fct-FePt nanoparticles can be dispersed in hexane solution by aid of hexadecanethiol and oleic acid without seve re agglomeration. All these series of progress may offer the fabrication of ordered nanomagnet arrays with controlled magnetic alignment\, which is an important goal to achieve high-density information storage and hi gh performance permanent magnets.\nPt-based metal alloys can be also use d as electrocatalysts in fuel cells. They catalyze hydrogen oxidation at the anode and oxygen reduction at the cathode\, especially in proton ex change membrane fuel cells. However\, platinum catalysts without any sec ondary metal elements are very expensive\, which hinders the development of large-scale fuel cell applications. To reduce the costs of fuel cell s and improve the performance\, nano-sized FePt electrocatalysts have be en prepared and evaluated for anodic and cathodic electron-transfer reac tions. FePt nanoparticles as electrocatalysis show good performance in b oth oxygen reduction reactions at cathode and small molecule (methanol a nd formic acid) oxidation reactions at anode.\n UID:C0ADBD4A-798E-465E-A780-1D2337DB8177-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090420T130000 DTSTAMP:20090416T152128Z SUMMARY:PhD Thesis Defense: Jaemin Kim\, Brown University. \"The Magneti c & Electocatalytic Studies of FePt Nanoparticles.\" Presiding Officer: Shouheng Sun. 1:00\, GC 449. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090420T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:81E052BE-ED6D-45E2-B7FD-E7C8BCE19820-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070417T110000 DTSTAMP:20070413T165825Z SUMMARY:Milton Brown. Organic Chemistry Seminar\, 11:00 - 12:30\, GC 351 . \"Voltage Gated Sodium Channel Blockers: A New Therapy for Prostate C ancer.\" Host: Carthene Bazemore-Walker. (Fletcher House) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070417T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Glasses are solids that structurally resemble liqu ids. They thus defy the typical description of solidity as arising from periodic structural order. Equally unusual is the behavior of supercoole d liquids as they approach the formation of such disordered solids. Clos e to the glass transition\, very small changes in pressure or temperatur e result in enormous changes in the liquid's viscosity. In the 125th ann iversary issue of Science\, the \"glass transition\" problem was listed as one of the 125 scientific puzzles that point to gaps in our basic sci entific knowledge. Despite the recognition of the importance of the prob lem\, no consensus exists regarding the nature and theoretical descripti on of supercooled liquids and glasses. Recent experiments and simulation s have shown that supercooled liquids are dynamically heterogeneous\; mo lecules separated by merely a few nanometers in space may show transient relaxation rates that differ by orders of magnitude. It is generally ac cepted that this dynamical heterogeneity is a key to understanding glass formation. I focus on two important questions related to this heterogen eous behavior. First\, is there something in the structure of a supercoo led liquid that is directly linked to such heterogeneous dynamics? Secon d\, how can one theoretically describe dynamic heterogeneity in terms of correlation functions? UID:2A2882A5-64DB-4BB2-B43F-34AE8EB0CCC1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080320T150000 DTSTAMP:20080305T200447Z SUMMARY:Physical Tea Session: David R. Reichman\, Columbia University. 3 :00\, GC 351. \"The Heterogeneous Nature of Supercooled Liquids & Glass Formation.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080320T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:F42F601E-F0B1-40DB-8F5A-1FCF91B3D498-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110304T160000 DTSTAMP:20100625T200320Z SUMMARY:Friday Chemistry Colloquium: David MacMillan\, Princeton Univers ity. Title and abstract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110304T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:AE615094-9C22-45B5-B1CC-E0F3E13C43F5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110429T150000 DTSTAMP:20100615T183838Z SUMMARY:Friday Chemistry Colloquium: Stephen J. Lippard\, MIT. Title & a bstract to come. Host: Eunsuk Kim. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110429T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:BB86B58E-7150-11D9-9AC2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050210T150000 DTSTAMP:20050203T155445Z SUMMARY:Physical Tea Session: Richard Martin\, Los Alamos National Labor atory. GC 351\, 3:00 - 4:15. \"The Next Generation Lighting Initiative. What's Quantum Chemistry Got To Do With It?\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050210T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Terpenoids are among the largest families of natur al products comprising numerous organic compounds with a broad range of physiological properties and immense structural diversity. These metabol ites serve crucial roles in primary metabolism and ecological interactio ns of their organisms as well as display medically and economically valu ed characteristics. \n\nMethylisoborneol is a common volatile terpenoid metabolite of many actinomycetes\, as well as cyanobacteria and myxobact eria\, with an extremely low threshold for human detection. Together wit h geosmin\, methylisoborneol is responsible for the characteristic odor of moist soil and the undesirable musty flavors found in fish and water systems. The sco7700 and sco7701 genes in Streptomyces coelicor have sho wn to correspond to a two-gene operon responsible for methylisoborneol b iosynthesis. The biochemical functions of SCO7700 and SCO7701 have been characterized\, establishing the two-step conversion of geranyl diphosph ate to methylisoborneol by way of 2-methylgeranyl diphosphate.\n\nThe se squiterpene phytotoxin botrydial secreted by the necrotrophic fungus Bot rytis cinerea is the causal agent of the important gray mold disease tha t affects over 200 plant host species worldwide. The botrydial biosynthe tic gene cluster identified recently contains a sesquiterpene cyclase ge ne (BcBOT2) and three putative cytochrome P450-encoding genes (BcBOT1\, BcBOT3\, and BcBOT4)\, as well as an acetyl transferase gene (BcBOT5). T he cyclase encoded by BcBOT2 has shown to catalyze the conversion of far nesyl diphosphate to presilphiperfolan-8β-ol\, the parent sesquiterpene alcohol of the botrydial biosynthetic pathway. Detailed cyclization mech anism and stereochemistry have been established. To further investigate the biosynthesis of botrydial and elucidate the role of the clustered P4 50s\, cloning of the BcBOT3 and BcBOT4 genes and expression of the corre sponding proteins have also been described. \n UID:70457350-CC2B-429F-9ABD-D17B8E5E7951-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100426T120000 DTSTAMP:20100406T201200Z SUMMARY:Thesis Defense: Chieh-Mei Wang\, Brown University. \"Terpenoids Biosynthesis: I. Biosynthesis of the Earthy Odorant Methylisoborneol in Streptomyces coelicolor A3(2). II. Biosynthesis of the Phytotoxin Botryd ial in Botrytis cinerea.\" Presiding Officer: David E. Cane. GC 351. 12: 00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100426T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: During the past three decades\, several natural me tabolites of 1α\,25(OH)2D3 (Vitamin D hormone) were identified. For a lo ng time it has been the general belief that the various intermediary met abolites formed during the process of inactivation of 1α\,25(OH)2D3 are only metabolites with no biological significance. During the past severa l years\, we evaluated carefully the biological activities of various na tural metabolites of 1α\,25(OH)2D3. We then found out that the natural metabolites\, especially with 24-oxo and 3-epi modifications\, have sign ificant biological activities. Furthermore\, these 24-oxo and 3-epi meta bolites were found to be less toxic when compared to 1α\,25(OH)2D3. Base d on these observations\, we have put forward the concept that various b iological activities produced by the hormone 1α\,25(OH)2D3 represent a c ombination of the actions generated by the hormone and its natural metab olites. I will discuss how we used the aforementioned concept to develop unique synthetic vitamin D analogs with 24-oxo and 3-epi modifications which appear to have great potential to become novel drugs. \n\nReddy\, G.S.\, Tserng\, K Y.: Biochemistry 28\, 1763 1769\, 1989.\nLee\, N.E.\, Reddy\, G.S.\, Brown\, A.J.\, Williard\, P.G.: Biochemistry 36:9429 943 7\, 1997.\nReddy G.S.\, Muralidharan\, K.R.\, Okamura\, W.H.\, Tserng\, K Y.\, McLane\, J.A.: Steroids 66(3 5): 441 450\, 2001.\nLaverny G.\, Pe nna G.\, Uskokovic M.\, Marczak S.\, Maehr H.\, Jankowski P.\, Ceailles C.\, Vouros P.\, Smith B.\, Robinson M.\, Reddy G.S.\, Adorini L.: Journ al of Medicinal Chemistry\; 52(8):2204-13\, 2009.\n UID:E6533BB9-7C83-4C75-AC26-4BC9F749EE0F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090918T160000 DTSTAMP:20090910T131726Z SUMMARY:Friday Chemistry Colloquium: Satya Reddy\, Brown University. \" Development of 24-oxo Metabolites of Vitamin D & its Analogs as Novel Dr ugs: A Dream & Journey of Three Decades.\" Host: Jason Sello. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090918T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:59E1D127-6939-4353-96E6-50097E2B3DE8-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T134500 DTSTAMP:20080813T124818Z SUMMARY:Efstatios Kamitos\, PhD\, '84. National Hellenic Research Instit ute\, GREECE. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T141500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: With increasing demand on fossil fuels\, innovativ e alternative energy resources are a worldwide research initiative. Fuel Cells\, electrochemical devices that convert chemical energy to electri cal energy\, have emerged as one of the many enabling technologies being currently investigated as a key player. Given their small size\, nanopa rticle (NP) catalysts are believed to be possible solutions to the cost and durability issues hindering low temperature fuel cells. This present ation will first introduce the principal concerns on this matter from a catalysis point of view. Then\, it will discuss the development of a ver satile synthesis methodology of core/shell nanoparticles for the key rea ction of oxygen reduction. This procedure allows other metals to be inco rporated into either the core or shell structure in a sub-10 nanometer r egime and provides a novel route to the development of practical catalys ts for fuel cell applications. UID:F56ED52A-F74C-4F49-B4BC-073122EF7B29-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100318T120000 DTSTAMP:20100311T212513Z SUMMARY:Inorganic Chemistry Seminar: Vismadeb Mazumder\, Brown Universit y. \"Engineering Nanoparticle Catalysis via a Multi-metallic Core/Shell Structure.\" Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100318T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:E0A384B4-814F-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060420T150000 DTSTAMP:20060420T195504Z SUMMARY:Physical Chemistry Tea Session: Shougang Wang\, Brown University . 3:00 - 4:15\, GC351. \"Imaging using the Ultrasound Vibration Potentia l.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060420T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: We worked on the co-deposition of metals from aque ous mixtures in a spouted particulate electrode. Here we present results on the co-removal of copper and nickel mixtures from acidic solutions i n a cylindrical spouted bed electrolytic reactor. The effects of pH and temperature on the net recovery and corrosion rates of the co-deposited metals were investigated under galvanostatic conditions. The maximum rem oval rate occurred at about 40°C and a pH of 4. The quantitative and qua litative behavior of co-deposition of the metals from mixtures differed from that of the single metal solutions. This is attributed primarily to the metal displacement reaction between Ni0 and Cu2+. This effectively reversed the copper corrosion reaction and augmented that for nickel (at least initially). This also amplified the separation of the deposition regimes in time for both metals\, suggesting that the recovery of each a s a relatively pure metal deposit from the mixture was possible. These f indings will be incorporated into the design and operation of our cyclic electrowinning/precipitation system for the removal of heavy metal mixt ures from contaminated wastewaters. UID:45BCE1FD-DC11-4927-A258-B55A223217AD-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090305T150000 DTSTAMP:20090303T215603Z SUMMARY:Physical Chemistry Tea Session: Pengpeng Yao\, Brown University. \"Removal of Copper/Nickel Mixtures from Aqueous Solutions with a Spout ed Particulate Electrode.\" Host: Gerald Diebold. 3:00. GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090305T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:BC0E1297-F092-4CEB-A2B4-4A2AA4FB531E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090313T080000 DTSTAMP:20090113T150840Z SUMMARY:Prospective Graduate Student Visitation CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090313T081500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:2CDBAE14-04EE-11DA-8657-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060427T160000 DTSTAMP:20060317T213724Z SUMMARY:Appleton Lecture: Hisashi Yamamoto\, University of Chicago. 4:00 - 5:30\, MM117. \"Metal Catalysis for Asymmetric Synthesis: Ligand Desi gn for New Reactivity & Higher Selectivity.\" Host: David Cane. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060427T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: Mast cells play a central role in type I hypersens itivity reactions and allergic disorders such as anaphylaxis and asthma. Activation of mast cells\, through a cascade of phosphorylation events\ , leads to the release of mediators of the early phase allergic response . Understanding the molecular architecture underlying mast cell signalin g may provide possibilities for therapeutic intervention in asthma and o ther allergic diseases. Although many details of mast cell signaling hav e been described previously\, a systematic\, quantitative analysis of th e global tyrosine phosphorylation events that are triggered by activatio n of the mast cell receptor is lacking. In many cases\, the involvement of particular proteins in mast cell signaling has been established gener ally but the precise molecular mechanism of the interaction between know n signaling proteins often mediated through phosphorylation is still obs cure. Using recently advanced methodologies in mass spectrometry\, inclu ding automation of phosphopeptide enrichments and detection\, we have no w substantially characterized\, with temporal resolution as short as 10 s\, the sites and levels of tyrosine phosphorylation across 10 min of Fc εRI-induced mast cell activation. These results reveal a far more extens ive array of tyrosine phoshorylation events than previously known\, incl uding novel phosphorylation sites on canonical mast cell signaling molec ules\, as well as unexpected pathway components downstream of FcεRI acti vation. Furthermore\, our results\, for the first time in mast cells\, r eveal the sequence of phosphorylation events for 171 modification sites across 121 proteins in the MCP5 mouse mast cell line and 179 modificatio n sites on 117 proteins in mouse bone marrow-derived mast cells. UID:2BBD53C5-AD0D-4ECE-8C68-45EC5FA8A500-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070925T090000 DTSTAMP:20071119T204128Z SUMMARY:Student Organic Seminar: Lulu Cao\, Brown University. 11:00 - 12 :30\, GC 351. \"Quantitative Time-Resolved Phosphoproteomic Analysis of Mast Cell Signaling\,\" Host: Jason K. Sello.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070925T100000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Nowadays\, based on nanotechnology\, bio-inspired self-assembled nanomaterials emerged as a type of charming biomaterials for bone and cartilage repair. For example\, rosette nanotubes (RNTs) ar e novel biomimetic self-assembled supramolecular structures\, whose basi c building blocks are guanine (G) and cytosine (C) DNA base-pairs. Their units undergo a hierarchical process to form a six-membered supermacroc ycle by hydrogen bonds in physiological conditions\, and then the rosett es form a stable stack with an inner channel 11Å in diameter. They can d issolve in physiological environments and solidify into a viscous gel at body temperatures binding to severed tissue. Moreover\, RNTs are simila r in size to natural collagen in bone and cartilage and previous studies have found that they can enhance cell adhesive protein adsorption and i mprove cell attachment and long-term functions. In addition\, RNTs are a ble to be incorporated with a variety of drugs or growth factors for imp roving tissue regeneration. In this thesis\, the ability of RNTs to impr ove bone and cartilage repair was in vitro tested from three aspects: ma terial properties\, drug/growth factor delivery and biological functions . More importantly\, in vivo studies showed that RNT composites were inj ected and solidified in the bone defects created in the tibia and femur of pigs. Especially\, such composites enhanced bone healing compared to negative (empty) and positive (autograft) controls. Thus\, the present t hesis provides a novel biomaterial (RNTs) that can be in situ injected t o improve bone and cartilage repair. UID:71A3C288-FE6F-4658-8CEC-E1DCA27D9DFC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100506T100000 DTSTAMP:20100430T191448Z SUMMARY:PhD Thesis Defense: Yupeng Chen\, Brown University. \"Self-Assem bled Rosette Nanotubes for Drug Delivery & Bone/Cartilage Tissue Regener ation.\" Presiding Officer: Thomas Webster. GC 349\, 10:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100506T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:14052408-D061-4CB1-99BF-ADCF224CADAB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061130T160000 DTSTAMP:20061107T172732Z SUMMARY:Organic Faculty Candidate Research Seminar: Anne McNeil\, MIT. 4 :00 - 5:50\, MM117. Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061130T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:0E3E65AD-C4C1-11DA-A162-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060410T150000 DTSTAMP:20060410T125558Z SUMMARY:Thesis Defense: Artur Adib\, Brown University. 3:00 - 5:00\, B&H 410. \"Exact Results in Nonequilibrium Statistical Mechanics: Formalism & Applications in Chemical Kinetics &\nSingle-Molecule Free Energy Esti mation.\" Presiding Officer: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060410T163000 END:VEVENT BEGIN:VEVENT SEQUENCE:15 DESCRIPTION:Abstract: Long considered as a passive genetic material\, DN A was recently shown to possess very rich chemical functions such as cat alysis and molecular binding\, which offers ample opportunities to advan ce chemistry\, nanotechnology\, and materials science. DNA metalloenzyme s with metal-dependent catalytic activities were isolated with a combina torial biology technique called in vitro selection. The design of highly sensitive and selective fluorescent metal sensors for Pb(II)\, U(VI)\, Cu(II)\, and Hg(II) was demonstrated with a signal transduction method t ermed catalytic molecular beacon. Aptamers are DNA-based binding molecul es that can recognize essentially any molecule of choice. Metallic nanop articles\, quantum dots\, and magnetic nanoparticles were functionalized with catalytic DNA and aptamers to prepare functional nanomaterials tha t can sense a wide range of molecules with various detection methods. Mi crofluidic and lateral flow devices were used to improve the performance of the sensors. Finally\, the bioinorganic chemistry and biophysical be havior of these functional DNA molecules were studied by fluorescence re sonance energy transfer (FRET) and single molecule FRET. UID:549B49B1-EE0E-4264-8D67-CDC7EFE8EEE2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080118T160000 DTSTAMP:20080111T193854Z SUMMARY:Nano Faculty Candidate: Juewen Liu\, University of New Mexico\, Center for Micro-Engineered Materials. 4:00 - 5:30\, MM 115. \"Applicat ions of DNA Metalloenzymes & Aptamers in Ultrasensitive Detection & Nano technology.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080118T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:C2879208-93F5-11DA-A88D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060526T083000 DTSTAMP:20060202T142233Z SUMMARY:Alumni Relations Tours/Commencement Weekend - MM 115 not availab le (per Kit email 2/1) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060526T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:1DEFEE6A-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041019T130000 DTSTAMP:20040930T164538Z SUMMARY:Deyu Li: organic seminar CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041019T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:2AA04998-FF35-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20030925T150000 DTSTAMP:20031015T173014Z SUMMARY:Tea Session Speaker: James M. Lisy\, University of Illinois CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20030925T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:4D69E66E-E157-43DE-8428-FE241AC1E94E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080403T150000 DTSTAMP:20080307T214550Z SUMMARY:Physical Tea Session: Sanghamitra Deb\, Brown University. 3:00\, GC 351. Title to come. Host: Jimmie Doll CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080403T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:2CB46BF7-0F1C-11DA-B005-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051014T160000 DTSTAMP:20050920T164251Z SUMMARY:Friday Chemistry Colloquium: Wendy B. Young\, Celera. 4:00 - 5:3 0\, MM115. \"Development of fVIIa Inhibitors for the Treatment of Cardi ovascular Disease.\" Host: William Trenkle. Fletcher House.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051014T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: We found that we can generate clusters of Dimethyl isopropylamine (DMIPA) in molecular beams. By varying experimental condi tions we can tune the size distributions. Ultrafast time-resolved mass a nd Rydberg photoionization/photoelectron spectra show the characteristic signatures of the clusters. This presentation will highlight the dramat ic changes of the Rydberg electron binding energies with increasing clus ter size\, as well as the time-dependent fragmentation\, cluster dissoci ation and proton transfer dynamics. UID:11059758-808E-4029-9B8C-2337F06F9FF7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080911T150000 DTSTAMP:20080909T140501Z SUMMARY:Physical Chemistry Tea Session: Sanghamitra Deb\, Brown Universi ty. \"Adventures With Clusters.\" Host: Christoph Rose-Petruck. 3:00 - 4:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080911T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:F6548ACF-D3E1-48D1-995C-DF67E9672502-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100727T130000 DTSTAMP:20100622T130801Z SUMMARY:PhD Thesis Defense: Youngmin Lee. Title & Abstract to come. Pres iding Officer: Shouheng Sun. 1:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100727T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:ABSTRACT: Mechanical phenomena such as crack growth (by high loading\, fatigue or chemical embrittlement)\, dislocation nucleation a nd grain boundary deformation\, all require explicit retention of nanosc ale details but are also strongly influenced by\, for instance\, disloca tions and their motion (plasticity) at the micron and larger scales. Ef ficient\, accurate calculations of such material behavior rely on multi- scale methods to reduce the number of degrees of freedom in any computat ion. To handle these multiple scales simultaneously\, the coupled atomis tic and discrete dislocation (CADD) method is introduced wherein atomist ic and continuum regions communicate across a seamless boundary and exch ange dislocations back and forth as dictated by the mechanics of the pro blem. The atomistic region can experience any deformations that occur un der the applied loading while the continuum region evolves according to discrete dislocation plasticity. Comparisons of CADD against full atomis tic simulations validate the method. Extension of the method to include finite-temperature molecular dynamics in the atomistic region is describ ed and demonstrated. The CADD method is then used to predict the tendenc y of fcc metals to form twins emanating from crack tips\, which is shown to be a rate-dependent process. The simulation results motivate an anal ytic model for the energy barriers for twinning and other crack tip proc esses\, and the model is consistent with the simulations and explains th e broad trends found across the fcc metals. \n UID:EAA0D3F5-09F9-4501-9F98-E690E8F3C994-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070920T150000 DTSTAMP:20071119T203704Z SUMMARY:Physical Tea Session: William Curtin\, Divison of Engineering\, Brown University. 3:00 - 4:15\, GC 351. \"Multiscale Modeling in Materia ls & Mechanics.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070920T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Modular polyketide synthase enzymology has been in tensively investigated for about twenty years\, which provided lots of p rofound enzymatic information such as substrate tolerance\, stereochemis try specificity\, domain-domain communication and so on. However\, up un til now\, it has not been possible to obtain a recombinant single polyke tide synthase module harboring all the condensation and β-keto modificat ion domains in active form. We have investigated nanchangmycin synthase module 2 (NanSM2)\, a single module with the full complement of KS\, AT\ , KR\, DH\, ER and ACP domains. NanSM2+DEBSTE was constructed by fusing 6-deoxyerythronolide B synthase thioesterase (DEBSTE) to the carboxylic end of acyl carrier protein. Then the enzyme activity was investigated w ith the natural substrate analog 2-methyl-3-oxo-butyric-SNAC. At the abs ence of NADPH\, 4-hydroxy-3\, 5\, 6-trimethyl-pyrone was afforded as the control assay product. At the presence of NADPH\, a mixture of two trik etide acids with opposite configuration on 4-methyl group was afforded a s the activity assay product\, which indicated that the ketosynthase dom ain has limited stereochemistry selectivity over the racemic substrate. The main result is that the recombinant module is fully active\, allowin g each of the component activities to be investigated. The fact that the KS domain does not readily distinguish among the enantiomers of the SNA C substrate is interesting\, but not the main take home message. Since t he 4-methyl group was strictly fixed to R configuration in the natural s ystem\, this apparent lack of specificity of the racemic SNAC substrate possibly means that only the correct diketide diastereomer is generated by NanSM1 and that NanSKS2 never sees its incorrect diketide diastereome r during its natural function. UID:38F89BB6-74A0-4FA3-8935-4CDCCBD6E458-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091201T110000 DTSTAMP:20091125T184026Z SUMMARY:Fourth Year Organic Student Seminars. Xun Guo\, Brown University . \"Preliminary Mechanistic Study on Polyketide Synthase NanSM2+DEBSTE.\ " Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091201T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:E5D6E648-B724-11D9-96B6-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050505T110000 DTSTAMP:20050427T140155Z SUMMARY:Physical Tea Session: Michael Minitti\, Brown University. GC 351 \, 3:00 - 4:15. \"Time Resolved Structural Analysis: An Application of R ydberg Fingerprint Spectroscopy.\" Host: Christoph Rose-Petruck. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050505T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:D7463BD3-C398-42B6-AA82-2E7D74461A23-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090930T120000 DTSTAMP:20090924T182331Z SUMMARY:Departmental Review - Focus: Undergradute Program. 12:00 noon\, GC 246. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090930T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:5E6A52A7-C4AC-4FE0-ACB0-F1C68DA13776-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070201T150000 DTSTAMP:20070205T201701Z SUMMARY:Physical Chemistry Tea Session: James Anderson\, Brown Universit y. 3:00 - 4:15\, GC 351. \"Cognitive Computation: The Ersatz Brain Proj ect.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070201T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Ribonucleotide reductases (RNRs) catalyze the conv ersion of nucleotides to deoxynucleotides. They play an essential role i n DNA replication and repair by supplying the monomeric precursors\, in ratios and amounts\, required for fidelity of these processes. Multiple RNRs are found in almost all organisms and they use both transient (thiy l\, tyrosyl\, tryptophanyl) and stable (tyrosyl\, glycyl) protein radica ls. They share a common mechanism of nucleotide reduction in structurall y homologous subunits in which a transiently generated thiyl radical med iates 3’ hydrogen abstraction from the nucleotide substrate. They diverg e in the mechanism by which the transient thiyl radical is generated by metallo-cofactors and the regulation of the reduction process. RNRs have successfully harnessed the reactivity of these radicals with exquisite specificity. Insight into their secrets will be presented based on studi es with mechanism-based inhibitors\, site-specific incorporation of unna tural amino acids and paramagnetic resonance methods. UID:4F587F65-1AE6-4AB7-86AE-19FD11737EB2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090402T160000 DTSTAMP:20090303T215707Z SUMMARY:Appleton Lecture: JoAnne Stubbe\, MIT. \"Ribonucleotide Reductas es: Something for Everyone.\" Host: Jason Sello. 4:00\, MM 117. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090402T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: The vulnerability of the genome to UV photodamage has sustained interest in excited electronic states in DNA for more than 50 years. Progress in understanding the nature and dynamics of electron ic excitations in DNA has accelerated rapidly thanks in large measure to ultrafast spectroscopy. Most excitations in single DNA bases decay nonr adiatively in hundreds of femtoseconds. Surprisingly\, much longer-lived excited states are observed in femtosecond pump-probe experiments on si ngle- and double-stranded DNAs. Experiments on pairs of π-stacked nucleo bases have established that most initial excitations decay to charge tra nsfer or exciplex states in which an electron is transferred from one ba se to its stacked neighbor. Similar signals are observed for the adenine dimer and longer runs of adenine bases (A tracts)\, suggesting that loc alized charge transfer states are the ultimate trap state in longer sequ ences. DNA is polymorphic and can adopt a range of structures beyond the iconic B-form double helix. The effect of helix conformation on excited -state dynamics has been studied in a double-stranded oligonucleotide th at can be switched between B- and Z-forms. Experiments on G quadruplex s tructures and on i-motif DNA reveal that these forms have significantly slower relaxation than B-DNA. By altering π-π stacking and hydrogen bond ing\, structure profoundly affects the complex photoprocesses observed i n DNA\, including photochemical reactions. Using UV pump/mid-IR probe sp ectroscopy we have shown that the thymine dimer\, the most common DNA ph otoproduct\, is formed in <1 ps. By combining time-resolved spectroscopy \, molecular dynamics simulations and site-specific measurements of phot oproduct yields in DNA-protein complexes\, comprehensive understanding o f the mechanisms behind UV damage is closer than ever. UID:E6C58E57-1547-49CD-8E8F-EB0BCBAE8B21-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081211T160000 DTSTAMP:20081202T211214Z SUMMARY:Biophysical Faculty Candidate Seminar: Bern Kohler\, Ohio State University. \"Ultrafast Photodynamics in DNA Structures from A-tracts to Z-DNA.\" Host: Peter Weber. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081211T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Structure architecture at nanoscale is a challengi ng task to develop advanced functional materials. Particularly in the ca talyst design for chemical-electrical energy conversion\, it becomes cri tical in order to achieve both the targets of high catalytic activity an d long durability simultaneously. Here I present our recent research eff orts on tuning the size\, shape\, composition and composite heterostruct ure of Pt-based nanoparticles for improving their performance in electro catalytic reduction of oxygen – the key reaction in fuel cells. Specific ally\, our target is to establish nanostructure architecture based on fu ndamental studies of well-defined extended surfaces\, e.g.\, composition -profile-tailored Pt-Ni alloy nanocatalysts were conceived in the invest igation of Pt thin films over Ni substrates. Such combinational studies thus provide a persuasive approach toward advanced nanomaterials for cat alytic and other functional applications. UID:5424AA58-A4C7-4BB9-8003-4BEF27E8579C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100429T120000 DTSTAMP:20100414T165334Z SUMMARY:Inorganic Chemistry Seminar: Chao Wang\, Argonne National Labora tory. \"Nanostructure Architecture of Electrocatalyst for Energy Convers ion Applications.\" Host: Shouheng Sun. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100429T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:F0FCF462-1BB8-498E-B861-7597601E0BD2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100908T083000 DTSTAMP:20100604T202101Z SUMMARY:Helmut Schwarz\, Title and abstract to come. Host: Lai-Sheng Wa ng. Time & location TBD. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100908T084500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:407E7A40-17EC-11DB-A68C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061024T160000 DTSTAMP:20061016T152436Z SUMMARY:Appleton Lecture: Jean-Marie Lehn. \"From Matter to Life: Chemis try? Chemistry!\" 4:00 - 5:30\, MM117\, Host: Brian Moulton CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061024T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:3DB66684-60CC-11D9-9053-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050308T110000 DTSTAMP:20050228T215633Z SUMMARY:Organic Seminar: Eric Anslyn\, UTexas at Austin. 11:00 - 12:15\, GC 351. \"Organic Chemistry Approaches to Molecular Sensing.\" Host: Am it Basu. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050308T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:6B040A24-4B8E-41BD-B018-F1F09D48C21C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061019T150000 DTSTAMP:20061016T212655Z SUMMARY:Physical Chemistry Tea Session: Peter Weber\, Brown University. 3:00 - 4:15\, GC 351. \"Purely Electronic Spectroscopy: Probing Molecula r Structure & Dynamics with Rydberg States.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061019T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:60875EA0-17EC-11DB-A68C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061025T110000 DTSTAMP:20061016T152457Z SUMMARY:Chemistry Colloquium: Jean-Marie Lehn. \"From Supramolecular Ch emistry to Constitutional Dynamic Chemistry.\" Host: Brian Moulton. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061025T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:3C0035B2-206C-4A8C-B77B-9EFA41FAB5C9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060927T130000 DTSTAMP:20060919T182945Z SUMMARY:Thesis Defense: Yanhu Wei. 1:00 - 3:30\, GC 351. Presiding Offic er: Matthew Zimmt. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060927T153000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:0F91EBD2-1576-11DA-9364-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051020T120000 DTSTAMP:20051017T150715Z SUMMARY:Inorganic Seminar: Hongwei Gu\, MIT. 12noon - 1:00\, GC351. \"Sy nthesis & Application of Biofunctional\nNanostructures.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051020T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Reversible protein phosphorylation plays a vital r ole in the regulation of cellular signaling pathways. With recent breakt hrough developments in mass spectrometry-based proteomics technologies\, including phosphopeptide enrichment and separation techniques\, high-ac curacy mass spectrometry and associated bioinformatics\, MS-based quanti tative phosphoproteomics have now gained great popularity. This technolo gy has enabled the simultaneous identification and quantification of tho usands of phosphorylation sites from entire phosphoproteomes. Current ap proaches in phosphoproteomics focus on analysis of the global phosphopro teome in a single cellular state or of receptor stimulation time course experiments\, often with a restricted number of time points. Although th ese studies have provided some insights into newly discovered phosphoryl ation sites that may be involved in pathways\, they alone do not provide enough information to make precise predictions of the placement of indi vidual phosphorylation events within a signaling pathway. Protein disrup tion and site-directed mutagenesis are essential to clearly define the p recise biological roles of the hundreds of newly discovered phosphorylat ion sites uncovered in modern proteomics experiments.\n\nMast cells play a central role in type I hypersensitivity reactions and allergic disord ers such as anaphylaxis and asthma. Understanding the molecular architec ture underlying mast cell signaling may provide possibilities for therap eutic intervention in asthma and other allergic diseases. Using recently advanced methodologies in mass spectrometry\; a systematic quantitative analysis of the global tyrosine phosphorylation events triggered by act ivation of the mast cell receptor was performed. We have substantially c haracterized and quantified a far more extensive array of tyrosine phosp horylation events than previously known\, with the kinetics of 171 uniqu e phosphorylation sites across 121 proteins in mouse mast cell line MCP5 and 179 unique phosphorylation sites on 117 proteins in mouse bone marr ow-derived mast cells.\n\nTo better understand the molecular mechanism u nderlying complex cellular signaling networks\, we have also developed a hybrid quantitative approach that combines label free and SILAC quantif ication techniques. Label free quantitation is applied to assemble high- density temporal data within a single cell type\, either wide-type (WT) or mutant (Mut) cells\, providing a list of phosphorylation sites that c hange in abundance after stimulation of a cellular receptor. SILAC quant ification is then used to compare WT and Mut cells across a time course of receptor stimulation\, providing direct information about how the new ly observed phosphorylation sites respond to the mutagenesis. We have su ccessfully applied this approach to ZAP-70 and SLP-76 deficient Jurkat T cell lines. These studies have provided great insights into the essenti al roles of these proteins in T cell signaling. Many hypotheses have bee n drawn and follow-up studies could provide directions for future invest igation.\n UID:77B13393-8080-479A-B56B-A749167E4B5E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090826T100000 DTSTAMP:20090817T160017Z SUMMARY:PhD Thesis Defense: Lulu Cao\, Brown University. \"Quantitative Phosphoproteomic Analysis to Unravel Mast Cell & T Cell Signaling Pathwa ys.\" Presiding Officer: Arthur Salomon. 10:00\, Sydney Frank Hall\, Roo m 220.\n\n\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090826T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:1A13D797-AB68-4543-9560-024BE409E0BA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090811T110000 DTSTAMP:20090806T153732Z SUMMARY:Inorganic Chemistry Seminar: Kyoungja Woo\, Korea Institute of S cience & Technology. \"Synthesis & Engineering of\nNanoparticles: Part 1 . Surface Engineering of Nanoparticles for\nBioapplication. Part 2. Synt hesis & Characteristics of QD-Shell-Doped Silica Colloid.\" Host: Dwight Sweigart. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090811T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 TRANSP:OPAQUE UID:49D5B407-7966-4247-977C-28D253B625B1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071011T133000 DTSTAMP:20071010T162718Z SUMMARY:Physical Tea Session: Maria Gomez\, Mount Holyoke College. 1:30 - 2:45\, GC 351. \"The Elusive Proton: Finding Conduction Pathways in So lid & Liquid Phases.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071011T144500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Active pharmaceutical ingredients (APIs) with poor physico-chemical properties such as low solubility or inappropriate lip ophilicity often present significant challenges in formulation developme nts and preclinical investigations. For example\, APIs with low solubili ties often require high dose formulation being administered to obtain th e necessary exposure level. So to overcome these problems\, it is of par ticular importance for chemists and pharmaceutical scientists to use che mistry approaches to develop novel molecular API forms with optimum phys ico-chemical properties at the molecular stage. \n\nThis research invest igates polymorphism of an antituberculosis drug\, 5-chloro-8-hydroxyquin oline\, supramolecular conformational isomerism of transition metal-(pyr idine-4-acetamide) self-assemblies and structure-activity (specifically solubility and lipophilicity) relationship and stability studies of mixe d-ligand metal-drug coordination species. \n\nSome of the known supramol ecular chemistry approaches to tune physico-chemical properties of APIs include formation of polymorph\, salt\, solvate and co-crystal. For all the approaches mentioned above\, in the solid material all the ingredien ts are held together through weak intermolecular forces such as hydrogen bonds\, pi-pi interactions and van de Walls forces. Therefore\, it is n ot surprising to explore other types of weak intermolecular forces such as coordination bonds to develop novel molecular API entities. \n\nIn su mmary\, several approaches for fine-tuning physico-chemical properties o f APIs will be discussed in this thesis using concepts in supramolecular chemistry. UID:19C33B55-B4E1-4998-9CCD-17EC3FE697BA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080918T090000 DTSTAMP:20080911T152249Z SUMMARY:PhD Thesis Defense: Zhenbo Ma\, Brown University. \"Supramolecu lar Chemistry Approaches For Fine Tuning Physico Chemical Properties of Active Pharmaceutical Ingredients.\" Presiding Officer: Brian D. Moulton . 9:00 - 12:00\, GC 449. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080918T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:9BC85134-680F-11DA-A229-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060407T160000 DTSTAMP:20051208T174103Z SUMMARY:Friday Chemistry Colloquium: Moungi Bawendi\, MIT. 4:00 - 5:30\, MM 115. \"Semiconductor Nanocrystals: Science & Technology.\" Host: Sho uheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060407T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:D9C3EED3-B5D9-11DA-87EC-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060327T083000 DTSTAMP:20060405T162959Z SUMMARY:Thesis Defense: Jeffrey Reingold\, Brown University. \"Pi-Bonded Organometallic Complexes of Manganese & Rhodium.\" GC351\, 8:30am. Pres iding Officer: Dwight Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060327T103000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:C6A5001E-31C9-11DA-88B5-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051006T130000 DTSTAMP:20050930T154950Z SUMMARY:Thesis Defense: Jerel Banks. 1:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051006T143000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:021F354D-FF35-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20030918T150000 DTSTAMP:20031015T172902Z SUMMARY:Tea Session Speaker: Sandra J. Rosenthal\, Vanderbilt University CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20030918T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Isolated metal clusters in the gas phase and their complexes with small molecules like CO\, O2\, NO or H2O are frequently suggested as model systems for the study of active sites of heterogeneou s catalysts.\nMass-specific vibrational spectra of these species down to the far-infrared (<100 cm-1) are obtained by multiple photon dissociati on\n(MPD) spectroscopy. This technique requires an intense and widely tu nable IR light source\, in our experiments the Free Electron laser for\n Infrared eXperiment \"FELIX\"\, that generates IR light between ~40-3500 cm-1 and is therefore suited to induce resonant photodissociation by\ne xcitation of ligand vibrations but also of internal cluster modes. The e xperimental vibrational spectra in combination with complementary quantu m chemical calculation give information on the structure of the\nisolate d metal clusters and their complexes.\nIn my talk I will focus on invest igations of bare clusters of the transition metals gold and rhodium and the interaction of transition\nmetals with CO and H2. UID:2A71C5EA-B8F7-44BF-AA96-98EFB65EC594-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100617T150000 DTSTAMP:20100611T122304Z SUMMARY:Physical Chemistry Tea Session: André Fielicke\, Fritz-Haber-Ins titut der Max-Planck-Gesellschaft Abteilung Molekülphysik. \"Vibrational Spectroscopy of Metal Cluster Complexes: Investigating the\nChemistry o n a Small Surface.\" Host: Lai-Sheng Wang. GC 351\, 3:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100617T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:EC34C612-1301-11D9-88BD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20040924T130000 DTSTAMP:20040930T165826Z SUMMARY:Meaghan Richmond: defense CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20040924T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:83AA36BE-78CF-4EBC-8B98-02AF53E55147-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100910T150000 DTSTAMP:20100607T191552Z SUMMARY:Friday Chemistry Colloquium: Alexander Boldyrev. Title & abstrac t to come. Host: Lai-Sheng Wang. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100910T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:9657E32C-099E-11DA-B7FF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051018T110000 DTSTAMP:20051006T152425Z SUMMARY:Organic Seminar: Gregory R. Cook\, North Dakota State University . 11:00 - 12:15\, GC 351. \"New Developments in Stereoselective Indium-M ediated Reactions.\" Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051018T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:3CA89750-C64D-11DA-B1E5-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060420T120000 DTSTAMP:20060407T154500Z SUMMARY:Inorganic Seminar: Chunhua Yao\, Brown University. 12noon - 1:15 pm\, GC 351. \"Preparation & Characterization of Composites by Incorpora ting Various Nanoparticles in Polysaccharide Containing Substrates\, esp ecially Chitosan-Silica Aerogel & Cellulose.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060420T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Silica nanoparticles have been functionalized with carbohydrates using the copper promoted azide-alkyne cycloaddition. The loading of carbohydrates onto these particles has been characterized us ing a variety of methods\, including elemental analysis and a colorimetr ic assay. The interaction of these particles with carbohydrate binding p roteins has been visualized using transmission electron microscopy. The carbohydrate-carbohydrate interactions of these particles with glycolipi ds assay in microtiter plates have also been investigated. UID:107F07E6-DD97-42B1-8377-A07D9A332E55-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091027T110000 DTSTAMP:20100105T200622Z SUMMARY:Fourth Year Organic Student Seminars. Jing-Sha Zhao\, Brown Univ ersity. \"Investigating Carbohydrate-Carbohydrate Interactions using Flu orescent Silica Nanoparticles.\" Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091027T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: In the first part of my presentation\, I will sum marize my PhD research on the development of layer-by-layer (LBL) assemb le nanostructured composites. The LBL technique is a simple method of se quential deposition of oppositely charged species\, e.g.\, polyelectroly tes\, nanoparticles\, biomolecules and even whole cells\, with nanometer -scale precision. Because of its versatility and robustness\, the techni que has grown into an area of research with exceptional breadth of appli cability\, ranging from catalysis and drug delivery to batteries and ult ra-strong composites. In this respect\, I will first present preparation of biomimetic clay nanocomposites having record-high mechanical propert ies. (Podsiadlo et al.\, Science 2007) Understanding of nanoscale mechan ics and achieving efficient interfacial interactions between the inorgan ic nanomaterials and organic polymer matrix are key elements for success fully transferring the exceptional nanoscale properties to macroscale st ructures. Furthermore\, I will discuss the first preparation of nanostru ctured LBL materials from cellulose nanocrystals possessing high mechani cal\, anti-reflective and cell-guiding properties. Finally\, I will show development of self-structuring and hierarchically organized composites (nano- to macro-scale) based on “exponential” LBL assembly. Multiple ap plications of the resulting architectures will also be discussed.\n\n In the second part of my presentation\, I will present my current research on characterization of collective properties in self-assembled nanopart icle (NP) superlattices (SL). In these novel architectures\, NPs self-or ganize into crystal-like structures analogous to ionic crystals\, e.g.\, NaCl\, with NPs serving the roles of artificial atoms. Precise position ing of the NPs in single\, binary and even ternary assemblies leads to n ovel collective optical\, electronic\, magnetic and even mechanical prop erties. Furthermore\, the ability of the method to combine very differen t NPs into precise architectures\, e.g.\, plasmonic/magnetic or plasmoni c/semiconductor\, has the potential to yield novel metamaterials with un ique properties. First\, I will present my results on the characterizati on and control of SLs nucleation and growth. In particular\, I will show how thermal annealing can be used as a new method for controlling inter particle distance\, giving an important tool for controlling electronic coupling. Furthermore\, I will present the first experimental results fr om evaluation of mechanical properties of 3D SLs using nanoindentation t echnique. The results of this work show truly crystalline behavior of th e 3D SLs\, with mechanical properties being at least 2x greater when com pared to random films of the same NPs. Lastly\, I will discuss results f rom optical and electronic studies on 3D assemblies of semiconductor NPs \, i.e.\, CdSe and PbS. We observed anomalous optical behavior in the Cd Se SLs that can be attributed to different degrees of 3D organization an d electronic coupling between the NPs. In the case of PbS NPs SLs\, we o bserved enhanced electronic transport with several orders of magnitude h igher conductivity in 3D SLs when compared to disordered films. The resu lts presented here will show the unique potential and opportunities for exploration in these novel materials. \n UID:BF5C4152-56F7-4FBC-8A41-B4466B1842E4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091207T160000 DTSTAMP:20091125T184453Z SUMMARY:Nanoscience Faculty Search Candidate: Paul Podsiadlo\, Argonne N ational Laboratory. \"Multifunctional NanoArchitectures by Spontaneous & Directed Self-Assembly: Biomimetics\, Ultra-Strong Composites & Nanopar ticle Supercrystals.\" Host: Shouheng Sun. MM 317\, 4:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091207T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The propagation of ultrasonic waves through colloi dal solutions gives rise to alternating potential\, known as ultrasonic vibration potentials\, within the solution. We developed ultrasonic vibr ation potential theories and proposed and implemented a new acoustic ima ging method based on ultrasonic vibration signals. \n\nExperiments showe d that in soft tissue\, the induced polarization is the dominant mechani sm for signal generation. The frequency dependence of the ultrasonic vib ration current in canine blood and in several dilutions of silica suspen sions was also reported. Further study on ultrasonic vibration potential was carried out. The problem of acoustic polarization was solved to giv e the theory of potential and electric field distribution within the col loidal solution. Finally\, several experiments focusing on 3D imaging we re conducted to give a very good consistency with the theory of current generation for 3D objects.\n UID:39DC7522-FCC4-4406-BBBF-266B3A0BECA9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080925T150000 DTSTAMP:20080919T172911Z SUMMARY:Physical Chemistry Tea Session: Cuong K. Nguyen\, Brown Univers ity. \"Ultrasonic Vibration Potential Imaging: Mechanisms\, Potential Di stribution & 3D Approach.\" Host: Christoph Rose-Petruck. 3:00 - 4:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080925T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:2F8AF206-0E58-11DA-8A11-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051111T160000 DTSTAMP:20051103T202354Z SUMMARY:Friday Chemistry Colloquium: Jerry Murry\, Merck Research Labora tories. 4:00 - 5:30\, MM115. \"Synthetic Organic Chemistry as Applied to Pharmaceutical Research.\" Host: William Trenkle. (Fletcher House 11/10 ) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051111T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The decline in global petroleum supplies has inten sified efforts to harness abundant natural gas reserves for use as a fue l and chemical feedstock. However\, the low density of methane\, the pri mary component of natural gas and the remote location of many natural ga s reservoirs have inhibited its cost-effective transportation and distri bution. This presentation will describe my postdoctoral research into th e rational design of iridium platforms for methane C-H bond activation. Efforts to synthesize proposed reaction intermediates and analyze their kinetic profiles will be discussed. UID:659305B0-B254-41E7-A643-519621ED6C1E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100311T120000 DTSTAMP:20100305T142806Z SUMMARY:Inorganic Chemistry Seminar: Wesley Bernskoetter\, Brown Univers ity. \"Exploring Mechanistic Pathways for Iridium Mediated Methane Activ ation.\" GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100311T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:20947392-8148-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060323T150000 DTSTAMP:20060320T150024Z SUMMARY:Physical Chemistry Tea Session: Job Cardoza\, Brown University. 3:00 - 4:15\, GC351. Title to come. Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060323T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:78DE5E6B-BA8B-46FB-9843-A25BD6E8C793 DTSTART;TZID=US/Eastern:20100530T091500 DTSTAMP:20100520T144448Z SUMMARY:diplomas 0 huan yang CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100530T101500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:081A7039-A188-4CD9-81D3-1DBFF95E0979-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070412T120000 DTSTAMP:20070320T200028Z SUMMARY:Chemistry Seminar: Daniel Repeta\, WHOI. 12:00 - 1:15\, GC 351. \"Iron Binding Ligands in Seawater: Are Marine Siderophores Part of the Mix?\"Host: ChemDUG/Keriann Backus. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070412T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Nowadays\, based on nanotechnology\, bio-inspired self-assembly nanomaterials emerged as a type of charming biomaterials f or orthopedic implantation applications. For example\, rosette nanotubes (RNTs) are novel biomimetic self-assembled supramolecular structures\, whose basic building blocks are guanine (G) and cytosine (C) DNA base-pa irs. Their units undergo a hierarchical process to form a six-membered s upermacrocycle by hydrogen bonds in physiological conditions\, and then the rosettes form a stable stack with an inner channel 11Å in diameter. The present study will report the bioactive influence of RNTs on bone an d cartilage cell functions and demonstrate the promising potential of su ch nanotubes to deliver multiple growth factors and drugs for orthopedic applications. This study will also include recent in vivo results that successfully applied RNT/polymer composites as novel\, injectable bone h ealing materials. UID:849ACEF5-20A3-4A33-BBBC-26CD1EB0AF71-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100218T150000 DTSTAMP:20100215T214814Z SUMMARY:Physical Chemistry Tea Session: Yupeng Chen\, Brown University. \"Self-Assembled Rosette Nanotubes for Drug Delivery & Tissue Regenerat ion.\" Host: Gerald Diebold. GC 351\, 3:00. (Refreshments by Jie Bao) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100218T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:A0D17EED-563D-42B0-86FE-ACE58814EE86-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T114500 DTSTAMP:20080813T124550Z SUMMARY:Lunch. Chancellor's Dining Room - Sharpe Refectory. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Soil bacteria degrade a vast array of naturally oc curring aromatic compounds such as benzoate. While the associated bioche mical conversions have diverse applications ranging from the production of chiral synthons to the detoxification of aromatic pollutants\, the im plementation of such applications is often stymied by biological regulat ory mechanisms. This presentation centers on the interactions of two tra nscriptional regulatory proteins with benzoate and its metabolite\, cis\ ,cis-muconate. Genetic approaches reveal interesting features of protein conformational changes that impact transcription\, metabolite accumulat ion and the development of biosensors. In addition\, these metabolic stu dies led to the unexpected discovery of a novel type of DNA recombinatio n that underlies gene amplification\, a process of significant medical a nd evolutionary importance. UID:C62861AD-9A8B-44B6-AF9C-D680C535C11A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091013T130000 DTSTAMP:20091006T185348Z SUMMARY:Organic Chemistry Seminar: Ellen Neidle\, Dept. of Genetics\, Un iversity of Georgia. \"Benzoate Metabolism: Surprising Lessons on Pollut ion & Cancer from a Soil Bacterium.\" Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091013T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:33AA21EA-1021-11DA-A22D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051129T120000 DTSTAMP:20051128T194642Z SUMMARY:Inorganic Chemistry Seminar: Helmut Werner\, University of Wuerz burg. 11:00 - 12:30\, GC 351. \"To Bridge or not to Bridge: A New Bondin g Mode of Tertiary Phosphines\,\nArsines & Stibines.\" Host: Dwight Swei gart. (The Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051129T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: Perhaps the greatest challenge of 21st century sci ence is understanding the human brain. Using a combination of organic c hemistry\, molecular biology\, and electrophysiology\, chemical-scale in sights into the structure and function of the neuroreceptors and ion cha nnels that lie at the foundation of neuronal function can be obtained. Using this approach\, we have obtained new insights into the unique phar macology of nicotine and have produced a detailed understanding of an im portant class of neuroreceptors. UID:27791095-0E3E-4F47-83DE-1DE0BBA2B622-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081016T160000 DTSTAMP:20081010T215916Z SUMMARY:The Leallyn Burr Clapp Lecture: Dennis Dougherty\, Caltech. \"C hemistry on the Brain: Understanding the Nicotine Receptor.\" Host: Pau l Williard. 4:00 - 5:30\, B&H 166.. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081016T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:554A8C67-30FF-4B2B-8CB4-9ED3E70C58C0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061205T160000 DTSTAMP:20061107T172815Z SUMMARY:Organic Faculty Candidate Research Seminar: David Speigel\, Broa d Institute of Harvard/MIT. 4:00 - 5:50\, MM115. Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061205T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: The seminar will provide an overview of research i n the Sello research group. UID:9A71A02B-DEAF-4F03-B47E-AA6332D6433E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090515T160000 DTSTAMP:20090512T152127Z SUMMARY:Friday Chemistry Colloquium: Jason Sello\, Brown University. \"S ignals\, Poisons & Fuels.\" Host: Eunsuk Kim. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090515T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The glycosylation status of cell surface proteins and lipids influences interactions of individual cells and even whole or ganisms\, with one another and with the environment. For example\, epith elial cellular adhesion via adherens junctions is mediated by multi-prot ein complexes. Similarly\, cell-surface carbohydrates provide critical s ignals that govern expansion of tumors and activation of growth factors. Assembly of multimers of P0 protein\, a major component in myelin is de pendent on its glycosylation. Furthermore\, changes in cell surface glyc osylation\, either species-specific or due to genetic mutations\, cause changes in each system’s susceptibility to microbial infection. We are d eveloping new and improved methods\, centered on MS\, for detailed struc tural determinations of glycans and glycoconjugates present as component s of these complex mixtures. We utilize glycomics and proteomics-based a pproaches to investigate the interactions and correlate changes in the p henotypes of individual cells and whole organisms with degrees of glycos ylation and differences in glycans. UID:D0CFDBA7-6AE9-4897-BA8A-7FE0275F3D1D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091023T160000 DTSTAMP:20091019T160023Z SUMMARY:Friday Colloquium: Catherine E. Costello\, Boston University Sch ool of Medicine. \"Mass Spectrometry-Based Methodologies for Investigati ons of N- & O-linked Glycans & Their Effects on Assembly & Interactions of Cells & Organisms.\" Host: Carthene R. Bazemore-Walker. 4:00\, MM 115 . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091023T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:A4D9A182-419D-11DA-9BED-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051025T110000 DTSTAMP:20051020T192034Z SUMMARY:Organic Seminar: Zheng You\, Brown University\, 11:00 -12:30\, G C 351. \"A Gene Cluster for Pentalenolactone Biosynthesis in Streptomyce s avermitilis.\" Host: William Trenkle CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051025T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Semiconductor nanostructures are promising buildin g blocks for future-generation solar cell devices. In this presentation\ , two types of nanocrystal-based solar cells will be introduced: the hyb rid solar cells composed of nanocrystal/polymer blend and all-inorganic nanocrystal solar cells based on non-toxic and abundant materials. The e ffects of the\nmorphology\, the surface ligands\, and the chemical compo sition of these nanocrystals will be discussed in detail. UID:FF28E559-30BE-453A-8F1C-0FDB6D99EA67-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090202T160000 DTSTAMP:20090120T152049Z SUMMARY:Nano Chemistry Search Candidate: Yue Wu\, University of Californ ia\, Berkeley. “Semiconductor Nanocrystal-Based Solar Cells.” Host: Shou heng Sun. 4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090202T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Direct sensing of an effector molecule by a nascen t RNA transcript has emerged recently as a common mechanism for regulati on of gene expression in bacteria. RNAs of this type\, termed “riboswitc hes\,” interact with the cognate regulatory signal. This interaction mod ulates the structure of the nascent transcript\, which in turn can deter mine whether the RNA folds into the helix of an intrinsic terminator\, r esulting in premature termination of transcription. Similar RNA rearrang ements mediate translational regulation by sequestration of the ribosome binding site\; in this case\, regulation can occur by interaction of th e effector with either the nascent RNA or the full-length transcript. We have identified several systems of this type\, including the T box syst em\, which monitors the charging ratio of a specific tRNA\, the S box an d SMK box systems\, which respond to S-adenosylmethionine (SAM)\, and th e L box system\, which responds to lysine. Each class of riboswitch RNA recognizes its signal with high specificity and an affinity appropriate to the in vivo pools of the effector. Characterization of the RNA-effect or interaction in these systems has provided new information about how d ifferent classes of effectors are recognized\, and about the impact of t hese regulatory mechanisms on the cell. \n\n UID:5DB9132A-3BE2-415E-875F-C1D9353040A0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100518T110000 DTSTAMP:20100423T125701Z SUMMARY:Organic Chemistry Seminar: Tina Henkin\, Ohio State University. \"Riboswitch RNAs: Sensing Metabolic Signals with Nascent Transcripts.\ " Host: Jason Sello. GC 351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100518T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Charge transfer to and from quantum dots (QDs) is of intense interest because of its important roles in QD-based devices\, such as solar cells and light emitting diodes. Recent reports of multip le exciton generation (MEG) by one absorbed photon in some QDs offer an exciting new approach to improve the efficiency of QD-based solar cells and to design novel multi-electron/hole photocatalysts. However\, the ap plication of the MEG process requires ultrafast exciton dissociation by charge transfer to electron donors and acceptors before the exciton-exci ton annihilation process that occurs on the 10s to 100s ps time scale. W e report a series of studies of exciton dissociation dynamics in quantum dots by electron or hole transfer to adsorbed electron or hole acceptor s\, respectively. We showed that exciton in CdS and CdSe could be dissoc iated on the few picosecond time scale to various adsorbates. We will di scuss the dependence of these rates on the size and the nature of the qu antum dots and possible approaches for multiple exciton dissociation. UID:D97058A2-10F6-4249-AB2A-F4F56FA6A9EF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080912T160000 DTSTAMP:20080905T193426Z SUMMARY:Special Colloquium. Tianquan Lian\, Emory University. \"Ultrafa st Electron & Hole Transfer from Quantum Dots: Towards Multi-Exciton Dis sociation.\" Host: Richard M. Stratt. 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080912T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:3BED3420-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041005T130000 DTSTAMP:20040930T164623Z SUMMARY:Yanhu Wei: organic seminar CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041005T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Atomic clusters containing a few to several hundre d atoms exhibit dramatic size-dependent chemical and physical properties \, forming the foundation of nanoscience. We use photoelectron spectrosc opy to probe the size-dependent electronic and atomic structures of a va riety of clusters. I will focus on our recent studies on boron and gold clusters. Bulk boron is a refractory material consisting of covalently- linked B12 cages. However\, we will show that small boron clusters posse ss planar or quasi-planar structures. Chemical bonding analyses reveal t hat the planarity of boron clusters derive from their delocalized pi ele ctrons. We find that these planar clusters can be classified as aromatic or antiaromatic according to the number of pi electrons (i.e.\, the Huc kel rules)\, analogous to hydrocarbon molecules. Gold clusters have attr acted considerable attention partly due to the remarkable catalytic effe cts discovered in gold nanoparticles\, despite the fact that bulk gold i s the most inert metal. Well-defined gold clusters provide ideal models to understand the catalytic mechanisms of nano-gold. We will present joi nt photoelectron spectroscopic and theoretical studies to elucidate the structures of gold clusters\, including the golden cage (Au16–) and the golden pyramid (Au20). UID:6822FC9D-6409-49B2-8977-2F046C33615E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091113T160000 DTSTAMP:20091105T164815Z SUMMARY:Friday Chemistry Colloquium: Lai-Sheng Wang\, Brown University. \"Probing the Size-Dependent Chemical & Physical Properties of Nanoclust ers.\" Host: Eunsuk Kim. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091113T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:50BD22E1-A162-48FE-9A78-427731CFF97E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070424T110000 DTSTAMP:20070420T160351Z SUMMARY:Organic Seminar: Coran Watanabe\, Texas A&M University\, 11:00 - 12:30\, GC 351. Inspiration from Nature: Natural Produces in Drug Disco very Efforts. Host: David Cane. (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070424T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: This presentation will focus on the development of two types of biofunctional nanostructures: magnetic nanoparticles and n anofibers formed by small therapeutic molecules. First\, we will discuss the applications of magnetic nanoparticles for pathogen detections\, pr otein separations and intracellular manipulations. Compared to conventio nal used magnetic particles (with the sizes of 1-5 μm) in biological sep aration of drug delivery\, magnetic nanoparticles\, combining with speci fic receptor-ligand interactions\, confer high sensitivity and selectivi ty for applications. Next\, we will show the self-assembly of small mole cules to form fibrillar nanostructures and result in hydrogels that act as the scaffolds for potential biomedical applications such as wound hea ling\, drug delivery and inhibitor screening. Moreover\, we will demonst rate the use of intracellular enzymatic reactions as a new way to trigge r the self-assembly of hydrogelators and its potential application for c ontrolling the fate of cells. UID:FF78EC7F-82DB-4B79-B137-8BFBE322D853-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081023T120000 DTSTAMP:20081009T140844Z SUMMARY:Inorganic Chemistry/Materials Seminar: Bing Xu\, Brandeis Univer sity. \"Design & Synthesis of Bionanomaterials for Applications from Out side to Inside Cells.\" Host: Shouheng Sun. 12:00 - 1:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081023T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract to come.\n UID:6290998C-8EBF-46C6-85BC-5B9F2A929DC2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090129T150000 DTSTAMP:20090127T140217Z SUMMARY:Physical Chemistry Tea Session: Baofeng Zhang\, Brown University . \"The MD Simulation of Vibrational Energy Relaxation of Big Perylene M olecules in Liquid Argon Solvent.\" Host: Christoph Rose-Petruck. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090129T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:71036B1B-FACA-43CE-9FA6-B0F4267B9109-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061109T150000 DTSTAMP:20061107T173239Z SUMMARY:Physical Chemistry Tea Session: Fedor Rudakov\, Brown University . 3:00 - 4:15\, GC 351. \"Title not Supplied.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061109T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:339AD274-287B-11DB-AF1C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061110T160000 DTSTAMP:20060818T144221Z SUMMARY:Friday Chemistry Colloquium: Lloyd J. Whitman\, Naval Research L aboratory. 4:00 - 5:30\, MM115. \"Interfacing Magnetic Materials with Bi ological Sensors & Systems.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061110T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:F5368B28-7855-4DE3-AFF3-0B5816A3B078 DTSTART;TZID=US/Eastern:20100521T150000 DTSTAMP:20100520T144416Z SUMMARY:wei zhu CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100521T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:B7D0A8FA-1301-11D9-88BD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20040916T130000 DTSTAMP:20040930T165702Z SUMMARY:Claude Jean Baillat: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20040916T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: In the first part of this presentation\, bio-mimet ic studies of cytochrome c oxidase will be presented. This includes the generation and characterization of small molecule heme-peroxo-copper spe cies derived from FeII/CuI/O2 reactions. Comparison of a series of relat ed complexes leads to a finding that the coordination nature of the pero xo bridging group binding between heme and copper can be dramatically al tered by the copper ligand environment. Then\, a platinum compound progr ammed to be selectively toxic in specific cancer cells\, (Est-en)Pt(II)C l2\, will be discussed. (Est-en)Pt(II)Cl2 is a bi-functional molecule th at consists of a DNA damaging agent and a ligand for the estrogen recept or (ER) which is aberrantly expressed in many breast and ovarian cancer cells. The selective toxicity of (Est-en)Pt(II)Cl2 has been observed in various ER positive cancer cells as compared to a control compound. UID:893D8ADD-AD5E-45A9-B117-4F4F045AABA0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080111T160000 DTSTAMP:20080108T141856Z SUMMARY:Inorganic Faculty Candidate: Eunsuk Kim\, MIT. 4:00 - 5:30\, MM 115. \"Synthetic Modeling of Cytochrome c Oxidase & Design of Programmab le Anticancer Agents.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080111T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:54A58882-33A0-46FA-B6A4-CAC5D837159E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T091500 DTSTAMP:20080813T122537Z SUMMARY:Gregory J. Exarhos\, PhD\, '74. Pacific Northwest National Labor atory. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T094500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:92C196EE-5BE7-4C56-8309-0C8D4E7B3FB9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101008T160000 DTSTAMP:20100607T191657Z SUMMARY:Friday Chemistry Colloquium: Xudong Yao\, University of Connect icut. Title & abstract to come. Host: Carthene Bazemore-Walker. 4:00\, M M 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101008T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:3B80D636-61E9-46A6-9E49-54E8F06F3A80-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101119T160000 DTSTAMP:20100629T122117Z SUMMARY:Friday Chemistry Colloquium: Chi-Huey Wong\, Academia Sinica\, T aiwan. Title & abstract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101119T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:EA517636-A5DF-49F4-975D-7AEE15A42D2B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110114T160000 DTSTAMP:20100625T191629Z SUMMARY:RESERVED: Faculty Search CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110114T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:489C07EE-1596-11DA-869D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051103T120000 DTSTAMP:20051024T194213Z SUMMARY:Organic Seminar: Daniel Singleton\, Texas A&M University. 12noon - 1:00\, GC351. \"No Transition State\, No Path: Trajectory-Controlled Mechanisms & Selectivities in Ordinary Organic Reactions.\" Host: Willia m Trenkle. (The Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051103T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:F064FDAE-8F18-11D9-8EF1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050407T150000 DTSTAMP:20050405T193738Z SUMMARY:Physical Tea Session: Guohua Tao\, Brown University. \"Nonlinear Rotational Dynamics in Liquids.\" Host: Christoph Rose-Petruck. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050407T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:E6F9132D-76B5-11D9-AD63-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050414T150000 DTSTAMP:20050204T140705Z SUMMARY:Physical Tea Session: Fedor Rudakov\, Brown University. GC 351\, 3:00 - 4:15. Title to come. Host: Christoph Rose-Petruck. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050414T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:CDB7B3D8-31E5-11DB-82DD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061019T120000 DTSTAMP:20061010T212122Z SUMMARY:Inorganic Seminar: Dwight A. Sweigart\, Brown University. 12:00 - 1:15\, GC 351. \"Organometallic Quinonoid Complexes in Supramolecular Self-Assembly & Multifunctional Catalysis.\" Host: Shuangbing Han CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061019T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:3A6020E3-BB27-11D9-AF94-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051006T120000 DTSTAMP:20051129T180223Z SUMMARY:Inorganic/Materials Seminar: Lynn K. Kurihara\, Naval Research L aboratory. \"Chemical Processing & Applications of Nanostructured Powder s.\" 12noon - 1:00pm\, GC 351. Host: Shouheng Sun. Fletcher House. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051006T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:066D1A4C-7BD6-11DA-84F7-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060131T110000 DTSTAMP:20060127T140826Z SUMMARY:Organic Seminar: Anthony Comeau\, Brown University. 11:00 -12:30 \, GC 351. \"Small Molecule Inhibitors: Inhibitors of PTPase & MMP-1.\" Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060131T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: I report our findings that when iron pentacarbonyl (IPC)\, Fe(CO)5\, is solvated in alcohols\, the IPC is not just surrou nded by a salvation shell. Instead\, IPC forms weak complexes with a sin gle solvent molecule. The equilibrium structure of IPC\, solvated in v arious alcohols was investigated by FTIR measurement and DFT calculation s. The complex results from interaction of IPC with the hydroxyl group o f an alcohol molecule and electron density shifts from alcohol to IPC\, which induces a dipole moment in IPC molecule. The stability of the comp lexes was found to depend on the alcohol chain length and branching. The formation of complexes might have significant implications for the liga nd substitution reactions in solution. UID:7B403287-2A11-4A79-B920-3B47616D4A58-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080515T150000 DTSTAMP:20080511T184337Z SUMMARY:Physical Tea Session: Xiaodi Li\, Brown University. 3:00 - 4:15\ , GC 351. \"Structure of Solvated Fe(CO)5: Complex Formation during Salv ation in Alcohols.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080515T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: Significant challenges exist in assembling the bui lding blocks of a nanoscale device. Self-assembly is one of the few prac tical strategies for making ensembles of nanostructures and will therefo re be an essential part of nanotechnology. In order to generate complex structures through self-assembly\, it is essential to develop methods by which different components in solution can come together in an ordered fashion. Using viruses as nanoscale scaffolds for devices offers the pro mise of exquisite control over positioning nanoscale components on a pro tein scaffold that also allows further self assembly of the nanoscale de vices. Using Cowpea Mosaic Virus\, modified to express cysteine residues on the capsid exterior\, gold nanoparticles were attached to the viral scaffold in a pattern to produce specific inter-particle distances. The nanoparticles were then interconnected using thiol-terminated conjugated organic molecules that can act as “molecular wires\,” resulting in a th ree-dimensional spherical conductive network which is only 30 nm in diam eter. By using molecules that exhibit bistable voltage controlled switch ing\, molecular memory circuits were assembled and characterized. UID:7892366F-CBD0-45E7-983B-7E5D10E34F1F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080114T160000 DTSTAMP:20080108T141839Z SUMMARY:Nano Faculty Candidate: Amy Szuchmacher Blum. 4:00 - 5:30\, MM 1 15. \"Molecular Memory Circuits on a Nanoscale Scaffold.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080114T174500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:01D0EC4F-85B0-11D9-B613-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050315T110000 DTSTAMP:20050223T153301Z SUMMARY:Organic First Year Seminar: Dezhi Fu & Jiaoyang Jiang\, Brown Un iversity. GC 351\, 11:00 - 12:00. Host: William Trenkle. Title to come. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050315T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:B1087FBE-901A-43CB-8A89-9A3D70D33BE7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060928T150000 DTSTAMP:20060927T201019Z SUMMARY:Physical Chemistry Tea Session: Christoph Rose-Petruck\, Brown U niversity. 3:00 - 4:30\, GC 351. “Ultrafast X-Ray Sources in Chemical Re search & Cancer Imaging with Partially Coherent X-Ray Sources.\" Host: J immie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060928T163000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:0473BF4C-1302-11D9-88BD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20040930T130000 DTSTAMP:20040930T165908Z SUMMARY:Guohua Cao: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20040930T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:3A41D414-A538-4CCA-A6C8-861ECD749920-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071025T120000 DTSTAMP:20071023T125341Z SUMMARY:Inorganic/Materials Seminar: Robert Hurt\, Brown University. 12: 00 - 1:15\, GC 351. \"The Materials Chemistry of Nanotoxicology.\" Host: Shouheng Sun (no schedule) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071025T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Life proceeds by converting the free energy releas ed by nucleoside triphosphate hydrolysis into useful mechanical work\, c hemical synthesis and information. The important class of enzymes respon sible for this free energy transduction includes all polymerases\, motor s\, signaling GTPases and tRNA synthetases. Understanding the biophysica l relationship between enzyme structure and function in these enzymes is important not only to further basic understanding in the field\, but is also important in drug design and protein engineering. Despite the subs tantial inroads that have been made\, there remain fundamental questions . Interestingly\, virtually all transducing enzymes use a metal ion for catalysis. The dominant paradigm for how metal ions work in enzymes is t hat they stabilize the charge in the transition state by interactions at the active site.\n\nTryptophanyl-tRNA synthetases exhibit properties th at do not fit this standard paradigm:\n1. The transition state binding a ffinity coincides with a protein conformation that has the least stable structure on the pathway (Kapustina et al.\, 2007).\n2. Interactions of the metal ion with the active site decrease the affinity for ATP\, i.e.\ , oppose catalysis\, in both the ground state and the transition state ( Weinreb & Carter\, 2008\; Weinreb et al.\, 2009).\n\nOur central hypothe sis is that for the α/β transducing enzymes responsible for free energy transduction\, the interaction of the metal ion in the active site oppos es catalysis\, while long-range interactions within the protein stabiliz e the transition state. Thus\, the catalytic effect of the metal ion req uires conformational changes and conversely\, conformational changes lea d to catalysis of phosphoryl transfer by the metal ion. Trajectories bet ween conformations along the structural reaction profile (Laowanapiban e t al.\, 2009) therefore contain key information on the mechanisms of fre e energy transduction.\n\nIn related work\, we have constructed and vali dated the catalytic activity of a 130-residue module containing an essen tially intact TrpRS active site\, but lacking many long-range interactio ns [Pham\, 2007\, #89]. We have called this construct an “urzyme” from U r = “primitive\, original\, earliest” + enzyme. Mutational studies show that full length TrpRS and its urzyme work by different mechanisms. Thus \, the TrpRS urzyme provides unprecedented access to the experimental in vestigation of how catalytic activity\, free energy transduction and spe cificity evolved.\n UID:A847A74A-C9A1-4150-B6FE-AD5CC1A9B4A7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090922T110000 DTSTAMP:20090904T124959Z SUMMARY:Organic Chemistry Seminar: Charles Carter\, University of North Carolina. \"Mechanistic Studies of a tRNA Synthetase Suggest the Evoluti on of a General Mechanism for Free-Energy Transduction.\" Host: Jason Se llo. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090922T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:323E840E-2258-417F-A7F0-F3AD65799F0F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T141500 DTSTAMP:20080813T124859Z SUMMARY:Break CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T144500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:47E8C0F2-8688-11D9-BC84-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050923T160000 DTSTAMP:20050914T201523Z SUMMARY:Friday Chemistry Colloquium: Younan Xia\, University of Washingt on. 4:00 -5:15\, MM115. \"Shape-Controlled Synthesis of Nanostructured M aterials.\" Host: Shouheng Sun. Fletcher House. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050923T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:1B63FA6C-5F5C-11D9-A18F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050415T160000 DTSTAMP:20050407T151754Z SUMMARY:Friday Colloquium: Robert Mulvey\, Strathclyde University. 4:00 - 5:30\, MM 115. \"Mixed-Metal Molecular Synergy: Deprotonation Reaction s of Arenes & Metallocenes by Mixed-Metal Bases.\" Host: Paul Williard. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050415T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Magnetic particles have been used in magnetic reso nance imaging (MRI) for nearly 25 years. In clinical use\, success has b een achieved in the diagnoses of diseases\, particularly those of the re ticuloendothelial and lymph systems. Experimentally\, magnetic particles have been used to target specific extracellular epitopes in animal mode ls\, such as cancer\, atherosclerotic plaques and activated endothelial cells\, among numerous others. Further experimental studies have used in tracellularly incorporated magnetic particles to report on the migration of transplanted cells in animals\, and most recently in humans. In part due to historical reasons\, and in part due to clinical aspirations\, t he basic magnetic nanoparticle common to all these experiments has remai ned unchanged. These particles are generally dextran-coated iron oxide n anoparticles with crystalline iron oxide cores of between 5 and 10 nm\, with overall particle size between 30 and 200 nm. As the magnetic materi al constitutes less than 1% of the volume of these particles\, they are inefficient at delivering high amounts of magnetic material. We have pio neered the use of micron sized iron oxide particles with ~ 50% magnetic material. These particles are detectable as single particles and as such \, greatly facilitate cell tracking by MRI. This presentation will focus on the properties of these particles and the advantages of using these micron sized iron oxide particles for cellular MRI. Finally\, I will add ress future improvements in magnetic nano- and micro-particle compositio ns and chemistry to enable additional applications\, including the asses sment of gene expression.\n UID:B6C66BC9-8D4E-4743-9777-EF83B2B02ABE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080320T120000 DTSTAMP:20080312T162404Z SUMMARY:Inorganic/Materials Seminar: Erik M. Shapiro\, Yale University S chool of Medicine. 12:00\, GC 351. \"Magnetic Particles & MRI.\" Host: S houheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080320T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Photochemical reactions of polyenes\, involving pe ricyclic rearrangements\, are important for synthetic chemistry\, as wel l as biological and technical processes. For example\, both the photosyn thesis of vitamin D and vision processes in pigments rely on electrocycl ic ring opening and closing reactions. Among the polyenes\, the conjugat ed 1\,3-cyclohexadiene (CHD) often serves as a model system for electroc yclic ring opening reactions. In previous works\, the early stages of 1\ ,3-cyclohexadiene to form its 1\,3\,5-hexatriene upon excitation to the ultrashort-lived 1 1B2 state\, have been explored. Our goal is to inve stigate the structural dynamics of 1\,3-cyclohexadiene associated with t he ring opening. Pumping with 4.64 eV and 5.98 eV photons respectively a nd probing with time-delayed ionization pulses with energies near 3 eV p rovides time dependent Rydberg binding energies that mirror the structur al changes of the molecule during the ring opening process. UID:51880907-D7B0-428D-81E7-8E665EF02F99-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100429T150000 DTSTAMP:20100423T183124Z SUMMARY:Physical Chemistry Tea Session: Christine Buehler\, Brown Univer sity. \"Spectroscopy & Femtosecond Dynamics of the Ring Opening Reaction of 1\,3-cyclohexadiene.\" Host: Gerald Diebold. GC 351\, 3:00. (Refresh ments Brian Ahr) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100429T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Rydberg fingerprint spectroscopy has proven to be a useful method to investigate molecular structure. This technique can b e carried out by a multi-photon ionization process where the Rydberg sta tes are reflected in the electron binding energy spectrum. Nevertheless\ , the connection between Rydberg electron binding energies and molecular properties\, such as size\, shape and charge distribution\, is not well understood. In this presentation\, we present a model of the molecular ion core\, and analytical approaches (perturbation theory) as well as nu merical approaches have been employed to study the model. Preliminary re sults describe the dependence of the Rydberg electron binding energy on molecular size and charge distribution. UID:975E9E70-2566-486A-8989-E7B0ABC80DCA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091203T150000 DTSTAMP:20091125T180621Z SUMMARY:Physical Chemistry Tea Session: Xiao Liang\, Brown University. \ "Theoretical Modeling of Rydberg Electron Binding Energies: Analytical & Numerical Approaches.\" Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091203T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: A collection of zirconocene and hafnocene dinitrog en complexes\, [(η5-C5RnH5-n)2M]2(μ2\, η2\, η2-N2) (M = Zr\, Hf\; R = al kyl\, silyl)\, have been prepared by alkali metal reduction of the corre sponding dihalide precursors. A combination of experimental and computat ional studies demonstrates that the canted\, dimeric ground state struct ures of the metallocene dinitrogen species impart an additional back-bon ding interaction between the metal and N2. This enhanced reduction of th e dinitrogen serves as the origin of the strong activation observed in t hese molecules. Functionalization of these metallocene dinitrogen specie s by 1\,2 addition\, cycloaddition and Chatt-type addition has yielded n umerous of new N-H\, N-Si and N-C bond forming transformations. UID:207D7A87-B26E-4EF1-B932-3468FB50F63F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081125T160000 DTSTAMP:20081117T191016Z SUMMARY:Inorganic Faculty Candidate: Wesley Bernskoetter\, UNC. \"Dinitr ogen Functionalization by Group 4 Metallocene Complexes: Origins & Mecha nism.\" Host: Dwight Sweigart. 4:00 - 5:00\, MM115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081125T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:E00970EA-7678-41B4-87C2-0F07990D2646-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071101T120000 DTSTAMP:20071029T154826Z SUMMARY:Inorganic Seminar: Chao Wang\, Brown University. 12:00 - 1:15\, GC 351. \"Shape & Size Controlled Synthesis of Pt Nanoparticles as Catal ysts for Oxygen Reduction Reaction.\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071101T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:FA2A05F4-86DF-4D78-B6F5-AA75944748CA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070614T150000 DTSTAMP:20070606T183153Z SUMMARY:Organic Chemistry Seminar: Jill Barber\, University of Mancheste r\, \"The Curious Aqueous Solution Chemistry of Erythromycin: Implicatio ns for Drug Design.\" 11:00 - 12:30\, GC 351. Host: David Cane. (Inn at Brown\, 6-13 & 14)\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070614T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:CFD7ADF8-43C2-4D0C-9A2D-688DC7135659-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071009T110000 DTSTAMP:20071004T152559Z SUMMARY:Student Organic Seminar: Xiang Liu\, Brown University. 11:00 - 1 2:30\, GC 351. No Title. Host: Jason Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071009T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:FDF4EFAE-D0A6-11DA-A22C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060525T100000 DTSTAMP:20060420T195154Z SUMMARY:Thesis Defense: Mike Minitti\, Brown University. 10:00 am - 12:0 0 noon\, GC 351. Title to come. Presiding Officer: Peter Weber. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060525T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:69BFE016-3E49-4298-ABAE-7A88BCEF1632-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090604T120000 DTSTAMP:20090522T173019Z SUMMARY:Inorganic Chemistry/Materials Seminar: Julian Carrey\, Departeme nt de Genie Physique\, INSA\, Toulouse\, France. \"Magnetic Hyperthermia & Magnetotransport Properties of Fe & FeCo Nanoparticles Synthesized by Organometallic Chemistry.\" Host: Shouheng Sun. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090604T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:ED105299-B8B4-11D9-8E24-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050513T100000 DTSTAMP:20050511T125940Z SUMMARY:Friday Colloquium. Banahalli Ratna\, Naval Research Laboratory. 4:00 - 5:30\, MM 115. \"An Engineered Plant Virus as a Scaffold for Nano scale Assembly.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050513T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:5333C5F7-6E75-42ED-A4E5-811CB59CBAF2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110121T160000 DTSTAMP:20100625T191713Z SUMMARY:RESERVED: Faculty Search CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110121T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: The recent endeavors on the development of synthet ic porous materials\, especially mesoporous silica materials\, for their great potentials in practical applications such as bioadsorption\, sepa ration\, biocatalysis\, biosensors and vehicles for drug delivery\, are based on their very attractive features: thermally and mechanically stab le mesoporous structure\, narrow and tunable pore size distribution\, ex tremely high specific surface area and pore volume\, non-toxic nature\, good biocompatibility. \n\nA monodisperse\, spherical mesoporous silica (Acid-Prepared Mesoporous Spheres\, APMS) was prepared. Our work provide s a method by which the surface of the porous silica can be functionaliz ed in a well-defined manner. The multifunctional\, highly porous silica microparticles were developed and used in the target delivery of DNA pla smids\, RNA\, chemotherapeutic drugs or other molecules to cells. The pa rticles were externally modified with antibodies\, membrane fusion enhan cers or other functional groups while leaving the internal pore volume u nmodified and available for storage of the species to be delivered to th e cells' interiors. The functional ligands and antibodies were covalentl y immobilized on the external surface of porous supports in a well-defin ed manner using a unique strategy based on self-assembly of nanospheres and highly porous microparticles. Particles modified in this manner with cell-specific antibodies allowing targeted delivery of their \"cargo\" will be invaluable in therapeutic approaches to numerous diseases.\n UID:FADE96A1-3171-4C40-981F-0AF90B89317B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080925T120000 DTSTAMP:20080905T193545Z SUMMARY:Inorganic Chemistry Seminar: Kai Cheng\, Brown University. \"De sign & Development of Functionalized Nanoporous Silica Spheres for Biome dical Applications.\" Host: Shouheng Sun. 12:00 - 1:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080925T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:50D1F91E-85B0-11D9-B613-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050329T110000 DTSTAMP:20050316T140916Z SUMMARY:Organic First Year Seminar: Amanda Stockton. Brown University. G C 351\, 11:00 - 12:00. \"Dynamic Combinatorial Chemistry: Recent Example s in Literature.\" Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050329T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:B991BF40-38A0-11D9-9525-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041118T090000 DTSTAMP:20041117T135826Z SUMMARY:Christian Reich: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041118T100000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Rotations about its three carbon-nitrogen bonds gi ve triethylamine a complex\, 3-dimensional potential energy landscape of conformeric structures. Electronic excitation to Rydberg states prepare s the molecule in a high-energy\, nonequilibrium distribution of such co nformers\, initiating ultrafast transitions between them. Time-resolved Rydberg electron binding energy spectra\, observed with photoionization- photoelectron spectroscopy\, can spectrally and temporally resolve these structures. The time-dependent structural fingerprint spectra can be as signed through a computational analysis of the potential energy landscap e. Upon 209 nm electronic excitation to the 3p Rydberg state\, triethyla mine decays to 3s with a 200 fs time constant. The initially prepared co nformer reacts to a mixture of structures with a time constant of 232 fs \, and settles in a final geometry distribution on a further sub-picosec ond time scale. The binding energy of the Rydberg electron is found to b e an important determinant of the conformeric energy landscape. UID:84F934F6-E4C3-449D-BB66-D2E805B3A43A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100204T150000 DTSTAMP:20100201T211607Z SUMMARY:Physical Chemistry Tea Session: Sanghamitra Deb\, Brown Universi ty. \"Ultrafast Conformational Dynamics of Rydberg-Excited Triethylamine .\" Host: Gerald Diebold. GC 351\, 3:00. (Refreshments by Crystal Nguyen ) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100204T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:F6EC025D-3B1C-4A81-BDC9-A9B553C4309D DTSTART;TZID=US/Eastern:20100418T000000 DTSTAMP:20100317T120449Z SUMMARY:scheudle lunch@faculty club with sorensons CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100418T010000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:49A2C68E-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041007T130000 DTSTAMP:20040930T164645Z SUMMARY:Jamie Gosselin: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041007T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:BD853788-62C8-4DD7-B061-EFD96C005E4E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071113T110000 DTSTAMP:20071113T165150Z SUMMARY:Organic Seminar: Christopher N. Boddy\, Syracuse University. 11: 00 - 12:30\, GC 351. \"Harnessing Biosynthetic Pathways to Produce Compl ex Molecules.\" Host: Jason Sello (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071113T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:DAF4B07A-BBE8-45E9-9D17-07F5C4106348-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100313T140000 DTSTAMP:20100121T184500Z SUMMARY:Prospective Graduate Student Visitation CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100313T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: The presentation will contain two distinct parts\, reflecting the diversity of scientific problems that are being pursued in the DeBoef group.\n\nI. The selective functionalization of strong C-H bonds in the presence of more reactive bonds is an unimaginable task us ing the traditional tools of organic chemistry. We have demonstrated tha t two C-H bonds can be oxidatively cross-coupled to form biaryl C-C bond s in the presence of palladium catalysts and either organometallic or ae robic oxidants. This novel transformation has the potential to streamli ne the synthesis of high-value biaryl molecules.\n\nII. The elucidation of the inner workings of the human brain is one of the most significant goals of modern science\, and molecular imaging promises to be one of th e key tools that will be used to accomplish this task. We have synthesiz ed the first MRI contrast agent for labeling a neuroreceptor\, specifica lly the dopamine transporter. This technology will allow medical researc hers and practitioners to quantitatively study disorders and diseases su ch as depression\, drug addiction\, schizophrenia and Parkinson's diseas e.\n UID:9839A365-E8B8-4DB3-9FE0-7FCC558022BF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100309T110000 DTSTAMP:20100303T152509Z SUMMARY:Organic Seminar: Brenton deBoef\, URI. Host: Jason Sello. GC 351 \, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100309T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract (Jarem): Huntington’s Disease\, a neurodegenerative condition that affects 1 in 10\,000 people in the western nations\, has been linked to the expansion of a region that has a repetitive CAG trin ucleotide motif. In the literature\, CAG repeats have been shown to form secondary structures\, most notably hairpins. The formation of these st ructures\, coupled to the repair of oxidative damage within these region s by the enzyme OGG1 (oxoguanine glycosylase) have been associated with the expansion of this CAG tract in the Huntington gene. To further inves tigate this CAGn oligonucleotides were synthesized on site and purified by reverse phase HPLC. Furthermore\, the secondary structures formed by these oligonucleotides were studied using UV-Vis spectrophotometry and b y reactions with diethyl pyrocarbonate (DEPC). Using the characterized h airpins the susceptibility of CAG sequence and structure to oxidation wa s determined by reactions with peroxynitrite\, a biologically relevant o xidant. Through analysis by polyacrylamide gel electrophoresis\, oxidati on was found to occur at specific sites of the oligonucleotide sequence. Further study is required to investigate the effect of CAG repeat lengt h on oxidation\, as well as assays that probe structural stability of ha irpins that contain oxidized lesions and corresponding repair activity b y OGG1.\n\nAbstract (Poston): Sigma receptors are a novel class of prote ins found throughout the body that are especially concentrated in the br ain\, liver and kidneys. Although two receptor subtypes (referred to as sigma-1 and sigma-2) have been pharmacologically identified\, their biol ogical function and mechanism of action have not yet been clearly define d. Both receptors are over-expressed in many tumor cells and so\, both a ppear to play a role in cell survival. For instance\, sigma receptor int eraction with a ligand can lead to proliferation or apoptosis in tumor c ells and this is controlled by the nature of the ligand\, i.e.\, whether it is an agonist or antagonist. In the case of the sigma-1 receptor\, a gonist binding leads to its activation and initiates a prosurvival signa ling cascade. Many proteins potentially involved in this prosurvival pro cess\, such as growth factor receptors\, reside in highly ordered membra ne domains known as lipid rafts. Interestingly\, sigma-1 receptor activa tion modulates the lipid composition of lipid rafts and may also alter t he activity of these important proteins. As a first step to understandin g how the sigma-1 receptor controls cellular survival signals\, I will m onitor how the protein composition of lipid rafts change in response to sigma-1 receptor activation using a global proteomic technique. Our meth odology makes use of strong cation exchange chromatography (SCX)\, nano- reversed-phase liquid chromatography (nRP-LC)\, tandem mass spectrometry and novel amine-specific isobaric tagging reagents (iTRAQ) that allow f or relative quantification of multiple samples simultaneously. UID:248686DF-FFAC-4CAE-92CF-B12DF8D099FF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080527T110000 DTSTAMP:20080523T211814Z SUMMARY:1st Year Student Organic Seminars: \"Finding a Link between Trin ucleotide Repeats & Huntington’s Disease\,\" Daniel Jarem & \"A Quantita tive Proteomic Approach to Understanding the Sigma-1 Receptor Signaling Pathway.\" Chloe Poston\, Brown University. Host: Jason Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080527T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: Total system hamiltonians can be decomposed into s ubsystem or site hamiltonians and coulombic interactions. Site hamiltoni ans can be evaluated in a spectral representation once an integer number of electrons is assigned. The coulombic interactions between pairs of s ites can be expressed as the difference between the pair hamiltonian and the two site hamiltonians. For both pair and individual site hamiltonia ns\, many sites are better understood as possessing a fractional charge. The nature of the energy dependence on this fractional charge is invest igated. Two distinct\, quantum-based charge-dependent energy contributio ns emerge\, arising from intra- and inter-subsystem charge transfer. The charge dependence is developed from a 3-state model\, at the level of n eglecting state-to-state overlap. The energy as a function of charge is defined as with the help of an optimization over auxiliary variables. Th e addition of a third state smoothes the derivatives of the energy model with respect to charge at integer values of charge that are in the inte rior of the allowed charge range. These derivatives are related to the c hemical potential. At the dissociation limit\, this model converges to e stablished limits. The concepts are illustrated with calculations on an OH model. UID:3D3E95A8-0E26-4436-822B-2AC7D4CBD53F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071129T150000 DTSTAMP:20071120T140746Z SUMMARY:Physical Tea Session: Steven M. Valone\, LANL. 3:00 - 4:15\, GC 351. \"Potential Energy Surfaces from Spectral Representations.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071129T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:26019BB8-6027-11D9-B78E-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050328T150000 DTSTAMP:20050322T213717Z SUMMARY:Physical Tea Session: Jan Thoen\, Katholieke Universiteit Leuven \, 3:00 - 4:15\, GC 351. \"High-Resolution Thermal Studies of Phase Tran sitions by Adiabatic Scanning Calorimetry & Photothermal Techniques.\" H ost: Gerald Diebold. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050328T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:A25B4B37-1B95-4F00-84CF-C3871F470E3B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110304T080000 DTSTAMP:20100625T132413Z SUMMARY:Grad Student Visiting Day CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110304T081500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:BF69767A-82A9-493C-9CA2-70FBAD95FC5C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110318T160000 DTSTAMP:20100630T123527Z SUMMARY:Friday Chemistry Colloquium: W. Robert Scheidt\, University of N otre Dame. Title & abstract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110318T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:D143FC60-8E7E-11DA-997D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060331T160000 DTSTAMP:20060323T211616Z SUMMARY:Friday Chemistry Colloquium: Andrew G. Gehring\, USDA-ARS-ERRC. 4:00 - 5:15\, MM115. \"Rapid Methods for the Detection of Foodborne Path ogenic Bacteria.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060331T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:1EDB7662-810B-45AE-9ABE-0272C9CC4958-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061109T154500 DTSTAMP:20061107T173455Z SUMMARY:Organic Faculty Candidate Research Seminar: Corey Stephenson\, S wiss Federal Institute of Technology\, Zurich. 4:00 - 5:45\, MM115. \"Ne w Reactions for the Stereoselective Formation of Carbon-Carbon Bonds.\" Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061109T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:28984AC1-41A3-11DA-9BED-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051206T110000 DTSTAMP:20051128T195634Z SUMMARY:Organic Seminar: Lili Ma\, Brown University. 11:00 - 12:30\, GC 351. \"Polymer-Supported Chiral Lithium Amides: Synthesis & Application. \" Host: William Trenkle CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051206T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Hierarchical assembly is critical for the rational design of functional nanoscale materials. I will demonstrate how silver nanocrystals and nanowires are used as building blocks for the bottom-u p fabrication of plasmonic materials. Nanoscale organization using Langm uir-Blodgett compression is used to construct 1- and 2-D assemblies with impressive alignment over large areas. These plasmonic lattices are dem onstrated as promising platforms for photonics\, spectroscopy and chemic al sensing.\n\nNature provides endless examples of hierarchically organi zed\, responsive materials from which we can learn fundamental design pr inciples. I will also discuss the role of protein self-assembly in squid iridophores. Iridophores are specialized light-reflecting organelles fo und in cephalopod (squid\, octopus\, cuttlefish) skin tissue that displa y structural color. Aligned protein nanoplates within iridophores serve as Bragg reflectors and\, unlike other creatures\, squid control this co lor response based on biochemical signaling at the cellular level.\n UID:AEA1F2B7-D285-425C-B3B6-61B6F3471EEC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090130T160000 DTSTAMP:20090108T205254Z SUMMARY:Nano Chemistry Search Candidate: Andrea Tao\, University of Cali fornia\, Santa Barbara. \"Plasmons to Proteins: Self-Organized\, Tunable Optical Materials.\" Host: Shouheng Sun. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090130T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Transient covalent modifications\, such as phospho rylation\, are key regulatory processes in cells\, allowing for rapid ch anges in cellular physiology. Protein Phosphatase 1 (PP1) is an essentia l and ubiquitous serine/threonine protein phosphatase that is regulated by more than 80 known inhibitor and targeting proteins. However\, it is unclear how these proteins distinctly and specifically regulate PP1 to e nable rapid responses to cellular alterations. We demonstrate that three PP1 regulators\, the PP1 inhibitors DARPP-32 and I-2\, and the PP1 bind ing domain of the targeting protein spinophilin\, belong to the class of intrinsically unstructured proteins (IUPs). Notably\, each regulator di splays distinct local and long-range transient structural preferences. F urthermore\, our data suggests a role for these transient 3-dimensional topologies in binding mechanisms that enable extensive contacts with PP1 's invariant surfaces. The specificity of the regulator: PP1 interaction is likely initiated by the interaction of the IUP's transient structure with a small recognition site on the surface of the enzyme. Subsequentl y\, the assembly of an extended binding interface converts this transien t complex into a stable association. UID:FEA8686B-30BA-4D04-B94C-6B8FF1876EED-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080307T160000 DTSTAMP:20080307T214633Z SUMMARY:Friday Colloquium: Wolfgang Peti\, Brown University. 4:00\, MM 1 15. \"The Role of Transient Structure & Dynamics for Protein Phosphatase 1 Regulation.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080307T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:BDF1E8B4-48BC-49F4-8047-6ADADE1B97CA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110204T150000 DTSTAMP:20100625T200252Z SUMMARY:Friday Chemistry Colloquium: Roberto Kolter\, Harvard Medical Sc hool. Title and abstract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110204T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: The cooperativity of transition-metal ions and pro -radical ligands in metalloenzyme active sites is an area of current res earch interest. In an effort to better understand the intricacies of the interaction of metal ions with organic radicals we are investigating th e electronic structure of a series of oxidized metal complexes (Ni\, Cu\ , Zn) with the salen ligand N\,N’-bis(3\,5-di-tert-butylsalicylidene)cyc lohexane-1\,2-diamine (H2Sal)\, its half-reduced (H2Salhalf-red)\, and f ully reduced (H2Salred) forms. Oxidation of the neutral complexes with a variety of one electron oxidants leads to highly coloured species that can potentially exist in a metal ligand-radical (Mn+(L•)) or high-valent metal form (M(n+1)+(L−)). The characterization of the oxidized complexe s and the relationship between electronic structure and the oxidative re activity with externally added substrates will be discussed. UID:69669EB2-600A-4A42-B2EC-D66E21C2B8F1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080108T160000 DTSTAMP:20080108T141851Z SUMMARY:Inorganic Faculty Candidate: Tim Storr\, Stanford University. 4: 00 - 5:30\, MM 115. \"Oxidized Metal Salens: Correlating Electronic Stru cture & Reactivity.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080108T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:FA8A2DBC-1379-4657-AC3D-6B4B2AFE06D0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061003T150000 DTSTAMP:20060925T212054Z SUMMARY:Physical Chemistry Tea Session: Claudio Chuaqui\, Astra-Zeneca. 3:00 - 4:15\, GC 351. \"Discovery & Optimization of Kinase Inhibitors us ing Virtual Screening & Structure- Based Design.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061003T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Nanostructures made of metals and its oxides have received much attention in recent years because of their uses in many ar eas\, including photonics\, electronics\, biomedicine\, magnetic recordi ng media\, magnetic refrigeration systems\, catalysis\, permanent magnet s and energy technology. In order to understand their unique properties and further promote their utility\, one must fully understand the correl ation between chemistry\, structure\, particle size\, shape and processi ng. Chemical methods have been widely used to produce nanoscale material s due to their straightforward nature with controlled size\, shape\, com position and crystallinity\, which allows one to investigate the relatio nships between size/structure and physical/chemical properties. Here\, w e will examine the synthesis strategies for the size and structure contr olled metal (Co and Ni)\, metal alloy nanoparticles (FePt\, CoPt\, and F eCo) by deciphering the reaction kinetics using the modified polyol proc ess. The shape of the particles could also be controlled since shape can influence the crystal orientation and specifically net magnetic anisotr opy. We extended this process to study the effects on the preparation of rare earth (RE) based-Co nanoparticles that shows moderate magnetizatio n and coercivity at room temperature. The results will be discussed in d etail. UID:D00C4732-7061-4940-B650-81B9F4C798F1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090716T120000 DTSTAMP:20090619T143314Z SUMMARY:Inorganic Chemistry Seminar: C. N. Chinnasamy\, Northeastern Uni versity. \"Creating Highly Sought Magnetic Nanoparticles.\" Host: Shouhe ng Sun. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090716T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:13F103A3-1ABE-453B-9FC7-B264B32C2C05-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110225T160000 DTSTAMP:20100421T130900Z SUMMARY:Clapp Lecture: Jacqueline K. Barton\, CalTech. Title and abstra ct to come. Host: Sarah Delaney. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110225T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The modular polyketide synthase 6-deoxyerythronoli de B synthase (DEBS) catalyzes the biosynthesis of the aglycone precurso r of the antibiotic erythromycin. The mechanism of assembly of polyketid es is well known\, but the determinants of the exact chirality of the su bstituents on the growing polyketide chain remain unclear.\nThe ketosynt hase (KS)\, acyltransferase (AT) and acyl carrier protein (ACP) are nece ssary domains for condensation. Biosynthesis proceeds by condensation be tween the acyl-KS intermediate and methylmalonyl extender unit to form a α-methyl-β-ketoacyl-ACP. When a KR domain is present a α-methyl-β-hydox ylacyl-ACP is formed. During erythromycin biosynthesis two epimerization s of the α-methyl substituent must take place. The enzyme controlling th e α-methyl stereochemistry is unknown. We have developed a method to est ablish the exact stereochemistry of the intermediates when different com binations of DEBS domains were used. Our results demonstrate that the st ereochemistry at both the α- and β- position of the 2-methyl-3-hydroxyac yl-ACP substrate is specific for a given KR.\n\n \n UID:599717B1-F45C-4184-88DA-F0C301BABA09-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081118T110000 DTSTAMP:20081114T214249Z SUMMARY:Organic Chemistry Seminar: Chiara Valenzara\, Brown University. \"Biochemical Investigation of Stereochemical Control in Polyketides Bio synthesis.\" Host: Jason Sello. 11:00 - 12:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081118T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:3FD9D1CE-79A8-48E6-8223-9538E49C2AE0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20091001T150000 DTSTAMP:20090618T182832Z SUMMARY:Physical Chemistry Tea Session: Aihui Yan\, Brown University. Ti tle and abstract to come. Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091001T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: Research in our laboratory focuses broadly on two areas: atomic clusters and nanoscience and solution chemistry in the gas phase. I will give an overview of our research in these areas and highl ight a few recent results. Atomic clusters containing two to several hun dred atoms exhibit dramatic size-dependent properties and form the found ation of nano-science. My research group employs photoelectron spectrosc opy to probe the electronic and atomic structures of size-selected clust ers\, produced by a laser-vaporization supersonic cluster beam technique . We are interested in probing the electronic structure evolution as a f unction of cluster size\, using clusters as models for catalytic active sites and discovering highly stable clusters as potential building block s for cluster-assembled nanomaterials. I will focus on our recent studie s on gold and boron clusters. Gold clusters have attracted considerable recent attention due to the remarkable catalytic effects discovered in g old nanoparticles\, despite the fact that bulk gold is the most inert me tal. I will present joint photoelectron spectroscopic and theoretical st udies to elucidate the structures of gold clusters\, including the tetra hedral Au20 and the golden cage Au16. We have carried out extensive inve stigations of small boron clusters and found that they all prefer planar structures and exhibit aromaticity and antiaromaticity\, analogous to c yclic hydrocarbon molecules. The planar boron clusters are highly stable and may be used as new ligands in chemistry.\n \nElectrospray is not o nly a powerful soft-ionization method for biomolecules\, but also an ide al interface between the solution phase and the gas phase. We have devel oped an experimental technique by coupling an electrospray ion source wi th photoelectron spectroscopy to study solution anions in the gas phase\ , including multiply charged anions\, inorganic metal complexes and redo x species\, solvated clusters and bio-related molecules. I will discuss the unique properties of multiply charged anions\, such as the repulsive Coulomb barriers and negative electron binding energies\, as well as ou r investigations of solvation of complex anions and biomimetic [Fe-S] cl usters. Finally\, I will mention our recent technical development in ion cooling and photoelectron imaging of multiply charged anions. \n UID:2958AE03-94BE-4D97-B232-BB2AF1F48FF1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080926T160000 DTSTAMP:20080924T173324Z SUMMARY:Special Colloquium. Lai-Sheng Wang\, Washington State University & Pacific Northwest National Laboratory. \"Probing the Unique Electron ic & Atomic Structures of Nano-Clusters & Solution Chemistry in the Gas Phase Host.\" Richard M. Stratt. 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080926T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The volatile metabolite geosmin is a degraded sesq uiterpene that is responsible for the characteristic smell of moist soil . Geosmin is produced by a wide range of microorganisms\, including most species of Streptomyces and a variety of other actinomycetes\, myxobact eria and cyanobacteria\, as well as certain fungi and selected higher pl ants such as liverworts and beets. In S. coelicolor A3(2) a single 726-a mino acid protein\, encoded by the 2181-bp SCO6073 gene (cyc2)\, catalyz es the Mg2+-dependent cyclization of farnesyl diphosphate (FPP)\, the un iversal acyclic precursor of all sesquiterpenes\, to a mixture of geosmi n\, germacradienol\, germacrene D and small amount of 8\,10-dimethyl-1-o ctalin. The S. coelicolor germacradienol-geosmin synthase is in fact a b ifunctional enzyme in which the N-terminal domain catalyzes the cyclizat ion of FPP to a 85:15 mixture of germacradienol and germacrene D\, accom panied by traces of the octalin\, while the C-terminal domain catalyzes the Mg2+-dependent cyclization-fragmentation of germacradienol to geosmi n\, with release of the 2-propanol side chain as acetone. Site-directed mutagenesis experiments have confirmed that the N- and C-terminal domain s each harbor catalytically independent active sites. \n\nWe also demons trated geosmin biosynthesis in a model cyanobacterium\, Nostoc punctifor me PCC 73102\, which utilizes a single enzyme to catalyze the cyclizatio n of FPP to geosmin. Using this information\, we have developed a PCR-ba sed assay that allows the rapid detection of geosmin-producing cyanobact eria. This test may be utilized to confirm and track the emergence of ta ste and odor-producing cyanobacteria in any given water body and thus ca n be used as an early warning system by managers of water bodies that ma y suffer from adverse taste and odor episodes. \n\nPentalenolactone is a sesquiterpenoid antibiotic isolated from a variety of Streptomyces spec ies. The ptlE gene from the pentalenolactone biosynthetic gene cluster o f S. avermitilis encodes a 594 aa flavin-dependent monooxygenase\, which catalyzes the Baeyer-Villiger oxidation of 1-deoxy-11-oxopentalenic aci d to an unexpected product of neopentalenolactone D. The structure of th is compound has been confirmed by GC-MS and NMR. \n UID:8615A79D-8404-40D5-AF5C-F5A5B2915B54-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080918T110000 DTSTAMP:20080905T193503Z SUMMARY:PhD Thesis Defense: Jiaoyang Jiang\, Brown University. \"Natural Products Biosynthesis: I. Geosmin Biosynthesis in Streptomyces coelicol or A3(2) & Nostoc punctiforme PCC 73102. II. Pentalenolactone Biosynthet ic Pathway in Streptomyces avermitilis.\" Presiding Officer: David E. C ane. 11:00 - 2:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080918T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:E5045DDA-9405-11DA-A88D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060908T160000 DTSTAMP:20060821T135616Z SUMMARY:Friday Chemistry Colloquium: Steve Regen\, Lehigh University. 4: 00 - 5:30\, MM 115. \"Nearest-Neighbor Recognition in Lipid Bilayers.\" Host: Amit Basu. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060908T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:5FFAD974-810F-11D9-AE8C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050303T120000 DTSTAMP:20050224T135449Z SUMMARY:Inorganic Seminar: Jack Breen\, Providence College\, noon - 1:00 \, GC 351. \"Scanning Tunneling Microscopy of Molecular Systems.\" Host: Dwight Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050303T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: The talk will describe recent progress in two area s: (a) the application of fragment-based drug discovery methods to devel op enzyme inhibitors. The approach involves using biophysical techniques to identify small molecular fragments that bind to the target protein w ith low affinity. The binding is confirmed by X-ray crystallography. Th ere then follows iterative cycles of synthesis and analysis as the fragm ent is elaborated to a more potent inhibitor. There will be a particular focus on targeting enzymes from Mycobacterium tuberculosis. (b) (b) The development of microdroplets in microfluidics as microreactors for chem istry and biology. The fabrication of devices will be described and thei r use for droplet generation and manipulation. Experiments will be descr ibed using droplets for cell-based assays\, and for IVTT protein express ion experiments.\n UID:B88D93E4-F0DC-4288-BF8E-D568DFA2DF9D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080422T110000 DTSTAMP:20080415T132337Z SUMMARY:Organic Seminar: Chris Abell\, Cambridge University. 11:00\, GC 351. \"Droplets & Fragments.\" Host: David Cane. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080422T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:2A9C1A87-BCD3-4517-84ED-7183FADDDEA6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061003T090000 DTSTAMP:20060928T182240Z SUMMARY:Organic Seminar: Wenjun Tong\, Brown University. 11:00 - 12:30\, GC 351. “Controlling Self-Assembled Monolayer’s Pattern by Dipolar Inte ractions: Molecules Design & STM Images Analysis.” Host: Jason K. Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061003T100000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:11DFF540-FC51-4560-AC93-66FC87CCCA54-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070406T160000 DTSTAMP:20070315T152507Z SUMMARY:Friday Chemistry Colloquium: \"Attosecond Science & Transient Gr ating Spectroscopy\,\" Paul Corkum\, National Research Council of Canada . 4:00 - 5:30\, MM 115. Host: Peter Weber. (Fletcher House) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070406T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Antibiotic production among Streptomyces in soil i s hypothesized to be important to species interactions\, yet we have lit tle understanding of the dynamics of antibiotic phenotypes within microb ial communities in soil or the impacts of antibiotic interactions to the ecology and fitness of soilborne microbes. Our work explores the ecolog y and evolutionary biology of antibiotic inhibitory activities among soi lborne Streptomycetes in native and agricultural habitats\, and addresse s a diverse collection of questions including: Do soilborne microbes eng age in a coevolutionary antibiotic “arms race?” What are alternatives to an arms race\, and what is the role of microbial signals in mediating a ntibiotic interactions? What are the impacts of a microbial arms race on plant populations and communities? Do plants selectively create soilbor ne microbial communities to enhance their own fitness\, and\, if so\, ho w? In total\, our work provides insight into the factors that structure soil microbial community diversity and composition\, and into the potent ial significance of microbial antibiotic and signaling interactions to p lant and microbial fitness. This research also suggests novel strategies for managing plant diseases in diverse habitats. UID:3DE80F10-5FF0-4D02-A4E3-C66D93DA7ABB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100209T110000 DTSTAMP:20100120T151448Z SUMMARY:Organic Chemistry Seminar: Linda Kinkel\, University of Minneso ta. \"The Underground Arms Race: Competition & Coevolution among Soilbo rne Bacteria.\" Host: Jason Sello. GC 351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100209T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:ABSTRACT: Coherent Control provides a direct quantum mechani cal approach to controlling a wide variety of molecular processes. Speci fically\, by designing laser-based scenarios where the final state is re ached by multiple pathways\, we can take advantage of quantum interferen ce effects to alter the probability of achieving desired results. \n\nI will introduce the basic concepts of Coherent Control and describe appli cations to a variety of processes\, including intermolecular and intramo lecular dynamics\, and current generation in nanowires. Experimental cha llenges in need of resolution will also be discussed.\n UID:9EE16C5B-DDB9-478D-9052-C7338AB67C90-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080306T150000 DTSTAMP:20080307T214625Z SUMMARY:Physical Tea Session: Paul Brumer\, University of Toronto. 3:00\ , GC 351. \"Controlling Molecular Processes with Lasers: Fundamentals & Developments.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080306T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The primary pathogenic element of several neurodeg enerative disorders has been pinpointed as a dynamic DNA mutation. Dynam ic mutations are characterized by expansion of a triplet repeat sequence such as (CAG)n/(CTG)n. As part of the expansion process the formation o f non-B DNA conformations by the repeat sequence has previously been pro posed. Furthermore\, the base excision repair enzyme 7\,8-dihydro-8-oxog uanine glycosylase (OGG1) has recently been implicated in the repeat exp ansion [Kovtun\, I. V.\, Liu\, Y.\, Bjoras\, M.\, Klugland\, A.\, Wilson \, S. H.\, and McMurray\, C. T. (2007) Nature 447\, 447-452]. We have fo und that the non-B conformation adopted by (CAG)10\, a hairpin\, is hype r-susceptible to DNA damage relative to (CAG)10/(CTG)10 duplex and\, in particular\, that a hot spot for DNA damage exists. Specifically\, we fi nd that a single guanine in the loop of the hairpin is susceptible to mo dification by peroxynitrite. Interestingly\, we find that human OGG1 (hO GG1) is able to excise 7\,8-dihydro-8-oxoguanine (8-oxoG) from the loop of a hairpin substrate\, albeit with a marked decrease in efficiency rel ative to duplex substrates\; the hOGG1 enzyme removes 8-oxoG from the lo op of a hairpin with a rate that is ~700-fold slower than that observed for DNA duplex. Thus\, while damage is preferentially generated in the l oop of the hairpin\, DNA repair is less efficient. These observed struct ure-dependent patterns of DNA damage and repair may contribute to the OG G1-dependent mechanism of dynamic mutation. UID:9E9B1039-E733-4620-A9C7-547B964893ED-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090915T110000 DTSTAMP:20091112T150711Z SUMMARY:Organic Chemistry Seminar: Sarah Delaney\, Brown University. \"T he Role of DNA Damage & Repair in Dynamic Mutations.\" Host: Jason Sello . 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090915T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:7DBEA165-101F-11DA-A22D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051115T110000 DTSTAMP:20051114T160540Z SUMMARY:Organic Seminar: D. Tyler McQuade\, Cornell University. 11:00 - 12:30\, GC 351. \"Synthesis of Enzymes\, Materials & Small Molecules at Interfaces.\" Host: William Trenkle. (Fletcher House) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051115T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:0D5BFD1F-A5E7-482A-905F-455C1B1CFAE2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101203T160000 DTSTAMP:20100625T191433Z SUMMARY:RESERVED: Faculty Search CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101203T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Histone deacetylase (HDAC) inhibition is a recent\ , clinically validated therapeutic strategy for cancer treatment. HDAC i nhibitors hold great promise in cancer therapy due to their demonstrated ability to arrest proliferation of nearly all transformed cell types. H owever\, most of these agents are non-selective inhibitors of all HDAC i soforms\; and a large number of the identified HDAC inhibitors have not progressed beyond preclinical characterizations. Of the several structur ally distinct small molecule HDACi reported\, macrocyclic depsipeptides have the most complex recognition cap-group moieties and present an exce llent opportunity for the modulation of the biological activities of HDA C inhibitors. Unfortunately\, the structure-activity relationship (SAR) studies for this class of compounds have been impaired largely because m ost macrocyclic HDAC inhibitors known to date comprise of complex peptid e macrocycles. In addition to retaining the pharmacologically disadvanta ged peptidyl backbone\, they offer only limited opportunity for side cha in modifications. Therefore\, if there is no significant paradigm shift in the current molecular design approaches\, the vast therapeutic potent ials of HDAC inhibition may remained largely untapped. Toward improving the therapeutic indices of current HDAC inhibitors\, my lab is developin g novel approaches for organ-selective delivery of HDAC inhibitors for p otential use in targeted lung cancer therapy applications. In this prese ntation\, I will discuss the discovery and SAR studies of a new class of macrocyclic HDAC inhibitors based on the macrolide antibiotics skeleton s. I will also present preliminary evidence for lung selective accumulat ion of selected examples of this new class of HDAC inhibitors. In genera l\, the prospect of tissue-selective HDAC inhibition is a particularly e nticing alternative to isoform selective inhibition and could lead to th e identification of new chemotherapeutic agents with broad application i n targeted cancer therapy.\n\nAcknowledgement: This work was financially supported by Georgia Institute of Technology\, by the Blanchard fellows hip and by NIH Grant R01CA131217.\n UID:5E3785FD-1D72-47C3-B5A9-6828F1055E6D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100302T110000 DTSTAMP:20100215T221215Z SUMMARY:Organic Chemistry Seminar: Adegboyega Oyelere\, Georgia Tech. \" Nonpeptide Macrocyclic Histone Deacetylase Inhibitors for Targeted Cance r Treatment.\" Host: John Oliver. GC 351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100302T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:ABSTRACT: A variety of organometallic molecules have been st udied for catalysis\, electrochemistry\, etc. For applying organometalli c chemistry to materials chemistry\, surface chemistry was though of as a kind of bridge between them and studied for organometallic molecules (Mn\, Rh\, Ir and Ru complexes). UID:042E17E8-A97B-4779-9CA7-7C60363D6ACF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071206T120000 DTSTAMP:20071127T210143Z SUMMARY:Inorganic Seminar: Sang Bok Kim\, Brown University. 12:00 - 1:15 \, GC 351. \"A Study on Organometallic Surface Chemistry.\" Host: Shouhe ng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071206T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:25D929E6-5E91-11D9-AD5B-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050105T160000 DTSTAMP:20050104T210856Z SUMMARY:Lara A. Estroff\, Harvard University\, Organic Faculty Candidate \, 4:00 - 5:15\, GC 351\, \"Examples of Multivalency in Biology: Antibod ies & Crystal Growth\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050105T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:E53ADF6F-7CC5-4668-8529-1679C26AA74E DTSTART;TZID=US/Eastern:20100524T130000 DTSTAMP:20100519T172246Z SUMMARY:rose barriera CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100524T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:79990257-5093-40F5-8CE6-405A1361424B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090409T120000 DTSTAMP:20090326T154359Z SUMMARY:Inorganic Chemistry Seminar: Lise Lacroix\, Brown University. \" Fe Nanoparticles Synthesis for Biomedical Applications.\" Host: Shouheng Sun. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090409T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:A0062D30-813D-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060324T140000 DTSTAMP:20060221T143122Z SUMMARY:Friday Chemistry Colloquium: Lin X. Chen\, Argonne National Labo ratory. 4:00 - 5:30\, MM 115. \"Taking Molecular Snapshots in Photochemi cal Reactions.\" Host: Christoph Rose-Petruck. (TOO) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060324T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:158124EA-2D53-11DB-8778-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060929T160000 DTSTAMP:20060919T182816Z SUMMARY:Friday Chemistry Colloquium: Dan Luo\, Cornell University. 4:00 - 5:30\, MM115. \"Nucleic Acid Engineering: Molecular Engineering DNA as a Generic Material.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060929T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:965B6FFD-B4BE-443B-B54D-1416E21D1409-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110415T170000 DTSTAMP:20100617T203359Z SUMMARY:Friday Chemistry Colloquium: Marc Greenberg\, JHU. Title & abst ract to come. Host: Sarah Delaney. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110415T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: We report on the ultrafast dynamics of the ligand substitution reaction of iron pentacarbonyl (IPC) solvated in ethanol me asured by x-ray absorption near edge structure (XANES) spectroscopy with 4-ps temporal resolution using streak camera detection at the Advanced Photon Source (APS).\n\nSolvated IPC is of particular interest because F TIR data and DFT calculations suggest that the solvent forms a weakly co upled complex with IPC prior to excitation\, though the type of complex depends upon the solvent. Streak camera measurements of the transmission XANES spectra were taken at the 7ID-C beamline at the APS. Excitation w ith 400nm caused a rapid change in absorbance near time zero that recove rs with a time constant of 9 ps. This signature is likely caused by liga nd photo-dissociation followed geminate recombination. Further\, tempora l features are consistent with theoretical XAFS spectra for the formatio n of the product\, iron tetracarbonyl-ethanol within a few tens of picos econds. UID:FA236AFD-9366-4297-962F-05F28E8F94FC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100513T120000 DTSTAMP:20100416T190025Z SUMMARY:Physical Chemistry Tea Session: Brian Ahr\, Brown University. \" Ultrafast Dynamics of Ligand Substitution of Iron Pentacarbonyl.\" Host: Gerald Diebold. GC 351\, 3:00. (Refreshments Christine Buehler) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100513T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:BEF90539-8729-48F5-9B1F-C5CFFCD7E846-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100503T130000 DTSTAMP:20100416T200820Z SUMMARY:Senior Talks in Chemistry/Chemical Physics. GC 351\, 1:00 - 6:00 . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100503T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: An implementation of harmonic quantum transition s tate theory has been developed to make it possible to calculate thermal rate constants for transitions such as diffusion and chemical reactions where tunneling is the dominant mechanism. The calculations can be carri ed out by using directly atomic forces obtained from ab initio methods\, such as plane-wave-based density functional theory. The method\, theref ore\, does not require parametrization of a potential energy surface. Al so\, calculations of quantum dynamics are not required if the goal is to find thermal rate. We have applied the method to various systems\, such as hydrogen diffusion\, formation of ammonia on the Ru(0001) surface an d associative desorption of hydrogen from Cu surfaces. The method is bas ed on a quantum mechanical extension of the minimum mode method and a ha rmonic approximation to a more general\, Feynman-path-integral-based qua ntum rate theory. UID:96F30505-F44C-47A8-8A28-B3726A25BD34-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090427T140000 DTSTAMP:20090423T154943Z SUMMARY:Seminar: Hannes Jonsson\, University of Iceland. \"Calculations of Hydrogen Atom Tunneling in Surface Adsorption/Desorption\, Reaction & Diffusion.\" Host: Jimmie Doll. GC 246\, 2:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090427T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:8A924868-2620-11DA-B08D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050927T150000 DTSTAMP:20050915T194231Z SUMMARY:Physical Chemistry Tea Session: Markus Meuwly. 3:00 - 4:15\, MM3 17. \"Computer Simulations of Nuclear Dynamics in Proteins: Structures\, Energies & Vibrational Spectroscopy.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050927T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:09FB9E43-2EB6-11DB-AAF2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061208T160000 DTSTAMP:20061130T195740Z SUMMARY:Friday Chemistry Colloquium: Sheng Dai\, ORNL. 4:00 -5:30\, MM 1 15. \"Self-Assembly Synthesis & Functionalization of Mesoporous Carbon M aterials.\" Hosts: J. William Suggs & Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061208T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Polyketides (e.g. antibiotic erythromycin\, picrom ycin and tylosin) are complex natural products characterized by broad bi ological activity. Modular polyketide synthases (PKS) are multifunctiona l enzymes responsible for the biosynthesis of these diverse molecules. 6 -deoxyerythronolide B synthase (DEBS) is a model polyketide synthase tha t catalyzes the biosynthesis of the aglycone precursor of erythromycin.\ n\nThe mechanism of assembly of polyketides is well known\, but the dete rminants of the exact chirality of the substituents on the growing polyk etide chain remain unclear.\n\nThe ketosynthase (KS)\, acyltransferase ( AT) and acyl carrier protein (ACP) are necessary domains for condensatio n. Polyketides biosynthesis proceeds by condensation between the acyl-KS intermediate and methylmalonyl extender unit to form a α-methyl-β-ketoa cyl-ACP. When a KR domain is present a α-methyl-β-hydoxylacyl-ACP is for med. During erythromycin biosynthesis two epimerizations of the α-methyl substituent must take place. The enzyme controlling the α-methyl stereo chemistry is unknown. We have developed a method to establish the exact stereochemistry of the intermediates when different combinations of DEBS domains were used and the timing of epimerization reaction. Our results demonstrate that the stereochemistry at both the α and β position of th e 2-methyl-3-hydroxyacyl-ACP substrate is specific for a given KR.\n\nWh en a KR domain is coupled with a DH domain a double bond is formed. Our method allowed for investigation the substrate specificity of DH and its mechanism of catalysis.\n UID:56A7E4DD-257F-4504-96C7-29E4339AB312-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100414T130000 DTSTAMP:20100407T175658Z SUMMARY:Thesis Defense: Chiara Valenzano\, Brown University. \"Polyketid e Biosynthesis: The Biochemical Basis for Stereochemical Control.\" Pres iding Officer: David E. Cane. 1:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100414T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:6C047833-94E6-4F14-AAB7-BB72920D611F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061116T160000 DTSTAMP:20061115T201532Z SUMMARY:Organic Faculty Candidate Research Seminar: Daesung Lee. 4:00 - 5:50\, GC351. \"Metal-Catalyzed Ene-Yne Coupling Reactions & their Use i n Synthesis.\" Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061116T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:No abstract supplied.\n UID:38297EBD-19E3-42F0-9DD8-18CB6FE5F92B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070907T120000 DTSTAMP:20071113T180748Z SUMMARY:Nanomedicine Seminar: Xiaoyuan (Shawn) Chen\, Stanford Universit y. 12:00 - 12:50\, MM 317. \"Multimodality Imaging of Tumor Angiogenesis .\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070907T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:62BD0CFF-DDFF-46DC-9DBF-1960C9824557-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110422T160000 DTSTAMP:20100611T183217Z SUMMARY:Friday Chemistry Colloquium: Bruce Kay\, Pacific Northwest Natio nal Laboratory. Title & abstract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110422T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: A series of 1\,5-bis(alkoxymethyl) anthracene deri vatives were designed and synthesized for development of structure - mon olayer morphology relationships. The morphologies and unit cells of the self-assembled monolayers (SAMs) formed by these molecules at the soluti on-graphite interface were determined using scanning tunneling microscop y (STM). The presence of ether groups and/or difluoromethylene (-CF2-) g roups in the side chains alters the SAM morphology in position specific ways. A dipolar lock and key model was developed that explains the relat ionship between SAM morphology and two properties of self-repulsive side chains: length and location of a key dipolar group. Guided by this mode l\, several pairs of molecules with complementary side chains were prepa red and used for self assembly of two component\, spatially patterned mo nolayers. The development of the lock and key model was aided by MM+ sim ulations of monolayer sections on graphene sheets. The relative ordering s of the MM+ derived self-assembly energies for the morphologies each co mpound could form were in excellent agreement with the experimental STM results. UID:2061D9E9-1A40-432B-A73D-47C3A0411D19-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090827T140000 DTSTAMP:20090821T143531Z SUMMARY:PhD Thesis Defense: Wenjun Tong\, Brown University. \"Controllin g Self-Assembled Monolayer Morphology with Dipolar Interactions: Prepara tion\, STM Image Analysis & Simulations of 1\,5(Disubstituted)-Anthracen e Monolayers.\" Presiding Officer: Matthew Zimmt. 2:00\, GC 351.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090827T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:E4A5217C-04EE-11DA-8657-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051028T160000 DTSTAMP:20051024T215056Z SUMMARY:Friday Chemistry Colloquium: Peter Searson\, JHU. 4:00 - 5:30\, MM115. \"Multifunctional Nanowires.\" Host: Shouheng Sun. (Inn at Brown ) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051028T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: I will present our progress on functional material s for energy conversion and storage. I will first discuss Co3O4 nanowire arrays. Co3O4 is a versatile and multi-functional material with excitin g applications in catalysis\, electrocatalysis\, Li-ion batteries and so lar selective absorbers. I will talk about the growth mechanism of Co3O4 nanowire arrays\, their electrocatalytic properties toward oxygen evolu tion reaction and their use in Li-ion batteries. I will then discuss our work on graphene-based composites for Li-ion batteries. The idea is to utilize the high electric conductivity and large surface area of graphen e to enhance the battery capacity and rate capability. Finally\, I will discuss oxide semiconductors for dye sensitized solar cells (DSCs) Zinc stannate (Zn2SnO4) will be used as an example for our systematical study on the energetics of the conduction band and valence band of Zn2SnO4 na noparticles by optical\, electrochemical and photoelectrochemical method s and their promising uses in DSCs. UID:5140814E-0D66-4BB5-9E21-A2F6FDAD9D86-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100506T120000 DTSTAMP:20100428T141104Z SUMMARY:Inorganic Chemistry Seminar: Yiying Wu\, Ohio State University. \"Oxides\, Graphene & Their Composites for Li-Ion Batteries & Dye-Sensit ized Solar Cells.\" Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100506T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Part 1: Squaric Acid-Based Peptidic Inhibitors of Matrix Metalloprotease-1\nMatrix metalloproteases (MMPs) are a family of structurally related endopeptidases that degrade and remodel components of a number of tissues to maintain normal physiology. Overexpression of MMPs is associated with a variety of pathological conditions including tumor growth and metastasis\, angiogenesis\, destruction of joints that causes osteoarthritis and rheumatoid arthritis and periodontal disease. There is significant interest in developing MMP inhibitors for therapeut ic applications. We have designed and synthesized a series of squarate b ased peptidic inhibitors and evaluated them as inhibitors of Matrix Meta lloprotease-1. The synthesis and the inhibition potency of this new type of MMP-1 inhibitor will be discussed.\n\nPart 2: Highly Enantioselectiv e Synthesis of 1-Aryl-Tetrahydroisoquinolines\nTetrahydroisoquinolines ( THIQs) substituted at the C-1 position constitute the framework of many bioactive compounds. We have developed chiral ligands that promote the e nantioselective addition of arylzinc reagents to 3\,4-dihydroisoquinolin e N-oxide to yield chiral 1-aryl-THIQs. Our optimized conditions generat ed up to 99% enantiomeric excess and 99% isolated yield. \n\nPart 3: An Enzymatic Method for Determining the Enantiomeric Excess: EMDee\nIn anot her area of research\, we have developed a new enzyme based high-through put screening assay to measure the enantiomeric excess of allylic acetat es. This assay accommodates reaction products that range in stereochemis try from 100% (S) to 100% (R)\, functions well with crude samples utiliz ing only µg quantities of analyte per sample. Using this enzymatic metho d we measured the enantiomeric excess of approximately 200 crude reactio n products in one hour. \n UID:F6899909-4BED-4F96-BA92-AF4F7EE7354C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080218T100000 DTSTAMP:20080212T142050Z SUMMARY:Thesis Defense: Burak M. Onaran\, Brown University. 3:00 - 4:30\ , GC 351. \"Design & Synthesis of Bioactive Small Molecules & High-Throu ghput Identification of Enantiomeric Excess.\" Host: Christopher T. Seto . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080218T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:2CAC92BB-1020-11DA-A22D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060120T160000 DTSTAMP:20051208T174908Z SUMMARY:Friday Chemistry Colloquium: Fraser Fleming\, Duquesne Universit y. 4:00 - 5:30\, MM 115. \"Diastereoselective Alkylations of Metalated N itriles.\" Host: William Trenkle. Inn at Brown.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060120T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:5260AAD7-63DE-4926-9127-D04687E61710-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061012T150000 DTSTAMP:20060908T153410Z SUMMARY:Physical Chemistry Tea Session: David Z. Goodson\, University of Massachusetts\, Dartmouth. 3:00 - 4:15\, GC 351. \"Singularities in Qua ntum Chemistry.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061012T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:6A8B0D1E-B856-423C-8BFB-2DD2BEAD126C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070420T160000 DTSTAMP:20070413T165815Z SUMMARY:Friday Chemistry Colloquium: Arunava Gupta\, University of Alaba ma. 4:00 - 5:30\, MM115. \"Half-Metallic Oxides for Spintronics.\" Host: Shouheng Sun (Fletcher House) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070420T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:6234F012-04EE-11DA-8657-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060428T160000 DTSTAMP:20060317T213806Z SUMMARY:Friday Chemistry Colloquium: Hisashi Yamamoto\, University of Ch icago. 4:00 - 5:30\, MM115. \"Rich Chemistry of Nitroso Compounds.\" Hos t: David Cane. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060428T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:D7E815C3-972A-11DA-B068-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060316T120000 DTSTAMP:20060207T201158Z SUMMARY:Inorganic/Materials Seminar: Ron D. Sanderson\, University of St ellenbosch\, South Africa. 12:00 - 1:15\, GC 351. Title to come. Host: S houheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060316T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:B3E70906-5BA0-447D-8C82-7EAC1C3C8823-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071115T120000 DTSTAMP:20071030T131312Z SUMMARY:Inorganic Seminar: Aihui Yan\, Brown University. 12:00 - 1:15\, GC 351. Title to come. Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071115T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:5CAD505B-D0C9-4E00-8BAC-0BF49ACA86AF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20091029T170000 DTSTAMP:20091022T183403Z SUMMARY:First Year Students Meeting with Art Salomon\, 5:00\, GC 349. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091029T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:ABSTRACT: By using time resolved resonance-enhanced multipho ton ionization mass and photoelectron spectroscopy we explored the dynam ics of the 1\,2\,3\,4\,5-pentamethyl-cyclopentadiene (PMCPD) upon π->π* excitation. Femtosecond laser pulses at 267 nm are used to populate the 1B2 state. The energy relaxation pathway is probed using time-delayed fe mtosecond laser pulses at 400 nm\, which ionize the molecule in multipho ton processes and reveal the momentary state of the molecule in the phot oelectron spectra. The initially populated 1B2 state relaxes to a 2A1 st ate with a time constant of 182 fs \, from where the ground state is rea ched with a time constant of 60 fs. We can conclusively show that while the energy pumped into the molecule is sufficient to form isomers on the ground state surface\, no measurable structural changes take place on a femtosecond or picosecond timescale. UID:F3B1D9CF-BCDD-4A61-8681-40E2505EBC5D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071206T150000 DTSTAMP:20071203T180421Z SUMMARY:Physical Tea Session: Fedor Rudakov\, Brown University. 3:00 - 4 :15\, GC 351. \"Curve Crossing Dynamics in 1\,2\,3\,4\,5-Pentamethyl-Cyc lopentadiene.\" Host: Jimmie Doll CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071206T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: The concept of a plastic battery has been discusse d since the late 1970s when doped polyacetylene was found to be conducti ve. Since then\, other conductive polymers such as polypyrrole and polya niline have been investigated as battery materials. Plastic batteries ar e attractive because they are lightweight with flexible form and functio n. Past attempts at making batteries from conductive polymers relied pri marily on reversible electrochemical doping of the conductive polymer it self. The problem with relying on the conductive polymer as the sole cha rge carrier is that these materials have insufficient redox capacities a nd doped states that are often chemically unstable. Because of the attra ctive properties of conductive polymers in terms of their environmental compatibility\, chemical variety and ease in manufacturing\, i.e.\, ink- jet printing\, film and fiber formation\, a re-evaluation of these mater ials in the context of energy storage and delivery is warranted. I will describe our recent work with conductive polymers in the context of batt eries and fuel cells. By exploiting the polycationic nature of conductiv e polymers\, we have prepared new polymer composites that function as th e active component in the anode and cathode of plastic batteries and as bioelectrocatalytic materials in the cathode compartment of fuel cells. UID:C23FEEA1-72D7-4CEC-AC7F-EAAE4273C14E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090423T150000 DTSTAMP:20090422T151449Z SUMMARY:Physical Chemistry Tea Session: Tayhas Palmore\, Brown Universit y. \"Polymer Composites for Fuel Cells & Batteries.\" Host: Gerald Diebo ld. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090423T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:05F0EAFF-3991-4BBF-9085-EE9A7C5AD897-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110325T160000 DTSTAMP:20100611T183406Z SUMMARY:Friday Chemistry Colloquium: Daniel Neumark\, University of Cali fornia. Title & abstract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110325T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Molecular Insight Pharmaceuticals is a biopharmace utical company specializing in the emerging field of molecular medicine\ , applying innovations in the identification and targeting of disease at the molecular level to improve patient healthcare by addressing signifi cant unmet medical needs. UID:0A3D577B-8D01-43CC-B548-3924DDEFDB03-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090916T160000 DTSTAMP:20090924T151913Z SUMMARY:Careers in Chemistry Seminar: Shawn Hillier & John Marquis from Molecular Insight Pharmaceuticals. Host: Sarah Delaney. 4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090916T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:13 DESCRIPTION:Abstract: Reducing the greenhouse gas emissions released as a consequence of energy generation is an important societal and technolo gical issue. Although current photovoltaic devices have high efficiency\ , their high cost prevents widespread use. As an alternative\, schemes b ased on the use of semiconductor nanoparticles and nanostructured organi cs have the potential advantage of substantially reducing the cost of ph otovoltaics. Understanding how these types of devices function\, and per haps improving their performance\, is dependent on a basic scientific un derstanding of light absorption and charge carrier transfer on nanometer length scales. The theoretical description of these processes must incl ude both atomistic details as well as multi-nanometer lengthscales\, cha llenging established computational methods. I will highlight some of the recent computational and theoretical developments involved in the desig n of new inorganic nanostructures and organic semiconduct or materials for solar energy utilization. UID:63CA2F01-518A-4E68-8759-818254751ABC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080121T160000 DTSTAMP:20080117T192602Z SUMMARY:Nano Faculty Candidate: Joshua Schrier\, Lawrence Berkeley Nati onal Laboratory. 4:00 - 5:30\, MM 115. \"Designing Photovoltaic Nanostru ctures using Atomistic Simulations.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080121T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The first project that will be discussed was inspi red by an observation made in our laboratory. In our lab we often use sm all molecule chemical probes in order to evaluate the secondary structur e of a DNA oligonucleotide in solution. The probes react selectively wit h solution-accessible bases and provide information about bases that are in loops\, bulges or overhangs. In work using an oligonucleotide contai ning the oxidatively damaged guanine lesion 8-oxo-7\,8-dihydroguanine (8 -oxoGua)\, other members of the laboratory observed modification of 8-ox oGua by the chemical probe diethylpyrocarbonate (DEPC). This observatio n was very interesting to us because the most widely accepted mechanism for modification of DNA by DEPC involves nucleophilic attack of the N7 o f a purine on DEPC. However\, as a result of its protonation state\, the N7 position of 8-oxoGua is not nucleophilic. The goal of my work was to explain this reactivity of 8-oxoGua towards DEPC.\n \nMy most recent wo rk has focused on hyperoxidized guanine lesions and their consequences f or biological processes such as replication. Of the four DNA bases\, gua nine has the lowest redox potential. It is most commonly oxidized to 8-o xoGua\, a DNA damage product that is found biologically. This DNA lesion \, which has been shown to be mutagenic in vivo\, can be further oxidize d to generate a number of hyperoxidized guanine products. Furthermore\, it is known that when present in DNA these hyperoxidized guanine product s are potently mutagenic and toxic. In fact\, these hyperoxidized produc ts are some of the most potently mutagenic lesions observed to date with mutation frequencies of nearly 100%. My goal is to define how these hyp eroxidized guanine products are replicated in various sequence contexts and\, additionally\, to define how hyperoxidized guanines are incorporat ed into DNA.\n UID:36B7A468-F618-4526-BBC6-FC721D243017-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100413T110000 DTSTAMP:20100409T160304Z SUMMARY:Organic Chemistry Seminar: Craig Yennie\, Brown University. \"Ch emical Reactivity of Oxidized Guanine Products & their Incorporation int o DNA.\" Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100413T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:33BF01AA-E1E9-11DA-9A7D-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060518T120000 DTSTAMP:20060512T191055Z SUMMARY:Inorganic Seminar: Sheng Peng\, Brown University. 12noon - 1:15p m\, GC 351. \"Synthesis\, Characterization & Stabilization of High Momen t Fe\, CoFe Nanoparticles.\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060518T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:A11C059F-5049-4ECE-AD87-E84C9E69D136-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T101500 DTSTAMP:20080813T123944Z SUMMARY:Break CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T104500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:EEECF28B-CB64-47B7-AB0C-40AB60B3A307 DTSTART;TZID=US/Eastern:20100524T090000 DTSTAMP:20100519T175311Z SUMMARY:Stockroom Coord Interview -Carl Nielson CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100524T100000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:8F827644-D65C-4213-9713-1A875E2D0C1F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061026T150000 DTSTAMP:20060926T152356Z SUMMARY:Physical Chemistry Tea Session: Nils Hansen\, Sandia\, Livermore . 3:00 - 4:15\, GC 351. \"Isomeric Composition of Combustion Intermediat es & their Roles in Molecular Weight Growth.\" Host: Peter Weber CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061026T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Multicomponent reactions are reactions in which mo re than two starting materials react to yield a product that retains mos t of the atoms from the starting materials. Isocyanide based multicompon ent reactions are particularly interesting because they are very versati le and diverse due to the unique reactivity of isocyanides. This talk wi ll touch on several aspects of multicomponent reaction\, including the c atalysis and applications of the Ugi reaction\, one of the better-known isocyanide based multicomponent reaction. UID:360D8469-FB1F-4EA5-9B6D-09C53407F9CC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081125T110000 DTSTAMP:20081124T162441Z SUMMARY:Organic Chemistry Seminar: Babajide Okandeji\, Brown University. \"Multicomponent Reactions: Catalysis\, Mechanism and Applications.\" H ost: Jason Sello. 11:00 - 12:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081125T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:26317052-D099-11DA-A22C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060502T110000 DTSTAMP:20060424T162403Z SUMMARY:Organic Seminar: Arthur Salomon\, Brown University. 11:00 - 12:3 0\, GC 351. \"High-Throughput Phosphoproteomics: Unraveling Nature's Com plexity.\" Host: David Cane. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060502T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:6E7F22F5-BC66-4F98-ABC6-C672CAA3918B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070322T150000 DTSTAMP:20070319T190209Z SUMMARY:Physical Chemistry Tea Session: George C. Shields\, Hamilton Uni versity. 3:00 - 4:15\, GC 351. \"Working with Undergraduates on Research : Cancer Drug Design & Modeling Atmospheric Chemistry Processes using Co mputational Methods.\" Host: Jimmie Doll. (Fletcher House) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070322T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: The movement of cells is central to a range of nor mal and disease processes\, including organismal development\, tissue re pair\, immune function\, blood vessel formation and cancer metastasis. S mall organic molecules that inhibit or accelerate cell migration have po tential as both research probes and therapeutic agents. We have identifi ed and characterized a number of antimigratory compounds and their prote in targets. This has revealed the involvement of new proteins and unexpe cted protein functions in cell motility. UID:EEF18751-B53B-4EEB-A8D6-E0E8BABDC35A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100409T160000 DTSTAMP:20100401T152709Z SUMMARY:Friday Chemistry Colloquium: Gabriel Fenteany\, University of C onnecticut. \"Chemical Approaches to Understanding & Controlling Cell Mi gration.\" Host: Jason Sello. MM 115\, 4:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100409T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The synthesis and characterization of three serie s of iron sulfur clusters is presented with relevance to biological syst ems and minerals. The synthesis\, crystallographic structures and reacti vity of these clusters are presented along with preliminary spectroscopi c characterization including magnetic susceptibility measurements\, cycl ic voltammetry\, infra-red and Mössbauer spectroscopy. \n\nThe first ser ies of compounds includes iron sulfur nitrosyl clusters with tetra-\, he xa- and octanuclear core structures. The interconversions between these three cores and their reactivity are presented. Comparative spectroscopi c characterization provides experimental evidence supporting that the be st description for iron-bound nitric oxide is NO-. These clusters can se rve as model compounds that can help to elucidate the interactions of ni tric oxide with iron sulfur proteins in biological systems. \n\nThe seco nd series of compounds includes heterometalic iron sulfur chloride clust ers containing a pentlandite-like M8S6 core\, with the heterometal being nickel\, copper or cobalt. The clusters presented provide several new c omplexes that can serve as structural and electronic models for the natu ral occurring pentlandites\, and the systematic synthesis provides a met hodology for the expansion of the M8S6 core to additional metals. \n\nTh e third series includes metal iron sulfur nitrosyl clusters containing a pentlandite-like M8S6 core\, with the metal being molybdenuym\, nickel\ , cobalt. Both chloro and nitrosyl clusters are compared in terms of syn thesis and electrnic properties and the possibility of these clusters to serve as potential building blocks for extended networks that could ser ve as multi-electron heterogeneous catalysts is discussed.\n UID:8A2DE513-097A-4326-9381-283C208824B7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081113T120000 DTSTAMP:20081106T175331Z SUMMARY:Inorganic Chemistry Seminar: Harris Kalyvas\, University of Mich igan. \"Synthesis of M/Fe/S Clusters Relevant to Biological Systems & Mi nerals.\" Host: Eunsuk Kim. 12:00 - 1:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081113T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:600FF3D3-3F1F-11DA-8618-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051020T150000 DTSTAMP:20051017T150733Z SUMMARY:Physical Chemistry Tea Session: Robert Pelcovits\, Physics Dept. \, Brown University. 3:00 - 4:15\, GC351. \"Simulation & Visualization o f Liquid Crystal Physics.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051020T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:04759F91-2CBD-4ADE-B550-3B33DC051F59 DTSTART;TZID=US/Eastern:20110506T160000 DTSTAMP:20100713T190153Z SUMMARY:Friday Chemistry Colloquium: Dr. Maurice Brookhart. Title and a bstract to come. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110506T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:A6D61B7F-588D-4E2E-851B-6E654B5D9620 DTSTART;TZID=US/Eastern:20100804T150000 DTSTAMP:20100714T131142Z SUMMARY:Energy Seminar: Dr. Nenad Markovic\, Argonne National Lab. Titl e and Abstract to come. Host: Shouheng Sun. GC351 3-4pm CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100804T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Rydberg fingerprint spectroscopy provides unique w ays to probe the structural and temporal dynamics of a target molecule. The binding energies of Rydberg electrons are inherently sensitive to th e structure of the molecular ion core. One interesting question is how R ydberg spectroscopy can be applied to study hydrogen bonded systems. The ubiquity of the hydrogen bond has many far-reaching implications. From water\, simple acid dimers\, proteins and even DNA\, life on Earth is gr eatly dependent upon the hydrogen bond. \n\nI will discuss the ability o f Rydberg photoelectron spectroscopy to study the seemingly simple\, yet nonetheless complex issue of hydrogen bonding. Formic and acetic acid s tudies will be shown along with interesting questions as far as the quan tum mechanics of the hydrogen bonding in these systems is concerned. Fin ally\, branching out from simple acids we hope to be able to use Rydberg photoelectron spectroscopy to provide insights into tautomeric systems\ , DNA transcription and protein structure.\n UID:5D5D938A-3FF6-40DE-84C4-3AD6FF027633-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080501T150000 DTSTAMP:20080501T133355Z SUMMARY:Physical Tea Session: Brad Taylor\, Brown University. 3:00\, GC 351. \"Hydrogen Bonding in Carboxylic Acid Dimers: A Rydberg Photoelectr on Spectroscopy Investigation .\" Host: Jimmie Doll CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080501T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: A series of 1\,5-bis(alkoxymethyl) anthracene deri vatives were designed and synthesized for development of structure - mon olayer morphology relationships. The morphologies and unit cells of the self-assembled monolayers (SAMs) formed by these molecules at the soluti on-graphite interface were determined using scanning tunneling microscop y (STM). The presence of ether groups and/or difluoromethylene (-CF2-) g roups in the side chains alters the SAM morphology in position specific ways. A dipolar lock and key model was developed that explains the relat ionship between SAM morphology and two properties of self-repulsive side chains: length and location of a key dipolar group. Guided by this mode l\, several pairs of molecules with complementary side chains were prepa red and used for self assembly of two component\, spatially patterned mo nolayers. The development of the lock and key model was aided by MM+ sim ulations of monolayer sections on graphene sheets. The relative ordering s of the MM+ derived self-assembly energies for the morphologies each co mpound could form were in excellent agreement with the experimental STM results. UID:39DB6BAB-4E09-479A-8489-EBF6E68DCC4D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090827T140000 DTSTAMP:20090821T143531Z SUMMARY:PhD Thesis Defense: Wenjun Tong\, Brown University. \"Controllin g Self-Assembled Monolayer Morphology with Dipolar Interactions: Prepara tion\, STM Image Analysis & Simulations of 1\,5(Disubstituted)-Anthracen e Monolayers.\" Presiding Officer: Matthew Zimmt. 2:00\, GC 351.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090827T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Don’t miss a great opportunity to learn about the research h appening in the Chemistry Department. Attendance is mandatory for the fi rst year graduate students. UID:1D4A7662-7B8D-44F0-B798-1162153F0AC7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091112T181500 DTSTAMP:20091106T161346Z SUMMARY:Student Poster Sessions\, 6:15 - 9:00\, MacMillan Lobby. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091112T210000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:E0441B3A-8393-4BC1-9732-41A0CB0CA63A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071106T110000 DTSTAMP:20071102T161912Z SUMMARY:Organic Seminar: Christina Smole\, Caltech 11:00 - 12:30\, GC 35 1. \"Foundational Advances in RNA Engineering Applied to Control of Bios ynthesis.\" Host: Jason Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071106T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:A1B572AC-7771-4F56-8B7F-A48319A7570F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061116T120000 DTSTAMP:20061107T192837Z SUMMARY:Inorganic Seminar: William M. Risen\, Jr.\, Brown University. 12 :00 - 1:15\, GC 351. \"Chemistry Related to Hybrid Silica-Chitosan Aero gels.\" Host: Shuangbing Han. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061116T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:6A949594-FF32-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20031017T160000 DTSTAMP:20031015T172059Z SUMMARY:Colloquium Speaker: Alexei Maznev\, Philips Analytical CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20031017T174500 LOCATION:Host: Gerald Diebold END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The transient grating is a powerful technique to s tudy many physical and chemical processes in solid\, liquid and gas phas es. In particular\, we found that this time-resolved method can be a ver y useful to monitor\nspectrally silent dynamics of biological protein re actions. We revealed many hidden dynamics of protein reactions\, which h ave not been observed so far. I will present some examples to demonstrat e this unique merit of this method. UID:0257B3D8-053B-40B0-9BCF-AF7F37FCA7C6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100616T150000 DTSTAMP:20100609T210032Z SUMMARY:Physical Chemistry Seminar: Masahide Terazima\, University of Ky oto. \"Protein Reactions Studied by the Time-Resolved Transient Grating .\" Host: Gerald Diebold. GC 351\, 3:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100616T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:83CA8130-672C-11DA-925F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051209T080000 DTSTAMP:20051208T173805Z SUMMARY:Defense Thesis: Jaimie Gosselin\, Brown University. \"Probing St ructure & Dynamics via Rydberg Fingerprint Spectroscopy.\" 7:00 - 10:00\ , GC 246. Presiding Officer: Peter Weber. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051209T100000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:29A61A83-04EF-11DA-8657-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050920T110000 DTSTAMP:20050901T194415Z SUMMARY:Organic Seminar: Lynn Hawkins\, Eisai Research Institute. 11:00 - 12:30\, GC351. \"Carbohydrate-Based Phospholipids: From Natural Produc ts to Potential Therapeutic Agents.\" Host: Amit Basu. Parking pass sent . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050920T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Phoslactomycin (Plm) and fostriecin are members of a group of potent and selective inhibitors of serine-threonine phosphat ase 2A (PP2A) and have various potential biological applications as anti fungal and anticancer agents. These polyketide natural products all cont ain an α\,β-unsaturated–δ-lactone which forms a covalent adduct with Cys 269 which is unique to PP2A. We have cloned the Plm biosynthetic gene cl uster and carried out a detailed analysis of this and the fostriecin bio synthetic gene cluster. Through a series of gene deletion and complement ation studies we have demonstrated that a new post polyketide synthase d ecarboxylative-dehydration step likely establishes this critical electro phile. These antibiotics also contain a linear unsaturated chain contain ing both cis (Z) and trans (E) double bonds. A series of studies have pr ovided the first experimental evidence that individual modules in a type I polyketide synthase are responsible for controlling the stereochemist ry of the double bond formation. We have also generated a series of bloc ked mutants that produce intermediates in the Plm pathway. Enzyme-cataly zed esterification of one of these intermediates has generated a series of new Plms. Directed-biosynthesis\, and combinatorial biosynthesis with the Plm and fostriecin biosynthetic genes have provided an additional a rray of new Plms with structural diversity across the structure. Compoun ds with relatively unchanged PP2A inhibition activity but altered (incre ased and decreased) antifungal activities are observed. Compounds with b oth increased and decreased PP2A inhibition activity and antifungal acti vity (<30 nM) are also observed. \n\nProdiginines are a family of line ar and cyclic oligopyrrole red-pigmented antibiotics with broad antifung al\, antibacterial\, antimalarial and anticancer activities. We have ana lyzed the 23-genes responsible encoding the biosynthetic pathway for for mation of undecylprodiginine and streptorubin B in Strepomyces coelicolo r and have delineated a process in which these complex antibiotics are g enerated from acetyl CoA\, malonyl CoA\, serine\, proline and glycine. N ew prodiginines have been generated by creation of hybrid pathways\, dir ected-biosynthesis\, use of blocked mutants and chemical synthesis. Prel iminary analyses of these have shown which structural features are requi red for potent activity (2-20 nm range) against the malaria parasite Pla smodial falciparum in the eryrthrocytic stage. \n UID:6B7B923E-E308-464A-8424-E6EADC904ED6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081114T160000 DTSTAMP:20081031T134821Z SUMMARY:Friday Chemistry Colloquium: Kevin Reynolds\, Portland State Uni versity. \"Generation & Analysis of Phoslactomycins & Prodiginines.\" Ho st: Jason Sello. 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081114T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:55F2A1FD-BF01-44E8-90A3-54B657CFF33F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100422T120000 DTSTAMP:20100421T125829Z SUMMARY:Inorganic Chemistry Seminar: Chen Cai\, Brown University. Title and abstract to come. Host: Wesley Bernskoetter. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100422T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:0 DESCRIPTION:Geological sciences lunch bunch.\nNote different location. UID:DDEA9461-2D02-4170-A13B-9C3E62CA4679-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE STATUS:CONFIRMED DTSTART;TZID=America/New_York:20091201T120000 DTSTAMP:20091130T164322Z SUMMARY:Galford lunch bunch: Biogeochemical influences of land use chang e in the Barzilian Amazon CREATED:20100714T131812Z DTEND;TZID=America/New_York:20091201T130000 LOCATION:Kassar House\, Foxborogh Auditorium END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:57C5A478-5F35-11D9-A18F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050110T160000 DTSTAMP:20050105T162028Z SUMMARY:Malika Jeffries-El\, Organic Faculty Candidate\, 4:00 - 5:15\, G C 351\, Title to come CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050110T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:4F31CE73-DCDC-4C54-B09B-0BBAD7F940A9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070504T160000 DTSTAMP:20070503T130729Z SUMMARY:Friday Chemistry Colloquium: Simon Lotz\, University of Pretoria \, 4:00 - 5:30\, MM115. \"Diverse Coordination Modes & Template Effects of Aryl\, Acyl & Carbene Complexes.\" Host: Dwight Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070504T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Nickel superoxide dismutase (NiSOD) is a metalloen zyme that catalyzes the disproportionation of superoxide by cycling betw een reduced Ni(II) and oxidized Ni(III) states. In the reduced Ni(II) ox idation state nickel is coordinated by the N-terminal amine nitrogen\, a deprotonated backbone amide nitrogen and two cysteinate sulfurs. Upon o xidation to Ni(III) the imidazole from His(1) coordinates to the Ni-cent er forming a square pyramidal structure about nickel. To understand how the coordination environment in NiSOD is contributing to superoxide dism utase activity\, a number of nickel complexes and metallopeptides have b een prepared that mimic the coordination environment and activity of NiS OD. These models are subjected to a variety of spectroscopic\, electroch emical and reactivity studies to delineate how the primary and secondary coordination environment in NiSOD is contributing to the metalloenzyme’ s reactivity and stability. In addition\, the total synthesis of NiSOD w ill be discussed.\n UID:2EE4F378-F47F-4008-B363-BD8968005607-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090417T160000 DTSTAMP:20090414T175534Z SUMMARY:Friday Chemistry Colloquium: Jason Shearer\, University of Nevad a. \"Probing How the Primary & Secondary Coordination Sphere Controls th e Reactivity & Properties of the Metalloenzyme Nickel Superoxide Dismuta se.\" Host: Eunsuk Kim. 4:00 - 5:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090417T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:48E21C86-1EF0-11DA-B525-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051103T150000 DTSTAMP:20051026T145008Z SUMMARY:Physical Chemistry Tea Session: Bret Jackson\, University of Mas sachusetts\, Amherst. 3:00 - 4:15\, GC 351. \"The Adsorption & Abstracti on of H Atoms on Graphite.\" Host: Jimmie Doll. (parking pass/directions sent) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051103T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:78707E9E-8769-11DA-B664-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060314T100000 DTSTAMP:20060301T154509Z SUMMARY:Organic Seminar: Jinquan Yu\, Brandeis University. 11:00 - 12:30 \, GC 351. \"Catalytic & Stereoselective C-H Functionalization: New Meth ods for Syntheses.\" Host: William Trenkle. Train that morning CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060314T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:D94CF9E9-B35C-47B1-BEFE-2DDB26101DBF DTSTART;TZID=US/Eastern:20100524T120000 DTSTAMP:20100519T175059Z SUMMARY:lynda tavares CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100524T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:3C4A9605-E004-4171-BE2F-8C9D49A5B564-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080507T083000 DTSTAMP:20080212T145321Z SUMMARY:Nanoscience Inaugural Events CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080507T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:AFCC0049-6A14-4783-BDFF-7680F062BCAA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090314T100000 DTSTAMP:20080501T131050Z SUMMARY:Prospective Graduate Student Visitation CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090314T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:5E034D84-FF35-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20031010T160000 DTSTAMP:20031015T173141Z SUMMARY:Colloquium Speaker: Rainer Weinkauf\, University of Dusseldorf CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20031010T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:659F607B-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041012T130000 DTSTAMP:20040930T164733Z SUMMARY:Joanna Turteltaub: organic seminar CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041012T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The polyhydroxyalkanoates\, PHAs\, are generated a s storage materials by many microorganisms under nutrient limited growth conditions and can account for up to 85% of the cell’s dry weight. The enzymes that catalyze their formation provide a paradigm for thinking ab out non-template dependent polymerization reactions in biology\, where s oluble monomers that play a central role in metabolism are converted int o insoluble inclusions or granules\, i.e.\, rubber\, starch\, polyphosph ate\, polyoxoesters. These polymers are of interest because they have pr operties of thermoplastics similar to oil based polymers (polyethylene a nd polypropylene)\, are biodegradable and are monodisperse with molecula r weights of 1.5 million. PHB production involves conversion of 3-hydrox ybutryl coenzymeA into insoluble granules using the synthase\, PhaC. The mechanism of the initiation\, elongation and termination of polymer pro duction by PhaC will be discussed\, as will the three models for granule formation. The long-range goal is to engineer production of different P HAs in biorenewable sources in a fashion that is economically competitiv e with the oil based polymers. UID:311E62AC-0A7C-4223-BA5D-302D6E3B508D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090403T160000 DTSTAMP:20090310T180258Z SUMMARY:Friday Chemistry Colloquium: JoAnne Stubbe\, MIT. \"Plastics & P eppers: Biodegradable Polymers with Properties of Thermoplastics.\" Host : Jason Sello. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090403T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The announcement of the completion of two draft se quences of \"the human genome\" was made in June of 2000. New DNA sequen cing technologies were a difficult sell to funding agencies and private investors until 2003. At that time it was realized that large numbers of human genomes needed to be sequenced in order to find clinically releva nt variation in genomes. In the last 5 years a number of new sequencing technologies have been developed that have significantly lowered the cos t of DNA sequencing but further reductions in cost and time to sequence genomes are required.\n\nI will discuss progress 8 years to develop new sequencing technologies in RI. The work has involved collaborations with researchers in the Chemistry\, Computer Science\, Physics\, and Electri cal Engineering Departments at Brown. UID:E80673F5-AE81-4F30-88DD-EB117E205869-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090227T160000 DTSTAMP:20090220T162116Z SUMMARY:Friday Chemistry Colloquium: John Oliver\, NABsys Inc. & Brown U niversity. \"Sequencing the Human Genome - Didn't We Do That Already?\"4 :00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090227T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Propagation-based differential phase contrast imag ing (PDPCI)\, which results in an air or fluid filled vasculature\, make s possible visualization of the smallest microvessels\, roughly down to 15?m\, in an excised murine liver. The perfusion experiment is also done with a murine liver. This imaging technique operates in combination wit h ultrasound-induced movement of tumor that highlights the tumor of inte rest. Briefly\, the ultrasound method uses high-frequency acoustic waves to cause microscopic mechanical displacements of an embedded tumor. UID:1FBC16B1-11BA-4AE2-96F7-86F08078B8FF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090219T150000 DTSTAMP:20090213T175132Z SUMMARY:Physical Chemistry Tea Session: Yanan Liu\, Brown University. \" Biomedical X-Ray Imaging.\" Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090219T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: The design of future complex organs can be acceler ated if model tissue constructs that mimic the structure of tissues in v ivo are available to systematically probe cellular response to a variety of cues. A novel tissue engineering methodology to generate complex tis sue architectures involves the construction of cell layers that resemble functional tissue units. These functional units have potentially wide a pplications in tissue engineering\, bioreactor devices\, and in drug del ivery.\n\n\nWe have developed a methodology to build cellular constructs that mimic hepatic architectures. Our approach is to deposit ultra-thin polymer scaffolds on the top of a confluent layer of cells by the seque ntial deposition of oppositely charged polyelectrolytes. Hepatocyte-spec ific function and morphology of cells in the in vitro liver-mimetic arch itectures will be discussed.\n\n\nThe second part of the presentation wi ll focus on the design of basement membrane mimetic structures derived f rom polyelectrolyte assemblies. In vivo\, corneal epithelial cells are a dhered on basement membranes that exhibit topography on the nanoscale wi th the diameters of pores and fibers ranging from 20 - 200nm. Polyelectr olyte multilayers with porosity ranging from the nano to the microscale were assembled to recapitulate the porosity and topography in vivo. The average pore diameter was found to be 100nm and 600nm for the nanoporous and sub-micron porous films respectively. In this study\, a purely phys ical feature\, specifically\, porosity\, provided cues to human corneal epithelial cells.\n UID:8868B1B3-C7C4-4AE4-A0E3-7D4DADA0B398-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080919T160000 DTSTAMP:20080912T130939Z SUMMARY:Friday Colloquium: Padmavathy Rajagopalan\, Virginia Tech. \"Po lyelectrolyte Multilayers: Applications in Tissue Engineering.\" 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080919T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:A9DA1450-674D-4402-9457-3D5EE84E4410-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20091007T120000 DTSTAMP:20091006T134527Z SUMMARY:Departmental Review - Focus: Undergraduate Meeting. 12:00 noon\ , GC 246. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091007T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:ABSTRACT: Dimethyldioxirane and methyl(trifluoromethyl)dioxi rane are effective reagents to carry out a variety of synthetically usef ul oxidations. Because of their very mild reaction conditions\, they are the reagents of choice to oxidize labile compounds and natural products . Some interesting examples of selective oxyfunctionalization of biologi cally relevant molecules by dioxiranes will be presented.\n\nThe first p art will be focused on the conversion of epoxy alcohols into the corresp onding epoxy ketones. Epoxy ketones are very useful building blocks in o rganic synthesis. The reactivity of methyl(trifluoromethyl)dioxirane wit h representative Boc-protected and acetyl-protected peptide methyl ester s bearing alkyl side chains will follow. The described oxidations of lin ear peptides give easy access to valuable synthons in the preparation of hydroxamates and polypeptides and can be used in the development of pep tide derivatives that are therapeutically useful.\n\nThe oxyfunctionaliz ation of cyslosporine and of a cyclosporine derivative\, dihydrocyclospo rine acetate\, by dioxiranes will also be presented. Cyclosporine is a p otent immunosuppressant\, and it is also effective in the treatment of m any immunoregulatory dysfunctions. However\, its clinical use is associa ted with toxic side effects. The structural modifications introduced by dioxiranes on cyslosporine might improve the bioavailability and/or the pharmacological profile of this drug\, and also will provide useful info rmation on the metabolic fate of the parent compound. The presentation o f the oxyfunctionalization of dihydrocyclosporine acetate by methyl(trif luoromethyl)dioxirane will finally show to the audience an example of ou tstanding selectivity in organic synthesis. UID:DF1092E1-8088-4FD5-A039-B06AD2FBA8D4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071001T123000 DTSTAMP:20071119T204404Z SUMMARY:Thesis Defense: Maria Rosaria Rella. 12:30 - 2:30\, GC 351. \"Di oxirane & Bioactive Molecules: Selective Oxyfunctionalization of Vitamin D Synthons\, Linear Peptides & Cyclosporins.\" Presiding Officer: Paul G. Williard. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071001T143000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract to come. UID:5F503E79-57B6-495B-83C9-9EB18EBB2DF3-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090320T160000 DTSTAMP:20090313T210813Z SUMMARY:Friday Chemistry Colloquium: William Fairbrother\, Brown Univers ity\, Bio Med Molecular\, Cellular Biology Biochemistry. \"An RNA Bindin g Map Reveals the Sequence & Structural Requirements of PTB Binding.\" H ost: Eunsuk Kim. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090320T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Streptomyces bacteria are fermented on an industri al scale to produce large quantities of their antibiotics that used as d rugs in clinical medicine. Upregulation of antibiotic biosynthesis often leads to higher product yields in drug fermentations. Thus\, there is m uch interest in understanding the regulation of antibiotic biosynthesis. Low molecular weight chemical messengers are often endogenous regulator s of antibiotic biosynthesis. Most of these chemical messengers are call ed inducers of antibiotic production. Studies of these inducers and thei r mechanisms of action will provide key insights into the regulation of antibiotic biosynthesis in Streptomyces bacteria. Moreover\, the inducer s have potential applications in the pharmaceutical industry where they can be added to Streptomyces fermentations to increase the yields of dru gs. \n\nStudies and applications of these inducers have been limited bec ause they are produced in extremely small quantities\, and often in comp lex mixtures. We have developed efficient synthetic routes to three type s of Streptomyces inducers. Our ability to access these molecules throug h chemical synthesis has allowed us to begin investigations regarding th eir biosynthesis\, mechanisms of action\, ecological relevance\, and pot ential use as additives in the fermentation industry.\n UID:7D33454D-C0DF-4259-9DD2-B04C7E87B584-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091020T110000 DTSTAMP:20091015T163829Z SUMMARY:Fourth Year Organic Student Seminars. Jesse Morin\, Brown Univer sity. \"Synthesis & Study of Inducers of Antibiotic Production in Strept omyces Bacteria.\" Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091020T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:868B46C2-C64D-11DA-B1E5-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060504T120000 DTSTAMP:20060428T192450Z SUMMARY:Inorganic Seminar: Shuangbing Han\, Brown University. 12noon - 1 :15 pm\, GC 351. \"Engineering Discrete Coordination Units.\" Host: Shou heng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060504T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:EB9D184E-02B5-4290-9198-8C6E9C22CE6A DTSTART;TZID=US/Eastern:20100521T100000 DTSTAMP:20100519T175018Z SUMMARY:marjorie lane CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100521T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:AF2B34F0-5524-4376-B655-E40BDACCBFB5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061103T130000 DTSTAMP:20061031T190147Z SUMMARY:Friday Chemistry Colloquium: Lee Josephson\, Harvard Medical Cen ter. 4:00 - 5:30\, MM115. \"Imaging Magnetic Nanoparticles: Technology f rom the Lab to the Clinic.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061103T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:DC65E189-7EAD-11D9-B5FA-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050405T110000 DTSTAMP:20050314T191831Z SUMMARY:Organic Seminar: Dai-Shi Su\, Merck. GC 351\, 11:00 - 12noon. Di scovery of a Potent\, Non-Peptide Bradykinin B1 Receptor Antagonist. Hos t: William C. Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050405T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Are you an undergraduate doing your summer researc h with a member of the Chemistry faculty? This Tools to Help with Inform ation Research in Science and Technology (THIRST) workshop is a hands-on opportunity in the Library’s computer lab to learn about literature sur veying your topic and to discover relevant information with key scholarl y resources\, which may include SciFinder\, Web of Science\, Reaxys\, Pu bMed\, and Knovel Library\, at the Brown University Library. Learn how t o get what you need. Identify and record books and articles that need fo llow up. Registrants will be contacted to complete an online self-evalua tion of information finding and using skills prior to attending the work shop. This will be used to determine the content of the session. They sh ould also come prepared to work on the literature discovery process for a topic of their own interest. UID:FBFCC15D-5D72-48C2-8995-A3A6CDE0624E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100623T100000 DTSTAMP:20100507T144241Z SUMMARY:Tools to Help with Information Research in Science & Technology (THIRST) Workshop. Led by Lee Pedersen. 10:00\, Hecker Instructional Co mputer Center\, Rockefeller Library. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100623T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: We have been investigating metal-metal interaction s in early/late heterobimetallic complexes supported by ambidentate phos phino(amide) ligands\, [R2PNR′]-. In a representative complex\, ClZr(Ph2 PNiPr)3CoI\, withdrawal of electron density from Co by the Lewis acidic Zr center leads to a dramatic shift in the two-electron reduction potent ial to ~1 V more positive than observed for a monometallic Co analogue\, ICo(Ph2PNHiPr)3.1 Moreover\, reduced heterobimetallic Co/Zr complexes f eature metal-metal multiple bonds that lead to unusual trigonal monopyra midal geometries at both Co and Zr.2 The reactivity of these highly redu ced\, coordinatively unsaturated metal-metal multiply-bonded complexes t owards the oxidative addition of R-X and the activation of small molecul es such as CO2\, H2\, and CO will be discussed.\n\n\n1Greenwood\, B. P\; Forman\, S. I.\; Rowe\, G. T.\; Chen\, C.-H.\; Foxman\, B. M.\; Thomas\ , C. M. Inorg. Chem. 2009\, 48\, 6251-6260.\n2 Greenwood\, B. P\; Rowe\, G. T.\; Chen\, C.-H.\; Foxman\, B. M.\; Thomas\, C. M. J. Am. Chem. Soc . 2010\, 132\, 44-45.\n UID:6FC70B2C-EE13-4EA7-BDCE-99C7F9DA5ABE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100415T120000 DTSTAMP:20100408T183406Z SUMMARY:Inorganic Chemistry Seminar: Christine Thomas\, Brandeis Univers ity. \"Synthesis & Reactivity of Early/Late Heterobimetallic Complexes F eaturing Metal-Metal Multiple Bonds.\" Host: Wesley Bernskoetter. GC 351 \, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100415T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:9CE6ADDF-A10B-4126-83BD-884581111596-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061113T163000 DTSTAMP:20061115T201715Z SUMMARY:Organic Faculty Candidate Research Seminar: Hubert Yin. 4:30 - 5 :50\, MM115. \"Designed Peptides that Target Integrin Transmembrane Doma ins.\" Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061113T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:F3306E0C-0B69-4BC4-96BD-F561B73A5D0E DTSTART;TZID=US/Eastern:20100526T110000 DTSTAMP:20100519T175414Z SUMMARY:Stockroom Coordinator Interview - Candace Boudreau CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100526T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:E111C504-5E91-11D9-AD5B-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050112T160000 DTSTAMP:20050104T204844Z SUMMARY:Chu-Young Kim\, Stanford University\, Organic Faculty Candidate\ , 4:00 - 5:15\, GC 351\, \"Erythromycin Biosynthesis\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050112T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:90D9BA4E-2492-11DA-A844-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051118T160000 DTSTAMP:20051114T160518Z SUMMARY:Friday Chemistry Colloquium: Craig Ogle\, University of North Ca rolina. 4:00 - 5:30\, MM115. \"Observation of Organolithium & Organocupr ate Conjugate Addition Reactions using Rapid Injection NMR Spectroscopy. \" Host: Paul Williard. (The Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051118T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:ABSTRACT: The explosion of molecular level information coupl ed with large epidemiological studies presents an exciting opportunity t o uncover the genetic underpinnings of complex diseases\; however\, seve ral analytical challenges remain to be addressed. Characterizing the com ponents to complex diseases inevitably requires consideration of synergi es across multiple genetic loci and environmental and demographic factor s. In addition\, it is critical to capture information on allelic phase\ , that is whether alleles within a a gene are in cis (on the same chromo some) or in trans (on different chromosomes.) In associations studies of unrelated individuals\, this alignment of alleles within a chromosomal copy is generally not observed. I consider two model-based approaches fo r this high dimensional data setting: (1) a combination of mixed effects modeling and multiple imputation and (2) a fully likelihood based appro ach. The proposed methods are applied to data arising from a cohort of human immunodeficiency virus type-1 (HIV-1) infected individuals at risk for anti-retroviral therapy associated dyslipidemia. UID:698B6B29-C026-4ACB-9DB9-7DCB3522C3A4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071004T150000 DTSTAMP:20071119T205849Z SUMMARY:Physical Tea Session: Andrea Foulkes\, University of Massachuset ts\, Amherst. 3:00 - 4:15\, GC 351. \"Modeling Pharmaco-Genomic Interact ions in Population-Based Investigations.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071004T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Recent advances in the speed and sensitivity of ma ss spectrometers and analytical methods\, the exponential acceleration o f computer speeds and the availability of genomic databases from an arra y of species have led to a deluge of proteomic data. Unfortunately\, thi s enhancement in data acquisition has not been accompanied by a concomit ant increase in the availability of tools allowing users to rapidly anal yze the data. Often the manual aggregation of proteomic data and analysi s in current software distract investigators from the biological meaning of their data\, leading to the all-too-frequent deposition of proteomic data into the scientific literature with little biological interpretati on. We seek to fill the gap by providing a flexible platform for high-th roughput autonomous proteomic analysis. Our platform is able to provide automated online phosphopeptide enrichment and reverse phase separation using LC/MS system. Acquired mass spec data are streamlined through a pi peline for database searching\, statistical peptide validation and quant itation. Results are directed into a relational database for organizatio n of expansive proteomic data sets\, collation of proteomic data with av ailable protein information resources and visual comparison of multiple quantitative proteomic experiments. The utility of this system is illust rated through analysis of insulin signaling pathway important to liver c ancers. We explored changes in phosphorylation profile quantitatively in hIRS1-transfected NIH3T3 cells in response to insulin stimulation. In a SILAC-labeled NIH3T3-hIRS1/NIH3T3-hIRS1 Y1180F time course\, we discove red a total of 2201 phosphorylation sites at 1% false discovery rate est imated by decoy database\, among which 1862 (84.6%) were on Serine\, 299 (13.6%) were on Threonine and 40 (1.8%) were on Tyrosine. Using a label -free/SILAC hybrid quantitation approach\, different phosphorylation pat terns were identified in wild\ntype and mutated cell lines.\n UID:63ED6A3C-3DE7-474A-97C1-0C1EA87D41D5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090806T100000 DTSTAMP:20090817T160426Z SUMMARY:PhD Thesis Defense: Kebing Yu\, Brown University. \"A Phosphopro teomic Study of Insulin Signaling Pathway Using A Novel High-Throughput Pipeline.\" Presiding Officer: Arthur Salomon. 10:00\, Sydney Frank Hal l\, Room 220. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090806T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: This presentation will focus on the development of new strategies for the preparation of nano- and micro-structured polyme r materials. First\, I will present a new approach to the self-assembly of inorganic nanoparticles [1\,2]. For the prototype system\, we used hy drophilic gold nanorods carrying hydrophobic polystyrene molecules at bo th ends\, which resembled amphiphilic block copolymers. By changing the solvent quality\, the polymer-tethered nanorods self-assembled into a wi de range of hierarchical structures\, such as chains\, rings\, and vesic les\, in a controllable and predictable manner. The assembly of nanopart icles in a well-organized manner allows the best exploitation of the uni que collective optical\, electronic\, and magnetic properties of individ ual nanoparticles\, and is vital for their utilization in optoelectronic s\, sensing\, and biomedical applications. In addition\, I will introduc e a versatile method to synthesize polymeric microparticles with extreme ly high control over their dimensions\, shapes\, compositions and morpho logies[3-6]. The method includes the emulsification of monomers in a mic rofluidic flow-focusing device and in-situ solidification of droplets vi a photopolymerization\, thermal gelation or ionic cross-linking. This po werful approach offers extraordinary research opportunities in material science\, biomedicine and cell biology and has a broad range of applicat ions\, such as in the encapsulation of drugs\, and in coating\, separati on and catalyst technologies. \n\nSelective references:\n[1] Nie\, Z.H.\ , Fava\, D.\, et al. Nature Mater. 2007\, 6\, 609.\n[2] Nie\, Z.H.\, Fav a\, D.\, et al. J. Am. Chem. Soc. 2008\, 130\, 3683.\n[3] Nie\, Z.H.\, X u\, S.Q.\, et al. J. Am. Chem. Soc. 2005\, 127\, 8058. \n[4] Nie\, Z.H.\ , Li\, W.\, et al. J. Am. Chem. Soc. 2006\, 128\, 9408.\n[5] Nie\, Z.H.\ , Park\, J. I.\, et al. J. Am. Chem. Soc. 2008\, 130\, 16508.\n[6] Park\ , J.I.\, Nie\, Z.H. et al. Angew. Chem. Int. Ed. 2009\, 48\, 5300.\n UID:E27492BC-F9B4-42D5-8A0A-B693704FF52D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091211T160000 DTSTAMP:20091204T193814Z SUMMARY:Nanoscience Faculty Search Candidate: Zhihong Nie\, Harvard Uni versity. \"Developing New Strategies for the Preparation of Nano- & Micr o-Structured Polymer Materials.\" Host: Shouheng Sun. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091211T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:C33702C9-813B-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060202T150000 DTSTAMP:20060123T201005Z SUMMARY:Physical Chemistry Tea Session: Stefan Vajda\, Argonne National Laboratory. 3:00 - 4:15\, GC 351. \"Supported Gold & Platinum Clusters: Synthesis\, X-Ray Studies of Thermal Stability & Growth\, UV-VIS Propert ies.\" Host: Christoph Rose-Petruck. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060202T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: Unnatural amino acid mutagenesis provides an espec ially powerful tool for producing chemical-scale insights into the struc tures and functions of the complex proteins of neuroscience. We will des cribe the methodology\; the broad scope of applications it enables\; and several examples in which the approach has produced valuable new insigh ts. UID:89DF8935-5563-435A-BA06-89FF1BAA859D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081017T160000 DTSTAMP:20080918T172901Z SUMMARY:Friday Chemistry Colloquium: Dennis Dougherty\, Caltech. \"Usin g Unnatural Amino Acids to Probe Neuroreceptors & Ion Channels.\" Host: Paul Williard. 4:00 - 5:30\, MM115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081017T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:A67AC597-5D37-442C-8087-A323BCB970F3-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061205T110000 DTSTAMP:20061115T174758Z SUMMARY:Organic Seminar: David Corey\, UT Southwestern\, 11:00 - 12:30\, GC 351. \"Inhibition or Activation of Gene Expression by Synthetic PNAs & Duplex RNAs that Target Chromosomal DNA.\" Host: Jason K. Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061205T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Mutagenesis is one of the most deleterious consequ ences of DNA damage\, and the relationship of the structure of a damage with its biological consequence has been the subject of numerous investi gations by chemists\, structural biologists and molecular biologists. We have been studying the biological effects of the DNA adducts formed by the nitroaromatic carcinogens\, 1-nitropyrene and the dinitropyrenes. We have also explored the mutagenic and genotoxic potential of several oth er DNA damages induced by radiation and antitumor agents. We determined that the types and frequencies of mutagenesis of these lesions depend on a number of factors including the structure of the lesion\, the DNA seq uence context\, the type of cell and the repair-status of the latter. In addition\, the presence of one or more lesions in the vicinity may infl uence the biological effects of the DNA damage. The identity of the DNA polymerase(s) and the repair proteins has been considered important for the mutagenic outcome. However\, explanation of the cellular data poses significant challenge. What we learned from the results of these studies will be discussed. UID:8262F0AA-F1FE-48F0-A0E0-EA4265DD516D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080502T160000 DTSTAMP:20080423T153538Z SUMMARY:Friday Colloquium: Ashis Basu\, University of Connecticut. 4:00 \, MM 115. \"DNA Damage & Mutagenesis: Research in Toxicology at the Int erface of Chemistry & Biology.\" Host: Sarah Delaney. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080502T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:891F22E5-EF42-49A2-BC0D-7D5FCC5E21A9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061117T170000 DTSTAMP:20061005T155330Z SUMMARY:Friday Chemistry Colloquium: Travis Holman\, Georgetown Universi ty. 4:00 - 5:30\, MM115. \"The Chemistry of Molecular Containers: From Molecular Recognition to Materials.\" Host: Dwight Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061117T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:B97B6257-11F3-4212-9CB0-27B64420ED6C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080805T110000 DTSTAMP:20080728T190457Z SUMMARY:Inorganic Seminar: Young Chung\, Seoul National University. 11:0 0 - 12:15\, GC351. \"Transition Metal-Catalyzed Cycloisomerization.\" Ho st: Dwight A. Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080805T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The aim of the DHS Center of Excellence in Explosi ves Detection\, Mitigation & Response is to prevent catastrophic damage to society that can be caused by explosive attacks. To this end\, we hav e assembles a multi-university team spanning the US and beyond. The Cent er is taking a three prong approach: 1) identify and neutralize the mate rials used to make explosives\; 2) detect explosives and improvised expl osive devices (IED’s)\; 3) mitigate the blast damage to individuals and critical infrastructure.\n UID:C926CA3F-017C-4F0A-A150-416BC93BE7BD-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090409T150000 DTSTAMP:20090403T125850Z SUMMARY:Physical Chemistry Tea Session: Jimmie Oxley\, Director of the U RI/DHS Center of Excellence in Explosives. \"Explosives Research at URI. \" Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090409T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:90BA3B09-BB27-11D9-AF94-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051021T160000 DTSTAMP:20051006T155345Z SUMMARY:Friday Chemistry Colloquium: Stephen O'Brien\, Columbia Universi ty. 4:00 -5:30\, MM115. \"Designing Nanomaterials.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051021T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:AEAD1902-7B9D-11DA-84F7-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060216T120000 DTSTAMP:20060207T201459Z SUMMARY:Inorganic/Materials Seminar: Michael Giersig\, Boston College. 1 2:00 - 1:15\, GC 351. \"Self-Assembly Induced by Chemical & Physical Met hods.\" Host: Shouheng Sun. Parking pass to be sent. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060216T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Nano-silver (nAg) containing consumer products tak e up the highest volume in current nanotechnology industry due to the ex traordinary broad-spectrum antimicrobial activity. The high production volume has led to concern about significant silver release to the enviro nment and its effect on a wide variety of environmental organisms. nAg may interact with biological targets directly as a particle\, or through the action of silver ion\, a known thiol toxicant\, which may coexist w ith nanoparticles in nAg suspension. Here we study the kinetics of Ag+ release from nAg suspension and its implications for nAg toxicity and en vironmental persistence. We found that Ag+ release is a kinetic process involving the concerted action of protons and dissolved oxygen\, and thi s process leads to partial or complete reactive dissolution and the loss of particle phase in oxygen-containing waters. This work helps to eluci date how nAg will behave in the natural environment\, and offer opportun ities to understand and control the biological response to nAg exposure. UID:94974F0C-FAE5-4CFA-B329-E271346394C7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091119T150000 DTSTAMP:20100105T200334Z SUMMARY:Physical Chemistry Tea Session: Jingyu Liu\, Brown University. \ "Kinetics of Ag+ Release from Nano-Silver Particles in Aqueous Suspensio n.\" Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091119T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:AB997808-31E5-11DB-82DD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061012T120000 DTSTAMP:20060822T154309Z SUMMARY:Inorganic Seminar: Zhenbo Ma\, Brown University. 12:00 - 1:15\, GC 351. Title to come. Host: Shuangbing Han CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061012T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:777E878B-D4B8-4601-895A-2CA90A10FD1D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070123T110000 DTSTAMP:20070110T202443Z SUMMARY:Organic Seminar: Jared Shaw\, Harvard University. 11:00 - 12:30\ , MM115. \"Stereoselective Synthesis of Complex Heterocycles & Natural P roducts that Modulate Transcription & Bacterial Cell Division.\" Host: W illiam C. Trenkle. (Driving\, sent parking pass 1/10) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070123T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:642A4B44-5F36-11D9-A18F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050119T160000 DTSTAMP:20050119T135142Z SUMMARY:Scott Grayson\, Organic Faculty Candidate\, 4:00 - 5:15\, GC 351 \, \"Exploring Polymer Architectures for Biological Applications\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050119T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: DNA nanotechnology utilizes reciprocal exchange be tween NDA double helices to produce branched motifs. These motifs have b een combined with single-stranded cohesion to construct objects\, device s and lattices. The objects include stick polyhedra and a variety of DNA nanotubes. Robust devices have been built that are predicated both on s tructural transitions and on hybridization topology. 1-D\, 2-D and 3-D l attices have also been assembled\, which has led to control over the geo metrical structure of matter based solely on the design of DNA sequences . Combinations of devices and lattices offer programmable control of the structure of matter on the nanometer scale.\n UID:A4DE8E6A-2EC6-4318-B1C3-909D87C912A5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081212T160000 DTSTAMP:20081208T145346Z SUMMARY:Friday Chemistry Colloquium: Ned Seeman\, NYU. \"DNA: Not Merely the Secret of Life.\" Host: Jimmy Xu/IMNI. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081212T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:6CABF77D-7A30-451A-85CE-5CC50AD29AE8-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070222T150000 DTSTAMP:20070215T200302Z SUMMARY:Physical Chemistry Tea Session: Xiaodi Li\, Brown University. 3: 00 - 4:15\, GC 351. \"Ultra-Fast Laser-Plasma X-Ray Source Generated by Liquid Mercury.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070222T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:01965E78-AD54-49B1-89BD-48FC25AB7EDD-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090507T150000 DTSTAMP:20090501T155141Z SUMMARY:Physical Chemistry Tea Session: Baofeng Zhang\, Brown University . \"The Mechanism of Vibrational Energy Relaxation of Big Molecule in Li quid Solvent.\" Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090507T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: A series of 1\,5-bis(alkoxymethyl) anthracene deri vatives were designed and synthesized for development of structure - mon olayer morphology relationships. The morphologies and unit cells of the self-assembled monolayers (SAMs) formed by these molecules at the soluti on-graphite interface were determined using scanning tunneling microscop y (STM). The presence of ether groups and/or difluoromethylene (-CF2-) g roups in the side chains alters the SAM morphology in position specific ways. A dipolar lock and key model was developed that explains the relat ionship between SAM morphology and two properties of self-repulsive side chains: length and location of a key dipolar group. Guided by this mode l\, several pairs of molecules with complementary side chains were prepa red and used for self assembly of two component\, spatially patterned mo nolayers. The development of the lock and key model was aided by MM+ sim ulations of monolayer sections on graphene sheets. The relative ordering s of the MM+ derived self-assembly energies for the morphologies each co mpound could form were in excellent agreement with the experimental STM results. UID:E5801E15-D4FC-4748-8EF1-2179718B4F45-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090827T140000 DTSTAMP:20090821T143531Z SUMMARY:PhD Thesis Defense: Wenjun Tong\, Brown University. \"Controllin g Self-Assembled Monolayer Morphology with Dipolar Interactions: Prepara tion\, STM Image Analysis & Simulations of 1\,5(Disubstituted)-Anthracen e Monolayers.\" Presiding Officer: Matthew Zimmt. 2:00\, GC 351.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090827T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:12 DESCRIPTION:Abstract: A new materials-general synthetic approach for hig h-area metal oxide photoelectrode architectures was designed and fabrica ted for dye-sensitized solar cells. The approach makes use of conformal\ , atomic layer deposition and exploits a templating strategy. The best v ersions of these new structures show areas equaling or exceeding those u sed in the best nanoparticulate electrodes\, while exhibiting faster cha rge transport - a key for successfully employing alternatives to iodide/ triiodide as a redox shuttle. Experimental measurements of electron dyna mics will also be presented. UID:D4C55D89-195F-421D-8A38-2CABB65FB58E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080124T160000 DTSTAMP:20080116T150654Z SUMMARY:Inorganic Faculty Candidate: Thomas Hamann\, Northwestern Univer sity. 4:00 - 5:30\, B&H 153. \"Aerogel Templated Metal Oxide Photoelectr odes.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080124T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:1618E9DE-A771-4B63-B3B5-07FE70142C39-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080505T083000 DTSTAMP:20080212T145234Z SUMMARY:Nanoscience Inaugural Events CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080505T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:B36AF478-9B05-4C44-8A0D-56D68C9032F4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20091008T120000 DTSTAMP:20091006T134501Z SUMMARY:Departmental Review - Focus: Graduate Program. 12:00 noon\, GC 2 46. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091008T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:B043D51B-B600-11DA-B973-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060418T110000 DTSTAMP:20060317T215542Z SUMMARY:Organic Chemistry Literature Seminar: Jamie Wang\, Brown Univers ity. 11:00 - 12:30\, GC 351. Title to come. Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060418T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:132C2F23-97EB-46EA-807D-089B95F11108 DTSTART;TZID=US/Eastern:20100524T230000 DTSTAMP:20100519T171723Z SUMMARY:Stockroom Coordinator Interviews - Gerald Caracciolo CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100525T000000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:437629CA-9EEB-4B69-B8F5-62CB38C5DAFF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070427T160000 DTSTAMP:20070103T203829Z SUMMARY:Friday Chemistry Colloquium: Mark M. Banaszak Holl\, University of Michigan. 4:00 - 5:30\, MM115. \"Quantitative Studies of Multivalent Polymers Designed for Targeted Drug Delivery.\" Host: Dwight Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070427T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:24A575B9-A1A7-4796-B4B7-864AD8778F4E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061127T150000 DTSTAMP:20061031T190411Z SUMMARY:Inorganic Seminar: Paul O'Brien\, University of Manchester. 4:00 - 5:30\, GC 351. \"Using Chemical Methods to Develop New Routes to New & Novel Materials.\" Host: Dwight A. Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061127T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:52DBE3AF-2D53-11DB-8778-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060921T120000 DTSTAMP:20060918T201327Z SUMMARY:Inorganic/Materials Seminar: Nathan Kohler\, Brown University. 1 2:00 - 1:15\, GC 351. \"Magnetic Nanoparticles for Cancer Diagnostics & Therapeutics.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060921T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:5EA4FF1E-7BD6-11DA-84F7-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060110T110000 DTSTAMP:20060110T140841Z SUMMARY:Inorganic Seminar: Young Keun Chung\, Seoul National University. 11:00 - 12:30\, GC351. \"The Pauson-Khand-Type Reaction Catalyzed by Tr ansition Metal Nanoparticles.\" Host: Dwight Sweigart. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060110T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:A0543ABC-50B2-4E10-813A-CE99F079E5BB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070202T170000 DTSTAMP:20070102T193425Z SUMMARY:Friday Chemistry Colloquium: Christopher Cahill\, George Washing ton University. 4:00 - 5:30\, MM 115. \"Synthesis\, Structural Chemistry & Luminescence of f-Metal Containing Organic/Inorganic Hybrid Materials .\" Host: Dwight Sweigart (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070202T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: Bacterial populations use cell-cell communication to coordinate community-wide regulation of processes such as bio-film fo rmation\, virulence and bioluminescence. This phenomenon\, termed quorum sensing\, is mediated by small molecule signals known as auto-inducers. While most auto-inducers are species specific\, auto-inducer-2 (AI-2)\, a signal derived from 4\,5- dihydroxy-2\,3-pentanedione and first ident ified in the marine bioluminescent bacterium Vibrio harveyi\, is produce d and detected by many Gram-negative and Gram-positive bacteria. Crystal lographic studies of AI-2/receptor protein complexes have revealed that different species recognize different forms of AI-2. I will discuss the identification and characterization of AI-2 receptors and AI-2 processin g proteins as well as implications for controlling bacterial behaviors t hrough manipulation of quorum sensing. UID:7BAF114D-83BA-4A33-9B8B-9E1579849519-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091117T110000 DTSTAMP:20091112T174608Z SUMMARY:Organic Chemistry Seminar: Stephen Miller\, Swarthmore College. \"The Chemical Basis of Interspecies Bacterial Communication.\" Host: J ason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091117T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The focus of our research is on developing and app lying new techniques for probing the structures of molecules as they und ergo ultrafast chemical reactions. Two techniques were developed in our laboratory. The first is the ultrafast megavolt electron diffraction. We demonstrated that using highly relativistic (5 MeV) electrons an ultra- short electron bunches containing tens of millions electrons can be crea ted and sustained. That allows not only to improve the time resolution b ut also to get a complete diffraction pattern with a single electron bun ch. We tested the technique on aluminum foil with 160 nm thickness at th e Stanford Linear Accelerator.\n\n\nThe second technique involves photoi onization from molecular Rydberg states\, which were found to be extreme ly sensitive to molecular structure\, yet remarkably insensitive to vibr ational motion. While most spectroscopic and diffraction techniques work well when the molecules are cold and thus vibrational motion is minimiz ed studying ultrafast chemical reactions runs counter to freezing the mo tion since the very ability of the molecule to undergo the ultrafast che mical reaction implies that its energy is very large. The combination of unique properties of Rydberg states allows us to use them for fingerpri nting molecular structure dynamics. We implemented the method to study t he ultrafast curve crossing dynamics of the conjugated 1\,3-cyclohexadie ne\, 1\,2\,3\,4-tetramethyl-cyclopentadiene\, 1\,2\,3\,4\,5-pentamethyl- cyclopentadiene. We followed the relaxation from the initially excited 1 B2 state through the previously elusive 2A1 state\, from where the molec ules relax through a conical intersection to the ground state. Since the spectroscopy applies to molecules on the ground state\, we can identify the molecular geometry immediately after the curve crossing. We observe d that cyclopentadiene derivatives revert back to the original cyclic st ructure\, cyclohexadiene opens its ring to form hexatriene.\n UID:B5184912-46B7-4E07-884C-B1D0F70BDE24-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081014T130000 DTSTAMP:20081015T193839Z SUMMARY:Thesis Defense: Fedor Rudakov\, Brown University. \"Electron Pro bes of Molecular Structure & Ultrafast Molecular Dynamics.\" 1:00 - 3:00 \, GC 351. Presiding Officer: Peter M. Weber. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081014T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:4E57A202-21F4-47D7-996A-9E975E9DCD24-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20081113T181500 DTSTAMP:20081105T154047Z SUMMARY:Research in Chemistry Poster Session: 6:15 - 8:00\, MacMillan Ha ll. Mandatory attendance for 1st year grad students - refreshments will be served. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081113T200000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:3E02AF05-1BC6-11DA-927F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050909T160000 DTSTAMP:20050909T124918Z SUMMARY:Friday Chemistry Colloquium: Amit Basu\, Brown University. 4:00 - 5:30\, MM115. \"Sweet Stuff: Organic Chemistry at the Intersection of Glycoscience & Materials Science.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050909T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Polyvalent gold nanoparticle conjugates are a uniq ue class of matter\, which consist of an inorganic nanoparticle core and a polyvalent oligonucleotide ligand shell. These materials have unique physical characteristics such as cooperative assembly and disassembly pr operties\, distance-dependent optical signatures and a high binding affi nity for target molecules. I will describe recent investigations that el ucidate the physical properties of these inorganic nanomaterials\, their ability to penetrate cells and their role in the development of nano-fl ares for detecting and regulating analytes in a living sample. Recent sy nthetic advances and the ability to measure\, quantify and rationalize t he physical properties of these metal-organic hybrid materials will be e mphasized. Additionally\, studies that determine the extent of p-couplin g in molecular junctions will be discussed. The investigations highlight how both molecular structure and ensemble structure influence propertie s at a metal surface or interface. UID:6B2B4EA0-0B61-4039-9F72-98D344CEB61E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090116T160000 DTSTAMP:20090107T215214Z SUMMARY:Nano Chemistry Search Candidate: Dwight Seferos\, Northwestern U niversity. \"Conjugated Oligomers & Polyvalent Nanoparticle Conjugates.\ " Host: Shouheng Sun. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090116T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:389D8994-5AB4-498D-A659-BE9345458C1B DTSTART;TZID=US/Eastern:20101029T160000 DTSTAMP:20100713T195206Z SUMMARY:Friday Chemistry Colloquium: Professor Jan-Uwe Rhode. Title and Abstract to come. Host:Eunsuk Kim CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101029T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Epoxides are important intermediates in organic sy nthesis. The ring opening of reaction of epoxides provides an easy appro ach to various 1\,2-difunctionalized organic compounds. Novel sandwich-t ype ruthenium complexes showed catalytic activity to the ring opening re action of epoxides. In addition\, the heterogeneous sandwich-type ruthen ium complexes demonstrated excellent substrate selectivity and recyclabi lity. UID:195CE8C4-B9B2-443A-9304-45B7A49B7FBF-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090423T120000 DTSTAMP:20090417T150852Z SUMMARY:Inorganic Chemistry Seminar: Chen Cai\, Brown University. \"Sand wich-Type Ruthenium Complex Catalyzed Ring Opening Reaction of Epoxides. \" Host: Shouheng Sun. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090423T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Rydberg fingerprint spectroscopy (RFS) has been de ftly applied to small molecules and shown exquisitely sensitive to globa l molecular structure. This has stimulated interest in its application t o proteins. To assess the potential viability of RFS for analyzing prote ins we begin by developing an understanding of the properties of Rydberg states in simple model systems of biomolecular constituents. In this th esis\, we investigate the RFS of N\,N-dimethylformamide (DMFA)\, to mimi c the peptide backbone and N\,N-dimethylphenethylamine (PENNA)\, and N\, N-dimethylcyclohexethylamine (CENNA)\, to mimic pendant amino acid side chains. \n\nWe observe the presence of overlapping Rydberg manifolds or iginating from near degenerate nO and π2 orbitals of DMFA. Using several different wavelengths for excitation we are able to explore the regions form the lowest valance transitions to the upper Rydberg manifold. \n\ nPENNA and its hydrogenated counterpart\, CENNA\, have been chosen for t heir two separate functional groups tethered in close proximity\, akin t o the amino acid side chains in proteins. The differences between the el ectronic structures of the phenyl and cyclohexyl groups provide an inter esting contrast to compare the Rydberg electron dynamics as a function o f neighboring functional groups. After photo-excitation at the amine\, w e observe the time evolution of the PENNA conformer distribution through the time dependent shift in the Rydberg electron binding energy. These conformer dynamics are driven by the photo-initiated Coulumbic interacti on of the positive charge center on the amine and the aromatic ring\, fo rming an intramolecular hydrogen bond. \n\nSeparately\, we observe a bi exponential decay kinetics of the 3s state that is indicative of a cross ing from the Rydberg state to a dissociative σ* state. The photoexcitati on process deposits a large amount of internal energy locally at the ami ne\, which has to pass through the bottleneck of the ethyl linkage to be distributed throughout the molecular coordinates. The initial localizat ion of internal energy extends the C-C bond of the ethyl linkage\, depre ssing the energy of the σ* state and thereby allowing for electronic sta te crossing. The σ* state of CENNA is found to be higher in energy than in the PENNA system\, effectively quenching this mechanism. Consequently \, no biexponential kinetics are observed. \n UID:187EC4E9-09BA-438F-AACA-4112ABCF85CE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100127T130000 DTSTAMP:20100126T164643Z SUMMARY:PhD Thesis Defense: Joseph Bush\, Brown University. \"Rydberg Fi ngerprint Spectroscopy on Biomolecular Model Systems.\" Presiding Office r: Peter Weber. GC 351\, 1:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100127T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Polymer-Based Battery Systems: Use of Conducting P olymers\nSujat Sen\, Brown University\n\nBattery and energy research in general has become a subject of considerable interest. While current met al-based batteries are being optimized to obtain higher efficiencies\, t here also is a need to explore unconventional storage systems that are m etal-free and hence possess various functional\, structural\, and proces sing advantages. Here we explore the use of conducting polymers\, in con junction with appropriate redox-active systems to produce new composites for batteries and EDLC (electric double layer capacitors). Besides bein g completely organic\, these composites are highly flexible\, easily pro cessed with low manufacturing costs\, and can be tailored to meet the en ergy and power density demands of a particular device or application. Th e current research will examine a variety of monomers and functionalised dopants that can be utilised in an appropriate fashion to develop compo sites with higher energy and power densities\, in an attempt to make the m comparable to existing inorganic systems. In addition\, we are explori ng alternate means (other than standard electrochemical methods) of synt hesizing such composite materials that will make them amenable to large scale manufacturing processes such as ink-jet printing.\n UID:F5D4E363-1492-44DD-AAFB-1EA80995664E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090908T110000 DTSTAMP:20090902T182143Z SUMMARY:Student Seminars: Zhenting Cai\, Sujat Sen\, Checheung Su\, Yiyi ng Zhu\, Brown University. Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090908T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:74888ADD-CF07-4473-A65F-4B81FC0BE3F7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061107T160000 DTSTAMP:20061107T173042Z SUMMARY:Organic Seminar: Nicole Seah\, Brown University. 11:00 - 12:30\, GC 351. \"No Title.\" Host: Jason K. Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061107T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:F1F96012-2170-11DA-A512-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051110T160000 DTSTAMP:20051103T202336Z SUMMARY:Physical Chemistry Tea Session: R. Scott Prosser\, University of Toronto. 3:00 - 4:15\, GC 351. \"Topology of the Outer Membrane Protein PagP by NMR O2/H2O Scanning Studies: A New Approach to Studies of Membr ane Proteins\, Protein Binding & Protein Unfolding.\" Host: Christoph Ro se-Petruck. (Fletcher House 11/9 - 11/11) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051110T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:B06D9465-94F9-44DE-92CE-DCC9E72A9938-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100723T120000 DTSTAMP:20100629T143214Z SUMMARY:Nanomaterials Seminar: Min Ouyang\, University of Maryland. Titl e & abstract to come. Host: Shouheng Sun. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100723T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:839FD914-521A-4019-92EB-C460ED21B9A7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101001T160000 DTSTAMP:20100421T131334Z SUMMARY:Friday Chemistry Colloquium: Toshiko Ichiye. Title and abstract to come. Host: Lai-Sheng Wang. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101001T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Over the past decade\, advances in both negative i ndex metamaterials and resonant optical antennas have challenged traditi onal assumptions about light-matter interactions. While metamaterials re search has shown that metallic structures can be engineered to support s trong optical frequency magnetic resonances\, resonant optical antennas have been designed to amplify and re-direct the emission from electric d ipole emitters. In this presentation\, we explore the intersection of th ese distinct fields and investigate how resonant optical effects may be used to challenge the electric dipole approximation. Specifically\, we w ill show how Purcell effects may be used to enhance the natural optical frequency magnetic dipole transitions in Lanthanide ions. We will presen t experimental and numerical results that demonstrate enhanced magnetic dipole emission from trivalent Europium ions near metallic films and nan oparticle composites. We will explore how the varying symmetries of elec tric and magnetic dipoles can be used to characterize and optimize magne tic light emission. Finally\, we will discuss the implications of enhanc ing and controlling higher-order optical transitions for optical spectro scopy and photonic devices.\n UID:FF374CA4-6993-43FE-BE7D-CF92DF3E2CF3-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090312T150000 DTSTAMP:20090209T162956Z SUMMARY:Physical Chemistry Tea Session: Rashid Zia\, Brown University. \ "Magnetic Light Emitters: Plasmon-Enhanced Magnetic Dipole Transitions.\ " Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090312T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:12 DESCRIPTION:Abstract: This presentation will focus on two distinct appro aches in materials design and synthesis. In the first part\, an in situ photopolymerization of stimuli-responsive hydrogels in microfluidic chan nels will be described. These unique biosensing hydrogels were prepare d by incorporating a chemoselective methacrylamide-modified 19-amino aci d long peptide\, which can be specifically hydrolyzed by Botulism Neurot oxin-A (BoNT)\, as a crosslinking agent. Introduction of a BoNT solution caused the hydrogel to dissolve and provided a visual macroscopic reado ut of a molecular recognition event. \n\nIn the second part\, the diver sity of hexabenzocoronene (HBC) as a building block to more complex mate rials will be discussed. HBC was used to prepare large\, shape-persisten t macrocycles and act as a precursor to a (6\,6)-carbon nanotube (CNT) e ndcap. Selective macrocycle formation was accomplished using a heterogen eous alkyne metathesis catalyst under thermodynamically controlled react ion conditions. Highly curved graphenes that mimic a CNT endcap were gen erated via the use of Pd-catalyzed Heck couplings. The electronic based applications of these HBC-based materials will also be discussed. \n UID:75D5505D-2C8E-4E39-96C1-D77B16E69999-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090129T160000 DTSTAMP:20090107T215321Z SUMMARY:Nano Chemistry Search Candidate: Kyle Plunkett\, Columbia Univer sity. \"Explorations in Materials Design: From Protease-Responsive Hydro gels to Carbon Nanotube Endcaps.\" Host: Shouheng Sun. 4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090129T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:DC4F5972-5F35-11D9-A18F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050114T160000 DTSTAMP:20050107T140354Z SUMMARY:Bart Kahr\, University of Washington\, Organic Faculty Candidate \, 4:00 - 5:15\, GC 351\, \"Dyeing Chiral Crystals\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050114T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:BE93B9D2-FED1-11D9-9A5B-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050916T160000 DTSTAMP:20050902T153132Z SUMMARY:Friday Chemistry Colloquium: Gorun Hilmerson. 4:00 - 5:30\, MM11 5. \"Lanthanide(II) Iodide: A Selective & Powerful Single Electron Trans fer Reagent.\" Host: Paul Williard. Fletcher House. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050916T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: This dissertation work focuses on preparations and applications of robust\, physisorbed SAMs on HOPG. The molecules contai n an anthracene derivative core and two -CH2OC6H12OC22H45 side chains. R obustness of the SAMs is examined through solvent rinse experiments. Sur vival of the SAMs suggests their high robustness against tetradecane (6° C)\, EtOH and pentane. These solvents are used to expose the SAMs by was hing off molecules not in SAMs.\n\nTwo applications of robust SAMs are i nvestigated. The first is templated AuNP capture and patterning. Acquisi tion of patterned AuNPs depends on strong SAM – HOPG and SAM – AuNP inte ractions. Starting with robust SAMs\, three strategies adopting differen t SAM – AuNP interactions are employed: (i) direct place-exchange on DMA P-AuNPs using carboxylic acid SAMs\; (ii) Cu2+ ion bridges using carboxy lic acid-functionalized AuNPs and SAMs\; and (iii) Grubbs coupling using norbornene-functionalized AuNPs and SAMs. The factors that affect AuNP capture and patterning are investigated\, including AuNP concentration\, incubation time\, surface density of gold-binding functional groups in SAMs\, and/or number of SAM-binding functional groups on AuNPs. The Cu2+ bridge strategy offers the best spatial control over AuNP capture and p atterning while the other two offer very low control. However\, AuNP sur face aggregations are commonly observed in all these three strategies\, indicating the controls are very limited. \n\nSurface polymerizations ad d inter-molecular covalent interactions within pre-formed SAMs\, affordi ng higher physisorptions of the SAMs to HOPG. Molecules containing two i sothiocyanates are further cross-linked through reactions with 1\,4-diam inobutane. MALDI-TOF MS is used to characterize the products collected f rom surface reactions. Optimizations of surface reaction conditions usin g n-butylamine establish 20mM amine and 2 hours afford considerable conv ersion. The surface cross-linking reactions produce the monomer\, dimer and trimer of the diisothiocyanate. The qualitative time dependence of t he surface polymerizations is measured.\n\nMolecular conformer rectifier s (MCRs) form robust SAMs on HOPG and rectifications originating from vo ltage-induced molecular conformational changes are investigated using ST M and STS. STM imaging reveals that the apparent aromatic heights of the MCRs don’s change consistently with voltage or current. STS studies pro vide encouraging results\, showing remarkable asymmetry in i-V curves. H owever\, the i-V curves are not constant due to thermal drifts. \n UID:B68790E2-5F8E-4555-BA0B-593E0A2E1CC7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090901T130000 DTSTAMP:20090821T143556Z SUMMARY:PhD Thesis Defense: Xiangliao Wei\, Brown University. \"Robust P hysisorbed Self-Assembled Monolayers on Graphite & Their Applications in Nanoscience.\" Presiding Officer: Matthew B. Zimmt. 10:00\, MM 317. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090901T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:9409E6DD-4DDD-4446-96C6-3BCB03EF0463-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070126T160000 DTSTAMP:20070109T194958Z SUMMARY:Friday Chemistry Colloquium: Michael C. Fitzgerald\, Duke Univer sity. 4:00 - 5:30\, MM115. \"SUPREX: A New Mass Spectrometry- & H/D Exch ange-Based Method for the Investigation of Protein Folding & Function.\" Host: C. Bazemore-Walker (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070126T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:5F5C59D0-5F5B-11D9-A18F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050201T110000 DTSTAMP:20050128T215314Z SUMMARY:Organic Seminar: Mark Peczuh\, University of Connecticut. 11:00\ , GC 351. \"Recognition of Ring Expanded Carbohydrates by Concanavalin A .\" Host: Amit Basu CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050201T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: UID:58B35796-51EB-470D-87CE-04B3B1FA5168-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071002T110000 DTSTAMP:20071119T204628Z SUMMARY:Student Organic Seminar: Jiaoyang Jiang\, Brown University. 11:0 0 - 12:30\, GC 351. \"Geosmin Biosynthesis.\" Host: Jason Sello. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071002T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The ability to interconvert different forms of ene rgy will be critical to solve many challenges in the near future. Conver sion of the sunlight into electricity or chemical energy\, for example\, holds great promise in meeting our enormous energy needs without devast ating the environment. Unfortunately\, to date this process either occur s with too low efficiencies or requires too costly materials to be compe titive. From a material chemistry perspective\, my presentation will int roduce the key challenges the scientific community is presented with in realizing efficient energy interconversion and offer our strategies in s olving these challenges. I will present our recent success in designing and synthesizing complex nanostructures with superior charge transport p roperties. When combined with photoactive components\, the complex nanos tructures act as structural support as well as charge collector and tran sporter\, yielding a new material. This new material possesses several f eatures that are important to energy interconversion - good light absorp tion\, fast charge transfer and effective charge transport. In addition\ , the complex nature of the nanostructure provides large surface areas w hile maintaining the crystallinity. Previously these features have not b een found simultaneously. I show that the resulting nanostructure is an excellent candidate for water photoelectrolysis. The presentation will c onclude with examples how this design strategy can benefit other energy interconversion applications. UID:86286F9D-7D45-4852-804F-1B864B322DCE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091015T150000 DTSTAMP:20091006T181451Z SUMMARY:Physical Chemistry Tea Session: Dunwei Wang\, Boston College. \" Energy Interconversion Using Nanomaterials: Challenges & Opportunities.\ " Host: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091015T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:A1216D29-EC0C-4554-BA68-87ED46F3E2C9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080115T160000 DTSTAMP:20080111T165601Z SUMMARY:Inorganic Faculty Candidate: David Jenkins\, Berkeley. 4:00 - 5: 30\, MM 115. \"Magnetic Materials with New Polydentate Capping Ligands ( & Late Metal Imide Complexes.)\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080115T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:6387731A-4645-43C1-A356-5FC16174D711-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080721T110000 DTSTAMP:20080715T183344Z SUMMARY:Organic Seminar: Saverio Florio\, Universita di Bari. 11:00 - 12 :15\, GC 351. \"Regio & Stereoselective Lithiation of Aziridines: Solven t & Ring Substitution Effect.\" Host: Paul Williard. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080721T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:84827C35-1F16-4097-81B7-E337D9174EF2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070405T160000 DTSTAMP:20070315T152455Z SUMMARY:Clapp Lecture: Paul Corkum. \"Using Attosecond Technology to Ima ge Molecular Orbitals\,\" Paul Corkum\, National Research Council of Can ada. 4:00 - 5:30\, MM117. Host: Peter Weber. (Fletcher House)\n\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070405T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:A061FBEA-815A-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060427T140000 DTSTAMP:20060420T195652Z SUMMARY:Physical Chemistry Tea Session: Theron Hamilton\, Brown Universi ty. 2:00 - 3\;15\, GC 351. Title to come. Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060427T151500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:DE29BD98-1301-11D9-88BD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20040921T130000 DTSTAMP:20040930T165805Z SUMMARY:Eckhart Foerster: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20040921T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:EDE9C434-15B9-48CC-A1FE-9EA0F49121F4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070921T160000 DTSTAMP:20070920T192519Z SUMMARY:Friday Colloquium: Shaowei Chen\, University of California. 4:00 - 5:30\, MM 115. “Electrochemistry of Nanoscale Functional Materials.” Host: Shouheng Sun (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070921T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Surface and interface play an important role in co ntrolling the properties of a broad range of materials. With the recent development of nanoscience and advanced surface analytical techniques\, our understanding of the surface and interface of nanomaterials has been significantly increased\, as with our ability to control and even to ta ilor the surface and interface characteristics for specific applications . I will present our work on controlled surface design and syntheses of polymer and carbon nanotube brushes\, with an emphasis on the structural elucidation of polymer brushes at the liquid-solid interface. Some of t he similarities between the polymer and carbon nanotube brushes and thei r combined synergetic effects will also be discussed. UID:F582B171-3EC4-48A5-BB0F-6E9518C6AD49-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080226T150000 DTSTAMP:20080307T214602Z SUMMARY:Chemistry Colloquium: Liming Dai\, University of Dayton. 4:00\, GC 351. \"The Surface Effect of Nanomaterials: Polymer & Carbon Nanotube Brushes.\" Host: Matthew Zimmt. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080226T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:A588D09D-E282-49AF-A3B6-0FF106610DF2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20081009T120000 DTSTAMP:20080925T180944Z SUMMARY:Inorganic Chemistry Seminar: Sheng Peng\, Brown University. Titl e and abstract to come. Host: Shouheng Sun. 12:00 - 1:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081009T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:C0F2B7EF-8D1D-471C-A104-2E98D2CE1385 DTSTART;TZID=US/Eastern:20101025T110000 DTSTAMP:20100713T190550Z SUMMARY:Physical Tea Session: Professor Yoshihiro Takagi. Title and Abs tract to come. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101025T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The use of nanomaterials has the potential to revo lutionize materials science and medicine. Currently\, a number of differ ent nanoparticles are being investigated. Viral nanoparticles (VNPs)\, s uch as the Cowpea mosaic virus and Potato virus X\, can be regarded as n aturally occurring nanomaterials. From a materials scientist’s point of view VNPs are attractive building blocks for several reasons: the partic les are monodisperse\, can be produced with ease on large scale\, are ex ceptionally stable and are biocompatible. VNPs are “programmable” units\ , which can be modified by either genetic modification or chemical bioco njugation methods.\n\nViral nanotechnology is a young and emerging disci pline. VNPs are promising candidate materials for the development of fun ctional devices at the nanoscale. I will discuss some of the design prin ciples that allow the fabrication of ordered arrays of VNPs. Such functi onalized arrays are envisioned to find applications in sensors and nanoe lectronic devices.\n\n\nBesides the utility of VNPs as building blocks f or the construction of materials\, VNPs are of tremendous interest for a pplications in biomedical research. A major goal in medicine is to devel op targeted therapies. Chemotherapy for cancer is not targeted\, thus ma ny undesired side effects occur. Targeting drugs specifically to sites o f disease while avoiding healthy tissues is expected to reduce toxic sid e effects\, improve quality of life and is an important goal in biomedic ine. I will highlight examples that demonstrate the feasibility of targe ting VNPs to sites of disease in vivo. VNPs can be interlinked with targ eting ligands\, imaging modalities and therapeutic moieties. Such “smart ” multifunctional devices are expected to find applications in targeted drug delivery.\n UID:F34D4455-DB9B-4A86-AFE5-D277E7AFE543-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091130T160000 DTSTAMP:20091125T182836Z SUMMARY:Nanoscience Faculty Search Candidate: Nicole Steinmetz\, The Sc ripps Research Institute. \"Viral Nanoparticles (VNPs): From Materials t o Medicine.\" Host: Shouheng Sun. MM 317\, 4:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091130T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:0C989C74-9758-11DA-B068-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061013T160000 DTSTAMP:20060926T161006Z SUMMARY:Friday Chemistry Colloquium: John Chisolm\, Syracuse University. 4:00 -5:30\, MM115. \"New Transition Metal Catalyzed Carbon-Carbon Bond Forming Reactions.\" Host: William C. Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061013T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 DESCRIPTION:Abstract: Group 4 metals supported by triamidoamine ligands are effective catalysts in the synthesis of element–element σ-bonds in t he main group with hydrogen loss. A general route to zirconium complexes of the type (N3N)ZrX (N3N = N(CH2CH2NSiMe3)33–\; X = anionic ligand) ha s been discovered\, and these complexes have been demonstrated to underg o selective P–P bond formation by dehydrocoupling of primary and seconda ry phosphines. Efforts currently involve applying that reactivity toward building P–P bond containing polymers. These zirconium complexes also p romote the formation of π-bonds. For example\, (N3N)ZrX complexes dehydr ocoupled 2\,6-dimesityphenylarsine (dmpAsH2) to give the diarsene produc t\, dmpAs=Asdmp with study suggesting the extrusion of a low-valent arse nic fragment (an arsinidene\, “AsR”) termed via α-arsinidene elimination occurring. Indirect generation of arsinidene and phosphinidene (“PR”) s ynthons has been achieved via a combination of insertion and rearrangeme nt. Zirconium primary phosphido complexes\, (N3N)ZrPHR\, react rapidly w ith isocyanides to give insertion products\, (N3N)ZrC(PHR)=NR’. These pr oducts thermally rearrange to form amido ligands featuring phosphaalkene (P=C) linkages. Recent developments suggest that this transformation ca n be made catalytic\, which is the first catalytic synthesis of phosphaa lkenes. UID:CA2BCE30-B5E6-47EC-AB00-3E3609D81DC8-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100408T120000 DTSTAMP:20100302T192445Z SUMMARY:Inorganic Chemistry Seminar: Rory Waterman\, University of Vermo nt. \"Zirconium-Mediated Bond Formation: Stripping off Hydrogen to Make σ- & π-Bonds.\" Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100408T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Cross-linked polymer shells are coated at the surf ace of gold nanoparticles through surface-initiated ring-opening metathe sis polymerization followed by selective cross-linking. The stability of the cross-linked nanoparticles toward cyanide etching was evaluated by UV-vis spectroscopy. The rate of etching decreases as cross-linker is wi th fewer degrees of conformational freedom. The distance of the cross-li nking block from the nanoparticle surface was systematically varied. Nan oparticles with the cross-linked block furthest from the surface were et ched most slowly. These results provide new insight into how fine-tuning the polymer cross-linking architecture can modulate nanoparticle stabil ity.\n\nAfter etching away the nanoparticle template\, cross-linked poly mer shells afford hollow polymer nanocapsules that have found wide appli cations in drug delivery and catalysis. These applications require insta llation of diverse chemical functionality in the capsule core. Despite m ethods for nanocapsule preparation\, methods for efficiently functionali zing the core of polymer nanocapsules are scarce. A versatile and modula r approach has been developed for the synthesis of hollow polymer nanoca psules that can be readily and diversely functionalized. Capsules functi onalized with pyrene\, ferrocene\, amines and carboxylic acids have been prepared and characterized using dynamic light scattering\, fluorescenc e spectroscopy and transmission electron microscopy. These core-function alized capsules can selectively extract hydrophilic cationic or anionic dyes into organic solutions based on the charge complementarity of the c ore functionality.\n UID:E91CB9A8-E828-43DD-9DDD-8EFB57214578-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090825T090000 DTSTAMP:20090817T155647Z SUMMARY:PhD Thesis Defense: Xiang Liu\, Brown University. \"Conjugates o f Gold Nanoparticles & Cross-Linked Polynorbornenes: Enhancement of Nano particle Stability & Templated Synthesis of Polymer Nanocapsules.\" Pres iding Officer: Amit Basu. 9:00\, GC 349. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090825T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:96135C3C-5F5B-11D9-A18F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050211T160000 DTSTAMP:20050128T215150Z SUMMARY:Friday Colloquium: Sarah Patch\, Ameritech. 4:00 - 5:30\, MM 115 . \"Thermoacoustic Tomography - Data Reconstruction.\" Host: Gerald Dieb old. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050211T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:7AA083EF-1442-4B5A-A6FA-B152F6F56519-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101217T160000 DTSTAMP:20100625T191527Z SUMMARY:RESERVED: Faculty Search CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101217T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:4A4B791C-89CE-11DA-9A74-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060223T150000 DTSTAMP:20060120T163009Z SUMMARY:Physical Chemistry Tea Session: Chengju Wang\, Brown University. 3:00 - 4:16\, GC 351. \"Characterizing the Potential Energy Landscape b y its Geodesic Paths.\" Host: Richard Stratt/Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060223T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:7612DB5C-F738-4888-9122-E67C8EA21036-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070403T110000 DTSTAMP:20070321T193343Z SUMMARY:Organic Seminar: Dean Tantillo\, University of California Davis\ , 11:00 - 12:30\, GC 351. \"Carbocation Cascades in the Biosynthesis of Polycyclic Terpenoid Natural Products.\" Host: David Cane. (Inn at Brown ) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070403T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:B0DC9854-5304-11DA-8FC5-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051117T150000 DTSTAMP:20051111T224443Z SUMMARY:Physical Chemistry Tea Session: David Laidlaw\, Brown University \, Dept. of Computer Science\, 3:00 - 4:15\, GC 351. Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051117T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:E8A4C709-75A2-4B6A-AA04-1D4E70115FC5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070216T160000 DTSTAMP:20070207T151946Z SUMMARY:Friday Chemistry Colloquium: Jonathan B. Spencer\, University of Cambridge\, 4:00 - 5:30\, MM115. \"Polyketide Biosynthesis on Land & at Sea.\" Host: David Cane (staying with the Canes) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070216T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:ABSTRACT: We develop biophotonic technologies for early-canc er detection and functional imaging by physically combining non-ionizing electromagnetic and ultrasonic waves. Unlike ionizing x-ray radiation\, non-ionizing electromagnetic waves\, such as optical and radio waves\, pose no health hazard and\, at the same time\, reveal new contrast mecha nisms. Unfortunately\, electromagnetic waves in the non-ionizing spectra l region do not penetrate biological tissue in straight paths as x-rays do. Consequently\, high-resolution tomography based on non-ionizing elec tromagnetic waves alone\, as demonstrated by confocal microscopy and two -photon microscopy as well as optical coherence tomography\, is limited to superficial imaging within about one optical transport mean free path (~1 mm) of the surface of biological tissue. Ultrasonic imaging\, on th e contrary\, provides good image resolution but has strong speckle artif acts as well as poor contrast in early-stage tumors. We have developed u ltrasound-mediated imaging modalities by combining electromagnetic and u ltrasonic waves synergistically to overcome the above problems. The hybr id modalities yield speckle-free images with high electromagnetic contra st at high ultrasonic resolution in relatively large volumes of biologic al tissue. The specific technologies to be reviewed in this presentation are summarized below.\n In ultrasound-modulated optical tomography\, a focused ultrasonic wave tags diffuse laser light in scattering biologica l tissue\, which is analogous to the encoding concept in MRI. Because th e tagged photons that carry the ultrasonic frequency originate from the localized ultrasonic wave\, they can be extracted from the observed opti cal speckles to achieve high-resolution tomographic imaging.\n In photo- acoustic tomography\, an expanded pulsed laser beam diffuses into the bi ological tissue and generates a small but rapid temperature rise\, which causes the emission of ultrasonic waves as a result of thermoelastic ex pansion. The short-wavelength ultrasonic waves are then detected to form high-resolution tomographic images.\n Thermo-acoustic tomography is sim ilar to photo-acoustic tomography except that low-energy radio-frequency pulses\, instead of laser pulses\, are used. Although the long-waveleng th radio-frequency waves diffract rapidly in the tissue\, the short-wave length ultrasonic waves provide high spatial resolution.\n UID:13B47CB8-52EA-4726-A8C8-D5BB5B8ACAC9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070906T150000 DTSTAMP:20071119T202803Z SUMMARY:Physical Tea Session: Lihong Wang\, Washington University\, St. Louis. 3:00 - 4:15\, GC 351. \"Ultrasound-Mediated High-Resolution Bioph otonic Imaging.\" Host: Gerald Diebold. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070906T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:781ED9C0-0665-4D39-8AB0-CABBD12F3880-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20091009T120000 DTSTAMP:20091006T134615Z SUMMARY:Departmental Review - Focus: Research Enterprise. 12:00 noon\, G C 449. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091009T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:41A6B7A8-CA01-4622-97CC-EF22F64B3CA3-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070223T160000 DTSTAMP:20070221T193708Z SUMMARY:Friday Chemistry Colloquium: Jarrod A. Marto\, Dana-Farber Cance r Institute. 4:00 - 5:30\, MM115. \"Proteomics: Model Systems to Stem Ce lls.\" Host: C. Bazemore-Walker. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070223T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:556F62B5-836C-4B7C-B4FF-866AE23B0155-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100504T110000 DTSTAMP:20100422T212229Z SUMMARY:1st Year Students Organic Chemistry Seminars. Kelly Schermerhorn \, Michael Zompa. Host: Jason Sello. GC 351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100504T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:890DB9DA-90BF-49AC-A585-AF749B888921-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080506T083000 DTSTAMP:20080212T145253Z SUMMARY:Nanoscience Inaugural Events CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080506T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Reversible protein phosphorylation plays a vital r ole in the regulation of cellular signaling pathways. With recent breakt hrough developments in mass spectrometry-based proteomics technologies\, including phosphopeptide enrichment and separation techniques\, high-ac curacy mass spectrometry and associated bioinformatics\, MS-based quanti tative phosphoproteomics have now gained great popularity. This technolo gy has enabled the simultaneous identification and quantification of tho usands of phosphorylation sites from entire phosphoproteomes. Current ap proaches in phosphoproteomics focus on analysis of the global phosphopro teome in a single cellular state or of receptor stimulation time course experiments\, often with a restricted number of time points. Although th ese studies have provided some insights into newly discovered phosphoryl ation sites that may be involved in pathways\, they alone do not provide enough information to make precise predictions of the placement of indi vidual phosphorylation events within a signaling pathway. Protein disrup tion and site-directed mutagenesis are essential to clearly define the p recise biological roles of the hundreds of newly discovered phosphorylat ion sites uncovered in modern proteomics experiments.\n\nMast cells play a central role in type I hypersensitivity reactions and allergic disord ers such as anaphylaxis and asthma. Understanding the molecular architec ture underlying mast cell signaling may provide possibilities for therap eutic intervention in asthma and other allergic diseases. Using recently advanced methodologies in mass spectrometry\; a systematic quantitative analysis of the global tyrosine phosphorylation events triggered by act ivation of the mast cell receptor was performed. We have substantially c haracterized and quantified a far more extensive array of tyrosine phosp horylation events than previously known\, with the kinetics of 171 uniqu e phosphorylation sites across 121 proteins in mouse mast cell line MCP5 and 179 unique phosphorylation sites on 117 proteins in mouse bone marr ow-derived mast cells.\n\nTo better understand the molecular mechanism u nderlying complex cellular signaling networks\, we have also developed a hybrid quantitative approach that combines label free and SILAC quantif ication techniques. Label free quantitation is applied to assemble high- density temporal data within a single cell type\, either wide-type (WT) or mutant (Mut) cells\, providing a list of phosphorylation sites that c hange in abundance after stimulation of a cellular receptor. SILAC quant ification is then used to compare WT and Mut cells across a time course of receptor stimulation\, providing direct information about how the new ly observed phosphorylation sites respond to the mutagenesis. We have su ccessfully applied this approach to ZAP-70 and SLP-76 deficient Jurkat T cell lines. These studies have provided great insights into the essenti al roles of these proteins in T cell signaling. Many hypotheses have bee n drawn and follow-up studies could provide directions for future invest igation.\n UID:18786955-3DB1-4FA5-8976-6A424EE08F74-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090826T100000 DTSTAMP:20090817T160017Z SUMMARY:PhD Thesis Defense: Lulu Cao\, Brown University. \"Quantitative Phosphoproteomic Analysis to Unravel Mast Cell & T Cell Signaling Pathwa ys.\" Presiding Officer: Arthur Salomon. 10:00\, Sydney Frank Hall\, Roo m 220.\n\n\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090826T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: One of the grand challenges in materials chemistry is in developing self-assembly pathways to create highly functional and organized systems that bridge the molecular-\, nano- and macroscopic le ngth scales. The ability to cheaply and reproducibly achieve this level of control holds great relevance for both energy-related and regenerativ e medicine applications. This presentation will discuss our efforts in u tilizing molecular self-assembly for optoelectronics and spinal cord inj ury regeneration.\n\nThe first system describes the formation of ordered p-type organic and n-type inorganic lamellar architectures for photocon ductor and photovoltaic applications. Here\, a lamellar hybrid\, contain ing periodic and alternating 1-nm thick sheets of polycrystalline ZnO se parated by 2-3 nm thick layers of conjugated molecules\, is self-assembl ed directly onto an electrode. These systems are technologically competi tive as low-power\, wavelength tunable\, flexible and environmentally be nign photoconductors\, having among the best reported performance values among organic\, hybrid and amorphous silicon photoconductors.\n\nThe se cond system describes the self-assembly of peptide-lipid molecules to ge nerate bioactive cylindrical nanostructures that can be used for cellula r signaling. We have recently discovered the capability of aligning thes e peptide amphiphile fibers into macroscopic flexible\, mechanically rob ust\, string-like matrices. The combination of nanoscale alignment and s ignaling efficacy of permanently bound peptide epitopes is unique for a three-dimensional scaffold\, making this an ideal platform to study the relative influence of each on cellular behavior. In the context of chron ic spinal cord injury repair\, we have synthesized complementary peptide amphiphile derivatives to signal different aspects of nervous system be havior and developed the capability of introducing spatially-controlled gradients of these derivatives\, in order to study these effects on neur onal behavior in vitro and functional recovery in vivo.\n UID:94A0CFF8-9CB7-4F9A-B9F4-B5B0629E4819-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091209T160000 DTSTAMP:20091204T193808Z SUMMARY:Nanoscience Faculty Search Candidate: Joshua Goldberger\, Northw estern University. \"Nanomaterial Self-Assembly for Energy & Medicine.\" Host: Shouheng Sun. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091209T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Superparamagnetic nanoparticles (NPs) have been at tractive for medical diagnostics and therapeutics due to their unique ma gnetic properties and their ability to interact with various biomolecule s of interest. The solution phase-based chemical synthesis provides a ne ar precise control on NP size\, and monodisperse magnetic NPs with stand ard deviation in diameter of less than 10% are now routinely available. Upon controlled surface functionalization and coupling with fragments of DNA strands\, proteins\, peptides or antibodies\, these NPs can be well -dispersed in biological solutions and used for drug delivery\, magnetic separation\, magnetic resonance imaging contrast enhancement and magnet ic fluid hyperthermia. UID:1A576C25-3B45-43A6-9285-F21E6FD31C8E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090422T130000 DTSTAMP:20090407T151453Z SUMMARY:PhD Thesis Defense: Chenjie Xu\, Brown University. \"Modificatio n of Superparamagnetic Nanoparticles for Biomedical Applications.\" Pres iding Officer: Shouheng Sun. 1:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090422T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Monodisperse nanoparticles in the size range below 20 nm are currently of intense research interest\, not only for the gen eral miniaturization of devices\, but also for their novel physical/chem ical properties. For example\, magnetic properties of magnetic nanoparti cles have shown dramatic size dependency when they get into nanoscale\, and the transition of these nanoparticles from ferromagnetic into superp aramagnetic occur within tens of nanometers. Recent advances in organic phase chemical synthesis have led to various monodisperse nanoparticles with controlled size\, shape\, composition and crystallinity\, which all ows us to investigate relationships between size/structure and physical/ chemical properties of such nanoscale materials. Organic solution-based syntheses of monodisperse NPs of magnetic Fe3O4\, Fe\, Co\, FeCo and SmC o5\, as well as noble metallic Au\, Ag and AuAg NPs will be discussed.\n Monodisperse magnetic ferrite NPs\, MFe2O4 (M = Fe\, Co\, Mn\, etc.) hav e been synthesized by high temperature organic solution-based reactions. The resulted ferrite NPs are of controllable size of 5 – 20nm\, and are superparamagnetic with moderate magnetic moments (up to 80emu/g) at roo m temperature.\nMetallic iron Fe and cobalt Co NPs have been synthesized by thermal decomposition of organometallic precursors\, with high initi al magnetic moments (> 120emu/g). However\, due to their chemical instab ility\, the metallic NPs are quickly oxidized in air\, leading to drasti c moment decrease and rapid dispersion agglomaration. A well-crystallize d magnetic iron oxide shell has been employed to protect the primitive m etal cores. The resulted bimagnetic core/shell NPs prove to possess grea tly enhanced chemical and magnetic stabilities. FeCo NPs were synthesize d by coating Co NP seeds with Fe followed by interfacial diffusions betw een the two components to give the alloy phase.\nThe synthesis of hollow iron oxide Fe3O4 NPs has been achieved by controlled deep oxidation of Fe NPs\, utilizing Kirkendall diffusions. The crystallinity and the surf ace pores of the hollow NPs can be readily tuned by controlling the reac tion temperature.\nNanocrystalline SmCo-based hard magnets have been fab ricated via solid-state reduction of SmCoO-based (Co/Sm2O3 and SmCoOx) N Ps with calcium Ca granules. The composition of the product is controlle d to give either SmCo5 or Sm2Co17. Hard magnetic properties (coercivity > 3kOe) have been revealed at room temperature.\nMonodispere non-thiolat ed Au and Ag NPs have been prepared in the presence of oleylamine. AuAg alloy NPs have been made by either interfacial diffusion of core/shell A g/Au or insitu co-reduction of Au- and Ag-precursors. The resulted Au an d AuAg NPs reveal high catalytic activity for carbon monoxide (CO) oxida tion.\nSuch nanoparticles with promising properties are thus interesting for various bio-medical\, magnetic and catalytic applications. Magnetic Fe3O4\, Fe\, Co\, FeCo and hollow Fe3O4 NPs are promising for drug deli very\, imaging and hyperthermia. Nanocrystalline SmCo is an excellent ca ndidate of high performance permanent magnets for magnetic energy storag e. Au and AuAg nanoparticles are promising future catalysts.\n UID:9E202086-C3AE-442D-BDF7-C8A0D034168D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090423T090000 DTSTAMP:20090416T145627Z SUMMARY:PhD Thesis Defense: Sheng Peng\, Brown University. \"Novel Monod isperse Nanoparticles: Synthesis\, Characterizations & Applications.\" P residing Officer: Shouheng Sun. 9:00\, GC 449. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090423T110000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:4EDA952E-0F33-11DA-B190-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051013T120000 DTSTAMP:20051109T220030Z SUMMARY:Inorganic Seminar: Sunghee Lee\, Iona College. 12noon - 1:00\, G C 351. \"Understanding the Surfaces & Interfaces in Soft Materials: Engi neering & Characterization of Microparticles using Micromanipulation Tec hnique.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051013T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:6E5ABF8E-20A7-11DA-99CB-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050915T150000 DTSTAMP:20050908T203214Z SUMMARY:Physical Chemistry Tea Session: Artur Adib\, Brown University. 3 :00 - 4:15\, GC 351. \"Nonequilibrium Generalization of Chemical Detaile d Balance.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050915T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:A6F401BB-01A2-42C5-9535-F076AD999600-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061121T163000 DTSTAMP:20061107T172548Z SUMMARY:Organic Faculty Candidate Research Seminar: Brandon Ashfeld. 4:3 0 - 5:50\, MM115. Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061121T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:02C1DAE1-1168-494C-971B-03F885EC45C8-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061027T160000 DTSTAMP:20061019T203618Z SUMMARY:Friday Chemistry Colloquium: David Mitzi\, IBM. 4:00 - 5:30\, MM 115. \"Soluble Inorganic Semiconductors: Structures\, Properties & Appl ications.\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061027T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The anticancer activity of the preclinical prodrug Cloretazine is a function of two reactive subspecies generated upon bas e-catalyzed activation in situ: a 2-chloroethylating species and methyl isocyanate. The 2-chloroethylating species ultimately forms cytotoxic\, interstrand DNA crosslinks while the carbamoylating activity of methyl i socyanate contributes synergistically to the cytotoxicity in neoplastic cells. The carbamoylating activity of Cloretazine can modify cellular pr oteins and affect their function. The subset of cellular lesions caused by methyl isocyanate likely to result in the enhancement of cytotoxicity includes those against enzymes of DNA repair and critical redox pathway s. The nucleotidyl-transferase activity of purified DNA polymerase beta\ , an enzyme specific to DNA base excision repair\, is inhibited by Clore tazine at clinically relevant concentrations. This inhibition is due to the agent’s carbamoylating activity rather than its 2-chloroethylating a ctivity. Other DNA base excision repair enzymes have thus far shown less substantial sensitivity to Cloretazine exposure. Methyl isocyanate’s re activity with sulfhydryl groups suggests oxidoreductases that rely on di thiol / disulfide chemistry as likely targets for carbamoylation. The th ioredoxin system\, which includes thioredoxin (Trx) and Trx reductase (T rxR)\, is involved in cellular antioxidant defense and metabolic redox e vents. TrxR\, which reduces oxidized Trx using reducing equivalents from NADPH\, is strongly inhibited by Cloretazine’s carbamoylating activity. This inhibition is observed against purified enzyme as well as enzyme w ithin the lysates of cultured mammalian leukemia cells. Also affected ar e Trx-mediated phenomena associated with cell proliferation. Among these is the maintenance of certain transcription factors in their active\, r educed state. Given the over-expression of TrxR in neoplastic cells\, th e inhibition of the Trx system by Cloretazine may prove to be critical t o the mechanism of action of this promising anticancer agent. UID:84A9033E-A0DE-4804-9704-3AD9A32020F7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090407T110000 DTSTAMP:20090327T184647Z SUMMARY:Organic Chemistry Seminar: Kevin P. Rice\, Colby College. \"The Constructive Participation of Methyl Isocyanate in the Anticancer Activi ty of Cloretazine.\" Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090407T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:C7078BE6-8F08-4428-A576-DEFCC90232DC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100420T134500 DTSTAMP:20100416T194351Z SUMMARY:Sc.B Biochemistry Thesis Talks\, Sidney Frank Hall\, Room 250\, 1:40. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100420T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:ABSTRACT: There are ~141 closed-shell neutral molecules\, ra dicals and ions that have been detected in the interstellar medium to da te. The identification of these molecules\, mostly by radio astronomy\, relies on ground-based laboratory production and spectroscopic detection of these species. One very powerful method for doing this is Fourier tr ansform microwave spectroscopy. Interstellar chemistry will be reviewed and the laboratory microwave spectroscopy of a “typical” radical will be discussed. UID:C8B3C6A6-1A49-4ADF-8E6D-55DB50E8AE2E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071213T150000 DTSTAMP:20071214T140045Z SUMMARY:Physical Tea Session: Stewart Novick\, Wesleyan College. 3:00 - 4:15\, GC 351. \"Laboratory Astrochemistry: High Resolution Spectroscopy of Radicals.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071213T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Our understanding of the enzymology of microbial n atural product biosynthetic systems has advanced to the point that it is now possible to routinely predict the chemical structures of the produc ts of these systems using DNA sequence data alone. A brief background an d description of polyketide and non-ribosomal peptide systems will be pr esented. Our work toward elucidating the \"secondary metabolome\" of the obligate marine actinomycete genera\, Salinispora will be discussed\, w ith a description of the elucidation of the novel polyene macrolactam\, salinilactam A\, as a particularly intriguing example. Unpublished detai ls on our discovery and analysis of 61 natural product biosynthetic gene clusters in plant root symbiont actinomycetes will also be shown. This work demonstrates the value of bionformatic analysis to guide and comple ment chemical isolation and drug discovery studies. UID:C7CD3CB1-8020-4D37-AB0A-C32CDCE249B6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080408T110000 DTSTAMP:20080325T181254Z SUMMARY:Organic Seminar: Daniel Udwary\, URI. 11:00\, GC 351. \"Accessin g Genomic Data for the Prediction & Elucidation of Actinomycete Natural Product Chemical Structures.\" Host: Jason Sello. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080408T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: The materials in cells are primarily diamagnetic a nd thus\, respond weakly to terrestrial magnetic fields. Nevertheless\, magnetic fields are available that are sufficiently intense to align bio polymers such as microtubules and biomolecular assemblies such as cell m embranes. In addition\, common organic materials can be magnetically le vitated. We are exploiting these weak intrinsic responses to manipulate cellular processes and materials. I will describe how we have used mag netic fields to learn about factors controlling the cell division geomet ry of frog embryos\, to probe an exquisitely sensitive force transductio n mechanism exhibited by a micro-organism\, and to investigate pattern f ormation in polymerizing tubulin solutions. UID:D31D345E-FA68-4272-BFBF-0CFD7638795F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090917T150000 DTSTAMP:20090911T155915Z SUMMARY:Physical Chemistry Tea Session: James Valles\, Brown University. \"Manipulating Life with Magnets.\" Host: Gerald Diebold. 3:00\, GC 351 . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090917T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Pulsed gradient spin-echo (PGSE) diffusion NMR spe ctroscopy was designed to measure diffusion coefficients and deduce the hydrodynamic radii of molecules in solution. By incorporation of this te chnique in a two-dimensional experiment – now referred to as diffusion-o rdered NMR spectroscopy (DOSY) - one can\, in principle\, determine form ula weights of different components in solution. We systematically devel oped multinuclear DOSY methods and extensively applied these DOSY techni ques to characterize organometallic reactive intermediates in solution.\ n\nThe first section describes DOSY techniques utilized in our lab. Thes e include DOSY experiments with nuclei such as 1H\, 6Li\, 7Li\, and 13C. Additionally\, we proposed a diffusion coefficient-formula weight relat ionship to determine formula weight\, aggregation number and solvation s tate of reactive intermediates. We also introduced an internal reference system to correlate unknown reactive intermediates with known molecules . Four types of molecules: aromatic compounds\, terminal olefins\, cyclo olefins and tetraalkylsilanes were evaluated as internal references due to their chemical and NMR properties. Examples of 1D spectrum slices ext racted from DOSY spectra are presented that provide resolution of indivi dual species in the chemical shift dimension. These DOSY methods greatly enhance our ability to differentiate species in solution by size thus e xemplifying that DOSY deserves the nickname chromatography by NMR.\n\nIn the second section\, examples of the determination of aggregation numbe r and solvation state of reactive intermediates by DOSY are presented. S uch information is crucial to interpret the reactivity\, kinetics and me chanism of organic reactions. By utilizing multinuclear DOSY techniques at various temperatures\, we correlated the solid state X-ray structures with those in solution and also discovered new reactive complexes. Seve ral specific examples are utilized to show the application of the DOSY s trategy in organometallic studies: a THF solvate LDA dimeric complex\, a mixed trimeric aggregate containing n-BuLi and lithium amide\, an inter mediate responsible for product-induced chirality inhibition and a chira l enolate aggregate.\n\nWe also discuss properties of a solution\, such as concentration\, viscosity and density\, which involve in the formula weight and diffusion coefficient correlation. We anticipate that these D OSY methods and applications will provide a practical and feasible NMR p rocedure for the characterization of new reactive intermediates.\n UID:0E314CFC-39D0-43AC-8405-2AC191EB0A04-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080827T090000 DTSTAMP:20080822T182728Z SUMMARY:PhD Thesis Defense: Deyu Li\, Brown University. 9:00\, GC 351. \ "Characterization of Reactive Intermediates by Multinuclear Diffusion-Or dered NMR Spectroscopy (DOSY).\" Presiding Officer: Paul G. Williard. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080827T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:A6C99616-419E-11DA-9BED-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051122T110000 DTSTAMP:20051109T201036Z SUMMARY:Organic Seminar: Jessica Plati\, 11:00 - 12:30\, GC 351. \"Inter actions of the Parathyroid Harmone (PTH) Receptor.\" Host: William Trenk le CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051122T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:7F319B9A-B600-11DA-B973-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060411T110000 DTSTAMP:20060317T215445Z SUMMARY:Organic Chemistry Literature Seminars: Allison Schmidtt & Chiara Valenzano\, Brown University. 11:00 -12:30\, GC 351. Titles to come. Ho st: William C. Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060411T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: Three oligomeric dehydrogenases\, each catalyzing a hydride transfer and proton abstraction have been studied to examine t he role of protein dynamics in both catalysis and allosteric regulation. While global stability of the three proteins has been assessed using DS C or Guanidine Hydrochloride unfolding approaches\, limited proteolysis and H/D exchange approaches have been used to examine the effects of bot h substrates and allosteric ligands on local flexibility. A novel techni que\, combining guanidine hydrochloride effects and dynamic light scatte ring approaches has been developed to assess the stability of subunit in terfaces. These techniques\, in conjunction with site directed mutagenes is and the use of alternative substrates with very different catalytic e fficencies\, allosteric activators or inhibitors reveal a pattern of fle xibility effects which indicate that efficient substrates or efficient e nzymes have significantly more flexible local structure and subunit inte rface interactions than less efficient substrates or enzymes. Similarly allosteric activators increase both global and local flexibility while a llosteric inhibitors decrease flexibility. Overall these studies show th at flexibility plays a critical role in catalytic efficiency and that al losteric regulation can be acheived by ligand induced modulations of fle xibility rather than simple induced switching from one conformation to a nother.\n\nThis work is supported by National Science Foundation Grant M CB 0448905 to Ellis Bell.\n UID:20034743-8802-4B52-B610-913975A206A6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090310T110000 DTSTAMP:20090213T195914Z SUMMARY:Organic Chemistry Seminar: Ellis Bell\, University of Richmond. \"The Role of Dynamics in the Activity & Regulation of Oligomeric Dehydr ogenases.\" Host: Jason Sello. 11:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090310T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:BB9C8446-0B3C-11DA-96AC-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050929T150000 DTSTAMP:20051209T205021Z SUMMARY:Physical Chemistry Tea Session: Torsten Fiebig\, Boston College. 3:00 - 4:15\, GC 351. \"DNA Photonics: Probing Electronic & Structural Properties of DNA on the Femtosecond Time Scale.\" Host: Christoph Rose- Petruck. Parking pass sent. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050929T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:DABE1A23-60F2-11D9-9FC6-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050506T160000 DTSTAMP:20050325T172331Z SUMMARY:Friday Colloquium. Maria Santore\, University of Massachusetts\, Amherst. 4:00 - 5:30\, MM 115. Title to come. Host: ChemDUG (Dong-In Ko o). CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050506T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:48B8D8B2-FF35-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20031003T160000 DTSTAMP:20031015T173106Z SUMMARY:Colloquium Speaker: John Higgins\, Sanofi-Synthelabo\, Malvern P A CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20031003T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:48215FF9-559E-4505-AA49-5637ADDED71A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070130T110000 DTSTAMP:20070102T193044Z SUMMARY:Organic Seminar: Jeffrey Katz\, Colby College. 11:00 -12:30\, GC 351. “Molecular Design through Nucleophilic Aromatic Substitution: Pla ying with an Oxacalixarene-Based Molecular Toolbox.\" Host: William C. T renkle (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070130T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:63C8FF12-814F-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060406T150000 DTSTAMP:20060322T140408Z SUMMARY:Physical Chemistry Tea Session: Joe Bush\, Brown University. 3:0 0 - 4:15\, GC351. Title to come. Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060406T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:C666D84E-1301-11D9-88BD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20040917T130000 DTSTAMP:20040930T165736Z SUMMARY:James Warner (UMASS Lowell): colloquium CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20040917T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: I will discuss computational methods to accurately calculate spectroscopic and thermodynamic properties of simple and comp lex systems. The systems considered include protonated water dimer\, car bon monoxide in myoglobin and carbon monoxide in ice. The results demons trate that for quantitative simulations detailed knowledge of the interm olecular interactions are necessary. UID:6DD9FB93-8D56-4181-A680-948467E1B17B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070831T140000 DTSTAMP:20071113T180125Z SUMMARY:Physical Chemistry Seminar: Markus Meuwly\, University of Basel\ , Switzerland. 2:00 - 3:00\, GC351. \"Computational Vibrational Spectros copy & Reactive Dynamics in Gas & Condensed Phase Systems.\" Host: Jimmi e Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070831T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:78C2DDE3-E785-44FC-8CBA-104989C89C51-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100816T143000 DTSTAMP:20100714T131642Z SUMMARY:Seminar: Professor Teizo Kitagawa. Institute for Molecular Scien ces in Okazaki and Hyogo University\, Japan. Title: \" Gas sensor protei ns: mechanism of sensing of diatomic molecules and communication to the active site\" GC351 CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100816T153000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: \nINTRODUCTION\nMolecular glycosylation is involve d in key developmental roles including control of cell differentiation\, innate immunity and signal transduction. Equally as demonstrable are nu merous aspects of tumor development\, from cellular proliferation to ang iogenesis and metastasis. This sensitivity to cellular development and p athology is reflected in the diversity of unique glycoforms presented on numerous glyconjugates. In spite of the potential utility of using mole cular glycosylation as prognostic and diagnostic biomarkers little has b een accomplished in bringing these capabilities to the clinic. Analysis of the N-linked glycans from murine tissues\; astrocytes\, a non-metasta tic astrocytoma\, and two metastatic cancer cell lines\, we summarize ho w a single ion trap instrument\, using sequential MSn\, unravels the num erous details of oligosaccharide structure to provide tissue specific si gnatures.\n\nMETHODS\nCells were prepared from spontaneous murine brain tumors. N-linked glycans were released enzymatically and purified via 1. 5 ml C18 SPE cartridges and Porous Graphitized Carbon mini-columns. Samp les were profiled in multiple ways\, e.g.\, +/- ion extraction\, native\ , and as various derivatives\, (reduced\, methylated\, reduced-methylate d). Glycan topologies were provided by sequential MSn analyses (LTQ) sup ported with related computational tools. Structures were entered into Gl ySpy\, a set of tools for data handling\, complete with the glycan topol ogy assignment algorithm\, OSCAR. Isomers were resolved non-chromatograp hically\, some not detected until multiple levels of MS3-5 disassembly.\ n\nPRELIMINARY DATA\nComparative glycan profiles portray compositions in dicative of brain origin. Interestingly\, two tumor cell lines were high ly invasive when grown in the brain and metastasized to multiple organ s ystems when grown subcutaneously in the flank. One tumor cell line was m alignant\, but not invasive in brain and did not metastasize when grown subcutaneously. Profiles were unique to each of these cell lines generat ing a distinct and unique mass spectral fingerprint. The epitopes found are known to influence cell migration and plasticity in the CNS and HNK- 1 has been positively correlated with cancer metastasis.\n\nNOVEL ASPECT S\nThe data strongly suggests that ion trapping will be a critical compo nent to achieve a comprehensive glycome analysis.\n UID:9C20356C-163B-4205-92F0-48E3D514217A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080411T160000 DTSTAMP:20080326T140722Z SUMMARY:Inaugural Glycomics & Glycoproteomics Seminar Series: Vernon N. Reinhold\, UNH. 4:00\, MM 115. \"Molecular Glycosylation: A Comprehensiv e Structural Evaluation using IT-MS.\" Host: Carthene Bazemore-Walker. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080411T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:ABSTRACT: FabH and FabF are essential enzymes in type II fat ty acid synthesis and are promising targets for antibacterial drug disco very and development. A new approach using a xylose inducible plasmid to express antisense RNA (AS-RNA) in Staphylococcus aureus has been recent ly described. In order to identify FabF/FabH target specific cell permea ble inhibitors from natural products\, we developed an agar-diffusion tw o-plate differential sensitivity assay. Because both the fabH and fabF g enes share the same operon\, the increase in fabF AS-RNA levels decrease s the expression of FabH and FabF proteins\, making the cells more sensi tive to FabF and/or FabH inhibitors. Using this assay\, we screened over 250\,000 natural product extracts followed by confirmation in biochemic al assays\, giving a hit rate of 0.1%. We discovered all known FabH and FabF inhibitors that included cerulenin\, thiolactomycin\, thiotetromyci n and Tu3010 from natural product extracts for the first time using a me chanism based screening approach. We discovered a number of novel natura l products as FabF inhibitors including platensimycin and platencin. The details of discovery process\, structures\, biological activities\, in vivo efficacy\, mechanism of action and inhibitor bound X-ray crystal st ructure\, key chemical modifications and biosynthesis will be discussed. UID:0900A939-8FA6-4A2C-91C1-63E943D683F2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071130T160000 DTSTAMP:20071121T174700Z SUMMARY:Friday Colloquium: Sheo Singh\, Merck. 4:00 - 5:30\, MM115. \"No vel Approaches for Antibiotic Discovery\, Discovery of Platensimycin & P latencin.\" Host: Jason Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071130T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:9165FE14-1A08-44BD-A6B4-A0B58A388DA7-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070215T120000 DTSTAMP:20070215T200317Z SUMMARY:Inorganic Seminar: Jaemin Kim\, Brown University. 12:00 - 1:15\ , GC 351. \"Synthesis of FePt Nanocubes & their Oriented Self-Assembly.\ " Host: Sheng Peng. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070215T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:8C29FC92-624C-4235-AC04-17CC3784F664-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061207T160000 DTSTAMP:20061109T202030Z SUMMARY:Organic Faculty Candidate Research Seminar: Xuefeng Guo. MM117\, 4:00 - 5:50. \"Assembly & Emergent Functions of Molecular Nanomaterials & Nanosystems.\" Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061207T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Interactions between positive charge centers and d elocalized electron systems play a large role in determining folding str uctures of biological and supra-molecular systems. As a model system we have chosen N\,N-dimethyphenethylamine (PENNA)\, which embodies a archet ypical cation-pi system with an amine and benzene held in close proximit y by a aliphatic spacer. By selective excitation to a Rydberg state of t he amine moiety we can watch the time evolution of the interaction of th e newly generated positive charge center with the delocalized electron d ensity of the phenyl group by time delay of the ionizing pulse. UID:75611F27-FF14-44BB-A463-BEAFA372DD13-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090326T150000 DTSTAMP:20090403T175858Z SUMMARY:Physical Chemistry Tea Session : Joseph Bush\, Brown University. \"Probing the Cation-Pi Interaction: N\,N-Dimethylphenethylamine.\" Hos t: Gerald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090326T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: A novel technique for probing molecular structures \, the relaxation-assisted two-dimensional infrared (RA 2DIR) spectrosco py method is proposed and illustrated. It relies on vibrational energy t ransport in molecules and has similarities to TOCSY and HMBC methods of 2D NMR. A correlation of the energy transport time with the transport di stance on a molecular distance scale is demonstrated. With the goal of c alibrating the distance dependence of the arrival time we have studied a set of molecular systems with various bridging motifs that feature vari ous types of bonds\, including hydrogen\, coordination and various coval ent bonds. The analytical power of the RA 2DIR method is demonstrated on several molecular systems\, including model compounds\, peptides and tr ansition metal complexes. Cross-peaks for modes separated by distances g reater than 11Å can be easily detected. UID:8BC2CD35-2017-4E55-9D3D-A80A50CB61CD-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080509T160000 DTSTAMP:20080512T191649Z SUMMARY:Friday Colloquium: Igor Rubtsov\, Tulane University. 4:00 - 5:30 \, MM 115. \"Bond Connectivity Accessed via Multi-Dimensional Infrared S pectroscopy.\" Host: Vlastimil Fidler/Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080509T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:F1E395D0-6A3A-11D9-A410-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050303T150000 DTSTAMP:20050128T215845Z SUMMARY:Physical Tea Session: Theis Sølling\, University of Copenhagen\, Denmark. 3:00 - 4:15\, GC 351. \"Are Conical Intersections Responsible for the Ultrafast Processes of\nAdenine\, Protonated Adenine & the Corre sponding Nucleosides?\" Host: Peter Weber. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050303T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Diffusion-ordered NMR spectroscopy (DOSY) has been established as an efficient means for the separation of the NMR resonan ces in mixtures of compounds in solution. With appropriate internal refe rences\, formula weights of organic compounds or organometallic complexe s can be estimated within ±10% error. In this talk\, backgrounds of DOSY will be explained in detail. A summary of research will be presented in two parts. The former is development of methods for diffusion NMR\, inc luding internal references for 1H\, 13C\, 31P\, 6Li\, 19F\, 29Si DOSY an d physically separated diffusion systems with its applications. The latt er is various DOSY applications in organolithium aggregates studies. The construction of the DOSY research platform\, in combination with variou s NMR techniques\, will greatly foster more chemical research projects. UID:98D0AF87-74C3-4C50-8E44-BC12D098EBE5-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100420T110000 DTSTAMP:20100421T125548Z SUMMARY:Organic Chemistry Seminar: Weibin Li\, Brown University. \"Devel opment of Diffusion-Ordered NMR Spectroscopy for Chemical Research.\" Ho st: Jason Sello. GC351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100420T114500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:335A20F8-94D6-4953-AD4C-39956F40C02F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101015T160000 DTSTAMP:20100421T144341Z SUMMARY:Friday Chemistry Colloquium: Carl Lineberger\, University of Col orado. Title and abstract to come. Host: Lai-Sheng Wang. GC 351\, 4:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101015T171500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:28B29F86-9141-43AD-85C7-237FB93DEBFD-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071108T120000 DTSTAMP:20071102T161017Z SUMMARY:Inorganic Seminar: Thomas Webster\, Brown University. 12:00 - 1: 15\, GC 351. \"Nanotechnology for Regenerating Tissues: Is it Hype or Re ality?\" Host: Shouheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071108T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: Lipids play important roles in regulating the acti vity of biological systems. With more than 10\,000 different lipids iden tified\, lipids have been implicated in all manner of cellular processes from signaling\, recognition\, adhesion to trafficking. While some lipi ds have been linked to certain cellular activities\, much remains unknow n regarding the import of lipid structure as related to biological funct ion. One example is the formation and role of lipid microdomains in biom embrane systems. Here we demonstrate the use of vibrational spectroscopy as a key tool in understanding lipid interactions in both model systems and intact cells. The vibrational spectrum arises from the oscillation of chemical bonds within molecules\, eliminating the need for a tag or r eporter molecule. Our current experimental results have successfully ide ntified chemical heterogeneity in model membrane bilayers and indicate l ipid domains on the order of 10’s of nanometers. Complementary measureme nts indicate possible roles of these microdomains in regulating cellular activity. To investigate these nanoscale domains further\, we are devel oping a high-spatial resolution microscope that has the potential to obs erve these microdomains in intact cells. High-resolution vibrational spe ctroscopic imaging offers tremendous promise for elucidating chemical an d spatial heterogeneity. We have achieved spatial resolution of approxim ately 100nm in our experiments\, and our Raman near field optical micros copy results suggest that label free\, nanoscale\, biological imaging is nearing reality. UID:CD2D9CC9-2B57-4DC7-B620-0B1073AFFFC1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081215T160000 DTSTAMP:20081126T202046Z SUMMARY:Biophysical Faculty Candidate Seminar: Zachary Schultz\, Nationa l Institutes of Health. “Characterization of Nanoscale Heterogeneity in Biomembrane Systems.\" Host: Christoph Rose-Petruck. 4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081215T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:4AEF4F47-2C2C-11D9-8174-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041104T130000 DTSTAMP:20041101T173447Z SUMMARY:C. Frez\, T. Hamilton\, M. Minitti: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041104T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Flexible molecules may assume numerous conformeric structures when interrogated at chemically significant temperatures. Bu ilding upon the breakthrough that low-n Rydberg states provide sensitive fingerprints of molecular structures\, we observe conformational change s of several tertiary amines in the presence of complex energy landscape s at internal temperatures exceeding 500K. Ultrafast time-resolved mass and photoelectron spectra were obtained by employing resonant enhanced m ulti-photon ionization through low-lying Rydberg states. We establish th e equilibrium composition and dynamics between such conformeric structur es using Rydberg Fingerprint Spectroscopy. Examples are presented for se veral tertiary amines\, such as N\,N-dimethyl-2-butanamine (DM2BA)\, N\, N-dimethyl-3-hexanamine (DM3HA) and N\,N\,N-triethylamine (TEA). Additio nally\, N\,N\,N'\,N'-tetramethyl-1\,2-ethanediamine (TMEDA) not only dem onstrates ultrafast conformeric conversion\, but exhibits distinctive cl uster dependent behavior resulting in spectacularly altered Rydberg elec tron binding energy spectra. UID:B0938352-25B7-4F83-89AC-8921BE122EF1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090319T150000 DTSTAMP:20090313T151721Z SUMMARY:Physical Chemistry Tea Session: Michael Minitti\, Brown Universi ty. \"Conformer Dynamics in Vibrationally Hot Tertiary Amines Probed wit h Ultrafast Rydberg Fingerprint Spectroscopy.\" Host: Gerald Diebold. 3: 00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090319T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: The nanotechnology movement has produced a variety of new materials with potential use in medical devices and therapies. A t the same time\, unintended human exposure to nanomaterials may cause a dverse health effects that cannot at present be predicted. In a simila r way\, nanomaterials may help the environment as engineered sorbents or catalysts\, but may also do harm to the environment through unanticipat ed interaction with microbial communities or terrestrial or aquatic orga nisms. Most of these interactions\, both the good and the bad\, are ulti mately governed by chemical pathways triggered by nanomaterials surface contact with biological or environmental molecules and fluid phases. Thi s presentation gives an overview of ongoing research on nanomaterials ch emistry in the Robert Hurt laboratory\, focusing on carbon nanotubes\, n anosilver\, and nanoselenium\, and their chemical interactions with biol ogical and environmental fluids\, cells\, subcellular structures and who le organisms. UID:CEF118F0-A564-4D85-BE0F-61B3CBA81371-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091104T120000 DTSTAMP:20091027T124509Z SUMMARY:Inorganic Chemistry Seminar: Robert Hurt\, Brown University. \"T he Biological & Environmental Chemistry of Nanomaterials.\" Host: Wesley Bernskoetter. 12:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091104T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:F962A4B2-5E93-11D9-AD5B-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050117T160000 DTSTAMP:20050104T210637Z SUMMARY:Craig Masse\, Amgen\, Organic Faculty Candidate\, 4:00 - 5:15\, GC 351\, \"Total Synthesis of (+)-Lactacystin: An Application of Chiral (E)-Crotylsilane Bond Constructions\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050117T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:77D32959-31E5-11DB-82DD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060928T120000 DTSTAMP:20060919T182924Z SUMMARY:Inorganic Seminar: Chao Wang\, Brown University. 12:00 - 1:15\, GC 351. \"Dumbbell-like Composite Nanoparticles: Chemical Synthesis & Ca talytic Applications.\" Host: Shuangbing Han. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060928T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:DFEBC3DE-04EF-11DA-8657-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050818T104500 DTSTAMP:20050810T132133Z SUMMARY:Organic Seminar: Paul O'Shea\, University of Nottingham. 10:45 - 12:00\, GC351. \"Visualising Molecular Interactions with/within Membran es.\" Host: Amit Basu. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050818T120000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:CB14FD5F-2841-42C6-AEA2-B3AB59DCA67E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100320T080000 DTSTAMP:20100309T213921Z SUMMARY:Prospective Graduate Student Visitation CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100320T090000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:1728A0CD-7BD6-11DA-84F7-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060124T110000 DTSTAMP:20060120T150800Z SUMMARY:Organic Seminar: Marcus Faust\, Brown University. 11:00 - 12:30\ , GC 351. \"Synthesis of Fluorinated Cytosine Analogues & Glycosyl Pyraz oles & a Synthetic Approach to a 'Schulzeine'.\" Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060124T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Recently developed methods for simulating electroc hemical processes will be presented with particular reference to reactio ns that relate to renewable energy and environmental issues\, such as fo rmation of hydrogen by electrolysis of water\, formation of ammonia from nitrogen and hydrogen and formation of methanol from CO2. A central iss ue is the search for better catalysts on the electrode surfaces. Computa tional studies could help identify likely candidates faster and with a l ower cost. UID:A3695AE5-9E7F-477D-AE4C-104B9C8189C2-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100318T150000 DTSTAMP:20100311T204851Z SUMMARY:Physical Chemistry Tea Session: Hannes Jonsson\, Brown Universit y. \"Theoretical Studies of Electrochemical Reactions Related to Energy & Environmental Issues.\" Host: Gerald Diebold. GC 351\, 3:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100318T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:5C8F29DA-1625-4210-929A-F631E546000F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061017T090000 DTSTAMP:20061011T154407Z SUMMARY:Organic Seminar: Rosaria Rella\, Brown University. 11:00 - 12:30 \, GC 351. Selective Oxyfunctionalization of Bioactive Molecules using D ioxiranes. Host: Jason K. Sello CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061017T100000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Fe-Pt composite nanoparticles showed slow release of Fe under acidic conditions\, which was related with different coating and compositions. The released iron has been identified as the oxidativ e stress inducing agent and caused lipid oxidation through Fenton reacti ons. After functionalization with c(RGD)\, Fe-Pt nanoparticles showed sp ecificity to U87 cancer cells and reduced the growth of U87 tumour growt h in mouse. UID:A3E807F8-444C-4839-831D-D1874057942C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081106T120000 DTSTAMP:20081030T194725Z SUMMARY:Inorganic Chemistry Seminar: Chenjie Xu\, Brown University. \"T herapeutic Nanoparticles: Controllable Fenton Reaction Induced by Fe-Pt Nanoparticles for Tumor Growth Inhibition.\" Host: Shouheng Sun. 12:00 - 1:15\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081106T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:C1BA72E5-73D6-4543-827A-C1B2CFA80CCA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20091202T130000 DTSTAMP:20091124T190128Z SUMMARY:PhD Thesis Defense: Tongsik Lee\, Brown University. Title and a bstract to come. Presiding Officer: Jimmie Doll. 1:00\, GC 246. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091202T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:E531C534-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041102T130000 DTSTAMP:20040930T165107Z SUMMARY:Julia Barkin: organic seminar CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041102T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:F59FED44-1301-11D9-88BD-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20040928T130000 DTSTAMP:20040930T165843Z SUMMARY:Fengtian Xue: organic seminar CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20040928T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:E31E4D63-A859-419B-B3CE-5F5CF597E85C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100427T110000 DTSTAMP:20100422T212200Z SUMMARY:1st Year Students Organic Chemistry Seminars. Daniel Carney\, Ro nald Okoth\, Kyle Totaro. Host: Jason Sello. GC 351\, 11:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100427T121500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:EE2AAD06-F274-4C79-92B2-9111E29DF70D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070308T150000 DTSTAMP:20070205T201535Z SUMMARY:Physical Chemistry Tea Session: Crystal Nguyen\, Brown Universit y. 3:00 - 4:15\, GC 351. Title to come. Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070308T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:43D97B9B-E68A-4B2E-915B-883FFA5E20CC-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101202T120000 DTSTAMP:20100618T151136Z SUMMARY:Physical Chemistry Tea Session: Mathias Weber\, JILA\, Universit y of Colorado. Title & abstract to come. Host: Lai-Sheng Wang. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101202T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Zn2+ has many well-understood structural and catal ytic functions of in biology\; in addition\, current research suggests t hat free Zn2+ may function as a neurotransmitter and have a role in the pathology of several neurological diseases. While fluorescent sensors ca n be used to image endogenous metal ions\, directly correlating fluoresc ence signals to specific biological events can be difficult. In order to elicit a physiological response\, Zn2+ can be released from synaptic ve sicles by electrical stimulation\, or applied exogenously. Although obse rvations made using these techniques may suggest certain functions\, the concentration of Zn2+ used to initiate the activity may not be physiolo gically relevant. Caged compound can circumvent this problem by allowing controlled release of the analyte. Caged compounds are metal ion chelat ors that release analytes when exposure to light of a specific wavelengt h. We are interested in developing several classes of caged-complexes fo r Zn2+ based on classic nitrobenzyl-based photochemistry. Two general st rategies have been pursued successfully to realize the primary goal of m aking caged complexes: placing a nitrobenzyl group onto an aniline ring such that photolysis weakens an aniline nitrogen-zinc interaction and in tegrating a nitrobenzyl group on the backbone of a zinc chelator so that uncaging fragments the ligand. We have devised several new synthetic st rategies for these two classes of ligands known as ZinCast and ZinCleav respectively and have conducted detailed binding and photochemical studi es with the Zn2+ complexes. UID:ED242AE3-D70A-4AA0-B4D3-B603197CD088-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091120T160000 DTSTAMP:20091106T205836Z SUMMARY:Friday Chemistry Colloquium: Shawn Burdette\, University of Conn ecticut. \"Development of Caged-Complexes for Studying Zn2+ Signaling & Homeostasis.\" Host: Eunsuk Kim. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091120T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:5660FA11-552D-48F6-BEFD-DB7AF8CE1ADD-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070419T150000 DTSTAMP:20070413T165742Z SUMMARY:Physical Chemistry Tea Session: Brenda Rubenstein\, Brown Univer sity. 3:00 - 4:15\, GC 351. \"Liquid Crystals: Unique Structure\, Unique Dynamics?\" Host: Jimmie Doll CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070419T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:4677FD93-0E73-4F08-AD76-9CF73496C4B8-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T154500 DTSTAMP:20080813T125138Z SUMMARY:Closing Remarks. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:BE2A1212-D0A4-11DA-A22C-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060508T160000 DTSTAMP:20060427T140655Z SUMMARY:Joint Physics/Chemistry Colloquium: J. Peter Toennies\, MPI\, Ge rmany. 4:30 - 5:30\, MM 117. \"Quantum Magical Helium & Hydrogen Cluster s.\" Host: Peter Weber. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060508T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:697E60B2-9812-11DA-8A50-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060223T120000 DTSTAMP:20060216T173543Z SUMMARY:Inorganic/Materials Seminar: Steve Barry\, BioScience\, Inc. 12: 00 - 1:15\, GC 351. \"Nanoparticles for Diagnosing & Treating Cancer.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060223T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: Tetrahydroisoquinolines (THIQs) are an important s tructural motif in many alkaloids\, and they display significant biologi cal and pharmacological properties. A majority of these compounds posses s a chiral center at the C-1 position\, while stereoisomers at this posi tion exhibit very different activities. Thus\, the enantioselective synt hesis of 1-substituted-THIQs is of great interest to both organic and me dicinal chemists.\n In this thesis\, we first report the enantioselectiv e addition of vinylzinc reagents to 3\,4-dihydroisoquinoline N-oxide. Wi th an N-acylethylenediamine ligand as the catalyst\, we obtained a group of chiral N-hydroxyl-1-vinyl-THIQs in 62-85% yield and 90-95% ee. A var iety of aliphatic\, cyclic and aromatic vinylzinc reagents was employed in the reaction. This method was used to synthesize a single enantiomer of the unnatural amino acid N-Cbz-D-1\,2\,3\,4-tetrahydroisoquinoline-1- carboxylic acid. \n Next\, we describe a novel\, expedient synthesis o f chiral 1-aryl-THIQs\, in which the key step is the asymmetric addition of arylzinc reagents to 3\,4-dihydroisoquinoline N-oxide catalyzed by t he diamine ligand. With aryl pinacolyl boronic esters as arylzinc precur sors\, we achieved good yields (35-99%) and excellent enantioselectiviti es (97-99% ee) in the reaction. This methodology was demonstrated throug h the enantioselective synthesis of the GlaxoSmithKline drug – Solifenac in. \n Finally\, we investigated the mechanism of the enantioselective addition of arylzinc reagents to 3\,4-dihydroisoquinoline N-oxide. We ad opted a systematic strategy to study this complex system by using a wide range of NMR techniques. This includes 1D and 2D NMR\, diffusion-order NMR spectroscopy\, job plot\, NMR titration and in-situ NMR kinetic meas urement. Through these studies\, we obtained information about bonding\, structure and molecular interactions of reactive intermediates along th e reaction pathway. We also found that the reaction occurs via a binucle ar-zinc intermediate in which one zinc atom serves as a Lewis acid while the other zinc atom carries the aryl nucleophile. Comparison of reactio n rates showed that the catalyzed arylation reaction proceeds faster tha n the non-catalyzed process. Altogether\, we propose a catalytic cycle f or the asymmetric arylation reaction. The preference for formation of th e (S)-product was rationalized by examining the conformations of differe nt transition states.\n UID:45AECE14-4EF9-420E-86CA-AD323D52E3AE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090930T130000 DTSTAMP:20090924T130011Z SUMMARY:PhD Thesis Defense: Synthesis\, Application & Mechanistic Studie s of Asymmetric Addition of Organozinc Reagents to 3\,4-Dihydroisoquinol ine N-Oxide\, Sa Wang\, Brown University. Presiding Officer: Christopher T. Seto. GC 351\, 1:00.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090930T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:C7554EFA-666C-417E-83A6-F13EF038520B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071019T160000 DTSTAMP:20071016T131600Z SUMMARY:Friday Colloquium: Vojislav Stamenkovic\, Argonne National Labs. \, 4:00 - 5:30\, MM 115. \"Nanocatalyst Engineering: From Extended to Na noscale Surfaces\" Host: Shouheng Sun. (Radisson) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071019T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Acetogenic bacteria such as Moorella thermoacetica can grow on the greenhouse gas CO2. These organisms use the Wood-Ljungda hl carbon fixation pathway to convert CO2 into acetyl coenzyme A. The bi functional carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS)\ , which is responsible for the reduction of CO2 to CO and subsequent ass embly of acetyl-CoA\, is a key enzyme in this pathway. In contrast\, met hanogens use a CODH/ACS in the degradation of acetyl-CoA to form CO2 and another greenhouse gas\, methane. Monofunctional CODH enzymes are found in organisms such as Rhodospirillum rubrum\, which have the ability to utilize CO as a sole carbon and energy source. As a consequence of these activities\, organisms that contain CODH and/or CODH/ACS enzymes are es sential for the proper regulation of environmental CO. Each year up to 1 08 tons of CO are oxidized to CO2 by aerobic and anaerobic bacteria cont aining CODH enzymes (Bartholomew\, G. W. & Alexander\, M. (1979) Appl. Environ. Microbiol. 37\, 932-937). Because of their unusual metalloclust ers\, their use of biological organometallic reaction intermediates and their role in reducing levels of gaseous pollutants CO and CO2 in our en vironment\, CODH enzymes have been the subject of intense study. Here\, we will present crystallographic snapshots of these enzymes in action an d discuss the mechanistic implications of these structural studies. UID:EAF55926-BDD6-4BAF-BE50-7FCFF5DB2A8B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090508T160000 DTSTAMP:20090429T201707Z SUMMARY:Friday Chemistry Colloquium: Catherine L. Drennan\, MIT. \"Regul ation of Environmental CO & CO2 Levels by Metalloenzymes.\" Host: Eunsuk Kim. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090508T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:11 DESCRIPTION:Abstract: Meeting the clean energy need of human activities is one of the most challenging scientific problems of the 21st century. Novel solar cells that are based on nanocomposites materials provide a p otential approach for efficient and low cost solar energy conversion. Th e performance of these as well as other nanoparticle-based devices depen ds critically on the dynamics of charge transfer in and out of semicondu ctor nanoparticles. We have systematically investigated these dynamics a t molecule/ nanoparticle interface by ultrafast transient absorption\, s ingle molecule fluorescence and nonlinear spectroscopic techniques. I w ill discuss how the interfacial electron transfer rate depends on the na ture of the semiconductor and the effect of quantum confinement. UID:63D72DCA-FEBD-481C-9703-8DF9C6960CBA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080204T160000 DTSTAMP:20080125T171801Z SUMMARY:Nano Faculty Candidate: Tianquan Lian. 4:00 - 5:30\, MM 115. \"U ltrafast Electron Transfer at Nanoparticle/Molecule Interface.\" CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080204T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:5932B958-E517-49C0-BE86-6ED97199916E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101014T160000 DTSTAMP:20100421T144327Z SUMMARY:Appleton Lecture: Carl Lineberger\, University of Colorado. Titl e and abstract to come. Host: Lai-Sheng Wang. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101014T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:32E2B3BE-9473-44CD-A463-AE6ADE4B1638-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070323T160000 DTSTAMP:20070319T183707Z SUMMARY:Friday Chemistry Colloquium: Forrest Michael\, University of Was hington. 4:00 - 5:30\, MM115. Title to come. Host: William C. Trenkle (F letcher House) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070323T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:01C8F70A-FB20-4748-879B-48390F16156A-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070301T120000 DTSTAMP:20070223T194711Z SUMMARY:Inorganic Seminar: Chenjie Xu\, Brown University. 12:00 - 1:15\, GC349. \"Application of Magnetic Nanoparticles in Cancer Cells Imaging & Detection.\" Host: Sheng Peng CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070301T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Hydrated electrons are ubiquitous intermediates in radiation-induced processes in aqueous environments. The delocalized el ectron formed by ionization of water turns into the hydrated electron re siding in a polarized cavity in a fast localization process. The resulti ng hydrated electron is a transient species that will readily react with various solutes. Some of these reactions are dangerous\, either because they damage the solutes or because they create dangerous products. An e xample of such a reaction\, important especially in acidic environments\ , is the reaction with a hydrated proton to form a hydrogen atom. Using ab initio molecular dynamics\, we follow the localization process after electron attachment to a water cluster and the formation of the hydrated electron. We study equilibrium properties of the hydrated electron and we also examine its reaction with a hydrated proton\, extracting the rea ction mechanism of this elementary process. This approach provides spati al and temporal resolution unavailable to other methods\, allowing extra ction of detailed information about the processes of interest.\n\nAnimat ions of several trajectories\, including the localization process and th e electron-proton reaction\, can be found at http://marge.uochb.cas.cz/~ marsalek/electron-animations/.\n UID:27BC2EFF-04E9-4618-A565-1C25C466203C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100726T150000 DTSTAMP:20100630T212121Z SUMMARY:Physical Chemistry Seminar. Ondrej Marsalek. \"Localization & Re activity of the Hydrated Electron.\" Host: Lai-Sheng Wang. 3:00\, GC 351 . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100726T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 DESCRIPTION:Abstract: The enzyme inhibitor studies reported in this thes is target protein tyrosine phosphatases (PTPases) and matrix metalloprot einase-1 (MMP-1). Hydroxamic acids are good inhibitors of MMP-1. However \, they lack specificity and as a result have not successfully passed cl inical trials. To address this issue we have designed a hybrid between squaric acid and a hydroxamic acid to create a vinylogous hydroxamic aci d inhibitor for MMP-1. \n\nHigh levels of PTP-1B activity impair the si gnaling cascade initiated by insulin. Knock out studies in mice show tha t PTP-1B is a negative regulator of glucose metabolism and is a contribu ting factor in Type II diabetes. The PTP Yop H contributes to the virule nce of the plague-causing bacterium Yersinia pestis. We have designed a series of inhibitors based on squaric acid to inhibit these PTPases. We have also designed multidentate bis-α-ketoacids as PTP inhibitors to add ress issues of specificity. This can be a significant challenge since ma ny biologically important PTPases are structurally homologous in their a ctive site regions.\n UID:B5A9625F-5155-4BAB-81CD-43ECCA97C73C-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091023T140000 DTSTAMP:20091015T194646Z SUMMARY:PhD Thesis Defense: Anthony Comeau\, Brown University. \"Design\ , Synthesis & Testing of Biologically Active Small Molecules.\" Presidin g Officer: Christopher Seto. 2:00\, MM 317. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091023T150000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:16E1C51E-FF34-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20031023T150000 DTSTAMP:20031015T172304Z SUMMARY:Tea Session Speaker: Arthur Suits\, SUNY at Stony Brook CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20031023T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 DESCRIPTION:Abstract: Many diseases cause changes in the mechanical prop erties of tissue. These changes are caused either by exudation of fluids from the vascular system into the extra- and/or intracellular space or by loss of lymphatic systems\, as in the case of cancer. The result is a n increase in stiffness or a change of elastic modulus of the tissue. Im aging of such changes holds great promise for an early diagnosis of path ological abnormalities in the soft tissue. \n\nOne of the goals of our r esearch group is to improve the X-ray imaging of the biological tissue b y utilizing the phase contrast generated by a transverse acoustic wave. The particular objective of my work I will be reporting on was to show w hether a displacement caused by the shear wave propagation can be imaged with an increased contrast\, and how it can provide useful information on the mechanical properties and their changes throughout the tissue.\n UID:43EBC081-A3B1-4352-8E42-F8BA302FB91B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090226T150000 DTSTAMP:20090220T210519Z SUMMARY:Physical Chemistry Tea Session: Eva Sebronova\, Brown University . \"Tissue X-Ray Imaging with Acoustic Shear-Wave Modulation.\" Host: Ge rald Diebold. 3:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090226T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:F75C111C-814E-11DA-BCA2-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060309T150000 DTSTAMP:20060224T225425Z SUMMARY:Physical Chemistry Tea Session: Art Voter\, Los Alamos National Laboratory. 3:00 - 4:15\, GC 351. \"Accelerated Molecular Dynamics Metho ds.\" Host: Jimmie Doll. Inn at Brown 3/8-10 CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060309T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:A0F84B4C-FF34-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20031121T160000 DTSTAMP:20031015T172630Z SUMMARY:Clapp Lecture - Speaker: Ruggero Curci\, University of Bari\, It aly CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20031121T174500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:60C27412-FCE1-490D-9323-C6BBDB4FBEF4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100408T150000 DTSTAMP:20100416T190109Z SUMMARY:Physical Chemistry Tea Session: Yanan Liu\, Brown University. T itle and abstract to come. Host: Gerald Diebold. GC 351\, 3:00. (Refresh ments Jinyu Liu) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100408T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:10 DESCRIPTION:Abstract: I shall report several major research findings fro m my group\, including new phases of low-dimensional nano-ices\, e.g.\, ice nanotubes and helical ices\, superhydrophobic phenomena at the nanos cale\, e.g.\, lotus effect at nanoscale and growth patterns of small-to- medium sized gold and silicon clusters. UID:C002AAD5-1162-45C6-972F-BDDB4FD2838B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20091216T160000 DTSTAMP:20091211T141016Z SUMMARY:Nanoscience Faculty Search Candidate: Xiao Cheng Zeng\, Universi ty of Nebraska. \"Computer-Aided Nanoscience Research: Nano-ice\, Nanocl usters & Superhydrophobicity.\" Host: Shouheng Sun. 4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20091216T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: An approach to anticancer drug design is described in which a DNA damaging nitrogen mustard is tethered to a ligand for th e estrogen or androgen receptors. DNA adducts formed by the mustard attr act the receptor\, which engages the adducts in a tight noncovalent comp lex. The androgen receptor is expressed in most prostate tumors\, and th e estrogen receptor is expressed in many breast and ovarian tumors. One consequence of the binding of a receptor to the DNA adduct is that the a dduct becomes shielded from DNA repair enzymes. Thus\, the adduct persis ts in vivo (in tumor cells) and shows enhanced toxicity in steroid recep tor positive tumors. The new DNA damaging agents also disrupt signaling pathways in malignant cells. The androgen receptor\, for example\, is a transcription factor that controls pathways of growth as well as mainten ance of secondary sexual characteristics. The compounds we designed form DNA adducts to which the androgen receptor binds – because the receptor is bound to the adducts (numbering in the tens of thousands) – its tran scription-promoting properties are thereby effectively “hijacked.” As a consequence\, cancer related gene expression is severely disrupted. UID:A9E34802-F31C-4AB1-BEA1-5AA62DA2048D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080321T160000 DTSTAMP:20080305T211943Z SUMMARY:Friday Colloquium: John Essigmann\, MIT. 4:00\, MM 115. \"Design of DNA Damaging Agents that Block DNA Repair & Disrupt Cancer Specific Cellular Signaling Programs.\" Host: Sarah Delaney. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080321T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Mastery over the shape of a nanostructure enables control over its properties and usefulness for a given application. I wi ll show that by controlling the crystallinity of the seeds from which na nostructures grow and the rate of atomic addition to seeds\, one can sel ectively produce pentagonal nanowires\, cuboctahedra\, nanocubes\, nanob ars\, bipyramids and nanobeams of silver with a solution-phase polyol sy nthesis. I will also show how single-crystalline nanowires of silver and gold can serve as plasmonic waveguides that enable the confinement and guiding of light at scales below its free-space wavelength. UID:566A0480-402F-413B-93AB-999DAC9920C6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090115T160000 DTSTAMP:20090107T215203Z SUMMARY:Nano Chemistry Search Candidate: Benjamin Wiley\, Harvard Unive rsity. \"Controlling the Assembly of Atoms into Nanostructures that Guid e Light at the Nanoscale.\" Host: Shouheng Sun. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090115T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:A721285E-3DC6-48BE-9F8C-D2FA7BAC4797-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20110128T120000 DTSTAMP:20100615T202041Z SUMMARY:Friday Chemistry Colloquium: Jonathan Lindsey\, North Carolina S tate University. Title & abstract to come. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20110128T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:B7E3844C-E92D-4D21-9936-E1E787696453-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T144500 DTSTAMP:20080813T124946Z SUMMARY:Kang Sun\, PhD\, '88. Index Capital Group. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T151500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:44049266-FF34-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20031024T160000 DTSTAMP:20031015T172349Z SUMMARY:Colloquium Speaker: Rob Hinkle\, College of William & Mary CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20031024T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Titanium is not widely appreciated as a \"biologic al metal\,\" even though it accumulates in (and can be used to image or treat) tumors\, it gets transported around the body and affects bacteria l growth\, and it is sequestered to remarkable concentrations by some ma rine organisms. The aqueous chemistry of Ti(IV) is challenging because t he ion is so prone to hydrolysis. This presentation will report on our s tudies of titanium coordination chemistry under biologically and environ mentally relevant conditions and of the interactions of titanium ions an d complexes with biological molecules.\n UID:4CFBA391-E6FE-452D-9E72-8696DF6A777D-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081107T160000 DTSTAMP:20081028T190055Z SUMMARY:Friday Chemistry Colloquium: Ann M. Valentine\, Yale University. \"Bioinorganic Chemistry of Titanium in Medicine & the Environment.\" H ost: Eunsuk Kim. 4:00 - 5:30\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081107T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Abstract: X-ray phase-contrast imaging methods have dramatic advantages over conventional X-ray imaging methods\, and are being acti vely developed for a variety of important biomedical imaging application s. These methods exploit the fact that\, at diagnostic X-ray energies\, variations in the real component of the refractive index of soft tissues are several orders of magnitude larger than variations in the imaginary component\, or equivalently\, the X-ray attenuation coefficient. Conse quently\, X-ray phase-contrast imaging may permit the visualization of t issues that have identical\, or very similar\, X-ray absorption properti es. We describe recent advancements in the image reconstruction theory f or phase-contrast imaging and tomography. Based on the imaging physics\, robust methods for phase-retrieval and tomographic image reconstruction from limited data sets are described. UID:845E43AE-9714-4D6B-8091-429461940666-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090220T160000 DTSTAMP:20090209T161722Z SUMMARY:Friday Chemistry Colloquium: Mark A. Anastasio\, Illinois Instit ute of Technology. \"Quantitative Methods for Image Reconstruction in X- Ray Phase-Contrast Imaging & Tomography.\" Host: Christoph Rose-Petruck. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090220T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:71A86D62-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041014T130000 DTSTAMP:20040930T164800Z SUMMARY:Faculty Research: tea session CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041014T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:DEC27D7E-053D-4929-B292-A238690569D4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20090508T110000 DTSTAMP:20090505T212954Z SUMMARY:Energy Forum\, 11:00 - 4:00\, GC 349/351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090508T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:BD92121B-370D-4CF8-9C44-9918712F6329-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070419T120000 DTSTAMP:20070226T222435Z SUMMARY:Inorganic/Materials Seminar: Michael McHenry\, Carnegie Mellon U niversity. 12:00 - 1:15\, GC 351. \"The Role of Surface Crystallography & Faceting & Chemical Order in Magnetic Applications of Nanoparticles & Nanocomposites.\" Host: Shouheng Sun. (Inn at Brown) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070419T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:Details: Four alumni from the Chemistry Department with diff erent career paths will be on hand to talk about their time after Brown and to answer any questions you have abut what you can do with a degree in chemistry. All concentrations welcome! UID:A19535D5-BB3F-4FD9-84D1-1447ACD4EBF3-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100316T180000 DTSTAMP:20100312T213834Z SUMMARY:Brown Degree Days: Connecting Concentrations to the Real World\, MM 115\, 6:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100316T190000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:8DBE926E-CB2B-11DA-875B-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060509T110000 DTSTAMP:20060420T193923Z SUMMARY:Organic Seminar: Glenn Micalizio\, Yale University. 11:00am - 12 :30pm\, GC 351. \"Group 4 Metal-Mediated Reactions for Convergent Carbon -Carbon Bond Formation.\" Host: William C. Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060509T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:A9F37A2C-6BC0-11D9-925A-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050324T150000 DTSTAMP:20050128T215959Z SUMMARY:Physical Tea Session: Thomas Baumert\, Universitaet Kassel\, Ger many. 3:00 - 4:15\, GC 351. \"Ultrafast-Spectroscopy: Electrons\, Atoms\ , Molecules & Sunflowers.\" Host: Christoph Rose-Petruck.\n CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050324T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:83350B30-1300-11D9-81C1-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20041015T130000 DTSTAMP:20040930T164838Z SUMMARY:David Kiszkiss et al: colloquium (no schedule) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20041015T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:4C9D1F13-FB0F-4E60-B5F8-13B2239EF170-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070222T120000 DTSTAMP:20070221T193835Z SUMMARY:Inorganic Seminar: Kevin Rowland\, Brown University. 12:00 - 1:1 5\, GC 351. \"Metal-Organic Coordination Polymer Gels.\" Host: Sheng Pen g CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070222T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:D2C431D1-7226-400F-A2F7-11E6F71C65EB-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070322T120000 DTSTAMP:20070316T194035Z SUMMARY:Inorganic Chemistry Seminar: Sheng Peng\, Brown University. 12:0 0 - 1:15\, GC 351. \"Hollow Fe3O4 Nanoparticles: Synthesis\, Characteriz ations & Potential Applications.\" Host: Souheng Sun CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070322T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:A19FCFC9-9CF9-4DB3-A47F-20113C44EDB0-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100304T120000 DTSTAMP:20100222T141405Z SUMMARY:Inorganic Chemistry Seminar: Hongwang Zhang\, Brown University. Title and abstract to come. Host: Wesley Bernskoetter. GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100304T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:77D28263-9FED-11DA-A38F-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061201T160000 DTSTAMP:20061115T141632Z SUMMARY:Friday Chemistry Colloquium: Dalibor Sames\, Columbia Universit y. 4:00 - 5:30\, MM115. \"From Organic Synthesis to Imaging Metabolism & Neurotransmission.\" Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061201T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 TRANSP:OPAQUE UID:C8FE1786-B47C-4D8A-8364-78904FDEB6DE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20100129T160000 DTSTAMP:20100121T184725Z SUMMARY:Friday Chemistry Colloquium: Pavel Jungwirth\, Academy of Scienc es of the Czech Republic. \"Ultrafast Dynamics Following Photoionization in Water: Electrons & Cationic Holes.\" Host: Lai-Sheng Wang. MM 115\, 4:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100129T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:ABSTRACT: The NOx storage reduction catalyst is one of the m ore attractive methods to purify exhaust gases from the lean-burn engine . To improve the thermal stability and sulfur durability of the NOx stor age reduction catalyst\, novel nano-composite oxide supports containing Al2O3\, ZrO2 and TiO2 were\nsynthesized. I will discuss how nano-compos ite oxides meet the need for the NOx storage reduction catalyst. UID:66B08456-8071-4B53-8C76-874871F35C85-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071204T120000 DTSTAMP:20071126T151828Z SUMMARY:Inorganic Seminar: Haruo Imagawa\, Toyota Central R&D Labs\, Jap an. 11:00 - 12:15\, GC 351. \"Recent Progress in the NOx Storage-Reducti on Catalyst: Application of Nano-Composite Oxides.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071204T130000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:ABSTRACT:Bacterial resistance to antibiotics arises through a variety of mechanisms. We have recently identified novel inhibitors of bacterial efflux transporters that contribute to the multi-drug resista nce phenotype in certain microorganisms\, and have been working to under stand the structural requirements of quinolone-class antibiotics to rapi dly kill organisms possessing mutation-mediated resistance to fluoroquin olone antibiotics. This presentation will cover the design\, synthesis a nd evaluation novel 4-phenylpiperidines and quinolone-class antibiotics as anti-infective agents toward overcoming efflux-mediated and mutation- mediated resistance to antibiotics. UID:5CA255BF-09AD-4BF9-820E-4986BBC5219F-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070911T110000 DTSTAMP:20071119T203043Z SUMMARY:Organic Seminar: Rob Kerns\, University of Iowa. 11:00 -12:30\, GC 351. \"Design & Synthesis of Anti-Infective Agents toward Overcoming Mutation-Mediated & Efflux-Mediated Resistance to Antibiotics.\" Host: A mit Basu. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070911T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:12 DESCRIPTION:ABSTRACT: The controlled ring-opening polymerization (ROP) o f cyclic esters using well-defined metal alkoxide initiators is an impor tant route to well-defined biodegradable and biocompatible polyesters su ch as polylactide. We have recently shown that metal alkoxides supported by C3-symmetric amine tris (phenolate)s ligands offer a unique combinat ion of selectivity and activity as ROP initiators\, particularly under s olvent-free reaction conditions. This presentation will cover some of th e unusual main group and transition metal coordination chemistry that ot hers and we have developed using these fascinating ligands. Their applic ation as ROP initiators will be described\, including kinetic studies an d polymer characterization that offers insight into some of the less wel l-understood mechanistic aspects of stereoselective metal alkoxide-catal ysts ROP. UID:1DAE6D14-E94B-4FFA-8364-82943D1A66D6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070907T160000 DTSTAMP:20071119T202858Z SUMMARY:Friday Colloquium: Matthew G. Davidson\, Bath University\, UK. 4 :00 - 5:30\, MM 115. \"Development of Benign\, Stereoselective & Highly Active Initiators for the Ring-Opening Polymerization of Cyclic Esters.\ " Host: Paul Williard CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070907T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:ACB0C4A8-099D-11DA-B7FF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20051209T160000 DTSTAMP:20051109T223220Z SUMMARY:Friday Chemistry Colloquium: Joseph Fox\, University of Delaware . 4:00 - 5:30\, MM115. \"Strain as a Design Principle in Synthesis.\" Ho st: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20051209T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:E6AE7170-1A37-11DA-8520-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060317T160000 DTSTAMP:20060301T210332Z SUMMARY:Friday Chemistry Colloquium: Viresh Rawal\, University of Chicag o. 4:00 - 5:30\, MM 115. \"Asymmetric Catalysis of Chemical Reactions Pr omoted by Hydrogen Bond Activation.\" Host: William Trenkle. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060317T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: No abstract supplied. UID:43ED8F19-9D74-4091-8957-5C9AA46EDB27-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20070703T150000 DTSTAMP:20071119T202749Z SUMMARY:Inorganic Chemistry Seminar: Zhen Huang\, Georgia State Universi ty. \"Synthesis of Selenium-Derivatized Nucleic Acids for Structure & Fu nction Studies.\" 2:00 - 3:00\, GC 351. Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070703T160000 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:15E3C4DC-FF35-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20030919T160000 DTSTAMP:20031015T172933Z SUMMARY:Colloquium Speaker: Fred Wingerath CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20030919T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:2 TRANSP:OPAQUE UID:DBEB26A6-FF34-11D7-85EF-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20030912T160000 DTSTAMP:20031015T172809Z SUMMARY:Colloquium Speaker: Todd Lowary\, University of Alberta CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20030912T174500 END:VEVENT BEGIN:VEVENT SEQUENCE:4 TRANSP:OPAQUE UID:C91970B9-4793-4140-97A8-E45F8E1EEEAA-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20080920T131500 DTSTAMP:20080813T124716Z SUMMARY:Vincent D. Mattera\, PhD\, '84. Compound Semiconductor Group\, I I-VI Inc. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080920T134500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:164A6B14-C666-11DA-8C44-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20060425T120000 DTSTAMP:20060407T192402Z SUMMARY:Inorganic Seminar: Gregory Exarhos\, Pacific Northwest National Laboratory. 12noon - 1:00pm\, GC 351. Title to come. Host: William Risen . CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20060425T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:1 TRANSP:OPAQUE UID:A39E7328-70A1-11D9-BBAA-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20050404T160000 DTSTAMP:20050325T194226Z SUMMARY:Inorganic Seminar: Hideo Daimon\, Hitachi-Maxell. 2:00 - 3:00\, GC 351. \"Magnetic Alumite Films\, Protective Layer & Lubrication for Th in Film Media & Nano Particles.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20050404T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 TRANSP:OPAQUE UID:B2EB9AEF-8521-41C0-963B-CB608D63D301-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20081205T160000 DTSTAMP:20081204T211759Z SUMMARY:Friday Chemistry Colloquium: Daniel G. Nocera\, MIT. \"A Cheap\, Efficient & Highly Manufacturable Artificial Photosynthesis.\" Host: Eu nsuk Kim. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081205T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:EDE45EF8-8079-4267-A560-03C54265EA5B-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061128T163000 DTSTAMP:20061107T172642Z SUMMARY:Organic Faculty Candidate Research Seminar: Sarah Delaney\, MIT. 4:30 - 5:50\, MM115. \"Genetic Effects of Hyperoxidized DNA Lesions.\" Host: Christopher Seto. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061128T180000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:824EE665-C396-4892-993F-A8B12CB4E490-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20101105T160000 DTSTAMP:20100713T190417Z SUMMARY:Friday Chemistry Colloquium: John Helmann. Title & abstract to c ome. Host: Jason Sello. 4:00\, MM 115. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20101105T170000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Lectins (ConA and PNA) were conjugated to fluoresc ent silica nanoparticles through reaction between amine groups in the le ctins' lysine residues and carboxylic groups on the nanoparticles' surfa ce. Functionalized fluorescent silica nanopartciles (lectin-fNPs) show s ilimar activity as free lectins. ConA and PNA conjugated fluorescence si lica nanoparticles were tested for use in breast cancer diagnosis by sta ining breast tissue specimen of various malignant grades. ConA-fNPs asso ciated fluorescence increases as the cancerous grade goes higher\, which provides qualitative information about breast tissue upon the transform ation from healthy to cancerous status. Further\, ConA-fNPs and PNA-fNPs co-stain breast cancer tissue. This project could facilitate the develo pment of cancer diagnoses and prognoses based on tissue glycoprofiling. UID:910A9ACC-AF3E-480E-9056-5268D7764C16-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20081030T120000 DTSTAMP:20081017T163931Z SUMMARY:Inorganic Chemistry Seminar: Yaqi Wang\, Brown University. \"Lec tin Fluorescent Nanoparticles for Tissue Glycoprofiling.\" 12:00 -1:15\, GC 351. Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20081030T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: There are ~141 closed-shell neutral molecules\, ra dicals and ions that have been detected in the interstellar medium to da te. The identification of these molecules\, mostly by radio astronomy\, relies on ground-based laboratory production and spectroscopic detection of these species. One very powerful method for doing this is Fourier tr ansform microwave spectroscopy. Interstellar chemistry will be reviewed and the laboratory microwave spectroscopy of a “typical” radical will be discussed. UID:A61F60D8-9D0D-49CB-9A9E-761E3D8E73FE-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20080313T150000 DTSTAMP:20080307T214516Z SUMMARY:Physical Tea Session: Stewart Novick\, Wesleyan University. 3:00 \, GC 351. \"Laboratory Astrochemistry: High Resolution Spectroscopy of Radicals.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20080313T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:7 TRANSP:OPAQUE UID:A124B1E3-B380-4BFC-A063-651032718268-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20071030T110000 DTSTAMP:20071024T145149Z SUMMARY:Organic Seminar: Sarah O'Connor\, MIT. 11:00 - 12:30\, GC 351. \ "Alkaloid Biosynthesis in Periwinkle.\" Host: Jason Sello. (parking pass & directions sent 10/19) CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071030T123000 END:VEVENT BEGIN:VEVENT SEQUENCE:8 DESCRIPTION:Abstract: Carbon nanomaterials are currently making a transi tion from the laboratory to the marketplace in the form of commercial pr oducts that include electronic devices\, catalysts\, structural composit es\, antioxidants and drug delivery vehicles\, and this transition has r aised concerns about their potential health risks. Research in the field of nanotoxicology is underway\, but the early toxicity and biocompatibi lity data of carbon nanotubes are inconsistent and in some cases directl y conflicting\, and there is no consensus on the overall risk to human h ealth. The apparently conflicting observations are likely caused in part by the complex and multi-feature of carbon nanomaterials whose properti es vary according to source\, formulation and batch. This thesis examine s the relationship between material properties of nanoscale carbons and their environmental and biological effects. It investigates the underlyi ng mechanism through which those responses are triggered by individual m aterial features such as metal catalyst residues\, surface chemistry\, g eometry and biopersistence. Finally\, from the viewpoint of materials ch emistry\, the thesis suggests strategies to reduce carbon nanomaterials health risk through modification or control of these features\, such as metal removal\, surface modification\, size and length control and engin eered biodegradability. UID:57F0797E-81A3-42F2-B93D-C5684A56E7B1-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20100428T120000 DTSTAMP:20100421T164317Z SUMMARY:PhD Thesis Defense: Xinyuan Liu\, Brown University. Presiding Of ficer: Robert Hurt. \"Role of Materials Chemistry in the Biological Resp onse to Carbon Nanomaterials.\" GC 351\, 12:00. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20100428T140000 END:VEVENT BEGIN:VEVENT SEQUENCE:6 DESCRIPTION:ABSTRACT: There is a rapidly growing literature on the biolo gical interactions of carbon nanotubes (CNTs)\, but the toxicity data ar e inconsistent and in some cases directly conflicting\, and there is no consensus on the overall risk to human health. To resolve this issue\, f urther study is needed to understand the material features (size\, shape \, surface chemistry\, metals content) responsible for toxicity and samp le-to-sample variations. Some of the elements used in nanotube catalysts (Fe\, Ni\, Y\, Co\, Mo) are known from the metals industry to pose inha lation health risks. Nickel is an established human carcinogen that indu ces gene silencing and hypoxia signaling through mechanisms involving in tracellular nickel cation. It is unclear whether carbon nanotube catalys t residues can trigger these toxicity mechanisms due to apparent encapsu lation of the nickel by carbon shells. Here we show the toxicologically significant amounts of nickel can be mobilized into model physiological fluids from a range of commercial nanotube samples. We quantify the exte nt of Ni2+ mobilization as a function of pH\, dissolved oxygen\, dissolv ed salts\, and post-processing involving sonication\, oxidation\, and me chanical grinding. We also report on the intracellular uptake of CNT-nic kel by human lung epithelial cells to quantify its bioavailability relat ive to soluble NiCl2 as a known reference nickel source. These results s uggest practical methods for managing nickel residues to minimize nanotu be health risks. UID:93BBA156-1BF2-4665-A311-76F94CB35334-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20071004T120000 DTSTAMP:20071119T205702Z SUMMARY:Inorganic Seminar: Xinyuan Liu\, Brown University. 12:00 - 1:15\ , GC 351. \"Bioavailability of Nickel in Single-Wall Carbon Nanotubes.\" Host: Shouheng Sun. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20071004T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:C0DDD991-B959-4D8D-A365-B5945A589825-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061030T160000 DTSTAMP:20061024T182102Z SUMMARY:Organic Seminar: S. V. Eswaram\, St. Stephen's College\, Delhi\, India. 4:00 - 5:15\, GC 351. \"Natural Products and Microelectronics.\" Host: David Cane/Jason Sello. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061030T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:ED4C4B55-C654-4F7F-999C-3C4D35D200B9-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061116T150000 DTSTAMP:20061109T172431Z SUMMARY:Physical Chemistry Tea Session: Guohua Tao\, Brown University. 3 :00 - 4:15\, GC 351. \"Molecular Origins of Nonlinear Response in Liquid Dynamics.\" Host: Jimmie Doll. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061116T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:3 TRANSP:OPAQUE UID:2E87E55E-9342-11DA-93B9-0003937ED626-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061006T160000 DTSTAMP:20060926T150903Z SUMMARY:Friday Chemistry Colloquium: Blake Peterson\, Pennsylvania State University. 4:00 -5:30\, MM115. “Synthetic Mimics of Mammalian Cell Sur face Receptors: Prosthetic Molecules that Augment Living Cells.” Host: A mit Basu. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061006T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:8EE1E16D-A19B-415A-AF20-0991FCA0EAC6-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20070315T150000 DTSTAMP:20070119T210609Z SUMMARY:Physical Chemistry Tea Session: Baofeng Zhang\, Brown University . 3:00 - 4:15\, GC 351. Title to come. Host: Jimmie Doll CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20070315T161500 END:VEVENT BEGIN:VEVENT SEQUENCE:5 TRANSP:OPAQUE UID:C3B4304D-C898-4C9F-87DF-416C2636BFA4-D6C8F81D-94DA-4744-95DE-68624A6 7D031 DTSTART;TZID=US/Eastern:20061026T120000 DTSTAMP:20061019T203505Z SUMMARY:Inorganic Seminar: Jin Xie\, Brown University. 12:00 -1:15\, GC 351. \"Synthesis\, Characterization & Modification of FeM2O4 (M=Fe\,Mn\, Co) Nanoparticles with Potential Application in DNA Sequence Detection.\ " Host: Shuangbing Han CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20061026T131500 END:VEVENT BEGIN:VEVENT SEQUENCE:9 DESCRIPTION:Abstract: Discussion about the role of coherence in biologic ally relevant excitation energy transfer in multi-chromophoric aggregate s\, which was started by recent advances in non-linear spectroscopy [1]\ , raises fundamental questions about the validity of our understanding o f primary processes in photosynthesis. In Ref. [1]\, surprisingly long l iving oscillations in two-dimensional (2D) Fourier transformed photon ec ho spectrum were observed for photosynthetic protein-chromophore complex FMO. These oscillations predicted earlier theoretically [2] were assign ed to the presence of electronic coherence. Moreover\, signs of coherenc e transfer were demonstrated by the same experiment in energy transfer d ynamics of the complex. The conclusion was made that the energy transfer proceeds in a wavelike coherent fashion (as opposed to the incoherent h opping) and it was suggested that quantum entanglement plays a role in i ncreasing energy transfer efficiency [1].\n \nI will discuss the role of various types of coherence in the dynamics of photo-excited molecular systems. I will demonstrate that coherence transfer has non-trivial con sequences for interpretation of even the simplest spectroscopic measurem ent - linear absorption [3]. I will analyze the origin of coherent oscil lations in 2D spectra and their relation to the dynamics of excited stat es of molecular aggregates and the dynamics of intra-molecular vibration s in small molecules. This analysis shows that vibrational coherence can be experimentally excluded as a source of the oscillations in FMO [4]. I will compare several relaxation theories and identify the second order non-Markovian quantum master equation the simplest theoretical descript ion where the dynamics of the system exhibits both comparatively long li ving coherences and significant coherence transfer within the range of p arameters relevant to photosynthetic systems. The results suggest that l ong living coherences are closely linked with non-Markovian memory effec ts in protein-chromophore interaction. Finally\, I will address the ques tion of non-trivial role of quantum effects in excitation energy transfe r by constructing a reference model of the aggregates that is completely classic. This classic model exhibits many effects usually associated wi th quantum nature of molecular aggregates\, and can be used as benchmark for identification of non-trivial quantum effects. \n\nReferences:\n[1] G. S. Engel\, T. R. Calhoun\, E. L. Read\, T.-K. Ahn\, T. Mančal\, Y.-C . Cheng\, R. E. Blankenship and G. R. Fleming\, Nature 446 (2007) 782\n[ 2] A. V. Pisliakov\, T. Mančal and G. R. Fleming\, J. Chem. Phys. 124 (2 006) 234505\n[3] T. Mančal\, L. Valkunas and G. R. Fleming\, Chem. Phys. Lett. 432 (2006) 301\n[4] A. Nemeth\, F. Milota\, T. Mančal\, V. Lukeš\ , H. Kauffmann\, and J. Sperling\, Chem. Phys. Lett. 459 (2008) 94\n UID:5795AE65-82F6-4FA9-BD59-8C29546C1B3E-D6C8F81D-94DA-4744-95DE-68624A6 7D031 TRANSP:OPAQUE DTSTART;TZID=US/Eastern:20090904T160000 DTSTAMP:20090817T161212Z SUMMARY:Friday Colloquium: Tomas Mancal\, Charles University in Prague\, Czech Republic. \"The Role of Coherence in Photosynthetic Energy Transf er.\" Host: Vlastimil Fidler. 4:00\, GC 351. CREATED:20100714T131812Z DTEND;TZID=US/Eastern:20090904T173000 END:VEVENT BEGIN:VEVENT SEQUENCE:7 DESCRIPTION:Abstract: Bacteria of the genus Streptomyces are famous as p roducers of a diverse array of antibiotic molecules. Antibiotic producti on is intimately linked to the organisms' complex life cycle\, which cul minates in sporulation. This presentation will focus on the proteomic co nsequences of SigU activity\, a protein involved in gene transcription w hose unregulated activity leads to defects in both sporulation and polyk etide antibiotic production. UID:C478EAFE-636